Hashimoto Takeshi

Faculty
Faculty of Medicine
School of Medicine
PositionAssistant Professor
Last Updated :2022/08/10

Researcher Profile and Settings

Education

  •  - 2004 , Osaka University, Graduate School, Division of Medical Sciences
  •  - 2004 , Osaka University

Degree

  • 修士(保健学), 大阪大学
  • 博士(保健学), 大阪大学

Association Memberships

  • 日本肥満学会
  • 日本薬理学会
  • 日本生理学会
  • The Japanese Pharmacological Society
  • The Physiological Society of Japan

Committee Memberships

  •   2014 03  - 現在, 日本生理学会, 評議員

Academic & Professional Experience

  •   2013 , - 香川大学自然生命科学系, 助教
  •   2011 , - 香川大学医学研究院, 助教
  •   2007 , - 香川大学医学部形態・機能医学講座 自律機能生理学, 助教
  •   2004 , - 香川大学医学部形態・機能医学講座 自律機能生理学, 助手

Research Activities

Research Areas

  • Life sciences / Metabolism and endocrinology
  • Life sciences / Pharmacology
  • Life sciences / Clinical pharmacy
  • Life sciences / Physiology

Research Interests

    obesity, adipose tissue, adipocyte, adipogenesis, Sphingosine Kinase, S1P, physiology, obesity, adipose tissue, adipocyte, adipogenesis, Sphingosine Kinase, S1P, physiology

Published Papers

  • Coagulation factor XI induced Ca2+ response and cell migration in vascular smooth muscle cells, Liu Wenhua, HASHIMOTO Takeshi, YAMASHITA TETSUO, HIRANO Katsuya, The Jpurnal of Physiological Sciences, 68,   2018 03 , [査読有り]
  • NAD(P)H and low ionic strength suppresses dissociation of apoptosis-inducing factor from E. coli membrane, YAMASHITA TETSUO, MATSUMOTO Kan, HASHIMOTO Takeshi, IGARASHI Junsuke, KOSAKA Hiroaki, HIRANO Katsuya, The Journal of Physiological Sciences, 67,   2017 03 , [査読有り]
  • Coagulation factor XIa induces Ca2+ influx via L-type Ca2+ channel in vescular smooth muscle cells, LIU Wenhua, HASHIMOTO Takeshi, YAMASHITA TETSUO, IGARASHI Junsuke, HIRANO Katsuya, The Journal of Physiological Sciences, 67,   2017 03 , [査読有り]
  • Mifepristone, a stroid receptor antagonist, induces hepatic steatosis in association with upregulation of resistin expression in liver, HASHIMOTO Takeshi, IGARASHI Junsuke, YAMASHITA TETSUO, HIRANO Katsuya, The Journal of Physiological Sciences, 67,   2017 03 , [査読有り]
  • A novel angiogenic agent COA-Cl promotes VEGF secretion from mouse C2C12 steletal myocytes via the activation of cAMP/PKA/CREB/PGC-1a signaling axia, IGARASHI Junsuke, Ryouji Okamoto, HASHIMOTO Takeshi, YAMASHITA TETSUO, KUBOTA Yasuo, TSUKAMOTO Ikuko, Sakakibara Norikazu, KONISHI Ryoji, HIRANO Katsuya, The Journal of Physiological Sciences, 67,   2017 03 , [査読有り]
  • Increase in tumor suppressor Arf compensates gene dysregulation in in vitro aged adipocytes, Arif U. Hasan, Koji Ohmori, Takeshi Hashimoto, Kazuyo Kamitori, Fuminori Yamaguchi, Kumi Konishi, Takahisa Noma, Junsuke Igarashi, Tetsuo Yamashita, Katsuya Hirano, Masaaki Tokuda, Tetsuo Minamino, Akira Nishiyama, Masakazu Kohno, BIOGERONTOLOGY, 18, (1) 55 - 68,   2017 02 , [Refereed]
  • G Protein-Coupled Receptor 87 (GPR87) Promotes Cell Proliferation in Human Bladder Cancer Cells, Zhang X, Liu D, Hayashida Yushi, Okazoe H, Hashimoto T, Ueda N, Sugimoto M, Kakehi Y(Zhang Xia, Liu Dage, Hayashida Yushi, Okazoe H, HASHIMOTO Takeshi, Ueda N, Sugimoto M, Kakehi Y, Int J Mol Sci., 14,   2015 10 , [Refereed]
  • Eicosapentaenoic acid upregulates VEGF-A through both GPR120 and PPAR gamma mediated pathways in 3T3-L1 adipocytes, Arif U. Hasan, Koji Ohmori, Kumi Konishi, Junsuke Igarashi, Takeshi Hashimoto, Kazuyo Kamitori, Fuminori Yamaguchi, Ikuko Tsukamoto, Toru Uyama, Yasuhiro Ishihara, Takahisa Noma, Masaaki Tokuda, Masakazu Kohno, MOLECULAR AND CELLULAR ENDOCRINOLOGY, 406, (C) 10 - 18,   2015 05 , [Refereed]
  • A novel angiogenic agent COA-Cl induced PGC-1alpha-mediated VEGF production in cultured human fibroblasts, OKAMOTO RYUJI, IGARASHI Junsuke, YAMASHITA TETSUO, HASHIMOTO Takeshi, SHOJI KAZUYO, KUBOTA Yasuo, TAKATA MAKI, TSUKAMOTO Ikuko, HIRANO Katsuya, The Journal of Physiological Sciences, 65,   2015 03 , [Refereed]
  • COA-Cl-induced adipogenesis is associated with an increased cell cycle progression and down-regulation of p27Kip1 in mouse pre-adipocyte 3T3L1 cells, HASHIMOTO Takeshi, IGARASHI Junsuke, TSUKAMOTO Ikuko, YAMASHITA TETSUO, HIRANO Katsuya, The Journal of Physiological Sciences, 65,   2015 03 , [Refereed]
  • Analysis of the binding mode of AIF to the membrane, 山下哲生, HASHIMOTO Takeshi, IGARASHI Junsuke, KOSAKA Hiroaki, 64,   2014 03 , [Refereed]
  • Mifepristone induces non-obese non-alcoholic fatty liver disease., Hashimoto T, Igarashi J, 山下哲生, 小坂博昭, 124,   2014 03 , [Refereed]
  • Thr239 suppresses ROS production in yeast mitochondrial NADH dehydrogenase (NDH-2), 山下哲生, HASHIMOTO Takeshi, IGARASHI Junsuke, KOSAKA Hiroaki, The Journal of Physiological Sciences, 63,   2013 03 , [Refereed]
  • Mifepristone increases anti-inflammatory M2 macrophages in obese adipose tissues, Hashimoto T, Igarashi J, Yamashita T, Kosaka H, The Journal of Physiological Sciences, 63,   2013 03 , [Refereed]
  • Valsartan ameliorates constitutive adipokine expression pattern in mature adipocytes, Arif U, Hasan, Koji Ohmori, Takeshi Hashimoto, Kazuyo Kamitori, Fuminori Yamaguchi, Yasuhiro Ishihara, Naoko Ishihara, Takahisa Noma, 徳田雅明, Masakazu Kohno, Hypertension Research,   2013 , [Refereed]
  • Mifepristoneは脂肪組織中のM2マクロファージを増加させる, 橋本剛, 五十嵐淳介, Arif U Hasan, 大森浩二, 山下哲生, 河野雅和, 小坂博昭, Journal of Japan Society for the Study of Obesity, 18(suppl),   2012 09
  • Mechanism of ROS suppression in yeast single subunit NADH-ubiquinone oxidoreductase (Ndi1), YAMASHITA TETSUO, HASHIMOTO Takeshi, IGARASHI Junsuke, KOSAKA Hiroaki, The Journal of Physiological Sciences, 62,   2012 03 , [査読有り]
  • RU486(Mifepristone) improved Diet-induced insulin resistance by increasing blood level of adiponectin, Hashimoto T, Igarashi J, Arif U Hasan, 永井由紀子, 山下哲生, 小坂博昭, 118,   2012 03 , [Refereed]
  • RU486 (Mifepristone) enhances adiponectin secretion from matured adipocytes, Hashimoto T, Igarashi J, Arif U Hasan, 永井由紀子, Yamashita T, Kosaka H, The Journal of Physiological Sciences, 62(Suppl),   2012 03 , [Refereed]
  • RU486(Mifepristone)によるインスリン抵抗性の改善, 橋本剛, 五十嵐淳介, Arif U Hasan, 永井由紀子, 山下哲生, 小坂博昭, Journal of Japan Society for the Study of Obesity, 17(suppl),   2011 09 , [査読有り]
  • Pioglitazone promotes preadipocyte proliferation by downregulating p 16(ink4a), Hasan AU, 大森浩二, Hashimoto T, Kamitori K, Hirata Y, Ishihara Y, Okamoto N, Noma T, Kosaka H, Tokuda M, Kohno M, Biochem Biophys Res Commun., 411,   2011 07 , [査読有り]
  • New insight into mechanism of ROS suppression in single subunit NADH-ibiquinone oxidoreductase (Ndi1) from Saccharomyces cerevisiae, YAMASHITA TETSUO, Yu Yang, Eiko Nakamaru-Ogiso, HASHIMOTO Takeshi, Masatoshi Murai, IGARASHI Junsuke, Hideto Miyoshi, Akemi Matsuno-Yagi, Takao Yagi, KOSAKA Hiroaki, The Journal of Physiological Sciences, 61,   2011 03 , [査読有り]
  • Enhancement of adipogenesis induced by RU486(Mifepristone) is associated with perturbed expression patterns of cell-cycle proteins, p27kip, and Cyclin B1/D1/E., Hashimoto T, Igarashi J, 永井由紀子, 山下哲生, 小坂博昭, Journal of Pharmacological Sciences, 115,   2011 , [Refereed]
  • RU486 (Mifepristone) enhances adipogenesis pathways to cyclin-dependent kinase inhibitor, p27kip., Hashimoto T, Igarashi J, Nagai Y, Yamashita T, Kosaka H, The Journal of Physiological Sciences, 61,   2011 , [Refereed]
  • RU486(Mifepristone), Progesterone/Glucocorticoid receptor antagonist, enhances adipogenesis, Hashimoto T, Igarashi J, 永井由紀子, 山下哲生, 小坂博昭, Journal of Pharmacological Sciences, 112,   2010 , [Refereed]
  • Sphingosine Kinase-1, an S1P-producing enzyme, promotes adipogenesis, Hashimoto T, Igarashi J, Kosaka H, Journal of Pharmacological Sciences, 106,   2008 , [Refereed]
  • Sphingosine Kinase-1, an S1P-producing enzyme, promotes adipogenesis, Hashimoto T, Igarashi J, Kosaka H, The Journal of Physiological Sciences, 57,   2007 , [Refereed]
  • Efficient Synthesis of trans- or cis-4(5)-(5-Aminomethyltetrahydrofuran-2- yl)imidazoles via Diazafulvene Intermediates: Synthetic Approach toward Human Histamine H(4)-Ligands., Harusawa Shinya, Araki Lisa, Terashima H, Kawamura Makoto, Takashima Seiichiro, Sakamoto Yasuyuki, Hashimoto Takeshi, Yamamoto Yumiko, Yamatodani Atsushi, Kurihara Takushi, Chem Pharm Bull (Tokyo), 51, (7) 832 - 837,   2003 , [Refereed]
  • Possible involvement of the chorda tympani nerve in stimulation of the histaminergic system by leptin, Morimoto-Ishizuka T, Yada T, Yamamoto Yumiko, Yamamoto Kouichi, Hashimoto Takeshi, Yamatodani Atsushi, Inflammation Research, 51,   2002 , [Refereed]
  • Involvement of S1P1 receptor pathway in angiogenic effects of a novel adenosine-like nucleic acid analog COA-Cl in cultured human vascular endothelial cells, Junsuke Igarashi, Takeshi Hashimoto, Yasuo Kubota, Kazuyo Shoji, Tokumi Maruyama, Norikazu Sakakibara, Yoh Takuwa, Yoshihiro Ujihara, Yuki Katanosaka, Satoshi Mohri, Keiji Naruse, Tetsuo Yamashita, Ryuji Okamoto, Katsuya Hirano, Hiroaki Kosaka, Maki Takata, Ryoji Konishi, Ikuko Tsukamoto, Pharmacology Research and Perspectives, 2,   2014 10 01 , [Refereed]
  • Mifepristone Promotes Adiponectin Production and Improves Insulin Sensitivity in a Mouse Model of Diet-Induced-Obesity, Takeshi Hashimoto, Junsuke Igarashi, Arif U. Hasan, Koji Ohmori, Masakazu Kohno, Yukiko Nagai, Tetsuo Yamashita, Hiroaki Kosaka, PLOS ONE, 8,   2013 11 , [Refereed]
  • Dexamethasone induces caveolin-1 in vascular endothelial cells: Implications for attenuated responses to VEGF, Junsuke Igarashi, Takeshi Hashimoto, Kazuyo Shoji, Kozo Yoneda, Ikuko Tsukamoto, Tetsuya Moriue, Yasuo Kubota, Hiroaki Kosaka, American Journal of Physiology - Cell Physiology, 304, (8) C790 - C800,   2013 04 15 , [Refereed]
  • Transforming growth factor-beta 1 downregulates caveolin-1 expression and enhances sphingosine 1-phosphate signaling in cultured vascular endothelial cells, Junsuke Igarashi, Kazuyo Shoji, Takeshi Hashimoto, Tetsuya Moriue, Kozo Yoneda, Tomoko Takamura, Tetsuo Yamashita, Yasuo Kubota, Hiroaki Kosaka, AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY, 297, (5) C1263 - C1274,   2009 11 , [Refereed]
  • Sphingosine kinase is induced in mouse 3T3-L1 cells and promotes adipogenesis, Takeshi Hashimoto, Junsuke Igarashi, Hiroaki Kosaka, JOURNAL OF LIPID RESEARCH, 50, (4) 602 - 610,   2009 04 , [Refereed]
  • Hydrogen peroxide induces S1P(1) receptors and sensitizes vascular endothelial cells to sphingosine 1-phosphate, a platelet-derived lipid mediator, Junsuke Igarashi, Megumi Miyoshi, Takeshi Hashimoto, Yasuo Kubota, Hiroaki Kosaka, AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY, 292, (2) C740 - C748,   2007 02 , [Refereed]
  • Statins induce S1P(1) receptors and enhance endothelial nitric oxide production in response to high-density lipoproteins, J. Igarashi, M. Miyoshi, T. Hashimoto, Y. Kubota, H. Kosaka, BRITISH JOURNAL OF PHARMACOLOGY, 150, (4) 470 - 479,   2007 02 , [Refereed]
  • N-substituted piperidinyl alkyl imidazoles: Discovery of methimepip as a potent and selective histamine H-3 receptor agonist, R Kitbunnadaj, T Hashimoto, E Poli, OP Zuiderveld, A Menozzi, R Hidaka, IJP de Esch, RA Bakker, WMPB Menge, A Yamatodani, G Coruzzi, H Timmerman, R Leurs, JOURNAL OF MEDICINAL CHEMISTRY, 48, (6) 2100 - 2107,   2005 03 , [Refereed]
  • Formation of two 4-imidazolylmethylphosphonium salts and their synthetic studies toward histamine H-3-ligands, S Harusawa, M Kawamura, S Koyabu, T Hosokawa, L Araki, Y Sakamoto, T Hashimoto, Y Yamamoto, A Yamatodani, T Kurihara, SYNTHESIS-STUTTGART, (18) 2844 - 2850,   2003 12 , [Refereed]
  • A selective human H-4-receptor agonist: (-)-2-cyano-1-methyl-3-{(2R,5R)-5-[1H-imidazol-4(5)-yl]tetrahydrofuran-2-yl}methylguanidine, T Hashimoto, S Harusawa, L Araki, OP Zuiderveld, MJ Smit, T Imazu, S Takashima, Y Yamamoto, Y Sakamoto, T Kurihara, R Leurs, RA Bakker, A Yamatodani, JOURNAL OF MEDICINAL CHEMISTRY, 46, (14) 3162 - 3165,   2003 07 , [Refereed]
  • Constitutive activity of histamine H-3 receptors stably expressed in SK-N-MC cells: Display of agonism and inverse agonism by H-3 antagonists, K Wieland, G Bongers, Y Yamamoto, T Hashimoto, A Yamatodani, WMBP Menge, H Timmerman, TW Lovenberg, R Leurs, JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 299, (3) 908 - 914,   2001 12 , [Refereed]
  • A possible involvement of the chorda tympani in the enhancement of the hypothalamic histamine release by leptin, T Morimoto-Ishizuka, Y Yamamoto, K Yamamoto, T Hashimoto, A Yamatodani, HISTAMINE RESEARCH IN THE NEW MILLENNIUM, 1224,   2001
  • Structure-activity relationship of histamine H-3-ligands: Organic synthesis of imidazole C-nucleoside derivatives, S Harusawa, T Imazu, S Takashima, L Araki, H Ohishi, T Kurihara, Y Sakamoto, Y Yamamoto, T Hashimoto, A Yamatodani, HISTAMINE RESEARCH IN THE NEW MILLENNIUM, 1224,   2001

Books etc

  • 最新医学大辞典第3版, 医歯薬出版株式会社,   2005
  • ○×問題でマスター薬理学, 医歯薬出版株式会社,   2004
  • MEDICAL DICTIONARY, 医歯薬出版株式会社,   2005
  • ○×問題でマスター薬理学, 医歯薬出版株式会社,   2004

Conference Activities & Talks

  • Mifepristoneは非肥満非アルコール性脂肪肝を発症する, 第87回日本薬理学会,   2014
  • アディポネクチン分泌促進能を有するMifepristoneの脂肪細胞分化への関与, 第91回日本生理学会,   2014
  • Mifepristoneは脂肪組織中の抗炎症性M2マクロファージを増加させる, 第90回日本生理学会,   2013
  • RU486 (Mifepristone)は脂肪細胞からのアディポネクチン分泌を促進させる, 第89回日本生理学会,   2012
  • RU486:Mifepristoneは血中アディポネクチンを増加させインスリン抵抗性を改善させる, 第85回日本薬理学会,   2012
  • RU486:Mifepristoneはp27(Kip1)の発現レベルを調節することで脂肪細胞への分化能に影響する, 第84回日本薬理学会,   2011
  • RU486 (Mifepristone)はサイクリン依存性キナーゼ阻害因子p27kipの発現抑制することで脂肪生成能を増強する, 第88回日本生理学会,   2011
  • RU486(Mifepristone)によるインスリン抵抗性の改善, 第32回日本肥満学会,   2011
  • Pioglitazone links PPARg dependent adipogenesis pathways to tumor suppressor p53 pathways through p16, The 3rd Joint Symposium between CMU and KU,   2010
  • PPAR-gamma enhances adipogenesis by down-regulating a cell cycle inhibitor, p16INK4a, in adipocytes, European Society of Cardiology Congress 2010,   2010

Research Grants & Projects

  • トロンビン受容体を標的とした新たなインスリン抵抗性改善策の開発, 日本学術振興会, 基盤研究(C),   2019 04  - 2021 03
  • 新たな非肥満非アルコール性脂肪肝モデル動物の開発と脂肪肝改善法確立, 日本学術振興会, 基盤研究(C),   2017 04  - 2019 03
  • サイトカインTGF1による血管成熟化機構-VEGFR2とのクロストーク-, 日本学術振興会, 基盤研究(C),   2013 04  - 2015 03
  • 脂肪組織におけるグルココルチコイドとスフィンゴ脂質分子群とのクロストークの解明, 日本学術振興会, 若手研究(B),   2013 04  - 2015 03
  • 虚血心筋における脂質メディエータースフィンゴシン1リン酸(S1P)の機能解析, 日本学術振興会, 基盤研究(C),   2009 04  - 2011 03
  • 脂肪細胞のライフサイクルにおけるスフィンゴシン1-リン酸(S1P)とS1P受容体の生理的メカニズムの解明, 日本学術振興会, 若手研究(B),   2007 04  - 2009 03
  • Elucidation of physiological roles of sphingosine 1-phosphate and its receptors in adipose tissue,   2004  - 2006


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