Hirano Katsuya

Faculty
Faculty of Medicine
School of Medicine
PositionProfessor
Last Updated :2022/08/10

Researcher Profile and Settings

Profile & Settings

    Research funding number:80291516
    ORCID ID:0000-0003-0164-1283

Education

  •   1991 07 , Kyushu University
  •   1979 04  - 1985 03 , Kyushu University, Facultyof Medicine

Degree

  • M. D., Ph.D., Kyushu University

Association Memberships

  • 日本循環薬理学会
  • 日本病態生理学会
  • 国際心臓研究学会
  • 日本平滑筋学会
  • 日本心脈管作動物質学会
  • 日本生理学会
  • 日本分子生物学会
  • 日本内科学会
  • 日本循環器学会
  • American Heart Association
  • 日本薬理学会

Committee Memberships

  •   2020 03  - 現在, Physiological Society of Japan, Vice President
  •   2019 11  - 現在, Physiological Society of Japan, member of the committee for meetings
  •   2018 03  - 現在, 日本生理学会, 理事
  •   2018 03  - 現在, Physiological Society of Japan, Member of the committee for Awards
  •   2016 08  - 現在, Japan Society of Smooth Muscle Research, Board member
  •   2016 08  - 現在, Japan Society of Smooth Muscle Research, Member of the committee for Academic Program
  •   2016 08  - 現在, Japan Society of Smooth Muscle Research, Member of the committee for Publications
  •   2016 08  - 現在, Japan Society of Smooth Muscle Research, Member of the committee for Future planning
  •   2016 04  - 現在, 香川大学医師会, 香川大学医師会理事, 理事
  •   2015 02  - 現在, Japanese Society of Circulation Research, Board member
  •   2014 11  - 現在, Frontiers in Cardiovascular Medicine, Frontiers in Cardiovascular Medicine, Review editor, Review editor
  •   2014 06  - 現在, Japanese Pharmacological Society, Editorial adviser of Journal of Pharmacological Sciences
  •   2014  - 現在, 日本病態生理学会, 評議員
  •   2013 10  - 現在, American Heart Association (米国心臓協会), Fellow of American Heart Association (FAHA)
  •   2013 07  - 現在, International Society of Heart Research, Japan Section, Council member
  •   2013 04  - 現在, 日本生理学会, 評議員
  •   2013  - 現在, Japan Society of Smooth Muscle Research, Council member
  •   2012 04  - 現在, Physiological Society of Japan, Member of the committee for Publications and Public Relations
  •   2010 11  - 現在, Frontiers in Integrative and Regenerative Pharmacology, Frontiers in Integrative and Regenerative Pharmacology, Review editor
  •   2010 02  - 現在, 日本心脈管作動物質学会, 評議員
  •   1998 04  - 現在, 日本薬理学会, 学術評議員
  •   2020 08  - 2021 08 , Japan Society of Smooth Muscle Research, The president of the 63rd Annual Meeting of Japan Society of Smooth Muscle Research
  •   2019 08  - 2020 08 , 日本平滑筋学会, 第62回総会副会長
  •   2016 11  - 2018 03 , Physiological Society of Japan, 95th Annual Meeting of the Physiological Society of Japan
  •   2018 03 , 第95回日本生理学会大会, 第95回日本生理学会大会企画シンポジウム「平滑筋生理学から病態生理学へのトランスレーション(Translation from smooth muscle physiology to pathophysiology)」
  •   2015 06  - 2017 06 , Pulmonary Vascular Research Institute, Pulmonary Circulation, Editorial board
  •   2014 02  - 2015 02 , 日本心脈管作動物質学会, 第44回年会長
  •   2014 11  - 2014 11 , 日本生理学会, 第66回中国四国地方会 世話人
  •   2012 10  - 2014 10 , 日本薬理学会, 代議員
  •   2012 06  - 2014 04 , 日本薬理学会, Journal of Pharmacological Sciences誌Editorial Advisor
  •   2008 10  - 2010 10 , 日本薬理学会, 代議員
  •   2008 06  - 2010 06 , 日本薬理学会, Journal of Pharmacological Sciences誌Editorial Advisor
  •   2006 06  - 2008 06 , 日本薬理学会, Journal of Pharmacological Sciences誌Editorial Advisor
  •   2004 10  - 2006 10 , 日本薬理学会, 代議員
  •   1998 12  - 1999 12 , International Society of Heart Research, Japan Section, Secretary general, the 16th Annual Meeting of Japanese section of International Society of Heart Research

Academic & Professional Experience

  •   2014 04 , Kagawa University, Faculty of Medicine, Department of Cardiovascular Physiology, Professor
  •   2006 08 ,  - 2014 03 , Kyushu University, Graduate School of Medicine, Department of Molecular Cardiology, Associate Professor
  •   2000 04 ,  - 2006 07 , Kyushu University, Graduate School of Medicine, Department of Molecular Cardiology, Assistant professor, Lecturer
  •   1999 04 ,  - 2000 03 , Kyushu University, Graduate School of Medicine, Department of Molecular Cardiology, Assistant professor, Lecturer
  •   1996 11 ,  - 1999 03 , Kyushu University, Faculty of Medicine, Department of Molecular Cardiology, Assistant professor, Lecturer
  •   1993 09 ,  - 1996 11 , University of Arizona, Tucson, AZ, USA, Department of Physiology, Biochemistry, Animal Sciences; Muscle Biology Group, Assistant Research Scientist
  •   1990 10 ,  - 1993 08 , University of Arizona, Tucson, AZ, USA, Department of Physiology, Biochemistry, Animal Sciences; Muscle Biology Group, Research Associate
  •   1987 06 ,  - 1990 10 , Kyushu University, Graduate School of Medicine, Department of Molecular Cardiology, Research fellow (thesis work)
  •   1985 06 ,  - 1987 05 , Kyushu University Hosptical, Department of Cardiovascular Medicine, Resident

Research Activities

Research Areas

  • Life sciences / Cardiology
  • Life sciences / Pharmacology
  • Life sciences / Physiology

Research Interests

    細胞内シグナル伝達, 循環器, 病態生理学, 生理学, Intracellular signal transduction, Cardiovascular system, Pathophysiology, Physiology

Published Papers

  • Pro-arrhythmic signaling of thyroid hormones and its relevance in subclinical hyperthyroidism, Tribulova N, Kurahara LH, Hlivak P, Hirano K, Bacova BS, Int J Mol Sci, 21,   2020 04 , [Refereed]
  • Proteinase-activated receptor 1 antagonism ameliorates experimental pulmonary hypertension, Kuwabara Y, Tanaka M, Abe K, Hirano M, Hirooka Y, Tsutsui H, Sunagawa K, Hirano K, Cadiovasc Res, 115, (8) 1357 - 1368,   2019 07 , [Refereed]
  • 血液凝固第XI因子の血管機能調節因子としての新たな機能の発見, 劉 文華, 橋本 剛, 山下 哲生, 平野 勝也, 日本生理学雑誌, 81, (2) 35 - 35,   2019 05
  • Involvement of different receptor subtypes in prostaglandin E2-induced contractionand relaxation in the lower esophageal sphincter and esophageal body, Bai X, Ihara E, Otsuka Y, Tsuruta S, Hirano K, Tanaka Y, Ogino H, Hirano M, Chinen T, Akiho H, Nakamura K, Oda Y, Ogawa Y, Eur J Pharmacol, 857,   2019 05 , [Refereed]
  • COA-Cl prevented TGF-beta1-induced CTGF expression by Akt dephosphorylation in normal human dermal fibroblasts, and it attenuated skin fibrosis in mice models of systemic sclerosis, Nakai K, Karita S, Igarashi J, Tsukamoto I, Hirano K, Kubota Y, J Dermatol Sci, 94, (1) 205 - 212,   2019 04 , [Refereed]
  • Coagulation factor XI induces Ca2+ response and accelerates cell migration in vascular smooth muscle cells via proteinase-activated receptor 1, Liu W, Hashimoto T, Yamashita T, Hirano K, Am J Physiol Cell Physiol, 316, (3) C377 - C392,   2019 03 , [Refereed]
  • 血管平滑筋細胞において凝固第XI因子はトロンビン受容体PAR1を活性化し、細胞内Ca2+シグナルを発生させ、細胞遊走を促進する, 平野 勝也, 劉 文華, 橋本 剛, 山下 哲生, 血管, 42, (1) 54 - 54,   2019 01
  • Proteinase-activated receptor 1 (PAR1)-mediated cellular effects of coagulation factor XI in vascular smooth muscle cells, Hirano Katsuya, Liu Wenhua, Hiashimoto Takeshi, Yamashita Tetsuo, Proceedings for Annual Meeting of The Japanese Pharmacological Society, 92,   2019
  • 新規競合阻害剤および混合型阻害剤との共結晶構造解析による酵母Type II NADH脱水素酵素Ndi1におけるユビキノン結合部位の同定, 山下 哲生, 稲岡 健ダニエル, 志波 智生, 大橋 拓未, 岩田 想, 矢木 隆雄, 小坂 博昭, 三芳 秀人, 原田 繁春, 北 潔, 平野 勝也, 日本生化学会大会プログラム・講演要旨集, 91回,   2018 09
  • 嫌気条件とNAD(P)HはApoptosis-inducing factorの大腸菌膜からの解離を抑制する, 山下 哲生, 松本 感, 橋本 剛, 五十嵐 淳介, 小坂 博昭, 平野 勝也, 日本生理学雑誌, 80, (3) 36 - 36,   2018 08
  • 血液凝固第XI因子が引き起こす血管平滑筋細胞のCa2+シグナルの発生メカニズムの解明, 劉 文華, 橋本 剛, 山下 哲生, 平野 勝也, 日本生理学雑誌, 80, (3) 37 - 37,   2018 08
  • 血液凝固第XI因子は電位作動性Ca2+チャネルを介して血管平滑筋細胞にCa2+シグナルを発生させる, 平野 勝也, 劉 文華, 橋本 剛, 山下 哲生, 血管, 41, (1) 37 - 37,   2018 01
  • Apoptosis-inducing factorと大腸菌膜との相互作用の解析, 松本 感, 山下 哲生, 橋本 剛, 五十嵐 淳介, 小坂 博昭, 平野 勝也, 日本生理学雑誌, 79, (1) 43 - 44,   2017 02
  • Increase in tumor suppressor Arf compensates gene dysregulation in in vitro aged adipocytes, Arif U. Hasan, Koji Ohmori, Takeshi Hashimoto, Kazuyo Kamitori, Fuminori Yamaguchi, Kumi Konishi, Takahisa Noma, Junsuke Igarashi, Tetsuo Yamashita, Katsuya Hirano, Masaaki Tokuda, Tetsuo Minamino, Akira Nishiyama, Masakazu Kohno, BIOGERONTOLOGY, 18, (1) 55 - 68,   2017 02 , [Refereed]
  • 凝固第XI因子が引き起こす血管平滑筋細胞のカルシウムシグナル伝達, 平野 勝也, 劉 文華, 橋本 剛, 山下 哲生, 五十嵐 淳介, 血管, 40, (1) 40 - 40,   2017 01
  • 肺循環薬理学研究の最前線 序文, 平野勝也, 山村 彩, 日本薬理学雑誌, 148,   2016 11
  • Role of microvasculature in regulation of coronary blood flow, 平野勝也, 74,   2016 06
  • A key role of PGC-1α transcriptional coactivator in production of VEGF by a novel angiogenic agent COA-Cl in cultured human fibroblasts., Junsuke Igarashi, Ryuji Okamoto, Tetsuo Yamashita, Takeshi Hashimoto, Sakiko Karita, Kozo Nakai, Yasuo Kubota, Maki Takata, Fuminori Yamaguchi, Masaaki Tokuda, Norikazu Sakakibara, Ikuko Tsukamoto, Ryoji Konishi, Katsuya Hirano, Physiological reports, 4, (6) e12742 - 10,   2016 03 , [Refereed]
  • 新規アデノシン類似化合物COA-CI(コアクロル)はcAMP/CREB/PGC-1αの経路を介して血管内皮成長因子(VEGF)の産生を促進する, 岡本 隆司, 五十嵐 淳介, 橋本 剛, 山下 哲生, 苅田 咲子, 窪田 泰夫, 高田 麻紀, 小西 良士, 塚本 郁子, 平野 勝也, 日本生理学雑誌, 78, (1) 4 - 4,   2016 01
  • 新規アデノシン類似化合物COA-C1(コアクロル)はヒト皮膚由来線維芽細胞において結合組織成長因子(CTGF)の発現を抑制する, 苅田 咲子, 五十嵐 淳介, 岡本 隆司, 山下 哲生, 橋本 剛, 窪田 泰夫, 塚本 郁子, 小西 良士, 平野 勝也, 日本生理学雑誌, 78, (1) 9 - 9,   2016 01
  • 第5土曜特集 Vascular biology of proteinase-activated receptors, 平野勝也, 256,   2016 01
  • Purinergic P2Y(6) receptors heterodimerize with angiotensin AT1 receptors to promote angiotensin II-induced hypertension, Akiyuki Nishimura, Caroline Sunggip, Hidetoshi Tozaki-Saitoh, Tsukasa Shimauchi, Takuro Numaga-Tomita, Katsuya Hirano, Tomomi Ide, Jean-Marie Boeynaems, Hitoshi Kurose, Makoto Tsuda, Bernard Robaye, Kazuhide Inoue, Motohiro Nishida, SCIENCE SIGNALING, 9,   2016 01 , [Refereed]
  • 新規アデノシンアナログCOA-Clの血管新生作用, 塚本 郁子, 五十嵐 淳介, 橋本 剛, 山下 哲生, 榊原 紀和, 丸山 徳見, 高田 麻紀, 窪田 泰夫, 平野 勝也, 小西 良士, 西日本皮膚科, 77, (3) 312 - 312,   2015 06
  • アデノシン類似化合物COA-ClによるVEGF分泌促進機序の検討, 岡本 隆司, 五十嵐 淳介, 山下 哲生, 橋本 剛, 平野 勝也, 高田 麻紀, 小西 良士, 塚本 郁子, 小路 和代, 窪田 泰夫, 日本生理学雑誌, 77, (1) 25 - 25,   2015 01
  • Role of calcium in the regulation of smooth muscle function, 平野勝也, Katsuya Hirano, CLINICAL CALCIUM, 25,   2015 01
  • Bone and Calcium Research Update 2015. Role of calcium in the regulation of smooth muscle function, Hirano K, Clinical calcium, 25, (1) 59 - 68,   2015 , [Refereed]
  • Dysregulation of membrane receptor activity in cerebral vasospasm: A special pathogenic role of thrombin receptor PAR1, 平野勝也, Japanese Journal of Circulation Research, 37,   2014 12 , [Refereed]
  • 3T3-L1細胞の脂肪細胞分化に及ぼすミフェプリストンの促進作用, 橋本 剛, 五十嵐 淳介, 山下 哲生, 平野 勝也, 肥満研究, 20, (Suppl.) 215 - 215,   2014 10
  • HUVECにおけるCOA-Clの血管新生作用に対するS1Pレセプターの関与, 塚本 郁子, 五十嵐 淳介, 橋本 剛, 山下 哲生, 小路 和代, 榊原 紀和, 丸山 徳見, 高田 麻紀, 窪田 泰夫, 平野 勝也, 小西 良士, 日本生化学会大会プログラム・講演要旨集, 87回,   2014 10
  • トロンビン受容体を標的とした脳血管攣縮予防, 平野勝也, 平野真弓, 日本臨牀, 72,   2014 07
  • 肺高血圧症の薬物治療の最前線:序文, 平野勝也, 渡邉裕司, 日本薬理学雑誌, 143,   2014 04
  • プロテイナーゼ活性化型受容体を標的とした肺高血圧治療の可能性, 平野勝也, 日本薬理学雑誌, 143,   2014 04
  • Vascular Intrinsic Circadian Rhythm of Vascular Contractility under the Regulation of Clock Gene RORα, Saito Toshiro, Ide Tomomi, Ichiki Toshihiro, Sunagawa Kenji, Hirano Katsuya, BME, 51,   2013
  • くも膜下出血後の脳血管平滑筋収縮性亢進の分子機構, 吉川 雄一郎, 佐々木 富男, 平野 真弓, 平野 勝也, 福岡医学雑誌, 102, (12) 325 - 332,   2011 12 , [査読有り]
  • [Molecular mechanisms underlying the increased contractility of smooth muscle in cerebral artery after subarachnoid hemmorhage]., Kikkawa Y, Sasaki T, Hirano M, Hirano K, Fukuoka igaku zasshi = Hukuoka acta medica, 102,   2011 12 , [Refereed]
  • [Role of thrombin receptors in vascular physiology and pathophysiology]., Hirano K, Fukuoka igaku zasshi = Hukuoka acta medica, 100,   2009 07 , [Refereed]
  • 平滑筋におけるcAMPシグナル伝達系の新展開-Na+/Ca2+交換体の関与-, 辛島詠士, 平松伸一, 小田代敬太, 赤司浩一, 丸山徹, 山中淳, 岩本隆宏, 喜多紗斗美, 平野勝也, 平野真弓, 金出英夫, 犀川哲典, 臨牀と研究, 85, (9) 1356 - 1359,   2008
  • Rac1-dependent transcriptional up-regulation of p27Kip1 by homophilic cell-cell contact in vascular endothelial cells., Hirano M, Kanaide H, Hirano K, Biochimica et biophysica acta, 1773,   2007 10 , [Refereed]
  • Prostaglandin F-2 alpha, but not latanoprost, increases the Ca2+ sensitivity of the pig iris sphincter muscle, Yuhei Hasegawa, Junji Nishimura, Naohisa Niiro, Katsuya Hirano, Tatsuro Ishibashi, Hideo Kanaide, INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 47, (11) 4865 - 4871,   2006 11 , [Refereed]
  • Regulation of myosin phosphorylation and myofilament Ca2+ sensitivity in vascular smooth muscle, Katsuya Hirano, Mayumi Hirano, Hideo Kanaide, Journal of Smooth Muscle Research, 40, (6) 219 - 236,   2004 12 , [Refereed]
  • Inhibition of interferon-7-activated nuclear factor-kappa B by cyclosporin A: a possible mechanism for synergistic induction of apoptosis by interferon-gamma and cyclosporin A in gastric carcinoma cells, K Beppu, T Morisaki, H Matsunaga, A Uchiyama, E Ihara, K Hirano, H Kanaide, M Tanaka, M Katano, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 305, (4) 797 - 805,   2003 06 , [Refereed]
  • Protein kinase network in the regulation of phosphorylation and dephosphorylation of smooth muscle myosin light chain, K Hirano, DN Derkach, M Hirano, J Nishimura, H Kanaide, MOLECULAR AND CELLULAR BIOCHEMISTRY, 248, (1-2) 105 - 114,   2003 06
  • An important role for the Na+/Ca2+ exchanger in decreasing cytosolic Ca2+ concentration by isoprenaline in the porcine coronary artery., Yamanaka J, Nishimura J, 平野勝也, Kanaide H, J Physiol., 549,   2003 , [査読有り]
  • Role of protease-activated receptors in the vascular system., Hirano K, Kanaide H, Journal of atherosclerosis and thrombosis, 10, (4) 211 - 225,   2003 , [Refereed]
  • [Regulative mechanism in smooth muscle tonus]., Kaneide H, Hirano K, Nishimura J, Masui. The Japanese journal of anesthesiology, 51 Suppl,   2002 12 , [Refereed]
  • Inhibitory effect of brefeldin A on the bradykinin-induced relaxation mediated by endothelium-dependent hyperpolarization in the porcine coronary artery., Ohnishi Y, 平野勝也, Nishimura J, Furue M, Kanaide H, Br J Pharmacol., 134,   2001 , [査読有り]
  • Peroxisome proliferator-activated receptor gamma activators downregulate angiotensin II type 1 receptor in vascular smooth muscle cells, K Takeda, T Ichiki, T Tokunou, Y Funakoshi, N Iino, K Hirano, H Kanaide, A Takeshita, CIRCULATION, 102, (15) 1834 - 1839,   2000 10 , [Refereed]
  • A combination of cyclosporin-A (CsA) and interferon-gamma (INF-gamma) iduces apoptosis in human gastric carcinoma cells, T Morisaki, H Matsunaga, K Beppu, E Ihara, K Hirano, H Kanaide, M Mori, M Katano, ANTICANCER RESEARCH, 20, (5B) 3363 - 3373,   2000 09 , [Refereed]
  • Interactions of the subunits of smooth muscle myosin phosphatase., 平野勝也, Phan BC, Hartshorne DJ, J Biol Chem., 272,   1996 , [査読有り]
  • Lactulose Modulates the Structure of Gut Microbiota and Alleviates Colitis-Associated Tumorigenesis, Keizo Hiraishi, Feiyan Zhao, Lin Hai Kurahara, Xiaodong Li, Tetsuo Yamashita, Takeshi Hashimoto, Yoko Matsuda, Zhihong Sun, Heping Zhang, Katsuya Hirano, Nutrients, 14,   2022 02 01
  • Increased lung uric acid deteriorates pulmonary arterial hypertension, Takanori Watanabe, Mariko Ishikawa, Kohtaro Abe, Tomohito Ishikawa, Satomi Imakiire, Kohei Masaki, Kazuya Hosokawa, Tomoko Fukuuchi, Kiyoko Kaneko, Toshio Ohtsubo, Mayumi Hirano, Katsuya Hirano, Hiroyuki Tsutsui, Journal of the American Heart Association, 10,   2021 12 07
  • Substantial involvement of TRPM7 inhibition in the therapeutic effect of Ophiocordyceps sinensis on pulmonary hypertension., Keizo Hiraishi, Lin Hai Kurahara, Jianlin Feng, Aya Yamamura, Yuanyuan Cui, Eiji Yahiro, Hiroyasu Yokomise, Tetsuhiko Go, Kaori Ishikawa, Naoya Yokota, Atsushi Fujiwara, Miki Onitsuka, Kohtaro Abe, Shoji Ohga, Toru Satoh, Yasumasa Okada, Lixia Yue, Ryuji Inoue, Katsuya Hirano, Translational research : the journal of laboratory and clinical medicine, 233,   2021 07
  • Chronic Inhibition of Toll-Like Receptor 9 Ameliorates Pulmonary Hypertension in Rats., Tomohito Ishikawa, Kohtaro Abe, Mariko Takana-Ishikawa, Keimei Yoshida, Takanori Watanabe, Satomi Imakiire, Kazuya Hosokawa, Mayumi Hirano, Katsuya Hirano, Hiroyuki Tsutsui, Journal of the American Heart Association, 10,   2021 04 06
  • Inhibitory Effects of Breast Milk-Derived Lactobacillus rhamnosus Probio-M9 on Colitis-Associated Carcinogenesis by Restoration of the Gut Microbiota in a Mouse Model, Haiyan Xu, Keizo Hiraishi, Lin-Hai Kurahara, Yuko Nakano-Narusawa, Xiaodong Li, Yaopeng Hu, Yoko Matsuda, Heping Zhang, Katsuya Hirano, NUTRIENTS, 13,   2021 04
  • Eicosapentaenoic acid ameliorates pulmonary hypertension via inhibition of tyrosine kinase Fyn., Lin Hai Kurahara, Keizo Hiraishi, Aya Yamamura, Ying Zhang, Kohtaro Abe, Eiji Yahiro, Mikiko Aoki, Kaori Koga, Hiroyasu Yokomise, Tetsuhiko Go, Kaori Ishikawa, Zhang Bo, Hiroko Kishi, Sei Kobayashi, Narumi Aoki-Shoi, Satoh Toru, Ryuji Inoue, Katsuya Hirano, Journal of molecular and cellular cardiology, 148,   2020 09 02 , [Refereed]
  • Ubiquinone binding site of yeast NADH dehydrogenase revealed by structures binding novel competitive- and mixed-type inhibitors, Tetsuo Yamashita, Daniel Ken Inaoka, Tomoo Shiba, Takumi Oohashi, So Iwata, Takao Yagi, Hiroaki Kosaka, Hideto Miyoshi, Shigeharu Harada, Kiyoshi Kita, Katsuya Hirano, Scientific Reports, 8,   2018 12 01 , [Refereed]
  • Endogenous Hydrogen Sulfide Contributes to Tone Generation in Porcine Lower Esophageal Sphincter Via Na+/Ca2+ Exchanger., Xiaopeng Bai, Eikichi Ihara, Katsuya Hirano, Yoshimasa Tanaka, Kayoko Nakano, Satomi Kita, Takahiro Iwamoto, Haruei Ogino, Mayumi Hirano, Yoshinao Oda, Kazuhiko Nakamura, Yoshihiro Ogawa, Cellular and molecular gastroenterology and hepatology, 5, (3) 209 - 221,   2018 03 , [Refereed]
  • Protein phosphatases 1 and 2A and their naturally occurring inhibitors: current topics in smooth muscle physiology and chemical biology, Akira Takai, Masumi Eto, Katsuya Hirano, Kosuke Takeya, Toshiyuki Wakimoto, Masaru Watanabe, Journal of Physiological Sciences, 68,   2018 01 01 , [Refereed]
  • A protease-activated receptor-1 antagonist protects against podocyte injury in a mouse model of nephropathy, Yu Guan, Daisuke Nakano, Yifan Zhang, Lei Li, Wenhua Liu, Motohiro Nishida, Takashige Kuwabara, Asahiro Morishita, Hirofumi Hitomi, Kiyoshi Mori, Masashi Mukoyama, Tsutomu Masaki, Katsuya Hirano, Akira Nishiyama, JOURNAL OF PHARMACOLOGICAL SCIENCES, 135, (2) 81 - 88,   2017 10 , [Refereed]
  • Trypsin induces biphasic muscle contraction and relaxation via transient receptor potential vanilloid 1 and neurokinin receptors 1/2 in porcine esophageal body, Bai Xiaopeng, Yoshimasa Tanaka, Eikichi Ihara, Katsuya Hirano, Kayoko Nakano, Mayumi Hirano, Yoshinao Oda, Kazuhiko Nakamura, EUROPEAN JOURNAL OF PHARMACOLOGY, 797,   2017 02 , [Refereed]
  • Functional loss of DHRS7C induces intracellular Ca2+ overload and myotube enlargement in C2C12 cells via calpain activation, Shinobu Arai, Masataka Ikeda, Tomomi Ide, Yuka Matsuo, Takeo Fujino, Katsuya Hirano, Kenji Sunagawa, Hiroyuki Tsutsui, AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY, 312, (1) C29 - C39,   2017 01 , [Refereed]
  • Myosin di-phosphorylation and peripheral actin bundle formation as initial events during endothelial barrier disruption, Mayumi Hirano, Katsuya Hirano, SCIENTIFIC REPORTS, 6,   2016 02 , [Refereed]
  • Trypsin-induced biphasic regulation of tone in the porcine lower esophageal sphincter, Yoshimasa Tanaka, Eikichi Ihara, Katsuya Hirano, Shunsuke Takahashi, Mayumi Hirano, Kazuhiko Nakamura, Hirotada Akiho, Yoshinao Oda, Ryoichi Takayanagi, EUROPEAN JOURNAL OF PHARMACOLOGY, 752,   2015 04 , [Refereed]
  • Nicorandil prevents sirolimus-induced production of reactive oxygen species, endothelial dysfunction, and thrombus formation, Ken Aizawa, Youko Takahari, Naoko Higashijima, Kenichi Serizawa, Kenji Yogo, Nobuhiko Ishizuka, Koichi Endo, Naoto Fukuyama, Katsuya Hirano, Hideyuki Ishida, JOURNAL OF PHARMACOLOGICAL SCIENCES, 127, (3) 284 - 291,   2015 03 , [Refereed]
  • Novel Dual Endothelin Receptor Antagonist Macitentan Reverses Severe Pulmonary Arterial Hypertension in Rats, Mutsumi Kunita-Takanezawa, Kohtaro Abe, Yoshitaka Hirooka, Yukimitsu Kuwabara, Katsuya Hirano, Masahiko Oka, Kenji Sunagawa, JOURNAL OF CARDIOVASCULAR PHARMACOLOGY, 64, (5) 473 - 480,   2014 11 , [Refereed]
  • Involvement of S1P1 receptor pathway in angiogenic effects of a novel adenosine-like nucleic acid analog COA-Cl in cultured human vascular endothelial cells, Junsuke Igarashi, Takeshi Hashimoto, Yasuo Kubota, Kazuyo Shoji, Tokumi Maruyama, Norikazu Sakakibara, Yoh Takuwa, Yoshihiro Ujihara, Yuki Katanosaka, Satoshi Mohri, Keiji Naruse, Tetsuo Yamashita, Ryuji Okamoto, Katsuya Hirano, Hiroaki Kosaka, Maki Takata, Ryoji Konishi, Ikuko Tsukamoto, Pharmacology Research and Perspectives, 2,   2014 10 01 , [Refereed]
  • Neuronatin is related to keratinocyte differentiation by up-regulating involucrin, Long Dugu, Takeshi Nakahara, Zhouwei Wu, Hiroshi Uchi, Min Liu, Katsuya Hirano, Takehiko Yokomizo, Masutaka Furue, JOURNAL OF DERMATOLOGICAL SCIENCE, 73, (3) 225 - 231,   2014 03 , [Refereed]
  • Voltage-dependent N-type Ca2+ channels in endothelial cells contribute to oxidative stress-related endothelial dysfunction induced by angiotensin II in mice, Motohiro Nishida, Tatsuya Ishikawa, Shota Saiki, Caroline Sunggip, Shizuka Aritomi, Eri Harada, Koichiro Kuwahara, Katsuya Hirano, Yasuo Mori, Shokei Kim-Mitsuyama, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 434, (2) 210 - 216,   2013 05 , [Refereed]
  • Pivotal role of rho-associated kinase 2 in generating the intrinsic circadian rhythm of vascular contractility, Toshiro Saito, Mayumi Hirano, Tomomi Ide, Toshihiro Ichiki, Noriyuki Koibuchi, Kenji Sunagawa, Katsuya Hirano, Circulation, 127, (1) 104 - 114,   2013 01 01 , [Refereed]
  • Measurement of [Ca<sup>2+</sup>]<inf>i</inf> in smooth muscle strips using front-surface fluorimetry, Hideo Kanaide, Katsuya Hirano, Methods in Molecular Biology, 937,   2013 , [Refereed]
  • Mechanisms underlying potentiation of endothelin-1-induced myofilament Ca2+ sensitization after subarachnoid hemorrhage, Yuichiro Kikkawa, Satoshi Matsuo, Katsuharu Kameda, Mayumi Hirano, Akira Nakamizo, Tomio Sasaki, Katsuya Hirano, JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 32, (2) 341 - 352,   2012 02 , [Refereed]
  • Combined argatroban and anti-oxidative agents prevents increased vascular contractility to thrombin and other ligands after subarachnoid haemorrhage, Katsuharu Kameda, Yuichiro Kikkawa, Mayumi Hirano, Satoshi Matsuo, Tomio Sasaki, Katsuya Hirano, BRITISH JOURNAL OF PHARMACOLOGY, 165, (1) 106 - 119,   2012 01 , [Refereed]
  • Cilostazol Suppresses Angiotensin II-Induced Vasoconstriction via Protein Kinase A-Mediated Phosphorylation of the Transient Receptor Potential Canonical 6 Channel, Kinue Nishioka, Motohiro Nishida, Marina Ariyoshi, Zhong Jian, Shota Saiki, Mayumi Hirano, Michio Nakaya, Yoji Sato, Satomi Kita, Takahiro Iwamoto, Katsuya Hirano, Ryuji Inoue, Hitoshi Kurose, ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 31, (10) 2278 - U304,   2011 10 , [Refereed]
  • Involvement of Reactive Oxygen Species in Thrombin-induced Pulmonary Vasoconstriction, Jun Maki, Mayumi Hirano, Sumio Hoka, Hideo Kanaide, Katsuya Hirano, AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 182, (11) 1435 - 1444,   2010 12 , [Refereed]
  • Current Perspective on the Role of the Thrombin Receptor in Cerebral Vasospasm After Subarachnoid Hemorrhage, Katsuya Hirano, Mayumi Hirano, JOURNAL OF PHARMACOLOGICAL SCIENCES, 114, (2) 127 - 133,   2010 10 , [Refereed]
  • Impaired feedback regulation of the receptor activity and the myofilament Ca2+ sensitivity contributes to increased vascular reactiveness after subarachnoid hemorrhage, Yuichiro Kikkawa, Katsuharu Kameda, Mayumi Hirano, Tomio Sasaki, Katsuya Hirano, JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 30, (9) 1637 - 1650,   2010 09 , [Refereed]
  • Thrombin activation of proteinase-activated receptor 1 potentiates the myofilament Ca2+sensitivity and induces vasoconstriction in porcine pulmonary arteries, Jun Maki, Mayumi Hirano, Sumio Hoka, Hideo Kanaide, Katsuya Hirano, BRITISH JOURNAL OF PHARMACOLOGY, 159, (4) 919 - 927,   2010 02 , [Refereed]
  • Upregulation of Proteinase-Activated Receptor-2 and Increased Response to Trypsin in Endothelial Cells after Exposure to Oxidative Stress in Rat Aortas, Murasaki Aman, Mayumi Hirano, Hideo Kanaide, Katsuya Hirano, JOURNAL OF VASCULAR RESEARCH, 47, (6) 494 - 506,   2010 , [Refereed]
  • Involvement of STIM1 in the Proteinase-Activated Receptor 1-Mediated Ca2+ Influx in Vascular Endothelial Cells, Katsuya Hirano, Mayumi Hirano, Akiko Hanada, JOURNAL OF CELLULAR BIOCHEMISTRY, 108, (2) 499 - 507,   2009 10 , [Refereed]
  • Enhanced Contractile Response of the Basilar Artery to Platelet-Derived Growth Factor in Subarachnoid Hemorrhage, Yoshihisa Maeda, Katsuya Hirano, Mayumi Hirano, Yuichiro Kikkawa, Katsuharu Kameda, Tomio Sasaki, Hideo Kanaide, STROKE, 40, (2) 591 - 596,   2009 02 , [Refereed]
  • Basic and Translational Research on Proteinase-Activated Receptors: Preface, Katsuya Hirano, Atsufumi Kawabata, JOURNAL OF PHARMACOLOGICAL SCIENCES, 108, (4) 406 - 407,   2008 12 , [Refereed]
  • Basic and Translational Research on Proteinase-Activated Receptors: The Role of Thrombin Receptor in Cerebral Vasospasm in Subarachnoid Hemorrhage, Yasutoshi Kai, Yoshihisa Maeda, Tomio Sasaki, Hideo Kanaide, Katsuya Hirano, JOURNAL OF PHARMACOLOGICAL SCIENCES, 108, (4) 426 - 432,   2008 12 , [Refereed]
  • Up-regulation of proteinase-activated receptor 1 and increased contractile responses to thrombin after subarachnoid haemorrhage, Y. Maeda, K. Hirano, Y. Kai, M. Hirano, S. O. Suzuki, T. Sasaki, H. Kanaide, BRITISH JOURNAL OF PHARMACOLOGY, 152, (7) 1131 - 1139,   2007 12 , [Refereed]
  • Prevention of the hypercontractile response to thrombin by proteinase-activated receptor-1 antagonist in subarachnoid hemorrhage, Yasutoshi Kai, Katsuya Hirano, Yoshihisa Maeda, Junji Nishimura, Tomio Sasaki, Hideo Kanaide, STROKE, 38, (12) 3259 - 3265,   2007 12 , [Refereed]
  • Rac1-dependent transcriptional up-regulation of p27(Kip1) by homophilic cell-cell contact in vascular endothelial cells, Mayumi Hirano, Kanaide Hideo, Katsuya Hirano, BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH, 1773, (10) 1500 - 1510,   2007 10 , [Refereed]
  • Dimethyl sulphoxide relaxes rabbit detrusor muscle by decreasing the Ca2+ sensitivity of the contractile apparatus, K-i Shiga, K. Hirano, J. Nishimura, N. Niiro, S. Naito, H. Kanaide, BRITISH JOURNAL OF PHARMACOLOGY, 151, (7) 1014 - 1024,   2007 08 , [Refereed]
  • Distinct Ca2+ requirement for NO production between proteinase-activated receptor 1 and 4 (PAR(1) and PAR(4)) in vascular endothelial cells, Katsuya Hirano, Namie Nomoto, Mayumi Hirano, Fumi Momota, Akiko Hanada, Hideo Kanaide, JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 322, (2) 668 - 677,   2007 08 , [Refereed]
  • Current topics in the regulatory mechanism underlying the Ca2+ sensitization of the contractile apparatus in vascular smooth muscle, Katsuya Hirano, JOURNAL OF PHARMACOLOGICAL SCIENCES, 104, (2) 109 - 115,   2007 06 , [Refereed]
  • Plasmin induces endothelium-dependent nitric oxide-mediated relaxation in the porcine coronary artery, Tetsuhiro Fujiyoshi, Katsuya Hirano, Mayumi Hirano, Junji Nishimura, Shosuke Takahashi, Hideo Kanaide, ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 27, (4) 949 - 954,   2007 04 , [Refereed]
  • Involvement of Na+-Ca2+ exchanger in cAMP-mediated relaxation in mice aorta: Evaluation using transgenic mice, E. Karashima, J. Nishimura, T. Iwamoto, K. Hirano, M. Hirano, S. Kita, M. Harada, H. Kanaide, BRITISH JOURNAL OF PHARMACOLOGY, 150, (4) 434 - 444,   2007 02 , [Refereed]
  • The roles of proteinase-activated receptors in the vascular physiology and pathophysiology, Katsuya Hirano, ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 27, (1) 27 - 36,   2007 01 , [Refereed]
  • Upregulation of proteinase-activated receptors and hypercontractile responses precede development of arterial lesions after balloon injury, Ryota Fukunaga, Katsuya Hirano, Mayumi Hirano, Naohisa Niiro, Junji Nishimura, Yoshihiko Maehara, Hideo Kanaide, AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, 291, (5) H2388 - H2395,   2006 11 , [Refereed]
  • Prostaglandin F-2 alpha, but not latanoprost, increases the Ca2+ sensitivity of the pig iris sphincter muscle, Yuhei Hasegawa, Junji Nishimura, Naohisa Niiro, Katsuya Hirano, Tatsuro Ishibashi, Hideo Kanaide, INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 47, (11) 4865 - 4871,   2006 11 , [Refereed]
  • Long-term inhibition of Rho kinase suppresses intimal thickening in autologous vein grafts in rabbits, T Furuyama, K Komori, H Shimokawa, Y Matsumoto, T Uwatoku, K Hirano, Y Maehara, JOURNAL OF VASCULAR SURGERY, 43, (6) 1249 - 1256,   2006 06 , [Refereed]
  • Involvement of G(i/0) in the PAR-4-induced NO production in endothelial cells, F Momota, K Hirano, M Hirano, J Nishimura, H Kanaide, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 342, (2) 365 - 371,   2006 04 , [Refereed]
  • Involvement of de novo ceramide synthesis in radiocontrast-induced renal tubular cell injury, Y Itoh, T Yano, T Sendo, M Sueyasu, K Hirano, H Kanaide, R Oishi, KIDNEY INTERNATIONAL, 69, (2) 288 - 297,   2006 01 , [Refereed]
  • Enhancement of trypsin-induced contraction by in vivo treatment with 17 beta-estradiol and progesterone in rat myometrium, M Aman, K Hirano, J Nishimura, H Nakano, H Kanaide, BRITISH JOURNAL OF PHARMACOLOGY, 146, (3) 425 - 434,   2005 10 , [Refereed]
  • Enhancement of trypsin-induced contraction by in vivo treatment with 17 beta-estradiol and progesterone in rat myometrium, M Aman, K Hirano, J Nishimura, H Nakano, H Kanaide, BRITISH JOURNAL OF PHARMACOLOGY, 146, (3) 425 - 434,   2005 10 , [Refereed]
  • Functional role of PKC in contraction of cultured human prostatic stromal cells, R Takahashi, J Nishimura, K Hirano, S Naito, H Kanaide, JOURNAL OF CELLULAR BIOCHEMISTRY, 96, (1) 65 - 78,   2005 09 , [Refereed]
  • Rac1 regulation of surface expression of protease-activated receptor-1 and responsiveness to thrombin in vascular smooth muscle cells, T Yufu, K Hirano, D Bi, M Hirano, J Nishimura, Y Iwamoto, H Kanaide, ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 25, (7) 1506 - 1511,   2005 07 , [Refereed]
  • The mechanism underlying the contractile effect of a chemotactic peptide, formyl-Met-Leu-Phe on the guinea-pig Taenia coli, H Kawata, K Hirano, J Nishimura, C Kubo, H Kanaide, BRITISH JOURNAL OF PHARMACOLOGY, 145, (3) 353 - 363,   2005 06 , [Refereed]
  • Long-term inhibition of RhoA attenuates vascular contractility by enhancing endothelial NO production in an intact rabbit mesenteric artery, N Shiga, K Hirano, M Hirano, J Nishimura, H Nawata, H Kanaide, CIRCULATION RESEARCH, 96, (9) 1014 - 1021,   2005 05 , [Refereed]
  • Contractile properties of the cultured vascular smooth muscle cells - The crucial role played by RhoA in the regulation of contractility, D Bi, J Nishimura, N Niiro, K Hirano, H Kanaide, CIRCULATION RESEARCH, 96, (8) 890 - 897,   2005 04 , [Refereed]
  • Physiology and pathophysiology of proteinase-activated receptors (PARs): Regulation of the expression of PARs, K Hirano, T Yufu, M Hirano, J Nishimura, H Kanaide, JOURNAL OF PHARMACOLOGICAL SCIENCES, 97, (1) 31 - 37,   2005 01 , [Refereed]
  • Akt plays a central role in the anti-apoptotic effect of estrogen in endothelial cells, M Koga, K Hirano, M Hirano, J Nishimura, H Nakano, H Kanaide, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 324, (1) 321 - 325,   2004 11 , [Refereed]
  • Facilitation of proteasomal degradation of p27(Kip1) by N-terminal cleavage and their sequence requirements, K Hirano, E Ihara, M Hirano, J Nishimura, H Nawata, H Kanaide, FEBS LETTERS, 574, (1-3) 111 - 115,   2004 09 , [Refereed]
  • Ca(2+) sensitization in contraction of human bladder smooth muscle, R Takahashi, J Nishimura, K Hirano, N Seki, S Naito, H Kanaide, JOURNAL OF UROLOGY, 172, (2) 748 - 752,   2004 08 , [Refereed]
  • Ca(2+) sensitization in contraction of human bladder smooth muscle, R Takahashi, J Nishimura, K Hirano, N Seki, S Naito, H Kanaide, JOURNAL OF UROLOGY, 172, (2) 748 - 752,   2004 08 , [Refereed]
  • Inactivation of protease-activated receptor-1 by proteolytic removal of the ligand region in vascular endothelial cells, T Nakayama, K Hirano, M Hirano, J Nishimura, H Kuga, K Nakamura, S Takahashi, H Kanaide, BIOCHEMICAL PHARMACOLOGY, 68, (1) 23 - 32,   2004 07 , [Refereed]
  • Endothelium-dependent and independent enhancement of vascular contractility in the ovariectomized rabbit, M Koga, K Hirano, J Nishimura, H Nakano, H Kanaide, JOURNAL OF THE SOCIETY FOR GYNECOLOGIC INVESTIGATION, 11, (5) 272 - 279,   2004 07 , [Refereed]
  • A critical period requiring Rho proteins for cell cycle progression uncovered by reversible protein transduction in endothelial cells, K Hirano, M Hirano, J Nishimura, H Kanaide, FEBS LETTERS, 570, (1-3) 149 - 154,   2004 07 , [Refereed]
  • Endothelial dysfunction and altered bradykinin response due to oxidative stress induced by serum deprivation in the bovine cerebral artery, Y Maeda, K Hirano, J Nishimura, T Sasaki, H Kanaide, EUROPEAN JOURNAL OF PHARMACOLOGY, 491, (1) 53 - 60,   2004 04 , [Refereed]
  • Transduction of the N-terminal fragments of MYPT1 enhances myofilament Ca2+ sensitivity in an intact coronary artery, K Hirano, DN Derkach, M Hirano, J Nishimura, S Takahashi, H Kanaide, ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 24, (3) 464 - 469,   2004 03 , [Refereed]
  • Intracellular alkalinization induces Ca2+ influx via non-voltage-operated Ca2+ channels in rat aortic smooth muscle cells, W Eto, K Hirano, M Hirano, J Nishimura, H Kanaide, CELL CALCIUM, 34, (6) 477 - 484,   2003 12 , [Refereed]
  • Rho-kinase inhibitor inhibits both myosin phosphorylation-dependent and -independent enhancement of myofilament Ca2+ sensitivity in the bovine middle cerebral artery, Y Maeda, K Hirano, J Nishimura, T Sasaki, H Kanaide, BRITISH JOURNAL OF PHARMACOLOGY, 140, (5) 871 - 880,   2003 11 , [Refereed]
  • Theophylline attenuates Ca2+ sensitivity and modulates BK channels in porcine tracheal smooth muscle, S Ise, J Nishimura, K Hirano, N Hara, H Kanaide, BRITISH JOURNAL OF PHARMACOLOGY, 140, (5) 939 - 947,   2003 11 , [Refereed]
  • Rho-kinase inhibitor inhibits both myosin phosphorylation-dependent and -independent enhancement of myofilament Ca2+ sensitivity in the bovine middle cerebral artery, Y Maeda, K Hirano, J Nishimura, T Sasaki, H Kanaide, BRITISH JOURNAL OF PHARMACOLOGY, 140, (5) 871 - 880,   2003 11 , [Refereed]
  • Cellular mechanism of vasoconstriction induced by angiotensin II - It remains to be determined, H Kanaide, T Ichiki, J Nishimura, K Hirano, CIRCULATION RESEARCH, 93, (11) 1015 - 1017,   2003 11 , [Refereed]
  • An important role for the Na+-Ca2+ exchanger in the decrease in cytosolic Ca2+ concentration induced by isoprenaline in the porcine coronary artery, J Yamanaka, J Nishimura, K Hirano, H Kanaide, JOURNAL OF PHYSIOLOGY-LONDON, 549, (2) 553 - 562,   2003 06 , [Refereed]
  • Inhibition of interferon-7-activated nuclear factor-kappa B by cyclosporin A: a possible mechanism for synergistic induction of apoptosis by interferon-gamma and cyclosporin A in gastric carcinoma cells, K Beppu, T Morisaki, H Matsunaga, A Uchiyama, E Ihara, K Hirano, H Kanaide, M Tanaka, M Katano, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 305, (4) 797 - 805,   2003 06 , [Refereed]
  • The modulation of Ca2+ sensitivity regulates contractility of rabbit corpus cavernosum smooth muscle, R Takahashi, J Nishimura, K Hirano, S Naito, H Kanaide, JOURNAL OF UROLOGY, 169, (6) 2412 - 2416,   2003 06 , [Refereed]
  • Sequence requirement for nuclear localization and growth inhibition of p27(Kip1R), a degradation-resistant isoform of p27(Kip1), K Hirano, Y Zeng, M Hirano, J Nishimura, H Kanaide, JOURNAL OF CELLULAR BIOCHEMISTRY, 89, (1) 191 - 202,   2003 05 , [Refereed]
  • Downregulation of vascular angiotensin II type 1 receptor by thyroid hormone, K Fukuyama, T Ichiki, K Takeda, T Tokunou, N Iino, S Masuda, M Ishibashi, K Egashira, H Shimokawa, K Hirano, H Kanaide, A Takeshita, HYPERTENSION, 41, (3) 598 - 603,   2003 03 , [Refereed]
  • Unproductive cleavage and the inactivation of protease-activated receptor-1 by trypsin in vascular endothelial cells, T Nakayama, K Hirano, Y Shintani, J Nishimura, A Nakatsuka, H Kuga, S Takahashi, H Kanaide, BRITISH JOURNAL OF PHARMACOLOGY, 138, (1) 121 - 130,   2003 01 , [Refereed]
  • Unproductive cleavage and the inactivation of protease-activated receptor-1 by trypsin in vascular endothelial cells, T Nakayama, K Hirano, Y Shintani, J Nishimura, A Nakatsuka, H Kuga, S Takahashi, H Kanaide, BRITISH JOURNAL OF PHARMACOLOGY, 138, (1) 121 - 130,   2003 01 , [Refereed]
  • The mechanisms for tachykinin-induced contractions of the rabbit corpus cavernosum, R Takahashi, J Nishimura, K Hirano, S Naito, H Kanaide, BRITISH JOURNAL OF PHARMACOLOGY, 137, (6) 845 - 854,   2002 11 , [Refereed]
  • Mechanism of down-regulation of L-type Ca2+ channel in the proliferating smooth muscle cells of rat aorta, E Ihara, K Hirano, M Hirano, J Nishimura, H Nawata, H Kanaide, JOURNAL OF CELLULAR BIOCHEMISTRY, 87, (2) 242 - 251,   2002 , [Refereed]
  • Mechanism of down-regulation of L-type Ca2+ channel in the proliferating smooth muscle cells of rat aorta, E Ihara, K Hirano, M Hirano, J Nishimura, H Nawata, H Kanaide, JOURNAL OF CELLULAR BIOCHEMISTRY, 87, (2) 242 - 251,   2002 , [Refereed]
  • Transcriptional up-regulation of p27(Kip1) during contact-induced growth arrest in vascular endothelial cells, M Hirano, K Hirano, J Nishimura, H Kanaide, EXPERIMENTAL CELL RESEARCH, 271, (2) 356 - 367,   2001 12 , [Refereed]
  • Downregulation of angiotensin II type 1 receptor by hydrophobic 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors in vascular smooth muscle cells, T Ichiki, K Takeda, T Tokunou, N Iino, K Egashira, H Shimokawa, K Hirano, H Kanaide, A Takeshita, ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 21, (12) 1896 - 1901,   2001 12 , [Refereed]
  • Transcriptional up-regulation of p27(Kip1) during contact-induced growth arrest in vascular endothelial cells, M Hirano, K Hirano, J Nishimura, H Kanaide, EXPERIMENTAL CELL RESEARCH, 271, (2) 356 - 367,   2001 12
  • Mechanism of trypsin-induced endothelium-dependent vasorelaxation in the porcine coronary artery, T Nakayama, K Hirano, J Nishimura, S Takahashi, H Kanaide, BRITISH JOURNAL OF PHARMACOLOGY, 134, (4) 815 - 826,   2001 10 , [Refereed]
  • Inhibitory effects of brefeldin A, a membrane transport blocker, on the bradykinin-induced hyperpolarization-mediated relaxation in the porcine coronary artery, Y Ohnishi, K Hirano, J Nishimura, M Furue, H Kanaide, BRITISH JOURNAL OF PHARMACOLOGY, 134, (1) 168 - 178,   2001 09 , [Refereed]
  • Ca2+ influx in the endothelial cells is required for the bradykinin-induced endothelium-dependent contraction in the porcine interlobar renal artery, E Ihara, DN Derkach, K Hirano, J Nishimura, H Nawata, H Kanaide, JOURNAL OF PHYSIOLOGY-LONDON, 534, (3) 701 - 711,   2001 08 , [Refereed]
  • Mechanism of trypsin-induced contraction in the rat myometrium: the possible involvement of a novel member of protease-activated receptor, Y Shintani, K Hirano, T Nakayama, J Nishimura, H Nakano, H Kanaide, BRITISH JOURNAL OF PHARMACOLOGY, 133, (8) 1276 - 1285,   2001 08 , [Refereed]
  • Hydroxyfasudil, an active metabolite of fasudil hydrochloride, relaxes the rabbit basilar artery by disinhibition of myosin light chain phosphatase, K Nakamura, J Nishimura, K Hirano, S Ibayashi, M Fujishima, H Kanaide, JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 21, (7) 876 - 885,   2001 07 , [Refereed]
  • Myotonic dystrophy protein kinase phosphorylates the myosin phosphatase targeting subunit and inhibits myosin phosphatase activity, A Muranyi, RX Zhang, FZ Liu, K Hirano, M Ito, HF Epstein, DJ Hartshorne, FEBS LETTERS, 493, (2-3) 80 - 84,   2001 03 , [Refereed]
  • Identification of hydrogen peroxide as an endothelium-derived hyperpolarizing factor in mice, H Shimokawa, T Matoba, M Nakashima, Y Hirakawa, Y Mukai, K Hirano, H Kanaide, A Takeshita, EDHF 2000,   2001 , [Refereed]
  • Cloning and functional expression of a degradation-resistant novel isoform of p27(Kip1), K Hirano, M Hirano, Y Zeng, J Nishimura, K Hara, K Muta, H Nawata, H Kanaide, BIOCHEMICAL JOURNAL, 353, (1) 51 - 57,   2001 01 , [Refereed]
  • Leukotriene C-4 enhances the contraction of porcine tracheal smooth muscle through the activation of Y-27632, a rho kinase inhibitor, sensitive pathway, H Setoguchi, J Nishimura, K Hirano, S Takahashi, H Kanaide, BRITISH JOURNAL OF PHARMACOLOGY, 132, (1) 111 - 118,   2001 01 , [Refereed]
  • The mechanism for the contraction induced by leukotriene C4 in guinea-pig taenia coli, Satoshi Ieiri, Junji Nishimura, Katsuya Hirano, Sachiyo Suita, Hideo Kanaide, British Journal of Pharmacology, 133, (4) 529 - 538,   2001 , [Refereed]
  • Cloning and functional expression of a degradation-resistant novel isoform of p27(Kip1), K Hirano, M Hirano, Y Zeng, J Nishimura, K Hara, K Muta, H Nawata, H Kanaide, BIOCHEMICAL JOURNAL, 353,   2001 01
  • Alteration of the [Ca2+](i)-force relationship during the vasorelaxation induced by a Ca2+ channel blocker SR33805 in the porcine coronary artery, S Ieiri, K Hirano, J Nishimura, S Suita, H Kanaide, BRITISH JOURNAL OF PHARMACOLOGY, 131, (8) 1597 - 1606,   2000 12 , [Refereed]
  • Enhanced contractile response to thrombin in the pregnant rat myometrium, Y Shintani, K Hirano, J Nishimura, H Nakano, H Kanaide, BRITISH JOURNAL OF PHARMACOLOGY, 131, (8) 1619 - 1628,   2000 12 , [Refereed]
  • Thrombin causes endothelium-dependent biphasic regulation of vascular tone in the porcine renal interlobar artery, DN Derkach, E Ihara, K Hirano, J Nishimura, S Takahashi, H Kanaide, BRITISH JOURNAL OF PHARMACOLOGY, 131, (8) 1635 - 1642,   2000 12 , [Refereed]
  • Differential effects of progesterone and 17 beta-estradiol on the Ca2+ entry induced by thapsigargin and endothelin-1 in in situ endothelial cells, JY Toshima, K Hirano, J Nishimura, H Nakano, H Kanaide, BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH, 1499, (1-2) 109 - 121,   2000 12 , [Refereed]
  • Hydrogen peroxide is an endothelium-derived hyperpolarizing factor in mice, T Matoba, H Shimokawa, M Nakashima, Y Hirakawa, Y Mukai, K Hirano, H Kanaide, A Takeshita, JOURNAL OF CLINICAL INVESTIGATION, 106, (12) 1521 - 1530,   2000 12 , [Refereed]
  • Mitogen-induced up-regulation of non-smooth muscle isoform of alpha-tropomyosin in rat aortic smooth muscle cells, K Hirano, M Hirano, W Eto, J Nishimura, H Kanaide, EUROPEAN JOURNAL OF PHARMACOLOGY, 406, (2) 209 - 218,   2000 10 , [Refereed]
  • Mechanisms of the thapsigargin-induced Ca2+ entry in in situ endothelial cells of the porcine aortic valve and the endothelium-dependent relaxation in the porcine coronary artery, M Kuroiwa-Matsumoto, K Hirano, A Ahmed, J Kawasaki, J Nishimura, H Kanaide, BRITISH JOURNAL OF PHARMACOLOGY, 131, (1) 115 - 123,   2000 09 , [Refereed]
  • Stimulus-specific alteration of the relationship between cytosolic Ca2+ transients and nitric oxide production in endothelial cells ex vivo, O Mizuno, S Kobayashi, K Hirano, J Nishimura, C Kubo, H Kanaide, BRITISH JOURNAL OF PHARMACOLOGY, 130, (5) 1140 - 1146,   2000 07 , [Refereed]
  • Mechanisms underlying the neurokinin A-induced contraction of the pregnant rat myometrium, Y Shintani, J Nishimura, N Niiro, K Hirano, H Nakano, H Kanaide, BRITISH JOURNAL OF PHARMACOLOGY, 130, (5) 1165 - 1173,   2000 07 , [Refereed]
  • Minimal requirements for the nuclear localization of p27(Kip1), a cyclin-dependent kinase inhibitor, Y Zeng, K Hirano, M Hirano, J Nishimura, H Kanaide, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 274, (1) 37 - 42,   2000 07 , [Refereed]
  • Minimal requirements for the nuclear localization of p27(Kip1), a cyclin-dependent kinase inhibitor, Y Zeng, K Hirano, M Hirano, J Nishimura, H Kanaide, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 274, (1) 37 - 42,   2000 07
  • Dissociation between the Ca2+ signal and tube formation induced by vascular endothelial growth factor in bovine aortic endothelial cells, J Kawasaki, K Hirano, M Hirano, J Nishimura, A Nakatsuka, M Fujishima, H Kanaide, EUROPEAN JOURNAL OF PHARMACOLOGY, 398, (1) 19 - 29,   2000 06 , [Refereed]
  • The mechanism of bradykinin-induced endothelium-dependent contraction and relaxation in the porcine interlobar renal artery, E Ihara, K Hirano, DN Derkach, J Nishimura, H Nawata, H Kanaide, BRITISH JOURNAL OF PHARMACOLOGY, 129, (5) 943 - 952,   2000 03 , [Refereed]
  • Changes in the cytosolic Ca2+ concentration and Ca2+-sensitivity of the contractile apparatus during angiotensin II-induced desensitization in the rabbit femoral artery, M Ushio-Fukai, H Yamamoto, K Toyofuku, J Nishimura, K Hirano, H Kanaide, BRITISH JOURNAL OF PHARMACOLOGY, 129, (3) 425 - 436,   2000 02 , [Refereed]
  • The mechanism of the decrease in cytosolic Ca2+ concentrations induced by angiotensin II in the high K+-depolarized rabbit femoral artery, M Ushio-Fukai, H Yamamoto, J Nishimura, K Hirano, H Kanaide, BRITISH JOURNAL OF PHARMACOLOGY, 129, (3) 437 - 447,   2000 02 , [Refereed]
  • Proteolysis and phosphorylation-mediated regulation of thrombin receptor activity in in situ endothelial cells, O Mizuno, K Hirano, J Nishimura, C Kubo, H Kanaide, EUROPEAN JOURNAL OF PHARMACOLOGY, 389, (1) 13 - 23,   2000 02 , [Refereed]
  • Thapsigargin-induced endothelium-dependent triphasic regulation of vascular tone in the porcine renal artery, E Ihara, K Hirano, J Nishimura, H Nawata, H Kanaide, BRITISH JOURNAL OF PHARMACOLOGY, 128, (3) 689 - 699,   1999 10 , [Refereed]
  • Troglitazone inhibits the capacitative Ca2+ entry in endothelial cells, J Kawasaki, K Hirano, M Hirano, J Nishimura, M Fujishima, H Kanaide, EUROPEAN JOURNAL OF PHARMACOLOGY, 373, (1) 111 - 120,   1999 05 , [Refereed]
  • NH2-terminal fragments of the 130 kDa subunit of myosin phosphatase increase the Ca2+ sensitivity of porcine renal artery, YB Zhou, K Hirano, C Sakihara, J Nishimura, H Kanaide, JOURNAL OF PHYSIOLOGY-LONDON, 516, (1) 55 - 65,   1999 04 , [Refereed]
  • Vasorelaxation and inhibition of the voltage-operated Ca2+ channels by FK506 in the porcine coronary artery, T Yasutsune, N Kawakami, K Hirano, J Nishimura, H Yasui, K Kitamura, H Kanaide, BRITISH JOURNAL OF PHARMACOLOGY, 126, (3) 717 - 729,   1999 02 , [Refereed]
  • Interactions of protein phosphatase type 1, with a focus on myosin phosphatase, DJ Hartshorne, K Hirano, MOLECULAR AND CELLULAR BIOCHEMISTRY, 190, (1-2) 79 - 84,   1999 01 , [Refereed]
  • The exogenously added small subunit of smooth muscle myosin phosphatase increases the Ca2+ sensitivity of the contractile apparatus in the permeabilized porcine renal artery, YB Zhou, J Nishimura, K Hirano, H Kanaide, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 254, (1) 158 - 163,   1999 01 , [Refereed]
  • Expression, subcellular localization, and cloning of the 130-kDa regulatory subunit of myosin phosphatase in porcine aortic endothelial cells, M Hirano, N Niiro, K Hirano, J Nishimura, DJ Hartshorne, H Kanaide, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 254, (2) 490 - 496,   1999 01 , [Refereed]
  • Mechanisms of vasorelaxation induced by troglitazone, a novel antidiabetic drug, in the porcine coronary artery, J Kawasaki, K Hirano, J Nishimura, M Fujishima, H Kanaide, CIRCULATION, 98, (22) 2446 - 2452,   1998 12 , [Refereed]
  • Mechanisms of galanin-induced contraction in the rat myometrium, N Niiro, J Nishimura, K Hirano, H Nakano, H Kanaide, BRITISH JOURNAL OF PHARMACOLOGY, 124, (8) 1623 - 1632,   1998 08 , [Refereed]
  • Mechanism of endothelium-dependent relaxation induced by thrombin in the pig coronary artery, O Mizuno, K Hirano, J Nishimura, C Kubo, H Kanaide, EUROPEAN JOURNAL OF PHARMACOLOGY, 351, (1) 67 - 77,   1998 06 , [Refereed]
  • Expression and function of alpha(1)-adrenoceptor subtypes in the porcine renal artery, Y Zhou, J Nishimura, H Seguchi, K Hirano, H Kanaide, EUROPEAN JOURNAL OF PHARMACOLOGY, 341, (1) 95 - 103,   1998 01 , [Refereed]
  • Cloning and characterization of a protein phosphatase type 1-binding subunit from smooth muscle similar to the glycogen-binding subunit of liver, K Hirano, M Hirano, DJ Hartshorne, BIOCHIMICA ET BIOPHYSICA ACTA-PROTEIN STRUCTURE AND MOLECULAR ENZYMOLOGY, 1339, (2) 177 - 180,   1997 05 , [Refereed]
  • Differential localization of myosin and myosin phosphatase subunits in smooth muscle cells and migrating fibroblasts, K Murata, K Hirano, E VillaMoruzzi, DJ Hartshorne, DL Brautigan, MOLECULAR BIOLOGY OF THE CELL, 8, (4) 663 - 673,   1997 04 , [Refereed]
  • Interactions of the subunits of smooth muscle myosin phosphatase, K Hirano, BC Phan, DJ Hartshorne, JOURNAL OF BIOLOGICAL CHEMISTRY, 272, (6) 3683 - 3688,   1997 02
  • Inter-action of protein phosphatase type 1 with a splicing factor, K Hirano, F Erdodi, JG Patton, DJ Hartshorne, FEBS LETTERS, 389, (2) 191 - 194,   1996 07 , [Refereed]
  • Interactions and properties of smooth muscle myosin phosphatase, K Ichikawa, K Hirano, M Ito, J Tanaka, T Nakano, DJ Hartshorne, BIOCHEMISTRY, 35, (20) 6313 - 6320,   1996 05 , [Refereed]
  • ENDOTHALL THIOANHYDRIDE INHIBITS PROTEIN PHOSPHATASE-1 AND PHOSPHATASE-2A IN-VIVO, F ERDODI, B TOTH, K HIRANO, M HIRANO, DJ HARTSHORNE, P GERGELY, AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY, 269, (5) C1176 - C1184,   1995 11 , [Refereed]
  • INTERACTION OF THE RIBOSOMAL-PROTEIN, L5, WITH PROTEIN PHOSPHATASE TYPE-1, K HIRANO, M ITO, DJ HARTSHORNE, JOURNAL OF BIOLOGICAL CHEMISTRY, 270, (34) 19786 - 19790,   1995 08 , [Refereed]
  • THE EFFECTS OF A NOVEL VASODILATOR, LP-805, ON CYTOSOLIC CA2+ CONCENTRATIONS AND ON TENSION IN RABBIT ISOLATED FEMORAL ARTERIES, M USHIOFUKAI, K HIRANO, H KANAIDE, BRITISH JOURNAL OF PHARMACOLOGY, 113, (4) 1173 - 1182,   1994 12 , [Refereed]
  • CHARACTERIZATION OF THE MYOSIN-BINDING SUBUNIT OF SMOOTH-MUSCLE MYOSIN PHOSPHATASE, H SHIMIZU, M ITO, M MIYAHARA, K ICHIKAWA, S OKUBO, T KONISHI, M NAKA, T TANAKA, K HIRANO, DJ HARTSHORNE, T NAKANO, JOURNAL OF BIOLOGICAL CHEMISTRY, 269, (48) 30407 - 30411,   1994 12 , [Refereed]
  • CYTOSOLIC CA2+ TRANSIENTS IN ENDOTHELIUM-DEPENDENT RELAXATION OF PIG CORONARY-ARTERY, AND EFFECTS OF CAPTOPRIL, K HIRANO, H KANAIDE, EUROPEAN JOURNAL OF PHARMACOLOGY, 250, (3) 439 - 446,   1993 12 , [Refereed]
  • PHOSPHORYLATION OF VIMENTIN IN THE C-TERMINAL DOMAIN AFTER EXPOSURE TO CALYCULIN-A, K HIRANO, DJ HARTSHORNE, EUROPEAN JOURNAL OF CELL BIOLOGY, 62, (1) 59 - 65,   1993 10 , [Refereed]
  • ROLE OF EXTRACELLULAR AND INTRACELLULAR SOURCES OF CA2+ IN SARAFOTOXIN S6B-INDUCED CONTRACTION OF STRIPS OF THE RAT AORTA, C WATANABE, K HIRANO, H KANAIDE, BRITISH JOURNAL OF PHARMACOLOGY, 108, (1) 30 - 37,   1993 01 , [Refereed]
  • ENHANCEMENT BY CAPTOPRIL OF BRADYKININ-INDUCED CALCIUM TRANSIENTS IN CULTURED ENDOTHELIAL-CELLS OF THE BOVINE AORTA, K HIRANO, M HIRANO, H KANAIDE, EUROPEAN JOURNAL OF PHARMACOLOGY-MOLECULAR PHARMACOLOGY SECTION, 244, (2) 133 - 137,   1993 01 , [Refereed]
  • MECHANISMS OF CAFFEINE-INDUCED CONTRACTION AND RELAXATION OF RAT AORTIC SMOOTH-MUSCLE, C WATANABE, H YAMAMOTO, K HIRANO, S KOBAYASHI, H KANAIDE, JOURNAL OF PHYSIOLOGY-LONDON, 456,   1992 10 , [Refereed]
  • CHANGES IN THE CYTOSKELETON OF 3T3 FIBROBLASTS INDUCED BY THE PHOSPHATASE INHIBITOR, CALYCULIN-A, K HIRANO, L CHARTIER, RG TAYLOR, RE ALLEN, N FUSETANI, H KARAKI, DJ HARTSHORNE, JOURNAL OF MUSCLE RESEARCH AND CELL MOTILITY, 13, (3) 341 - 353,   1992 06 , [Refereed]
  • EFFECTS OF GLIBENCLAMIDE ON CYTOSOLIC CALCIUM CONCENTRATIONS AND ON CONTRACTION OF THE RABBIT AORTA, K YOSHITAKE, K HIRANO, H KANAIDE, BRITISH JOURNAL OF PHARMACOLOGY, 102, (1) 113 - 118,   1991 01 , [Refereed]
  • TEMPORAL CHANGES IN THE CALCIUM-FORCE RELATION DURING HISTAMINE-INDUCED CONTRACTIONS OF STRIPS OF THE CORONARY-ARTERY OF THE PIG, K HIRANO, H KANAIDE, S ABE, M NAKAMURA, BRITISH JOURNAL OF PHARMACOLOGY, 102, (1) 27 - 34,   1991 01 , [Refereed]
  • Cytosolic calcium transients in vascular smooth muscle., Hirano K, Hirano M, Abe S, Kanaide H, in Ion Channels of Vascular Smooth Muscle Cells and Endothelial Cells, eds Sperelakis N and Kuriyama H., Elsivier, New York, 93-105, 1991.,   1991
  • EFFECTS OF DILTIAZEM ON CALCIUM CONCENTRATIONS IN THE CYTOSOL AND ON FORCE OF CONTRACTIONS IN PORCINE CORONARY ARTERIAL STRIPS, K HIRANO, H KANAIDE, S ABE, M NAKAMURA, BRITISH JOURNAL OF PHARMACOLOGY, 101, (2) 273 - 280,   1990 10 , [Refereed]
  • Effects of okadaic acid on cytosolic calcium concentration and contraction of porcine coronary artery., Hirano K, Kanaide H, Nakamura M, in Advances in Second Messenger and Phosphoprotein Research vol.24, ed. Nishizuka Y., 461-466, Raven Press, New York, 1990.,   1990
  • EFFECTS OF OKADAIC ACID ON CYTOSOLIC CALCIUM CONCENTRATIONS AND ON CONTRACTIONS OF THE PORCINE CORONARY-ARTERY, K HIRANO, H KANAIDE, M NAKAMURA, BRITISH JOURNAL OF PHARMACOLOGY, 98, (4) 1261 - 1266,   1989 12 , [Refereed]
  • ENDOTHELIN-INDUCED CA-INDEPENDENT CONTRACTION OF THE PORCINE CORONARY-ARTERY, M KODAMA, H KANAIDE, S ABE, K HIRANO, H KAI, M NAKAMURA, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 160, (3) 1302 - 1308,   1989 05 , [Refereed]

Misc

  • 血液凝固第XI因子の血管機能調節因子としての新たな機能の発見, 劉文華, 橋本剛, 山下哲生, 平野勝也, 日本生理学雑誌(Web), 81, (2),   2019
  • 血管平滑筋細胞において凝固第XI因子はトロンビン受容体PAR1を活性化し,細胞内Ca2+シグナルを発生させ,細胞遊走を促進する, 平野勝也, 劉文華, 橋本剛, 山下哲生, 血管, 42, (1),   2019
  • 競合および混合阻害剤との共結晶構造解析により明らかとなった酵母由来Type II NADH脱水素酵素のユビキノン結合部位, 山下哲生, 稲岡健ダニエル, 志波智生, 三芳秀人, 原田繁春, 北潔, 平野勝也, 日本農芸化学会中四国支部講演会講演要旨集(Web), 51st,   2018
  • 血液凝固第XI因子が引き起こす血管平滑筋細胞のCa2+シグナルの発生メカニズムの解明, 劉文華, 橋本剛, 山下哲生, 平野勝也, 日本生理学雑誌(Web), 80, (3),   2018
  • 嫌気条件とNAD(P)HはApoptosis-inducing factorの大腸菌膜からの解離を抑制する, 山下哲生, 松本感, 橋本剛, 五十嵐淳介, 小坂博昭, 平野勝也, 日本生理学雑誌(Web), 80, (3),   2018
  • 血液凝固第XI因子は電位作動性Ca2+チャネルを介して血管平滑筋細胞にCa2+シグナルを発生させる, 平野勝也, 劉文華, 橋本剛, 山下哲生, 血管, 41, (1),   2018
  • ポドサイト障害進展におけるProteinase‐activated receptor‐1の関与, 中野大介, GUAN Yu, 人見浩史, 平野勝也, 桑原孝成, 森潔, 向山政志, 西山成, 日本腎臓学会誌, 59, (6), 703 - 703,   2017 09 05
  • Proteinase‐activated receptor‐1はポドサイト障害によるアルブミン尿の病態に関与する, 管有, 中野大介, 人見浩史, 平野勝也, 西山成, 日本NO学会学術集会プログラム抄録集, 17th, 57,   2017 05 01
  • Apoptosis-inducing factorと大腸菌膜との相互作用の解析, 松本感, 山下哲生, 橋本剛, 五十嵐淳介, 小坂博昭, 平野勝也, 日本生理学雑誌(Web), 79, (1),   2017
  • 凝固第XI因子が引き起こす血管平滑筋細胞のカルシウムシグナル伝達, 平野勝也, 劉文華, 橋本剛, 山下哲生, 五十嵐淳介, 血管, 40, (1),   2017
  • 凝固第XI因子の血管平滑筋作用, 平野勝也, 劉文華, 橋本剛, 山下哲生, 日本循環薬理学会口演要旨集, 27th,   2017
  • Contribution of proteinase-activated receptor 1 on the development of podocyte injury, NAKANO Daisuke, GUAN Yu, LIU Wenhua, ZHANG Yifan, LI Lei, HITOMI Hirofumi, HIRANO Katsuya, NISHIYAMA Akira, Annual Meeting of the Japanese Society of Toxicology, 44, (0), O - 53,   2017
    【目的】腎ポドサイトはタンパク尿漏出に対する重要なバリアーを形成する。本研究ではトロンビン受容体であるProteinase-activated receptor-1 (PAR1)のポドサイト障害進展における役割を検討した。<br>【方法】雄性Balb Cマウスにdoxorubicin (15 mg/kg, i.v.)を投与したネフローゼモデルに対し、溶媒(n=5)あるいはPAR1拮抗薬Q94 (5 mg/kg/day, s.c., n=5)を2週間投与し、各種腎障害パラメーターを検討した。糸球体組織はレーザーキャプチャー法にて採取し、バリアー分子の発現を確認した。また、培養マウスポドサイトにおいてfura-2を使用して細胞内カルシウム濃度を測定し、caspase-9にてアポトーシスの評価を行った。<br>【成績】doxorubicin投与によって生じる尿中アルブミン排泄量は糸球体内PAR1発現量と有意な正の相関を示した。このアルブミン尿ならびに血漿クレアチニン値の増加は、Q94の投与により有意に抑制された。Q94の投与はdoxorubicinの投与による糸球体中バリアー分子ポドシンおよびネフリンのmRNA発現量の減少を抑制した。さらに、Q94はdoxorubicinによって生じる糸球体ポドサイト障害(デスミン陽性部位)と糸球体硬化病変(PAS陽性面積増加)を有意に抑制した。このようなQ94の作用は、腎組織中酸化ストレスの減少を伴っていた。培養ポドサイトにはPAR1が有意に遺伝子レベルで発現しており、トロンビン投与(1 U/mL)による細胞内カルシウム濃度の上昇ならびにdoxorubicin投与(0.5 μM)によるcaspase-9活性の上昇を認めたが、いずれもQ94により用量依存性に抑制された。<br>【結論】以上の結果より、PAR1はポドサイト障害によるアルブミン尿の病態に重要な役割を果たしているものと考えられた。
  • 新規アデノシン類似化合物COA-Cl(コアクロル)はcAMP/CREB/PGC-1αの経路を介して血管内皮成長因子(VEGF)の産生を促進する, 岡本隆司, 五十嵐淳介, 橋本剛, 山下哲生, 苅田咲子, 窪田泰夫, 高田麻紀, 小西良士, 塚本郁子, 平野勝也, 日本生理学雑誌(Web), 78, (1),   2016
  • DHRS7C NAD/NADH dehydrogenase catalytic core domain is essential for cellular calcium homeostasis and cell morphology, 新井しのぶ, 井手友美, 池田昌隆, 平野勝也, 松尾祐佳, 砂川賢二, 血管, 38, (1),   2015
  • 3T3-L1細胞の脂肪細胞分化に及ぼすミフェプリストンの促進作用, 橋本剛, 五十嵐淳介, 山下哲生, 平野勝也, 肥満研究, 20, (Supplement),   2014
  • 大腸菌発現系を用いたApoptosis-inducing factor(AIF)と生体膜との相互作用の解析, 山下哲生, 橋本剛, 五十嵐淳介, 平野勝也, 小坂博昭, 日本生体エネルギー研究会討論会講演要旨集, 40th,   2014
  • Thrombin receptor antagonists, HIRANO Katsuya, 138, (6), 258 - 259,   2011 12 01
  • くも膜下出血後の血管反応性亢進に、受容体活性および筋フィラメントのカルシウム感受性に対するフィードバック調節機構の障害が関与する, 吉川 雄一郎, 平野 勝也, 亀田 勝治, 中溝 玲, 吉本 幸司, 溝口 昌弘, 佐々木 富男, 脳血管攣縮, 26, 73 - 78,   2011 02
    脳血管平滑筋収縮に対するフィードバック調節機構が、くも膜下出血(SAH)後に実際に変化してるのかどうか、またどのような変化を来たしているかの観点から、SAH後の平滑筋収縮のメカニズムを明らかにした。日本白色ウサギを用いてSAHモデルを作製し、対照群とSAH群の2群に分けた。その結果、受容体の反復刺激実験において、対照群ではタキフィラキシーによる収縮反応の減弱を認めたが、SAH群ではタキフィラキシーが障害され、収縮反応性が維持されることが明らかになった。さらに、SAH後に受容体のシグナル伝達活性、および筋フィラメントのカルシウム感受性調節のレベルで作用するフィードバック調節機構も障害されることが示唆され、収縮反応が持続することが明らかになった。以上より、受容体のシグナル、筋フィラメントのカルシウム感受性に対するフィードバック調節機構の障害は、遅発性脳血管攣縮発症に重要な役割を果たすことが示唆された。
  • くも膜下出血後のウサギ脳底動脈におけるG蛋白質共役型受容体の脱感作障害, 吉川 雄一郎, 平野 勝也, 亀田 勝治, 甲斐 康稔, 宮城 靖, 溝口 昌弘, 庄野 禎久, 佐々木 富男, 脳血管攣縮, 25, 23 - 25,   2010 03
    受容体における脱感作機構の現象に注目して脳血管攣縮における受容体の活性制御異常について検討した。日本白ウサギを用いてくも膜下出血(SAH)モデルを作製し、麻酔下に0.5mlの髄液を大槽より採取、次に耳介動脈から採取した自家血2.5mlを大槽内に注入し、対照群では等量の生理食塩水を注入した。その結果、エンドセリン1・トロンビン・フェニレフリン刺激で対照群では一過性の収縮が発現し、SAH群では持続性に転じることが明らかとなった。この収縮反応性の変化は高カリウム脱分極刺激やホルボールエステルによるプロテインキナーゼCの直接刺激においては認められず、アゴニストによる受容体刺激に特徴的な現象と考えられた。更にまたアゴニストの連続刺激による反応性の減弱作用がSAH群において著明に低下することも明らかとなった。以上より、SAH後には受容体の脱感作が障害され、受容体シグナル活性が持続して収縮が持続性に転じたことが示唆された。
  • PJ-539 Novel Role of Rac1 in the Transcriptional Up-regulation of p27^ and Cell Cycle Arrest in Vascular Endothelial Cells(Molecular biology, vascular(02)(IHD),Poster Session(Japanese),The 72nd Annual Scientific Meeting of the Japanese Circulation Society), Hirano Mayumi, Kanaide Hideo, Hirano Katsuya, Circulation journal : official journal of the Japanese Circulation Society, 72, 648 - 648,   2008 03 01
  • PE-164 Up-regulation of Proteinase-Activated Receptor 2 by Oxidative Stress in Vascular Endothelial Cells both in vitro and in vivo(Cardiovascular pharmacology, basic/clinical(03)(H),Poster Session(English),The 72nd Annual Scientific Meeting of the Japanese Circulation Society), Hirano Katsuya, Hirano Mayumi, Kanaide Hideo, Circulation journal : official journal of the Japanese Circulation Society, 72, 401 - 401,   2008 03 01
  • OJ-066 Cyclooxygenase Plays a Key Role in the Up-regulation of PAR1 and the Hyper-contractile Response to Thrombin after Balloon Injury(Cardiovascular pharmacology, basic/clinical(02)(H),Oral Presentation(Japanese),The 72nd Annual Scientific Meeting of the Japanese Circulation Society), Hirano Katsuya, Hirano Mayumi, Kanaide Hideo, Circulation journal : official journal of the Japanese Circulation Society, 72, 304 - 304,   2008 03 01
  • OE-229 Thrombin Stimulation of Proteinase-Activated Receptor 1 (PAR1) Potentiated Ca2+-Independent and Rho kinase-Mediated Contractile Mechanism in the Normal Pulmonary Artery(Pulmonary circulation(01)(H),Oral Presentation(English),The 72nd Annual Scientific Meeting of the Japanese Circulation Society), Hirano Katsuya, Hirano Mayumi, Kanaide Hideo, Circulation journal : official journal of the Japanese Circulation Society, 72, 237 - 238,   2008 03 01
  • Regulatory mechanism of contraction in the dedifferentiated vascular smooth muscle, 223, (13), 1113 - 1118,   2007 12 29
  • PE-422 Distinct Ca^<2+> Requirement for Endothelial NO Synthase-mediated NO Production Between Proteinase-Activated Receptor-1 and 4(Endothelium-3, The 71st Annual Scientific Meeting of the Japanese Circulation Society), Hirano Katsuya, Hirano Mayumi, Kanaide Hideo, Circulation journal : official journal of the Japanese Circulation Society, 71, 430 - 430,   2007 03 01
  • OE-326 Thrombin Activation of Proteinase-Activated Receptor 1 (PAR1) Potentiates Myofilament Ca^<2+> Sensitivity and Induces Vasoconstriction in Pulmonary Artery(Pulmonary circulation-1, The 71st Annual Scientific Meeting of the Japanese Circulation Society), Hirano Katsuya, Hirano Mayumi, Kanaide Hideo, Circulation journal : official journal of the Japanese Circulation Society, 71, 232 - 232,   2007 03 01
  • 血管平滑筋収縮--MLCK作用を中心に (特集・血管壁), 平野 勝也, 金出 英夫, 生体の科学, 57, (6), 554 - 559,   2006 11
  • W-1.子宮平滑筋におけるプロテイナーゼ活性化型受容体の性ホルモンによる発現調節(産婦人科領域における最近の平滑筋研究,ワークショップ,第48回 日本平滑筋学会総会), 平野 勝也, 阿萬 紫, 金出 英夫, 日本平滑筋学会雑誌, 10, (1), "J - 19",   2006 04 28
  • PJ-647 Plasmin Induces Endothelium-dependent Nitric Oxide-mediated Relaxation in Coronary Artery(Cardiovascular pharmacology, basic/clinical-5 (H) PJ109,Poster Session (Japanese),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation Society), Fujiyoshi Tetsuhiro, Kanaide Hideo, Nishimura Junji, Hirano Katsuya, Hirano Mayumi, Circulation journal : official journal of the Japanese Circulation Society, 70, 649 - 650,   2006 03 01
  • PE-189 A Novel Thrombin Receptor Antagonist Prevented Vasospastic Response to Thrombin in the Basilar Artery after Subarachnoid Hemorrhage(Cerebrovascular circulation/Stroke-2 (IHD) PE32,Poster Session (English),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation Society), Kai Yasutoshi, Hirano Katsuya, Hirano Mayumi, Nishimura Junji, Kanaide Hideo, Circulation journal : official journal of the Japanese Circulation Society, 70, 382 - 382,   2006 03 01
  • PE-572 Proteinase-Activated Receptor-4 Preferentially Activates Ca^<2+>-independent, Akt-mediated NO Production in Vascular Endothelial Cells(Endothelium-4 (H) PE99,Poster Session (English),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation Society), Hirano Katsuya, Hirano Mayumi, Nishimura Junji, Kanaide Hideo, Circulation journal : official journal of the Japanese Circulation Society, 70, 475 - 475,   2006 03 01
  • The Phosphatidylinositol 3-kinase/Akt Pathway Mediates NO-independent Anti-apoptotic Effect of Estrogen in Vascular Endothelial Cells(Apoptosis/Necrosis/Regeneration 1 (M), The 69th Annual Scientific Meeting of the Japanese Circulation Society), Hirano Katsuya, Hirano Mayumi, Nishimura Junji, Kanaide Hideo, Circulation journal : official journal of the Japanese Circulation Society, 69, 190 - 190,   2005 03 01
  • Vascular Injury Induces Hyper-contractility Mediated by Proteinase-Activated Receptors (Vascular Smooth Muscle 2 (H), The 69th Annual Scientific Meeting of the Japanese Circulation Society), Fukunaga Ryota, Hirano Katsuya, Hirano Mayumi, Nishimura Junji, Kanaide Hideo, Circulation journal : official journal of the Japanese Circulation Society, 69, 556 - 556,   2005 03 01
  • Plasmin Antagonizes the Thrombin-induced Endothelium-dependent Relaxation in Coronary Artery (Cardiovascular Pharmacology, Basic/Clinical 2 (H), The 69th Annual Scientific Meeting of the Japanese Circulation Society), Fujiyoshi Tetsuhiro, Hirano Katsuya, Hirano Mayumi, Nishimura Junji, Kanaide Hideo, Circulation journal : official journal of the Japanese Circulation Society, 69, 599 - 599,   2005 03 01
  • Preventive Effect of a Thrombin Receptor Antagonist on Vasospasm in Subarachnoid Hemorrhage(Cerebrovascular Circulation/Stroke 1 (H), The 69th Annual Scientific Meeting of the Japanese Circulation Society), Kai Yasutoshi, Hirano Katsuya, Hirano Mayumi, Nishimura Junji, Kanaide Hideo, Circulation journal : official journal of the Japanese Circulation Society, 69, 508 - 509,   2005 03 01
  • Involvement of Na^+-Ca^<2+> Exchanger in Forskolin-induced Vasorelaxation in Mouse Thoracic Aorta : Evaluation Using NCX Transgenic Mouse Model(Vascular Smooth Muscle 1 (H), The 69th Annual Scientific Meeting of the Japanese Circulation Society), Karashima Eiji, Nishimura Junji, Iwamoto Takahiro, Hirano Katsuya, Kanaide Hideo, Circulation journal : official journal of the Japanese Circulation Society, 69, 175 - 175,   2005 03 01
  • FRS-080 17 β-estradiol inhibits TNF-α induced apoptosis by activating the phosphatidylinositol 3-kinase/Akt pathway in the vascular endothelial cells(NO and Cardiovascular System (H) : FRS10)(Featured Research Session (English)), Hirano Mayumi, Hirano Katsuya, Nishimura Junji, Kanaide Hideo, Circulation journal : official journal of the Japanese Circulation Society, 68, 110 - 111,   2004 03 01
  • PJ-150 Identification of cleavage sites responsible for a novel proteolytic mechanism of inactivation of protease-activated receptor-1 in vascular endothelial cells(Endothelium/NO 2 (H) : PJ25)(Poster Session (Japanese)), Hirano Katsuya, Hirano Mayumi, Nishimura Junji, Kanaide Hideo, Circulation journal : official journal of the Japanese Circulation Society, 68, 516 - 516,   2004 03 01
  • PE-232 Contractile Property of the Proliferating Vascular Smooth Muscle Cells : A Crucial Role of RhoA in Contractility(Vascular Smooth Muscle 1 (H) : PE40)(Poster Session (English)), Nishimura Junji, Hirano Katsuya, Kanaide Hideo, Circulation journal : official journal of the Japanese Circulation Society, 68, 419 - 419,   2004 03 01
  • PJ-367 Identification of a novel transcriptional regulatory element of p27^ gene that responds to formation of cell-cell contact in endothelial cells(Molecular Biology, Vascular 2 (H) : PJ61)(Poster Session (Japanese)), Hirano Mayumi, Hirano Katsuya, Nishimura Junji, Kanaide Hideo, Circulation journal : official journal of the Japanese Circulation Society, 68, 570 - 570,   2004 03 01
  • PJ-364 A role of Pad in maintenance of cell surface expression of protease-activated receptor-1 in the vascular smooth muscle cells(Molecular Biology, Vascular 2 (H) : PJ61)(Poster Session (Japanese)), Hirano Katsuya, Hirano Mayumi, Nishimura Junji, Kanaide Hideo, Circulation journal : official journal of the Japanese Circulation Society, 68, 569 - 569,   2004 03 01
  • OJ-422 Inhibition of RhoA signalling enhances NO production in endothelial cells and reduces contractility in the isolated rabbit mesenteric artery(Endothelium/NO 5 (H) : OJ51)(Oral Presentation (Japanese)), Hirano Katsuya, Nishimura Junji, Kanaide Hideo, Circulation journal : official journal of the Japanese Circulation Society, 68, 332 - 332,   2004 03 01
  • Changes in the contractility of the NIH3T3 fibroblast induced by the over-expression of CPI-17, NISHIMURA Junji, KANAIDE Hideo, Folia pharmacologica Japonica, 122, 43P - 45P,   2003 11 01
  • Rho Kinase-Dependent and Independent Inhibition of Myosin Phosphatase and Ca^<2+>-Sensitization of the Contractile Apparatus in the Basilar Artery, Hirano Katsuya, Nishimura Junji, Kanaide Hideo, Circulation journal : official journal of the Japanese Circulation Society, 67, 406 - 406,   2003 03 01
  • Functional Linkage of Reverse Mode Na^+Ca^<2+> Exchanger and Sarcoplasmic Reticulum Ca^<2+> Release in Porcine Coronary Arterial Smooth Muscle, Yamanaka Jun, Nishimura Junji, Hirano Katsuya, Kanaide Hideo, Circulation journal : official journal of the Japanese Circulation Society, 67, 407 - 407,   2003 03 01
  • An Important Role for the Na^+Ca^<2+> Exchanger in Decreasing Cytosolic Ca^<2+> Concentration by Isoprenaline in the Porcine Coronary Artery, Yamanaka Jun, Nishimura Junji, Hirano Katsuya, Kanaide Hideo, Circulation journal : official journal of the Japanese Circulation Society, 67, 407 - 407,   2003 03 01
  • A Novel Mechanism of Inactivation of Protease-Activated Receptor-1 by Thrombin in Endothelial Cells : An Additional Removal of the Tethered Ligand, Hirano Katsuya, Nishumura Junji, Kanaide Hideo, Circulation journal : official journal of the Japanese Circulation Society, 67, 526 - 526,   2003 03 01
  • Collagen Gel Constriction by Contractile Coronary Artery Smooth Muscle Cells : In-Vitro Model of Constrictive Remodeling, Nishimura Junji, Hirano Katsuya, Kanaide Hideo, Circulation journal : official journal of the Japanese Circulation Society, 67, 207 - 207,   2003 03 01
  • RhoA-Rho Kinase Pathway and Increased Ca^<2+> Sensitivity of the Vascular Smooth Muscle, Nishimura Junji, Hirano Katsuya, Kanaide Hideo, Circulation journal : official journal of the Japanese Circulation Society, 67, 58 - 58,   2003 03 01
  • 平滑筋収縮装置のCa^<2+>感受性調節 : ミオシンリン酸化と脱リン酸化機構, 平野 勝也, DERKACH Dmitry N., 平野 真弓, 西村 淳二, 金出 英夫, 血管, 25, (2), 53 - 61,   2002 05 19
  • Transduction of the N-terminal fragment of MYPT1 enhances the contraction in intact smooth muscle of porcine coronary artery, Hirano Katsuya, Hirano Mayumi, Nishimura Junji, Kanaide Hideo, Circulation journal : official journal of the Japanese Circulation Society, 66, 464 - 464,   2002 03 31
  • 平滑筋の緊張制御機序 ((社)日本麻酔科学会第49回大会講演特集号) -- (学術講演), 金出 英夫, 平野 勝也, 西村 淳二, 麻酔, 51, S33 - 40,   2002
  • 32. 妊娠ラット子宮平滑筋におけるトロンビン受容体発現増加と収縮反応の増強, 新谷 可伸, 平野 勝也, 西村 淳二, 金出 英夫, Journal of smooth muscle research. Japanese section, 4, (1), J - 32,   2000 04 30
  • 41. モルモット結腸紐自発収縮に対するY-27632の効果, 家入 里志, 西村 淳二, 平野 勝也, 金出 英夫, 水田 祥代, Journal of smooth muscle research. Japanese section, 4, (1), J - 37,   2000 04 30
  • 0264 内皮由来過分極因子(EDHF)は内皮型NO合成酵素(eNOS)由来の非NO物質である可能性 : eNOSノックアウトマウスにおける検討, 的場 哲哉, 下川 宏明, 平川 洋二, 竹下 彰, 中島 幹夫, 平野 勝也, 金出 英夫, Japanese circulation journal, 64, 251 - 251,   2000 03 01
  • IS162 Cloning of p27^, a Degradation-resistant Isoform of a Cyclin-dependent Kinase Inhibitor, in Vascular Endothelial Cells, Hirano Katsuya, Hirano Mayumi, Nishimura Junji, Kanaide Hideo, Japanese circulation journal, 64, 170 - 170,   2000 03 01
  • P749 トリプシンによる冠動脈の内皮依存性弛緩反応は内皮細胞Ca^<2+>貯蔵部位からのCa^<2+>放出によって制御されている, 平野 勝也, 西村 淳二, 金出 英夫, Japanese circulation journal, 64, 647 - 647,   2000 03 01
  • P716 増殖型血管平滑筋細胞においてMAPキナーゼ系はアンギオテンシンII受容体発現を抑制する。, 平野 勝也, 平野 真弓, 西村 淳二, 金出 英夫, Japanese circulation journal, 64, 639 - 639,   2000 03 01
  • P041 ミオシン軽鎖の特異的細胞内局在に必要なアミノ酸領域の決定とRhoキナーゼが引き起こす細胞形態変化への関わりについて, 安恒 亨, 西村 淳二, 平野 勝也, 金出 英夫, 安井 久喬, Japanese circulation journal, 64, 469 - 469,   2000 03 01
  • 増殖型血管平滑筋細胞においてMAPキナーゼは電位依存性L型Ca2+ channelの発現を抑制する, 伊原 栄吉, 平野 勝也, 西村 淳二, 金出 英夫, Japanese Circulation Journal, 64, (Suppl.I), 254 - 254,   2000 03
  • 血管平滑筋の緊張制御に関する最新情報--Ca2+感受性調節におけるミオシン脱リン酸化酵素の役割 (10月第5特集 Vascular biology--分子生物学と病態・治療) -- (血管の構築), 平野 勝也, 金出 英夫, 医学のあゆみ, 191, (5), 332 - 337,   1999 10 30
  • ラット大動脈培養平滑筋細胞の増殖に伴う電位依存性及び容量性Ca2+流入機構の変化, 伊原 栄吉, 平野 勝也, 西村 淳二, 名和田 新, 金出 英夫, 動脈硬化, 26, (8), 147 - 147,   1999 05
  • P-7. エストロゲン及びプロゲステロンによるモルモット結腸紐弛緩反応の相違, 家入 里志, 平野 勝也, 西村 淳二, 金出 英夫, 水田 祥代, Journal of smooth muscle research. Japanese section, 3, (1), J - 52,   1999 04 30
  • 0111 Vascular Endothelial Growth Factor (VEGF)による血管新生を、Ca^<2+>流入阻害剤SKF96365が阻止する, 川崎 純也, 平野 勝也, 西村 淳二, 金出 英夫, Japanese circulation journal, 63, (1), 175 - 175,   1999 03 01
  • 0585 平滑筋ミオシン脱リン酸化酵素調節サブユニットによる血管平滑筋収縮増強作用, 平野 勝也, 西村 淳二, 金出 英夫, Japanese circulation journal, 63, (1), 295 - 295,   1999 03 01
  • P316 caveolin-1およびcaveolin-2の細胞内局在 : 蛍光蛋白質との融合蛋白質発現系を用いた解析, 西村 淳二, 安恒 亨, 平野 勝也, 金出 英夫, Japanese circulation journal, 63, (1), 528 - 528,   1999 03 01
  • Thapsigarginは豚腎動脈において内皮依存性の収縮と弛緩の両反応を引き起こす, 伊原 栄吉, 平野 勝也, 西村 淳二, 金出 英夫, Journal of smooth muscle research. Japanese section, 2, (1), J - 44,   1998 04 30
  • 0498 免疫抑制剤FK506は豚冠動脈平滑筋を弛緩させる, 安恒 亨, 平野 勝也, 西村 淳二, 金出 英夫, 安井 久喬, Japanese circulation journal, 62, 229 - 229,   1998 02 28
  • P161 ブレフェルジンAは豚冠動脈において内皮由来過分極因子の産生を抑制する。, 平野 勝也, 西村 淳二, 金出 英夫, Japanese circulation journal, 62, 425 - 425,   1998 02 28
  • P591 血管平滑筋収縮におけるカルモジュリン機能の発現には第4Ca^<2+>結合部位が重要である。, 西村 淳二, 平野 勝也, 金出 英夫, Japanese circulation journal, 62, 533 - 533,   1998 02 28
  • 0905 トロンビンが引き起こす内皮細胞Caシグナルと内皮依存性血管弛緩反応との相関, 水野 修, 平野 勝也, 西村 淳二, 金出 英夫, Japanese circulation journal, 62, 332 - 332,   1998 02 28
  • 0918 新規糖尿病薬トログリタゾンによるブタ冠動脈平滑筋細胞の弛緩機序, 川崎 純也, 平野 勝也, 西村 淳二, 金出 英夫, Japanese circulation journal, 62, 335 - 335,   1998 02 28
  • P692 ラット大動脈初代培養平滑筋細胞においてアンギオテンシンIIが引き起こす細胞質Ca濃度上昇反応の細胞密度依存性, 平野 勝也, 西村 淳二, 金出 英夫, Japanese circulation journal, 62, 559 - 559,   1998 02 28
  • P849 内皮細胞の細胞間接触は増殖停止とストレスファイバーの形態変化を誘導する。, 平野 真弓, 平野 勝也, 西村 淳二, 金出 英夫, Japanese circulation journal, 62, 598 - 598,   1998 02 28
  • P302 ラット大動脈初代培養平滑筋細胞におけるトロポミオシンα発現のスプライシング反応による調節, 平野 勝也, 西村 淳二, 金出 英夫, Japanese circulation journal, 62, 460 - 460,   1998 02 28
  • -1243-Ca^<2+>-FORCE RELATION IN SARAFOTOXIN INDUCED CONTRACTION OF RAT AORTIC STRIPS : THE 54th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY, WATANABE Chiaki, HIRANO Katsuya, KANAIDE Hideo, NAKAMURA Motoomi, Japanese circulation journal, 54, (8), 1073 - 1074,   1990 08 20
  • -1092-EFFECTS OF DILTIAZEM ON, Ca^<2+>-TENSION RELATIONSHIP IN THE PORCINE CORONARY ARTERY : THE 54th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY, HIRANO Katsuya, KANAIDE Hideo, NAKAMURA Motoomi, Japanese circulation journal, 54, (8), 1029 - 1029,   1990 08 20
  • -0555-EFFECTS OF THE ANGIOTENSIN CONVERTING ENZYME (ACE) INHIBITOR, CAPTOPRIL ON BRADYKININ-INDUCED CALCIUM TRANSIENT IN CULTURED BOCINE AORTIC ENDOTHELIAL CELLS, Hirano Katsuya, Hirano Mayumi, Hisajima Hiroko, Kanaide Hideo, Nakamura Motoomi, Japanese circulation journal, 54, (7), 866 - 866,   1990 07 20
  • -113-ENDOTHELIN INDUCED Ca-INDEPENDENT CONTRACTION OF THE PORCINE CORONARY ARTERY : Cardiovascular Drugs : FREE COMMUNICATIONS(I) : PROCEEDINGS OF THE 53th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY, Kodama Mayuko, Abe Shimako, Hirano Katsuya, Kai Hisashi, Kanaide Hideo, Nakamura Motoomi, Japanese circulation journal, 53, (6), 511 - 511,   1989 06 20
  • -194-CHARACTERISTICS OF INTRACELLULAR Ca-STORE SITES IN SMOOTH MUSCLE CELLS OF PORCINE CORONARY ARTERY : Coronary Circulation : FREE COMMUNICATIONS(I) : PROCEEDINGS OF THE 53th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY, Hirano Katsuya, Abe Shimako, Kodama Mayuko, Kanaide Hideo, Nakamura Motoomi, Japanese circulation journal, 53, (6), 534 - 534,   1989 06 20
  • N-terminal region of apoptosis-inducing factor facilitates dimer formation by stabilizing the charge transfer complex, Tetsuo Yamashita, Takeshi Hashimoto, Junsuke Igarashi, Hiroaki Kosaka, Katsuya Hirano, The Journal of Physiological Science, 70, (Supplement 1), S137 - S137,   2020 03 , [Refereed]
  • Endogenous H2S maintains myogenic tone in lower esophageal sphincter: A possible target for treatment of lower esophageal sphincter dysfunction, Xiaopeng Bai, Eikichi Ihara, Yoshimasa Tanaka, Katsuya Hirano, Mayumi Hirano, Kazuhiko Nakamura, JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, 31, 11 - 11,   2016 11
  • Trypsin Induced a Transient Contraction via a PAR2/TRPV1/Neurokinin Receptors Pathway in Circular Smooth Muscle of Porcine Esophageal Body, Xiaopeng Bai, Eikichi Ihara, Yoshimasa Tanaka, Katsuya Hirano, Mayumi Hirano, Hirotada Akiho, Kazuhiko Nakamura, GASTROENTEROLOGY, 150, (4), S458 - S458,   2016 04
    0
  • Involvement of Different Subtypes of Receptor in Prostaglandin E2-Induced Motile Function in Lower Esophageal Sphincter and Esophageal Body Smooth Muscle, Xiaopeng Bai, Eikichi Ihara, Yoshimasa Tanaka, Katsuya Hirano, Mayumi Hirano, Kazuhiko Nakamura, GASTROENTEROLOGY, 150, (4), S458 - S458,   2016 04
    0
  • Activation of cAMP/CREB/PGC-1 alpha Pathway Plays a Key Role for a Novel Adenosine-like Angiogenic Agent COA-CI to Induce Production of Vascular Endothelial Growth Factor (VEGF) in Cultured Human Fibroblasts, Ryuji Okamoto, Junsuke Igarashi, Takeshi Hashimoto, Tetsuo Yamashita, Kazuyo Shoji, Yasuo Kubota, Norikazu Sakakibara, Ikuko Tsukamoto, Ryoji Konishi, Katsuya Hirano, CIRCULATION, 132,   2015 11
  • Proteinase-activated Receptor 1 Antagonist Inhibited the Progression of Monocrotaline Induced Pulmonary Hypertension in Rats, Yukimitsu Kuwabara, Kohtaro Abe, Mayumi Hirano, Yoshitaka Hirooka, Kenji Sunagawa, Katsuya Hirano, CIRCULATION, 132,   2015 11
  • A Key Role of PGC-1 alpha Co-transcription Factor, but not HIF1 alpha Transcription Factor, in Production of Vascular Endothelial Growth Factor (VEGF) by a Novel Angiogenic Agent COA-CI in Cultured Human Fibroblasts, Ryuji Okamoto, Junsuke Igarashi, Tetsuo Yamashita, Takeshi Hashimoto, Sakiko Karita, Kazuyo Shoji, Yasuo Kubota, Maki Takata, Fuminori Yamaguchi, Masaaki Tokuda, Norikazu Sakakibara, Ikuko Tsukamoto, Ryoji Konishi, Katsuya Hirano, CIRCULATION, 132,   2015 11
  • Endogenous H2S Contributes to Myogenic Tone Generation in Lower Esophageal Sphincter: Possible Involvement of Na+/CA(2+) Exchanger, Xiaopeng Bai, Eikichi Ihara, Yoshimasa Tanaka, Katsuya Hirano, Mayumi Hirano, Hirotada Akiho, Kazuhiko Nakamura, Ryoichi Takayanagi, GASTROENTEROLOGY, 148, (4), S78 - S78,   2015 04
  • Inhibition of Increased Thrombin Receptor Activity Attenuated Monocrotaline-induced Pulmonary Hypertension in Rats, Yukimitsu Kuwabara, Kohtaro Abe, Mayumi Hirano, Yoshitaka Hirooka, Katsuya Hirano, Kenji Sunagawa, CIRCULATION, 130,   2014 11
  • Different Contractile and Relaxant Effects of Trypsin in Phasic Smooth Muscles of the Esophageal Body and the Tonic Lower Esophageal Sphincter, Xiaopeng Bai, Yoshimasa Tanaka, Eikichi Ihara, Katsuya Hirano, Mayumi Hirano, Kazuhiko Nakamura, Hirotada Akiho, Ryoichi Takayanagi, GASTROENTEROLOGY, 146, (5), S862 - S862,   2014 05
  • Vascular intrinsic biological clock in the regulation of myofilament calcium sensitivity, Katsuya Hirano, JOURNAL OF VASCULAR RESEARCH, 51, 65 - 65,   2014
  • Submembranous di-phosphorylation of myosin light chain and actin fiber formation play a critical role as an initial event during endothelial barrier disruption, Mayumi Hirano, Katsuya Hirano, JOURNAL OF VASCULAR RESEARCH, 51, 106 - 106,   2014
  • Mechanisms underlying impaired desensitization of proteinase-activated receptor 1 (PAR(1)), Katsuya Hirano, Mayumi Hirano, JOURNAL OF PHARMACOLOGICAL SCIENCES, 124, 160P - 160P,   2014
  • Role of mono- and di-phosphorylation of myosin light chain in thrombin-induced endothelial barrier disruption, Mayumi Hirano, Katsuya Hirano, JOURNAL OF PHARMACOLOGICAL SCIENCES, 124, 223P - 223P,   2014
  • Trypsin Induced BiPhasic Contraction and Relaxation in the Porcine Lower Esophageal Sphincter, Yoshimasa Tanaka, Eikichi Ihara, Katsuya Hirano, Mayumi Hirano, Kazuhiko Nakamura, Hirotada Akiho, Ryoichi Takayanagi, GASTROENTEROLOGY, 144, (5), S857 - S857,   2013 05
    0
  • Rho Kinase-mediated Di-phosphorylation of Myosin Light Chain in the Sub-membranous Regions and Circumferential Actomyosin Contraction Mediate Thrombin-induced Barrier Disruption in Vascular Endothelial Cells, Mayumi Hirano, Katsuya Hirano, STROKE, 44, (2),   2013 02
  • Oxidative stress and Extracellular Signal-regulated Kinase (ERK) Play a Key Role in Impairment of Receptor Desensitization and Prolongation of Vascular Reactivity in the Cerebral Artery after Subarachnoid Hemorrhage, Katsuya Hirano, Katsuharu Kameda, Akiko Hanada, Mayumi Hirano, STROKE, 44, (2),   2013 02
  • Trypsin induced biphasic contraction and relaxation in the porcine lower esophageal sphincter, Yoshimasa Tanaka, Eikichi Ihara, Katsuya Hirano, Mayumi Hirano, Kazuhiko Nakamura, Ryoichi Takayanagi, JOURNAL OF PHARMACOLOGICAL SCIENCES, 121, 169P - 169P,   2013
  • A Clock Gene ROR alpha-mediated Regulation of the Activity of Rho-associated Coiled-coil Protein Kinase 2 (ROCK2) Plays a Key Role in Generating Vascular Intrinsic Circadian Rhythm of Myofilament Ca2+ Sensitivity and Vascular Contractility, Toshiro Saito, Mayumi Hirano, Tomomi Ide, Toshihiro Ichiki, Noriyuki Koibuchi, Kenji Sunagawa, Katsuya Hirano, CIRCULATION RESEARCH, 111, (12), E382 - E382,   2012 12
  • Oxidative Stress and Rho-Associated Coiled-Coil Protein Kinase (ROCK)-Mediated Double Phosphorylation of Myosin Light Chain in the Submembranous Region Plays a Key Role in Thrombin-Induced Barrier Dysfunction in Vascular Endothelial Cells, Mayumi Hirano, Akiko Hanada, Katsuya Hirano, CIRCULATION, 126, (21),   2012 11
  • Oxidative Stress Impairs Desensitization of G-protein Coupled Receptors and Increases Vascular Reactivity in Basilar Artery after Subarachnoid Hemorrhage (SAH), Katsuharu Kameda, Yuichiro Kikkawa, Mayumi Hirano, Satoshi Matsuo, Tomio Sasaki, Katsuya Hirano, JOURNAL OF PHARMACOLOGICAL SCIENCES, 118, 78P - 78P,   2012
  • Rho kinase-mediated di-phosphorylation of myosin light chain in the subjunctional regions plays a critical role in thrombin-induced endothelial barrier dysfunction, Mayumi Hirano, Akiko Hanada, Katsuya Hirano, JOURNAL OF PHARMACOLOGICAL SCIENCES, 118, 245P - 245P,   2012
  • Enhancement of Endothelin-1-induced myofilament sensitization to Ca2+ and its mechanisms after subarachnoid hemorrhage (SAH), Yuichiro Kikkawa, Satoshi Matsuo, Mayumi Hirano, Akira Nakamizo, Tomio Sasaki, Katsuya Hirano, JOURNAL OF PHARMACOLOGICAL SCIENCES, 118, 83P - 83P,   2012
  • Oxidative Stress Impairs Desensitization of the G-Protein Coupled Receptors (GPCRs) and Increases Vascular Reactivity by Prolonging the Contractile Responses in the Cerebral Arteries After Subarachnoid Hemorrhage, Katsuharu Kameda, Yuichiro Kikkawa, Mayumi Hirano, Satoshi Matsuo, Tomio Sasaki, Katsuya Hirano, CIRCULATION, 124, (21),   2011 11
  • Ca2+-Independent Di-phosphorylation of Myosin Light Chain by Rho-associated Coiled-Coil Protein Kinase (ROCK) in the Subjunctional Regions of Cell-Cell Contact Mediates Thrombin-Induced Barrier Dysfunction in Vascular Endothelial Cells, Mayumi Hirano, Akiko Hanada, Katsuya Hirano, CIRCULATION, 124, (21),   2011 11
  • Depletion of Intracellular Ca2+ Stores Induces Phosphorylation of Stromal Interaction Molecular 1 (STIM1), Which Contributes to the Sustained Phase of Store-operated Ca2+ Influx in Vascular Endothelial Cells, Katsuya Hirano, Akiko Hanada, Mayumi Hirano, CIRCULATION, 124, (21),   2011 11
  • ROCK2 plays a key role in the circadian change in thrombin-induced myosin light chain phosphorylation in smooth muscle, Toshiro Saito, Mayumi Hirano, Katsuya Hirano, JOURNAL OF PHARMACOLOGICAL SCIENCES, 115, 160P - 160P,   2011
  • The combination of argatroban and vitamin C normalizes the increased vascular reactivity after subarachnoid hemorrhage (SAH), Katsuharu Kameda, Yuichiro Kikkawa, Mayumi Hirano, Tomio Sasaki, Katsuya Hirano, JOURNAL OF PHARMACOLOGICAL SCIENCES, 115, 72P - 72P,   2011
  • Store-operated phosphorylation of endogenous STIM1 in the interphase cells as revealed by a Phos-tag SDS-PAGE analysis, Katsuya Hirano, Akiko Hanada, Mayumi Hirano, JOURNAL OF PHARMACOLOGICAL SCIENCES, 115, 272P - 272P,   2011
  • Thrombin causes barrier dysfunction via two distinct signal transduction pathways in vascular endothelial cells, Mayumi Hirano, Akiko Hanada, Katsuya Hirano, JOURNAL OF PHARMACOLOGICAL SCIENCES, 115, 157P - 157P,   2011
  • Identification of Rho-associated Kinase 2 (ROCK2) as a Key Molecule Generating the Intrinsic Circadian Rhythm of Vascular Contractility, Toshiro Saito, Mayumi Hirano, Tomomi Ide, Kenji Sunagawa, Katsuya Hirano, CIRCULATION, 122, (21),   2010 11
  • Rho-associated Kinase (ROCK) Mediates the Thrombin-Induced Production of Reactive Oxygen Species and Myosin Light Chain Phosphorylation-Independent Vasoconstriction in the Pulmonary Artery, Katsuya Hirano, Jun Maki, Mayumi Hirano, CIRCULATION, 122, (21),   2010 11
  • Intrinsic circadian oscillation of myosin light chain phosphorylation in vascular smooth muscle cells, Toshiro Saito, Mayumi Hirano, Tomomi Ide, Kenji Sunagawa, Katsuya Hirano, FASEB JOURNAL, 24,   2010 04
  • Differential regulation of the thrombin-induced mono- and di-phosphorylation of myosin light chain in vascular endothelial cells, Mayumi Hirano, Katsuya Hirano, JOURNAL OF PHARMACOLOGICAL SCIENCES, 112, 144P - 144P,   2010
  • The thrombin-induced myosin light chain phosphorylation exhibits an intrinsic circadian oscillation in vascular smooth muscle, Toshiro Saito, Mayumi Hirano, Katsuya Hirano, JOURNAL OF PHARMACOLOGICAL SCIENCES, 112, 149P - 149P,   2010
  • Mechanisms underlying increased vascular contractility in subarachnoid hemorrhage, Yuichiro Kikkawa, Katsuharu Kameda, Tomio Sasaki, Katsuya Hirano, JOURNAL OF PHYSIOLOGICAL SCIENCES, 60, S57 - S57,   2010
  • Impaired feedback regulation of the receptor signaling and the myofilament Ca2+ sensitization contributes to increased vascular reactivity after subarachnoid hemorrhage, Yuichiro Kikkawa, Katsuharu Kameda, Mayumi Hirano, Tomio Sasaki, Katsuya Hirano, JOURNAL OF PHARMACOLOGICAL SCIENCES, 112, 60P - 60P,   2010
  • The combination of thrombin inhibitor and vitamin C normalizes the increased vascular reactivity after subarachnoid hemorrhage, Katsuharu Kameda, Yuichiro Kikkawa, Mayumi Hirano, Tomio Sasaki, Katsuya Hirano, JOURNAL OF PHARMACOLOGICAL SCIENCES, 112, 148P - 148P,   2010
  • Regulation and physiological roles of store-operated Ca2+ influx in vascular endothelial cells, Katsuya Hirano, Mayumi Hirano, JOURNAL OF PHYSIOLOGICAL SCIENCES, 60, S55 - S55,   2010
  • Intracellular alkalinization activates STIM1-dependent but store-independent Ca2+ influx in vascular endothelial cells, Katsuya Hirano, Akiko Hanada, Mayumi Hirano, JOURNAL OF PHARMACOLOGICAL SCIENCES, 112, 144P - 144P,   2010
  • Thrombin Activation of Proteinase-Activated Receptor 1 (PAR(1)) Induces Ca2+-Independent Vasoconstriction by Activating the Production of Reactive Oxygen Species in the Pulmonary Artery, Jun Maki, Mayumi Hirano, Katsuya Hirano, CIRCULATION, 120, (18), S1022 - S1023,   2009 11
  • Roles of proteinase-activated receptors in the increased detrusor muscle contractility and pollakisuria in cystitis in mice, Ken-ichiro Shiga, Mayumi Hirano, Katsuya Hirano, JOURNAL OF PHARMACOLOGICAL SCIENCES, 109, 144P - 144P,   2009
  • A new method for analyzing myosin light chain phosphorylation with a Phos-tag (TM) technology, Mayumi Hirano, Katsuya Hirano, JOURNAL OF PHARMACOLOGICAL SCIENCES, 109, 259P - 259P,   2009
  • The impairment. of the desensitization of G protein-coupled receptors in subarachnoid hemorrhage in rabbit basilar arteries, Yuichiro Kikkawa, Katsuharu Kameda, Mayumi Hirano, Katsuya Hirano, JOURNAL OF PHARMACOLOGICAL SCIENCES, 109, 63P - 63P,   2009
  • Involvement of STIM1 in PAR1-mediated Ca2+ influx and NO production in vascular endothelial cells, Katsuya Hirano, Akiko Hanada, Mayumi Hirano, JOURNAL OF PHARMACOLOGICAL SCIENCES, 109, 265P - 265P,   2009
  • Identification of a novel STIM1-Binding protein as a regulator of store-operated Ca2+ influx, Katsuya Hirano, Akiko Hanada, Mayumi Hirano, JOURNAL OF PHARMACOLOGICAL SCIENCES, 109, 55P - 55P,   2009
  • Preventive effect of thrombin inhibitor argatroban on increased contractile response to thrombin in the basilar artery after subarachnoid hemorrhage, Katsuharu Kameda, Yuichiro Kikkawa, Mayumi Hirano, Katsuya Hirano, JOURNAL OF PHARMACOLOGICAL SCIENCES, 109, 231P - 231P,   2009
  • Roles of reactive oxygen species (ROS) and Rho-kinase in the thrombin-induced and proteinase-activated receptor 1(PAR(1))-mediated pulmonary artery vasoconstriction, Jun Maki, Mayumi Hirano, Katsuya Hirano, JOURNAL OF PHARMACOLOGICAL SCIENCES, 109, 259P - 259P,   2009
  • Enhancement of the bradykinin-induced contraction by thrombin and trypsin in the detrusor muscle of cyclophosphamide-treated mice, Ken-ichiro Shiga, Mayumi Hirano, Katsuya Hirano, JOURNAL OF PHARMACOLOGICAL SCIENCES, 106, 203P - 203P,   2008
  • Proteinase-Activated Receptor 1 (PAR1) induces Ca2+-independent, Rho kinase-mediated contraction in the normal pulmonary artery, Jun Maki, Mayumi Hirano, Katsuya Hirano, JOURNAL OF PHARMACOLOGICAL SCIENCES, 106, 69P - 69P,   2008
  • The role of thrombin receptor in cerebral vasospasm after subarachnoid hemorrhage, Yasutoshi Kai, Yoshihisa Maeda, Tomio Sasaki, Hideo Kanaide, Katsuya Hirano, JOURNAL OF PHARMACOLOGICAL SCIENCES, 106, 23P - 23P,   2008
  • Nipradilol decreases Ca2+ sensitivity of pig ciliary artery, Yuhei Hasegawa, Katsuya Hirano, Junji Nishimura, Mayumi Hirano, Hideo Kanaide, JOURNAL OF PHARMACOLOGICAL SCIENCES, 103, 270P - 270P,   2007
  • Plasmin induces relaxation through the activation of a novel proteinase-activated receptor in the porcine coronary artery, Tetsuhiro Fujisyohi, Katsuya Hirano, Mayumi Hirano, Hideo Kanaide, JOURNAL OF PHARMACOLOGICAL SCIENCES, 103, 194P - 194P,   2007
  • Involvement of cGMP-mediated activation of Na+-Ca2+ exchanger in isosorbide dinitrate-induced decreases in [Ca2+](i) in vascular smooth muscle, Eiji Karashima, Jun Yamanaka, Katsuya Hirano, mayumi Hirano, Takahiro Iwamoto, Satomi Kita, Hideo Kanaide, JOURNAL OF PHARMACOLOGICAL SCIENCES, 103, 204P - 204P,   2007
  • Involvement of Na+-Ca2+ exchange in replenishing the Ca2+ stores in vascular smooth muscle, Jun Yamanaka, Katsuya Hirano, Eiji Karashima, Mayurm Hirano, Hideo Kanaide, JOURNAL OF PHARMACOLOGICAL SCIENCES, 103, 152P - 152P,   2007
  • Oxidative stress enhanced a proteinase-activated receptor-2-mediated endothelium-dependent relaxation in the rat aorta, Murasaki Aman, Katsuya Hirano, Mayumi Hirano, Hideo Kanaide, JOURNAL OF PHARMACOLOGICAL SCIENCES, 103, 247P - 247P,   2007
  • A novel strategy to prevent the vasospastic response of the basilar artery to thrombin in subarachnoid hemorrhage using a selective proteinase-activated receptor-1 antagonist, Yasutoshi Kai, Katsuya Hirano, Junji Nishimura, Hideo Kanaide, CIRCULATION, 114, (18), 158 - 158,   2006 10
  • Homophilic cell contact activated Rac1 and up-regulated p27(Kip1) transcription in vascular endothelial cells, M Hirano, K Hirano, N Niiro, J Nishimura, H Kanaide, JOURNAL OF PHARMACOLOGICAL SCIENCES, 100, 182P - 182P,   2006
  • Relaxin relaxes rat myometrium by decreasing Ca2+ sensitivity of contractile apparatus via a cAMP/PKA signaling pathway, M Miyazaki, N Niiro, K Hirano, M Hirano, J Nishimura, H Kanaide, JOURNAL OF PHARMACOLOGICAL SCIENCES, 100, 62P - 62P,   2006
  • Balloon injury up-regulates the expression of proteinase-activated receptors and induces vasospasm at the injury site in rabbit femoral artery, R Fukunaga, K Hirano, M Hirano, N Niiro, J Nishimura, H Kanaide, JOURNAL OF PHARMACOLOGICAL SCIENCES, 100, 61P - 61P,   2006
  • Proteinase-activated receptor (PAR)-1 activation potentiates myofilament Ca2+ sensitivity and induces pulmonary artery contraction, J Maki, K Hirano, M Hirano, N Niiro, J Nishimura, H Kanaide, JOURNAL OF PHARMACOLOGICAL SCIENCES, 100, 278P - 278P,   2006
  • Oxidative stress enhanced a trypsin-induced endothelium-dependent relaxation in the rat aorta, M Aman, K Hirano, M Hirano, N Niiro, J Nishimura, H Kanaide, JOURNAL OF PHARMACOLOGICAL SCIENCES, 100, 280P - 280P,   2006
  • Plasmin-induced endothelium-dependent relaxation in coronary artery, T Fujiyoshi, K Hirano, M Hirano, N Niiro, H Kanaide, JOURNAL OF PHARMACOLOGICAL SCIENCES, 100, 277P - 277P,   2006
  • Mechanism underlying the dimethyl sulfoxide (DMSO)-induced relaxation of the rabbit detrusor smooth muscle, K Shiga, J Nishimura, N Niiro, M Hirano, K Hirano, H Kanaide, JOURNAL OF PHARMACOLOGICAL SCIENCES, 100, 214P - 214P,   2006
  • A crucial role of Rac1 in membrane targeting of thrombin receptor in vascular smooth muscle cells, W Eto, K Hirano, M Hirano, N Niiro, J Nishimura, H Kanaide, JOURNAL OF PHARMACOLOGICAL SCIENCES, 100, 280P - 280P,   2006
  • Prevention of hyper-contractile response to thrombin by proteinase-activated receptor-1 antagonist in rabbit double subarachnoid hemorrhage model, Y Kai, K Hirano, M Hirano, N Niiro, J Nishimura, H Kanaide, JOURNAL OF PHARMACOLOGICAL SCIENCES, 100, 106P - 106P,   2006
  • The vascular injury up-regulates the expression of proteinase-activated receptors and induces vasospasm at the injured site, R Fukunaga, K Hirano, M Hirano, J Nishimura, Y Maehara, H Kanaide, CIRCULATION, 112, (17), U76 - U76,   2005 10
  • Activation of proteinase-activated receptor-4 induces Ca2+-independent NO production in cultured bovine aortic endothelial cells, N Nomoto, M Hirano, K Hirano, J Nishimura, H Kanaide, JOURNAL OF PHARMACOLOGICAL SCIENCES, 97, 110P - 110P,   2005
  • RhoA plays a key role in regulating NO production in in situ enclothelial cells, N Shiga, K Hirano, J Nishimura, H Kanaide, JOURNAL OF PHARMACOLOGICAL SCIENCES, 97, 296P - 296P,   2005
  • Forskolin-induced vasorelaxation involves Na+/Ca2+ exchanger in mouse aorta, E Karashima, J Nishimura, T Iwamoto, K Hirano, H Kanaide, JOURNAL OF PHARMACOLOGICAL SCIENCES, 97, 244P - 244P,   2005
  • The Ca2+ refilling to the sarcoplasmic reticulum is important for the agonist-induced tonic contraction in the porcine coronary artery, R Fukunaga, J Nishimura, K Hirano, H Kanaide, JOURNAL OF PHARMACOLOGICAL SCIENCES, 97, 116P - 116P,   2005
  • Antagonizing effect of plasmin on the thrombin-induced endothelium-dependent relaxation in coronary artery, T Fujiyoshi, K Hirano, M Hirano, J Nishimura, H Kanaide, JOURNAL OF PHARMACOLOGICAL SCIENCES, 97, 296P - 296P,   2005
  • Proteinase-activated receptor-1 antagonist prevented hyper-contractile response to thrombin in rabbit subarachnoid hemorrhage model, Y Kai, K Hirano, M Hirano, J Nishimura, H Kanaide, JOURNAL OF PHARMACOLOGICAL SCIENCES, 97, 98P - 98P,   2005
  • Transduction of Rac1/Cdc42-inhibitory protein down-regulated proteinase-activated receptor-1 and attenuated responsiveness to thrombin in human coronary artery smooth muscle cells, T Yufu, K Hirano, M Hirano, J Nishimura, H Kanaide, JOURNAL OF PHARMACOLOGICAL SCIENCES, 97, 287P - 287P,   2005
  • The membrane trafficking plays an important role in maintaining the surface expression of proteinase-activated receptor-1 in vascular smooth muscle cells, W Eto, M Hirano, K Hirano, J Nishimura, H Kanaide, JOURNAL OF PHARMACOLOGICAL SCIENCES, 97, 295P - 295P,   2005
  • Substance P increases Ca2+ sensitivity of pig iris sphincter muscle (ISM), Y Hasegawa, J Nishimura, K Hirano, M Hirano, H Kanaide, JOURNAL OF PHARMACOLOGICAL SCIENCES, 97, 167P - 167P,   2005
  • De novo ceramide synthesis is involved in nephrotoxicity induced by radiographic contrast medium, T Yano, Y Itoh, T Sendo, T Kubota, K Hirano, H Kanaide, R Oishi, JOURNAL OF PHARMACOLOGICAL SCIENCES, 97, 96P - 96P,   2005
  • Thrombin and trypsin potentiate myofilament Ca2+ sensitivity and induce contraction in pulmonary artery, J Mai, K Hirano, M Hirano, J Nishimura, H Kanaide, JOURNAL OF PHARMACOLOGICAL SCIENCES, 97, 288P - 288P,   2005
  • Involvement of Na+/Ca2+ exchanger (NCX) in vasodilator-induced vasorelaxation, J Nishimura, J Yamanaka, K Hirano, H Kanaide, JOURNAL OF PHARMACOLOGICAL SCIENCES, 97, 56P - 56P,   2005
  • Long-term inhibition of RhoA enhances endothelial NO production and reduces vascular tone in an intact artery, N Shiga, K Hirano, J Nishimura, H Kanaide, CIRCULATION, 110, (17), 154 - 154,   2004 10
  • Thrombin induces vascular hypercontractility by upregulating protease-activated receptor-1 in subarachnoid hemorrhage, Y Maeda, K Hirano, M Hirano, J Nishimura, T Sasaki, H Kanaide, CIRCULATION, 110, (17), 332 - 333,   2004 10
  • Engagement of Na+-Ca2+ exchanger and Na+-K+ ATPase in the coronary artery relaxation induced by isosorbide dinitrate, J Yamanaka, J Nishimura, K Hirano, H Kanaide, JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, 37, (1), 232 - 232,   2004 07
  • Inhibition of Rac1 downregulates protease-activated receptor (PAR) 1 in the vascular smooth muscle cells, T Yufu, K Hirano, D Bi, M Hirano, J Nishimura, H Kanaide, JOURNAL OF PHARMACOLOGICAL SCIENCES, 94, 156P - 156P,   2004
  • A novel type of protease-activated receptor (PAR) mediates an enhanced myometrial response to trypsin in sex hormone-treated rats, M Aman, K Hirano, J Nishimura, H Kanaide, JOURNAL OF PHARMACOLOGICAL SCIENCES, 94, 182P - 182P,   2004
  • TGF-beta 1 enhances the fibroblast-mediated collagen gel contraction but not the isometric tension deveolpment, S Ise, J Nishimura, K Hirano, H Kanaide, JOURNAL OF PHARMACOLOGICAL SCIENCES, 94, 247P - 247P,   2004
  • 17 beta-estradiol inhibits TNF-alpha induced apoptosis via phosphatidylinositol 3-kinase/Akt pathway in vascular endothelial cells, M Koga, K Hirano, J Nishimura, H Kanaide, JOURNAL OF PHARMACOLOGICAL SCIENCES, 94, 152P - 152P,   2004
  • Relative contribution of PKC and Rho kinase in the contraction induced by PDBu, high K+ and U46619, E Karashima, J Nishimura, K Hirano, M Hirano, H Kanaide, JOURNAL OF PHARMACOLOGICAL SCIENCES, 94, 145P - 145P,   2004
  • Prostaglandin F2 alpha (PGF2 alpha) increases Ca(2+) sensitivity of pig iris sphincter muscle, Y Hasegawa, Y Hasegawa, J Nishimura, K Hirano, M Hirano, H Kanaide, JOURNAL OF PHARMACOLOGICAL SCIENCES, 94, 142P - 142P,   2004
  • Stimulation of Na+-Ca2+ exchanger by isosorbide dinitrate through Na+-K+ ATPase activation, J Yamanaka, J Nishimura, K Hirano, H Kanaide, JOURNAL OF PHARMACOLOGICAL SCIENCES, 94, 213P - 213P,   2004
  • Role of PKC in contraction of human prostatic stromal cells, R Takahashi, J Nishimura, K Hirano, H Kanaide, JOURNAL OF PHARMACOLOGICAL SCIENCES, 94, 263P - 263P,   2004
  • Homophilic cell-cell contact up-regulated transcription of p27(Kip1) gene in endothelial cells, M Hirano, K Hirano, J Nishimura, H Kanaide, JOURNAL OF PHARMACOLOGICAL SCIENCES, 94, 128P - 128P,   2004
  • RNA interference in vascular smooth muscle cells: A crucial role of rhoA in contractility, D Bi, J Nishimura, K Hirano, H Kanaide, JOURNAL OF PHARMACOLOGICAL SCIENCES, 94, 145P - 145P,   2004
  • Regulatory mechanism for the expression of protease-activated receptors: A role of small G proteins, K Hirano, T Yufu, M Hirano, J Nishimura, H Kanaide, JOURNAL OF PHARMACOLOGICAL SCIENCES, 94, 64P - 64P,   2004
  • Effect of hypergravity on the cell cycle progression in the vascular endothelial cells, K Hirano, M Hirano, J Nishimura, H Kanaide, JOURNAL OF PHARMACOLOGICAL SCIENCES, 94, 133P - 133P,   2004
  • Subarachnoid hemorrhage induced hypercontractile response to thrombin in the rabbit basilar artery, Y Maeda, K Hirano, M Hirano, J Nishimura, H Kanaide, JOURNAL OF PHARMACOLOGICAL SCIENCES, 94, 98P - 98P,   2004
  • Mechanism of the contraction induced by bradykinin in the guinea-pig taenia coli, H Kawata, K Hirano, J Nishimura, H Kanaide, JOURNAL OF PHARMACOLOGICAL SCIENCES, 94, 77P - 77P,   2004
  • A fundamental fole of kinase other than Rho kinase in the regulation of the myosin phosphatase activity and myofilament Ca2+-sensitivity in vascular smooth muscle, K Hirano, K Nakamura, J Nishimura, H Kanaida, CIRCULATION, 108, (17), 100 - 100,   2003 10
  • Myofilament Ca2+ sensitivity in enhanced by cell penetrating peptide-mediated transduction of the myosin light chain phosphatase targeting subunit in intact porcine coronary artery, K Hirano, DN Derkach, M Hirano, J Nishimura, H Kanaida, CIRCULATION, 108, (17), 101 - 101,   2003 10
  • HMG-CoA reductase inhibitor down-regulates expression of protease-activated receptor (PAR) 1 on the plasma membrane and reduces the responsiveness to thrombin in the human coronary artery smooth muscle cells, T Yufu, K Hirano, D Bi, M Hirano, J Nishimura, H Kanaide, CIRCULATION, 108, (17), 202 - 202,   2003 10
  • Inhibitors of HMG CoA reductase enhance the endothelial production of NO and attenuate vascular contractility in the isolated rabbit mesenteric artery., N Shiga, K Hirano, J Nishinura, H Kanaide, JOURNAL OF PHARMACOLOGICAL SCIENCES, 91, 139P - 139P,   2003
  • Theophylline decreases Ca2+ sensitivity of the contractile apparatus in the porcine tracheal smooth muscle., S Ise, J Nishimura, K Hirano, H Kanaide, JOURNAL OF PHARMACOLOGICAL SCIENCES, 91, 250P - 250P,   2003
  • Linkage of reverse mode Na+/Ca2+ exchanger and sarcoplasmic reticulum Ca2+ release in porcine coronary arterial smooth muscle., J Yamanaka, J Nishimura, K Hirano, H Kanaide, JOURNAL OF PHARMACOLOGICAL SCIENCES, 91, 273P - 273P,   2003
  • The contractile response to trypsin was enhanced by in vivo treatment with progesterone and estrogen in the isolated rat myometrium., M Aman, K Hirano, J Nishimura, H Kanaide, JOURNAL OF PHARMACOLOGICAL SCIENCES, 91, 271P - 271P,   2003
  • Mechanism of the contraction induced by N-formyl-L-methionyl-L-leucyl-L-phenylalanine in the guinea-pig taenia coli., H Kawata, K Hirano, J Nishimura, H Kanaide, JOURNAL OF PHARMACOLOGICAL SCIENCES, 91, 122P - 122P,   2003
  • Lipophilic inhibitors of HMG-CoA reductase suppress the response to thrombin in vascular smooth muscle., T Yufu, K Hirano, M Hirano, J Nishimura, H Kanaide, JOURNAL OF PHARMACOLOGICAL SCIENCES, 91, 158P - 158P,   2003
  • The modulation of Ca2+ sensitivity regulates contractility of human detrusor smooth muscle., R Takahashi, J Nishimura, K Hirano, H Kanaide, JOURNAL OF PHARMACOLOGICAL SCIENCES, 91, 263P - 263P,   2003
  • Collagen gel constriction by contractile coronary artery smooth muscle cells: in-vitro model of constrictive remodeling., D Bi, J Nishimura, K Hirano, H Kanaide, JOURNAL OF PHARMACOLOGICAL SCIENCES, 91, 127P - 127P,   2003
  • A novel mode of inactivation of protease-activated receptor-1 by thrombin in endothelial cells: An additional proteolytic removal of the tethered ligand other than the N-terminal 41 residues, K Hirano, J Nishimura, H Kanaide, CIRCULATION, 106, (19), 209 - 210,   2002 11
  • Temporal specific requirement of RhoA activity but not Rho-kinase for the G1 to S phase progression in the vascular endothelial cells, K Hirano, M Hirano, J Nishimura, H Kanaide, CIRCULATION, 106, (19), 143 - 143,   2002 11
  • Role of Na+/Ca2+ exchange in isoproterenol-induced relaxation of porcine coronary artery smooth muscle, J Yamanaka, J Nishimura, K Hirano, H Kanaide, JAPANESE JOURNAL OF PHARMACOLOGY, 88, 69P - 69P,   2002
  • HIV TAT protein-mediated transduction of the N-terminal fragments of MYPT1 enhanced contraction in intact smooth muscle of porcine coronary artery, DN Derkach, K Hirano, M Hirano, J Nishimura, H Kanaide, JAPANESE JOURNAL OF PHARMACOLOGY, 88, 71P - 71P,   2002
  • Rho-kinase potentiates the Ca2+ sensitivity with and without changing myosin phosphorylation in bovine middle cerebral artery, Y Maeda, K Hirano, J Nishimura, H Kanaide, JAPANESE JOURNAL OF PHARMACOLOGY, 88, 254P - 254P,   2002
  • Contraction of the cultured smooth muscle of porcine coronary artery, D Bi, J Nishimura, K Hirano, H Kanaide, JAPANESE JOURNAL OF PHARMACOLOGY, 88, 253P - 253P,   2002
  • Unproductive cleavage and desensitization of protease-activated receptor1 by trypsin in human enclotheial cells, T Nakayama, K Hirano, J Nishimura, H Kanaide, JAPANESE JOURNAL OF PHARMACOLOGY, 88, 220P - 220P,   2002
  • Mechanism for the theophylline-induced relaxation in porcine tracheal smooth muscle, S Ise, J Nishimura, K Hirano, H Kanaide, JAPANESE JOURNAL OF PHARMACOLOGY, 88, 129P - 129P,   2002
  • Role of PAR in the vascular system, K Hirano, T Nakayama, DN Derkach, J Nishimura, H Kanaide, JAPANESE JOURNAL OF PHARMACOLOGY, 88, 54P - 54P,   2002
  • The long-term deficiency of estrogen enhances the contractile response without affecting the Ca2+-sensitivity in arterial smooth muscle of the female rabbit, M Koga, K Hirano, J Nishimura, H Kanaide, JAPANESE JOURNAL OF PHARMACOLOGY, 88, 71P - 71P,   2002
  • The modulation of Ca2+sensitivity regulates the contractility of the rabbit corpus cavernosum, R Takahashi, J Nishimura, K Hirano, H Kanaide, JAPANESE JOURNAL OF PHARMACOLOGY, 88, 254P - 254P,   2002
  • A guanylyl cyclase inhibitor, ODQ, is also a potent K+ channel blocker, DN Derkach, K Hirano, J Nishimura, H Kanaide, CIRCULATION, 104, (17), 298 - 298,   2001 10
  • Cloning and characterization of a novel isoform of p27(kip1) in vascular endothelial cells, K Hirano, M Hirano, Y Zeng, J Nishimura, H Kanaide, CIRCULATION, 102, (18), 226 - 226,   2000 10
  • The amino acid sequence of myosin regulatory light chain required for its subcellular localization and for the involvement in the Rho kinase-induced changes in cell shape, T Yasutsune, J Nishimura, K Hirano, H Yasui, H Kanaide, CIRCULATION, 102, (18), 314 - 314,   2000 10
  • Subcellular localization of caveolins in intact endothelial cells: Analysis with a fluorescent fusion protein expression system, H Kanaide, T Yasutsune, J Nishimura, K Hirano, H Yasui, CIRCULATION, 100, (18), 416 - 416,   1999 11
  • Agonist-induced inhibition of myosin phosphatase via rho-rho kinase system is independent of Ca2+ in arterial smooth muscle, YB Zhou, JJ Nishimura, K Hirano, H Kanaide, CIRCULATION, 100, (18), 417 - 417,   1999 11
  • Differential role of four Ca2+ binding domains of calmodulin in smooth muscle contraction., N Niiro, J Nishimura, K Hirano, H Kanaide, CIRCULATION, 98, (17), 667 - 667,   1998 10
  • Ca2+ sensitivity of porcine renal artery is increased by the N-terminal mutants of 130 kDa subunit of smooth muscle myosin phosphatase., YB Zhou, K Hirano, J Nishimura, H Kanaide, CIRCULATION, 98, (17), 530 - 531,   1998 10
  • Troglitazone relaxes coronary artery by decreasing cytosolic calcium concentration, J Kawasaki, K Hirano, Abe, I, H Kanaide, M Fujishima, JOURNAL OF HYPERTENSION, 16, S57 - S57,   1998 06
  • SMOOTH-MUSCLE MYOSIN LIGHT-CHAIN PHOSPHATASE, H SHIMIZU, M ITO, M MIYAHARA, K ICHIKAWA, S OKUBO, T KONISHI, M NAKA, T TANAKA, K HIRANO, DJ HARTSHORNE, T NAKANO, CIRCULATION, 90, (4), 356 - 356,   1994 10
  • MORPHOLOGICAL-CHANGES OF CULTURED-CELLS INDUCED BY PHOSPHATASE INHIBITORS, K HIRANO, M HIRANO, R TAYLOR, N FUSETANI, H KARAKI, DJ HARTSHORNE, JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, 24, S63 - S63,   1992 05
  • GLIBENCLAMIDE-INDUCED RELAXATION OF RABBIT AORTIC SMOOTH-MUSCLE, K YOSHITAKE, K HIRANO, H KANAIDE, CIRCULATION, 82, (4), 411 - 411,   1990 10
  • SEROTONIN-SENSITIVE INTRACELLULAR CALCIUM STORE IN VASCULAR SMOOTH-MUSCLE CELLS, H KANAIDE, M HASEGAWA, H KAI, K HIRANO, M NAKAMURA, JAPANESE CIRCULATION JOURNAL-ENGLISH EDITION, 52, (8), 734 - 734,   1988 08

Books etc

  • The unique property of the pulmonary artery regarding the smooth muscle effects of proteinase-activated receptor 1: The possible contribution to the pathogenesis of pulmonary hypertension., Springer, Tokyo, Japan,   2017
  • Measurement of [Ca2+]i in smooth muscle strips using front-surface fluorimetry., Humana Press, New York,,   2013 , ISBN:9781627030854
  • Idendification of hydrogen peroxide as an endothelium-derived hyperpolarization factor in mice., Taylor & Francis, London, UK,   2001
  • Cytosolic calcium transients in vascular smooth muscle., in Ion Channels of Vascular Smooth Muscle Cells and Endothelial Cells, eds Sperelakis N and Kuriyama H., Elsivier, New York,,   1991
  • Effects of okadaic acid on cytosolic calcium concentration and contraction of porcine coronary artery., in Advances in Second Messenger and Phosphoprotein Research vol.24, ed. Nishizuka Y., Raven Press, New York,,   1990
  • Effecs of okadaic acid on cytosolic calcium concentration and contraction of porcine coronary arter, Raven Press, New York,   1990
  • The unique property of the pulmonary artery regarding the smooth muscle effects of proteinase-activated receptor 1: The possible contribution to the pathogenesis of pulmonary hypertension., Springer, Tokyo, Japan,   2017
  • Measurement of [Ca2+]i in smooth muscle strips using front-surface fluorimetry., Humana Press, New York,,   2013 , ISBN:9781627030854

Conference Activities & Talks

  • Novel role of coagulation factor XI as a regulator of vascular smooth muscle function., HIRANO Katsuya, The 9th Federation of the Asian and Oceanian Physiological Society Congress (FAOPS2019),   2019 03 29
  • Proteinase-activated receptor 1 (PAR1)-mediated cellular effects of coagulation factor XI in vascular smooth muscle cells, HIRANO Katsuya,   2019 03 16
  • 血管平滑筋細胞において凝固第XI因子はトロンビン受容体PAR1を活性化し、細胞内Ca2+シグナルを発生させ、細胞遊走を促進する, 平野 勝也, 第48回日本心脈管作動物質学会総会,   2019 02 08
  • トロンビンによる内皮バリアー機能障害の初期事象におけるRho-Rhoキナーゼの役割, 平野 勝也, 第59回日本脈管学会総会,   2018 10 25
  • Novel function of coagulation factor XI as a regulator of vascular smooth muscle, Hirano K, Liu W, Hashimoto T, Yamashita T, The 7th Chiang Mai University-Kagawa University Joint Symposium 2018,   2018 08 29
  • 凝固第XI因子の血管平滑筋作用, 平野 勝也, 第3回日本肺高血圧・肺循環学会学術集会,   2018 06 22
  • 血液凝固第XI因子は電位作動性Ca2+チャネルを介して血管平滑筋細胞にCa2+シグナルを発生させる, 第47回日本心脈管作動物質学会年会,   2018
  • 血液凝固第XI因子は電位作動性Ca2+チャネルを介して血管平滑筋細胞にCa2+シグナルを発生させる, 第47回日本心脈管作動物質学会年会,   2018
  • Coagulaton factor XI induced Ca2+ response and cell migration in vascular smooth muscle cells, 第95回日本生理学会大会,   2018
  • Novel strategy for treatment of pulmonary hypertension based on the unique property of pulmonary circulation regarding smooth muscle effect of proteinase-activated receptor 1, 第95回日本生理学会大会,   2018
  • 血管収縮の生理学‐平滑筋収縮装置のカルシウム感受性制御機構を中心に, 第95回日本生理学会大会,   2018
  • トロンビン受容体を標的とする新規肺高血圧治療の提案, 第46回日本心脈管作動物質学会,   2017
  • A novel angiogenic agent COA-Cl promotes VEGF secretion from mouse C2C12 skeletal myocytes via the activation of cAMP/PKA/CREB/PGC-1alpha signaling axis, 第94回日本生理学会大会,   2017
  • 循環生理学教育における個人的悩み:医学生理学でどこまで教えると良いのか?, 第94回日本生理学会大会シンポジウム「生理学から薬理学への医学教育キャリーオーバー:何をどこまで教えればよいのか?」,   2017
  • Involvement of Rho-Rho kinase pathway in peripheral actin filament formation, an initial event during thrombin-induced endothelial barrier disruption, 第94回日本生理学会大会,   2017
  • Mifepristone, a steroid receptor antagonist, induces hepatic steatosis in association with upregulation of resistin expression in liver, 第94回日本生理学会大会,   2017
  • Coagulation factor XIa induces Ca2+ influx via L-type Ca2+ channel in vascular smooth muscle cells, 第94回日本生理学会大会,   2017
  • NAD(P)H and low ionic strength suppresses dissociation of apoptosis-inducing factor from the E. coli membrane, 第94回日本生理学会大会,   2017
  • Proteinase-activated receptor-1はポドサイト障害によるアルブミン尿の病態に関与する, 第17回日本NO学会学術集会,   2017
  • 血管内皮細胞のはたらき~バリアー機能について~, 第5回香川県高校生科学研究発表会,   2017
  • 血管平滑筋細胞において凝固第XI因子が引き起こすプロテイナーゼ活性化型受容体1を介した電位作動性カルシウムチャネル依存性Ca2+流入作用, 第59回日本平滑筋学会総会,   2017
  • 実験的肺高血圧症に対するプロテイナーゼ活性化型受容体1(PAR1)拮抗薬の治療的効果, 第59回日本平滑筋学会総会,   2017
  • 凝固第Ⅺ因子が引き起こす血管平滑筋細胞内Ca2+シグナルの発生メカニズム, 生理研研究会2017心臓・血管系の頑健性と精緻な制御を支える分子基盤の統合的解明,   2017
  • 血液凝固第XI因子が引き起こす血管平滑筋細胞のCa2+シグナルの発生メカニズムの解明, 第69回日本生理学会中国四国地方会,   2017
  • 嫌気条件とNAD(P)HはApoptosis-inducing factorの大腸菌膜からの解離を抑制する, 第69回日本生理学会中国四国地方会,   2017
  • トロンビン受容体PAR1の阻害は肺高血圧症の病態形成を抑制する, 第132回日本薬理学会近畿部会,   2017
  • 凝固第Ⅺ因子の血管平滑筋作用, 第27回日本循環薬理学会,   2017
  • Increased contractile effects of thrombin in pulmonary artery of monocrotaline-induced pulmonary hypertension, 第93回日本生理学会大会,   2016
  • Vascular intrinsic circadian rhythm of myosin phosphatase activity, 第93回日本生理学会大会,   2016
  • Increased expression of thrombin receptor, PAR1 is a new therapeutic target for pulmonary hypertension, 第80回日本循環器学会学術集会,   2016
  • Mifepristone induces non-obese non-alcoholic fatty liver disease in association with upregulation of MGAT-1 expression, 第89回日本薬理学会年会,   2016
  • Cell aging Is related to impairment of store-operated Ca2+ entry and endotheium-derived relaxing factor production in porcine aortic endothelial cells, The 9th International Conference on the Biology, Chemistry, and Therapeutic Applications of Nitric Oxide, The 16th Annual Scientific Meeting of the Nitric Oxide Society of Japan,   2016
  • Involvement of different subtypes of receptor in prostaglandin E2-induced motile function in lower esophageal sphincter and esophageal body smooth muscle, Digestive Disease Week 2016,   2016
  • A key role of a second messenger cAMP in the induction of a transcriptional coactivator PGC-1α by a novel proangiogenic adenosine analogue COA-Cl in human fibroblasts, The 9th International Conference on the Biology, Chemistry, and Therapeutic Applications of Nitric Oxide, The 16th Annual Scientific Meeting of the Nitric Oxide Society of Japan,   2016
  • Trypsin induced a transient contraction via a PAR2/TRPV1/Neurokinin receptors pathway in circular smooth muscle of porcine esophageal body, Digestive Disease Week 2016,   2016
  • モノクロタリン誘発肺高血圧症におけるトロンビン受容体PAR1の発現亢進とトロンビンの肺動脈収縮作用の増強, 第129回日本薬理学会近畿部会,   2016
  • モノクロタリン誘発肺高血圧モデルにおけるトロンビン受容体PAR1の肺動脈収縮作用の亢進, 第58回日本平滑筋学会総会,   2016
  • Critical role of proteinase-activated receptor 1 in pathogenesis of pulmonary hypertension, 6th Kagawa University-Chiang Mai University Joint Symposium,   2016
  • 肺高血圧症におけるトロンビン受容体の役割, 生理研研究会2016心臓・血管系の包括的な機能統合研究,   2016
  • Specific and increased expression of thrombin receptor PAR1 in pulmonary artery plays a key role in the pathogenesis of monocrotaline-induced pulmonary hypertension in rats, American Heart Association Scientific Session 2016,   2016
  • プロテイナーゼ活性化型受容体の血管病態生理学 ~脳血管攣縮と肺高血圧症を中心に~, 第3回Heart & Brain Conference,   2016
  • Coagulation factor XIa induces Ca2+ response in rat aorta smooth muscle cells via proteinase-activated receptor 1, 第68回日本生理学会中国四国地方会,   2016
  • 肺高血圧症の病態形成におけるトロンビン受容体PAR1の役割, 第20回日本心血管内分泌代謝学会学術集会,   2016
  • Peripheral actin bundle formation due to myosin light chain di-phosphorylation proceeds stress fiber formation during thrombin-induced endothelial barrier disruption, 第33回国際心臓研究学会日本部会,   2016
  • 小胞体Ca2+センサー蛋白質STIM1のリン酸化による貯蔵部作動性Ca2+流入の制御, 第44回日本心脈管作動物質学会,   2015
  • DHRS7C NAD/NADH dehydrogenase catalytic core domain is essential for cellular calcium homeostasis and cell morphology, 第44回日本心脈管作動物質学会,   2015
  • The protective role of bone morphogenetic protein receptor II against thrombin-induced endothelial barrier dysfunction, 第44回日本心脈管作動物質学会,   2015
  • 細胞辺縁部に局在するミオシン軽鎖2リン酸化とアクチン繊維束形成が内皮細胞バリアー障害の初期事象として重要な役割を果たす, 第44回日本心脈管作動物質学会,   2015
  • トロンビン受容体の機能亢進がモノクロタリン誘発肺高血圧症の病態形成に重要な役割を果たす, 第44回日本心脈管作動物質学会,   2015
  • A novel angiogenic agent COA-Cl induced PGC-1α-mediated VEGF production in cultured human fibroblasts., 第92回日本生理学会大会,   2015
  • COA-Cl-induced adipogenesis is associated with an increased cell cycle progression and down-regulation of p27Kip1 in mouse pre-adipocyte 3T3-L1 cells, 第92回日本生理学会大会,   2015
  • Regulation of store-operated Ca2+ influx by STIM1 phosphorylation, 第92回日本生理学会大会,   2015
  • Increased thrombin receptor activity in monocrotaline-induced pulmonary hypertension., 第88回日本薬理学会年会,   2015
  • A novel adenosine-like angiogenic agent COA-Cl elevates VEGF production via the transcription co-activator PGC-1α in cultured human fibroblasts, 第79回日本循環器学会学術集会,   2015
  • Potential of increased activity of proteinase-activated receptor 1 (PAR1) in pulmonary hypertension as a new therapeutic target., 第79回日本循環器学会学術集会,   2015
  • Increased activity of proteinase activated receptor 1 (PAR1) plays a key role in pathogenesis of monocrotaline-induced pulmonary hypertension in rats, 第79回日本循環器学会学術集会,   2015
  • Proteinase activated receptor 1 (PAR1) plays a key role in pathogenesis of monocrotaline-induced pulmonary hypertension in rats, HAKATA Cardiovascular Conference,   2015
  • Endogenous H2S contributes to myogenic tone generation in lower esophageal sphincter: possible involvement of Na+/Ca2+ exchanger, Digestive Disease Week 2015,   2015
  • DHRS7C NAD/NADH dehydrogenase catalytic core domain is essential for cellular calcium homeostasis and cell morphology, HAKATA Cardiovascular Conference,   2015
  • A role of myosin light chain phosphorylation and actin bundle formation at cell periphery as an initial event during thrombin-induced disruption of endothelial barrier, HAKATA Cardiovascular Conference,   2015
  • Mechanism for impaired desensitization and irreversible activation of thrombin receptor in vascular smooth muscle, HAKATA Cardiovascular Conference,   2015
  • Possible role of thrombin receptor in pathogenesis of pulmonary hypertension, HAKATA Cardiovascular Conference,   2015
  • Store-operated phosphorylation of stromal interaction molecule 1 (STIM1) supports sustained Ca2+ entry, HAKATA Cardiovascular Conference,   2015
  • Functional role of store-operated STIM1 phosphorylation, NIPS International Workshop ~ TRPs and SOCs Unconventional Ca2+ Physiology ~,   2015
  • モノクロタリン誘発肺高血圧モデルにおける肺動脈のトロンビンに対する収縮反応性の亢進, 第57回日本平滑筋学会,   2015
  • ミオシン軽鎖リン酸化研究の新展開:循環器研究からシステム生物学へ, 第57回日本平滑筋学会 シンポジウム「ミオシン軽鎖リン酸化研究の新展開:循環器研究からシステム生物学へ」,   2015
  • ブタ下部食道括約筋の筋原性筋緊張調節における内因性硫化水素(H2S)の役割, 第57回日本平滑筋学会,   2015
  • 新規アデノシン類似化合物COA-Cl(コアクロル)はcAMP/CREB/PGC-1αの経路を介して血管内皮成長因子(VEGF)の産生を促進する, 第67回日本生理学会中国四国地方会,   2015
  • 新規アデノシン類似化合物COA-Cl(コアクロル)はヒト皮膚由来線維芽細胞において結合組織成長因子(CTGF)の発現を抑制する, 第67回日本生理学会中国四国地方会,   2015
  • トロンビン受容体PAR1拮抗薬は肺高血圧の病態形成を抑制する, 第3回肺高血圧学会・第4回肺循環学会合同学術集会,   2015
  • 内皮バリアー障害の初期事象としてのミオシン2リン酸化の特異的役割, 生理研研究会2015心臓・血管系の包括的な機能統合研究,   2015
  • トロンビンによる内皮バリアー機能障害の初期事象としてのミオシン軽鎖2リン酸化の特異的役割, 第67回日本生理学会中国四国地方会,   2015
  • 肺高血圧病態におけるトロンビン誘発大動脈収縮反応の増強, 第67回日本薬理学会西南部会,   2015
  • 新規血管新生促進物質コアクロル(COA-Cl)による血管内皮成長因子(VEGF)産生機序の検討, 第3回中国・四国地区医学生学術交流会,   2015
  • A key role of PGC-1α co-transcription factor, but not HIF1α transcription factor, in production of vascular endothelial growth factor (VEGF) by a novel angiogenic agent COA-Cl in cultured human fibroblasts, American Heart Association Scientific Session 2015,   2015
  • Activation of cAMP/CREB/PGC-1α pathway plays a key role for a novel adenosine-like angiogenic agent COA-Cl to induce production of vascular endothelial growth factor (VEGF) in cultured human fibroblasts, American Heart Association Scientific Session 2015,   2015
  • Proteinase-activated receptor 1 antagonist inhibited the progression of monocrotaline induced pulmonary hypertension in rats, American Heart Association Scientific Session 2015,   2015
  • Apoptosis-inducing factor依存的細胞死の制御機構の解析, 第55回(平成26年度)日本生化学会 中国・四国支部例会,   2014
  • トロンビン受容体拮抗薬はモノクロタリンによる肺高血圧症の誘発を抑制する, 第35回日本循環制御医学会総会,   2014
  • ブタ食道体部縦走筋と輪走筋におけるトリプシンの作用とその機序, 第56回日本平滑筋学会,   2014
  • STIM1のリン酸化による貯蔵部作動性カルシウム流入の制御, 第56回日本平滑筋学会,   2014
  • 内皮バリアー障害における細胞辺縁部のミオシン軽鎖2リン酸化の役割, 生理研研究会2014 心血管膜輸送分子の構造・機能・病態の統合的研究戦略,   2014
  • Submembranous di-phosphorylation of myosin light chain and actin fiber formation play a critical role as an initial event during endothelial barrier disruption, 11th International Symposium on Resistant Artery,   2014
  • Vascular intrinsic biological clock in the regulation of myofilament calcium sensitivity., 11th International Symposium on Resistant Artery,   2014
  • アデノシン類似化合物COA-ClによるVEGF分泌促進機序の検討, 第66回日本生理学会中国四国地方会,   2014
  • Inhibition of increased thrombin receptor activity attenuated monocrotaline-induced pulmonary hypertension in rats, American Heart Association Scientific Session 2014,   2014
  • 大腸菌発現系を用いたApoptosis-inducing factor (AIF)と生体膜との相互作用の解析, 日本生体エネルギー研究会 第40回討論会,   2014
  • Coagulaton factor XI induced Ca2+ response and cell migration in vascular smooth muscle cells, 第95回日本生理学会大会,   2018
  • Novel strategy for treatment of pulmonary hypertension based on the unique property of pulmonary circulation regarding smooth muscle effect of proteinase-activated receptor 1, 第95回日本生理学会大会,   2018
  • Physiology of vasoconstriction with a focus on the regulation of Ca2+ sensitivity of the contractile apparatus of smooth muscle, 第95回日本生理学会大会,   2018
  • Involvement of Rho-Rho kinase pathway in peripheral actin filament formation, an initial event during thrombin-induced endothelial barrier disruption, 第94回日本生理学会大会,   2017
  • 血管平滑筋細胞において凝固第XI因子が引き起こすプロテイナーゼ活性化型受容体1を介した電位作動性カルシウムチャネル依存性Ca2+流入作用, 第59回日本平滑筋学会総会,   2017
  • 実験的肺高血圧症に対するプロテイナーゼ活性化型受容体1(PAR1)拮抗薬の治療的効果, 第59回日本平滑筋学会総会,   2017
  • 凝固第Ⅺ因子が引き起こす血管平滑筋細胞内Ca2+シグナルの発生メカニズム, 生理研研究会2017心臓・血管系の頑健性と精緻な制御を支える分子基盤の統合的解明,   2017
  • 血液凝固第XI因子が引き起こす血管平滑筋細胞のCa2+シグナルの発生メカニズムの解明, 第69回日本生理学会中国四国地方会,   2017
  • 嫌気条件とNAD(P)HはApoptosis-inducing factorの大腸菌膜からの解離を抑制する, 第69回日本生理学会中国四国地方会,   2017
  • トロンビン受容体PAR1の阻害は肺高血圧症の病態形成を抑制する, 第132回日本薬理学会近畿部会,   2017
  • 凝固第Ⅺ因子の血管平滑筋作用, 第27回日本循環薬理学会,   2017
  • Vascular intrinsic circadian rhythm of myosin phosphatase activity, 第93回日本生理学会大会,   2016
  • Mifepristone induces non-obese non-alcoholic fatty liver disease in association with upregulation of MGAT-1 expression, 第89回日本薬理学会年会,   2016
  • Cell aging Is related to impairment of store-operated Ca2+ entry and endotheium-derived relaxing factor production in porcine aortic endothelial cells, The 9th International Conference on the Biology, Chemistry, and Therapeutic Applications of Nitric Oxide, The 16th Annual Scientific Meeting of the Nitric Oxide Society of Japan,   2016
  • Involvement of different subtypes of receptor in prostaglandin E2-induced motile function in lower esophageal sphincter and esophageal body smooth muscle, Digestive Disease Week 2016,   2016
  • A key role of a second messenger cAMP in the induction of a transcriptional coactivator PGC-1α by a novel proangiogenic adenosine analogue COA-Cl in human fibroblasts, The 9th International Conference on the Biology, Chemistry, and Therapeutic Applications of Nitric Oxide, The 16th Annual Scientific Meeting of the Nitric Oxide Society of Japan,   2016
  • Trypsin induced a transient contraction via a PAR2/TRPV1/Neurokinin receptors pathway in circular smooth muscle of porcine esophageal body, Digestive Disease Week 2016,   2016
  • Critical role of proteinase-activated receptor 1 in pathogenesis of pulmonary hypertension, 6th Kagawa University-Chiang Mai University Joint Symposium,   2016
  • Specific and increased expression of thrombin receptor PAR1 in pulmonary artery plays a key role in the pathogenesis of monocrotaline-induced pulmonary hypertension in rats, American Heart Association Scientific Session 2016,   2016
  • COA-Cl-induced adipogenesis is associated with an increased cell cycle progression and down-regulation of p27Kip1 in mouse pre-adipocyte 3T3-L1 cells, 第92回日本生理学会大会,   2015
  • Regulation of store-operated Ca2+ influx by STIM1 phosphorylation, 第92回日本生理学会大会,   2015
  • Increased thrombin receptor activity in monocrotaline-induced pulmonary hypertension., 第88回日本薬理学会年会,   2015
  • Potential of increased activity of proteinase-activated receptor 1 (PAR1) in pulmonary hypertension as a new therapeutic target., 第79回日本循環器学会学術集会,   2015
  • Increased activity of proteinase activated receptor 1 (PAR1) plays a key role in pathogenesis of monocrotaline-induced pulmonary hypertension in rats, 第79回日本循環器学会学術集会,   2015
  • Proteinase activated receptor 1 (PAR1) plays a key role in pathogenesis of monocrotaline-induced pulmonary hypertension in rats, HAKATA Cardiovascular Conference,   2015
  • DHRS7C NAD/NADH dehydrogenase catalytic core domain is essential for cellular calcium homeostasis and cell morphology, HAKATA Cardiovascular Conference,   2015
  • A role of myosin light chain phosphorylation and actin bundle formation at cell periphery as an initial event during thrombin-induced disruption of endothelial barrier, HAKATA Cardiovascular Conference,   2015
  • Mechanism for impaired desensitization and irreversible activation of thrombin receptor in vascular smooth muscle, HAKATA Cardiovascular Conference,   2015
  • Possible role of thrombin receptor in pathogenesis of pulmonary hypertension, HAKATA Cardiovascular Conference,   2015
  • Store-operated phosphorylation of stromal interaction molecule 1 (STIM1) supports sustained Ca2+ entry, HAKATA Cardiovascular Conference,   2015
  • Functional role of store-operated STIM1 phosphorylation, NIPS International Workshop ~ TRPs and SOCs Unconventional Ca2+ Physiology ~,   2015
  • Submembranous di-phosphorylation of myosin light chain and actin fiber formation play a critical role as an initial event during endothelial barrier disruption, 11th International Symposium on Resistant Artery,   2014
  • Vascular intrinsic biological clock in the regulation of myofilament calcium sensitivity., 11th International Symposium on Resistant Artery,   2014

Works

  • 日本平滑筋学会ロゴマークデザイン, その他

Patents

  • 特許第6243844号 : A therapeutic agent and a preventive agent for pulmonary hypertension comprising thrombin receptor antagonist as an active ingredient, HIRANO Katsuya
  • 特許第3425620号 : プロテアソーム分解に抵抗性を示す新規p27Kip1分子種の核酸及びアミノ酸配列と同蛋白質の発現ベクター及び発現細胞, 平野勝也
  • トロンビン受容体アンタゴニストを有効成分とするくも膜下出血に伴う血管攣縮の治療剤, 特許出願PCT/JP2005/005068
  • Nucleic acid and amino acid sequences of the degradation-resistant novel isoform of p27Kip1, and expression plasmid and cells expressing the protein, Patent3425620

Awards & Honors

  •   2020 03 , Japanese Pharmacological Society, Journal of Pharmacological Sciences Excellent Reviewer Award 2019
  •   2017 03 , Japanese Pharmacological Society, Journal of Pharmacological Sciences Excellent Reviewer Award 2016
  •   2014 08 , Japan Society of Smooth Muscle Research, Gold medal of logo mark design
  •   2013 , 第29回スパズム・シンポジウム 第4回優秀論文賞
  •   2011 , 第27回スパズム・シンポジウム 第2回優秀論文賞
  •   2010 03 , 財団法人宮田心臓病研究振興基金, 平成21年度未成年心臓血管病の教育研修に関する助成
  •   2010 , 第26回スパズム・シンポジウム 第1回優秀論文賞
  •   2002 , 第31回心血管作動物質学会若手研究者奨励賞
  •   2021 07 , American Heart Association, Arteriosclerosis, Thrombosis and Vascular Biology, Arteriosclerosis, Thrombosis and Vascular Biology Top Reviewer of 2020 Award

Research Grants & Projects

  • 血液凝固系の老化促進因子としての機能解明とその制御, 日本学術振興会, 科学研究費助成事業 基盤研究(B),   2022 04 01  - 2027 03 31
  • 凝固系を標的とした高齢者のインスリン抵抗性改善策の開発, 日本学術振興会, 科学研究費助成事業 挑戦的研究(萌芽),   2020 07 30  - 2023 03 31
  • トロンビン受容体を標的とする新規肺高血圧治療法の開発, 日本学術振興会, 科学研究費補助金(基盤研究(C)),   2016 04  - 2019 03
  • プロテイナーゼ活性化型受容体1を介する血管機能障害の分子機構解明, 日本学術振興会, 科学研究費補助金(基盤研究(C)),   2015 04  - 2018 03
  • トロンビン受容体を標的とする核心的脳血管攣縮治療法の開発, 日本学術振興会, 科学研究費補助金 挑戦的萌芽研究,   2014 04  - 2016 03
  • トロンビン受容体の活性制御異常の分子機構解明と新たな動脈硬化治療戦略の開発, 日本学術振興会, 科学研究費補助金(基盤研究(C)),   2012 04  - 2015 03
  • 肺高血圧症におけるプロテイナーゼ活性化型受容体の役割解明と治療応用, 文部科学省, 科学研究費補助金(基盤研究(C)),   2011 04  - 2013 03
  • Role of endothelial proteinase-activated receptors in the early phase of the development of vascular lesions., Ministry of Education, Culture, Sports, Science and Technology, Grants-in-Aid for Scientific Research(基盤研究(C)),   2008  - 2010 , The present study elucidated the role of proteinase-activated receptors(PARs) in the early phase of the development of atherosclerotic vascular lesions. Thrombin increased endothelial permeability by two distinct pathways by activating PAR1 ; one is mediated by Gα13, and independent of Ca^<2+>, but dependent of Rho kinase-mediated MLC di-phosphorylation ; other is mediated by Gαq, and independent of MLC di-phosphorylation, but dependent on Ca^<2+>.
  • Role of proteinase-activated receptors in the dysregulation of vascular tone and the enhancement of the proliferative state in vascular lesions, Ministry of Education, Culture, Sports, Science and Technology, Grants-in-Aid for Scientific Research(基盤研究(C)),   2005  - 2006 , Thrombus formation plays a critical role in the pathogenesis and pathophysiology of various vascular diseases. Proteinases, such as thrombin, activate proteinase-activated receptors (PARs), thereby exerting the vascular effects, including vasoconstriction, smooth muscle proliferation, vascular hyper-permeability, and production of the endothelium-derived vasoactive substances. However, the roles of PARs in the pathogenesis and pathophysiology of vascular diseases still remain to be elucidated. In the present study, we advanced our earlier studies on the physiological roles of PARs in the re...
  • Elucidation of the Intracellular Signaling Networks Involved in the Proliferation and Functional Differentiation Induced by Cell-cell Contact in Vascular Endothelial Cells., Ministry of Education, Culture, Sports, Science and Technology, Grants-in-Aid for Scientific Research(基盤研究(C)),   2004  - 2005 , The present study demonstrated for the first time that the activation of Rac1 due to the formation of the cell-cell contact plays a critical role in the transcriptional up-regulation of p27^, thereby facilitating the contact-induced growth arrest in vascular endothelial cells. The induction of the homophilic cell-cell contact by adding the extra numbers of endothelial cells facilitated the cell cycle arrest, activated Rac1 but not RhoA, and up-regulated p27^ mRNA. Such up-regulation of p27^ mRNA was abolished by introducing the Rac1 inhibitor protein conjugated with the ce...
  • Elucidation of the mechanisms regulating the vascular tone and proliferation : Development of a novel technique to introduce protein into the intact cells and its applications, Ministry of Education, Culture, Sports, Science and Technology, Grants-in-Aid for Scientific Research(基盤研究(C)),   2003  - 2004 , By using a cell-penetrating peptide, which is found in the human immunodeficiency viral transcription factor Tat and is composed of 11 amino acids, I have developed a novel technique to rapidly, reversibly and quantitatively introduce proteins into the vascular tissues and cells. The cargo protein to be introduced into the cells was prepared as a recombinant protein fused to the cell-penetrating peptide using a bacterial expression system. I have developed the expression vectors. Using this new technique of the protein transduction, I have made the following contribution to the vascular bio...
  • 内皮・平滑筋・繊維芽細胞の三次元共培養による血管構築を摸した血管モデルの作製, 文部科学省, 科学研究費補助金(萌芽研究),   2002  - 2003 , 動脈硬化や血管形成術後の血管局所では、収縮性の亢進・攣縮を認めることがある。病変局所の平滑筋細胞や浸潤・増殖細胞において、収縮性亢進に関係する種々の酵素・蛋白質の発現変化が起こっている、と一般に考えられているが、その直接証拠は少ない。人工血管を作製し、これらの酵素・蛋白質の遺伝子を人工血管壁構成細胞に発現させることによって、収縮性の亢進・攣縮におけるその役割の直接証明が可能となる筈である。本年度は線維芽細胞のcell lineであるNIH3T3細胞を用いる事によって、等尺性収縮を測定可能な人工血管中膜モデルを作成した。さらにNIH3T3細胞に高効率に遺伝子導入できるベクターを開発し、CPI-17の過剰発現による線維芽細胞の収縮性の変化を検討した。CPI-17を過剰発現させた細胞とコラーゲンゲルを用いて作製した血管中膜モデルのリング標本は、PKCの活性化剤であるPDBuの投与により、10%FBSによる収縮の2-3倍の張力を発生した。一方、ベクターだけを発現させたコントロールではPDBuの投与により、むしろ基線以下に弛緩した。また、PKCによるリン酸化部位である38番目のThrをAlaあるはGluに変異させたCPI(CPI38AおよびCPI38E)では、PDBuによる収縮は得られず、コントロールと同様に弛緩した。CPI-17を過剰発現させた細胞のPDBuによる収縮は、PKC in...
  • Elucidation of the Intracellular Signal Networks Involved in the Growth Arrest induced by Cell-cell Contact in Vascular Endothelial Cells, Ministry of Education, Culture, Sports, Science and Technology, Grants-in-Aid for Scientific Research(基盤研究(C)),   2002  - 2003 , 1.The vascular endothelial cells ceased their growth upon formation of the tight cell-cell contact. The expression level of the cell cycle regulator p27^ was upregulated during the contact-induced growth arrest. This up-regulation was found to be due to transcriptional up -regulation.2.We have developed an assay system to determine the transcriptional regulatory element that responds to the formation of cell-cell contact in the cultured endothelia cells.3.We obtained a porcine genomic clone containing a full-length p27^ gene, and examined the promoter activity by using a 1500-nt...
  • Molecular mechanisms of vasospasm : Intracellular signaling network underlying the Ca^<2+> of smooth muscle cells., Ministry of Education, Culture, Sports, Science and Technology, Grants-in-Aid for Scientific Research(基盤研究(B)),   2001  - 2003 , Molecular mechanisms of vasospasm, especially the intracellular signaling network working for the Ca^<2+>-sensitization of smooth muscle cells, were determined. Following results were obtained. (1)Treatment of α-toxin-permeabilized rings with 1 mM ATPγS in the Ca^<2+>-free, ATP-free media enhanced the subsequent contraction induced by increment of Ca^<2+> concentration, and potentiated the Ca^<2+>-sensitivity, which was only partly inhibited by Rho-kinase inhibitor, Y-27632. We found a fundamental role of this new kinase other than Rho kinase in the regulation of the myosin phosphatase acti...
  • p27^新規分子種の同定とがん抑制因子としての機能解明, 文部科学省, 科学研究費補助金(特定領域研究),   2002  - 2002 , 細胞間接触により増殖を停止したブタ大動脈由来培養内皮細胞からサイクリン依存性キナーゼ阻害因子p27^の新たなアイソフォーム(p27^)をクローニングした。p27^のがん抑制因子としての機能を、細胞および個体レベルで明らかにすることを目的として、核移行、細胞周期制御及び分解抵抗性に関わる構造を明らかにした。また、自然高血圧発症ラット(SHR)と正常ラットの大動脈における2つのアイソフォームの発現解析から、組織増殖性とアイソフォーム発現の相関を、個体レベルで明らかにした。1.p27^は、領域153-168が有意な核移行に必要な配列であることが明らかになった。この領域には塩基性アミノ酸は一残基(K168)しか含まれない。不足する塩基性アミノ酸に代わり疎水性アミノ酸が機能を果たすという点で非典型的な2分裂型核移行シグナルであることを明らかにした。2.GFP発現系を用いて細胞増殖に及ぼす影響を解析し、p27^の増殖抑制作用を明らかにした。増殖抑制には、p27^と共通のN末端領域が必要である。3.6週齢SHRの大動脈にはp27^が、正常ラットではp27^が、主なアイソフォームとして発現する。週齢を重ねると、SHRにおいてもp27^発現が優位になる。正常ラット大動脈を培養...
  • The assessment of the contractility of the proliferating vascular smooth muscle, Ministry of Education, Culture, Sports, Science and Technology, Grants-in-Aid for Scientific Research(基盤研究(C)),   2001  - 2002 , The purpose of the present study was to investigate the mechanism underlying the contractility of the proliferating airway smooth muscle. We could obtain the following results.1, Wd could construct the recombinant baculo virus vector, which can be infected with a high efficiency to the mammalian cell, by inserting the cytomegalo virus promoter and the cDNA of interest. This virus could successfully transfected to the NIH 3T3 fibroblast, porcine tracheal smooth muscle cells and porcine coronary smooth muscle cells. It took us long time to optimize the condition for the transfection. However,...
  • The assessment of the contractility of the proliferating airway smooth muscle., Ministry of Education, Culture, Sports, Science and Technology, Grants-in-Aid for Scientific Research(基盤研究(C)),   2001  - 2002 , The purpose of the present study was to investigate the mechanism underlying the contractility of the proliferating airway smooth muscle. We could obtain the following results.1. We could construct the recombinant baculo virus vector, which can be infected with a high efficiency to the mammalian cell, by inserting the cytomegalo virus promotor and the cDNA of interest. This virus could successfully transfected to the NIH 3T3 fibroblast, porcine tracheal smooth muscle cells and porcine coronary smooth muscle cells. It took us long time to opitimize the condition for the transfection. However...
  • Development of a system for the continuous and simultaneous measurement of vascular intracellular signalings and metabolism, Ministry of Education, Culture, Sports, Science and Technology, Grants-in-Aid for Scientific Research(基盤研究(B)),   2001  - 2002 , The only successful technique for "the continuous and simultaneous monitoring of the intracellular signalings, function and metabolism of blood vessels, without destructing the tissue structure" must be the front-surface fluorimetry. In the first year of this study, we have newly developed a system to carry out 3 sets of dual-wavelength front-surface fluorimetries simultaneously. Followings are characteristic features of the system: (1) In collaboration with the Japan Spectroscopic Co. (JASCO, Tokyo, Japan), we have developed a "shuttering system" which controls the on/off of the excitation...
  • Elucidation of the Mechanism for the cell cycle regulation by a novel isoform of p27^ in the vascular cells, Ministry of Education, Culture, Sports, Science and Technology, Grants-in-Aid for Scientific Research(基盤研究(C)),   2001  - 2002 , A novel isoform of p27^, a cyclin-dependent kinase inhibitor, has been isolated from a cDNA library of porcine aortic endothelial cells. The N-terminal 162 amino acid of the new isoform was identical to those of p27^, while it contained a unique 18 amino acid C-terminus. The novel isoform was found to be resistant toward protease-mediated degradation, thus naming it p27^, a degradation resistant sioform of p27^. The region 153-168 was determined to be necessary for its significant nuclear localization. However, this region contains only one basic amino acid, and an ...
  • p27^新規分子種の同定とがん抑制因子としての機能解明, 文部科学省, 科学研究費補助金(特定領域研究(C)),   2001  - 2001 , 正常細胞の増殖制御において最も重要で、生理的な役割を果たす細胞間接触による増殖停止に関して、そのメカニズムを明らかにするために、培養ブタ大動脈内皮細胞を用いてp27^の発現調節機構を明らかにした。内皮細胞を低密度(コンフルエント密度の25%)及び高密度(80%)の二つの異なる密度で植え付け、異なる時間経過で細胞同士の接触による増殖停止を誘導することにより、p27^蛋白質の発現変化と細胞周期進行との時間的相関を明らかにした。静止期の細胞を植え付け直すと、25%及び80%植え付け共に細胞は同調してS期に入り、20時間後にS期のピークに達した。その後、25%植え付けの場合は96時間後に、80%植え付けの場合は48時間後に細胞周期から外れた。核におけるp27^蛋白質の発現は、細胞周期に入る際に消失し、再び静止期に戻る際に回復した。このp27^蛋白質の発現変化は、Kip1 mRNAの発現変化を伴った。p27^蛋白質の分解活性は、細胞周期に入る際に増加したり、細胞周期から外れる際に低下することはなかった。Kip1 mRNAの安定性は増殖期に低下し、細胞周期から外れる時期及びコンフルエント(静止期)の時期に上昇した。Nuclear run-on assayによりKip1遺伝子の転写活性はKip1 mRNAの発現レベルと関連すること...
  • p27^新規分子種の同定とがん抑制因子としての機能解明, 文部科学省, 科学研究費補助金(特定領域研究(C)),   2000  - 2000 , 血管内皮細胞cDNAライブラリーからサイクリン依存性キナーゼ阻害蛋白質p27^の新規分子種をクローニングした。新規分子種は、従来種とは異なるC末端を有するスプライスアイソフォームである。細胞抽出液を用いた分解アッセイを行ったことろ、従来種は増殖期の細胞抽出液によって1時間以内に分解されたのに対し、新規分子種は抵抗性であった。このことから新規分子種を、p27^(degradation-resistant isoform of p27^)と命名した。新規分子種を緑色蛍光色(GFP)との融合蛋白質として培養細胞に発現させると、従来種と同様に核へ局在することが明かとなった。GFP蛍光顕微鏡画像解析により核局在の程度を定量評価する方法を確立し、従来種の変異体を解析したところ、従来種の核移行シグナルは2分裂型であり、領域153〜166が核移行に必要最小限の領域であることを明らかにした。ところが、従来種と新規分子種の共通領域では核への特異的集積が消失した。このことから、新規分子種に特異的なC末端領域にも核移行に必要は配列があり、新規分子種の核移行シグナルも2分裂型であることが示唆された。GFP蛍光を指標に、フローサイトメーターを用いて、組換え蛋白質発現陽性及び陰性細胞の増殖を評価する方法を確立した。すなわち、遺伝子導入後各時点で、総細胞数を計測し、発現...
  • The role of the small GTP binding protein, rho, in the vascular smooth muscle., Ministry of Education, Culture, Sports, Science and Technology, Grants-in-Aid for Scientific Research(基盤研究(C)),   1999  - 2000 , The small G protein, rho, has been shown to inhibit myosin light chain phosphatase (MLCP) through the phosphorylation of this enzyme by rho kinase. It was thus obvious that MLCP may be the key protein for the rho-mediated signal transduction to induce modulation of calcium sensitivity of the vascular smooth muscle. MLCP is composed of three subunits, namely, catalytic subunit, small regulatory subunit and large regulatory subunit. We focused on the function of two regulatory subunits of MLCP on the smooth muscle contractile apparatus in the present research program. The major findings were ...
  • Elucidation of the physiological role of myosin phosphatase in vascular endothelial cells and smooth muscle cells, Ministry of Education, Culture, Sports, Science and Technology, Grants-in-Aid for Scientific Research(基盤研究(C)),   1999  - 2000 , The phosphorylation of myosin light chain plays a key role in the regulation of vascular tone. In addition, myosin phosphorylation is also essential in the regulation of motility and cytoskeletal organization in the non-muscle cells. The myosin phosphatase has been recently cloned and is composed of three subunits ; a 38 kDa catalytic subunit and two regulatory subunits of 20 kDa and 110 kDa. However, the physiological role of myosin phosphatase in the vascular smooth muscle and endothelial cells remained to be investigated.In this project, we first elucidated the regulatory role of the myo...
  • Development of the optical system for continuous and multi-factorial monitoring of the intracellular signaling network in endothelial and smooth muscle cells in vascular strips., Ministry of Education, Culture, Sports, Science and Technology, Grants-in-Aid for Scientific Research(基盤研究(B)),   1998  - 2000 , The purpose of this study is to develop optical systems for continuous and multi-factorial monitoring of the intracellular signaling network in endothelial and smooth muscle cells in vascular strips. Using newly developed systems, we investigated the mechanisms underlying the regulation of the vascular tonus. Following results were obtained in this study : (1) We have developed a system to monitor changes in [Ca^<2+>]i and tension of the vascular strips simultaneously. This system was reported as a chapter "Measurement of [Ca^<2+>]i in smooth muscle strips using front-surface fluorimetry" i...
  • 血管内皮細胞カドヘリン複合体結合蛋白質の同定と生理機能の解明, 文部科学省, 科学研究費補助金(奨励研究(A)),   1998  - 1999 , 細胞間接触による血管内皮細胞増殖の抑制は、内皮細胞を機能的成熟に導く重要な機構である。本研究では、(1)細胞間接触の受容から核における増殖制御に至る細胞質及び核内シグナル伝達系(Ca情報、蛋白質リン酸化あるいは脱リン酸化酵素、転写因子、細胞周期制御蚤白質など)を分子細胞生物学的に解明すること、(2)細胞接着因子の一つ内皮型カドヘリンとその機構複合体の形成に関与する構造を、ツーハイブリッド法を用いて明らかにすることを目的として研究を行った。1.培養内皮細胞の増殖及び細胞周期を、Bromod eoxyuridine(BrdU)の取り込みで評価する方法を確立した。コンフルエントの細胞は、BrdU陽性細胞の割合は0.1%であり、細胞間接触の完成した時期の内皮細胞は増殖を停止していることが明かとなった(Hirano et al.,1999)。2.静止期にある培養内皮細胞及び生体内皮細胞(大動脈弁条片)における、Ca情報伝達機構を明らかにし、血管緊張調節における内皮細胞内Ca情報伝達の役割を明らかにした(Ihara et al.,1999;Kawasaki et al.,1999)3.内皮細胞cDNAライブラリーからミオシン脱リン酸化酵素調節サブユニット(MYPT1)をクローニングした (Hirano et al.,1999)。初めに平滑筋で同定されたMYPT1と相同性が高く、また、細胞...
  • 血管平滑筋トロポミオシンの発現調節に関与するスプライシング因子の同定, 文部科学省, 科学研究費補助金(特定領域研究(A)),   1998  - 1998 , 血管平滑筋の形質転換に伴うαトロポミオシン・アイソフォーム変換の調節に関与する情報伝達機構を明らかにする事を目的として今年度の研究を行った。1. 平滑筋細胞を培養すると、培養3〜5日目を最大に、一過性に非平滑筋型αトロポミオシンの発現が増加した。非平滑筋型アイソフォームの発現増加に一致して、BrdUの取り込みが、培養3日目を最大に一過性に増加した。2. コンフルエントの細胞を、2日間血清を含まない培地で培養し、再び血清刺激を行うと、刺激1.5時間で、非平滑筋型αトロポミオシンの発現が増加した。血清濃度1%から増強作用が認められ、3%で最大効果に達した。この時、非平滑筋型アイソフォームの発現は刺激前の約2倍に増加した。3. 血清再添加による非平滑筋型アイソフォーム発現増加は、H-7処理により完全に抑制されたが、wortmanninは有意な抑制作用を示さなかった。4. phorbil 12,13 dibutyrateは、血清刺激と同様に、刺激1.5時間で非平滑筋型アイソフォーム発現を増加させた。1nMから増強作用が認められ、100nMで最大効果に達した。この時、非平滑筋型アイソフォームの発現は刺激前の約2倍に増加した。5. Phorb01 12,13 dibutyrateは、1.5時間あるいは24時間刺激を行っても、BrdU取り込みには影響を与えなかった。血清刺激も、1.5時間で...
  • Studies on molecular cell biology of the inhibition of coronary vasoconstriction and intimal thickening., Ministry of Education, Culture, Sports, Science and Technology, Grants-in-Aid for Scientific Research(一般研究(A), 基盤研究(A)),   1995  - 1998 , For the prevention of coronary vasoconstriction and intimal thickening, following studies were performed : In smooth muscle and endothelial cells, (1)the characterization of the intracellular signal transduction networks, (2) the elucidation of the relationships between cell cycle progression and the cellular functions, and (3) the elucidation of the relationships between signaling factors and cellular functions/structures. (4) The clinical applicatopn of the results of these experimental studies.Following results/conclusions were obtained : (1) We have developed a method to monitor [Ca]i c...
  • 血管平滑筋細胞の分化に関与する平滑筋特異的スプライシング因子の同定, 文部科学省, 科学研究費補助金(重点領域研究),   1997  - 1997 , 本研究は、平滑筋特異的スプライシング因子を同定するために、培養平滑筋細胞を用いて、平滑筋細胞の形質変換に伴うトロポミオシンのアイソフォ-ムの変換調節機構を明らかにすることを目的として行った。培養細胞には、ラット大動脈平滑筋細胞の初代培養を用いた。10%胎児牛血清を含む培地で培養し、コンフルエントに達した細胞を無血清培地で2日間培養して、実験に用いた。α-トロポミオシンアイソフォ-ム発現の解析は、逆転写-PCRにより行った。ラットα-トロポミオシンのエクソン1、2、3、4に特異的なプライマ-を作製し、平滑筋細胞から精製した総RNAを1μg用い、RT-PCRによりトロポミオシン発現を解析した。1.無血清培地で培養した平滑筋細胞を、再び血清で刺激すると1.5時間以内に、エクソン3を含む非平滑筋型アイソフォ-ムの発現が増加した。エクソン1、エクソン2の発現は変化しなかった。血清濃度1%から増強作用が認められ、3%で最大効果に達し、エクソン3の発現は刺激前の約2倍になった。2.血清によるエクソン3の発現増強は、1-10μM H-7の前処理により完全に抑制された。wortmanninは、0.1μMの濃度において、不完全な抑制作用を示した。3.フォルボ-ル12,13ジブチレ-トで平滑筋を刺激すると、エクソン3の発現が増加した。1nMから増強作用が認められ、100nMで最大効果に達し、エクソ...

Educational Activities

Teaching Experience

  • Two-Hybrid system, University of Arizona
  • Cardiovascular Pharmacology, University of Arizona
  • 蛋白質リン酸化脱リン酸化, 九州大学、福岡大学
  • カルシウムシグナル伝達, 九州大学、福岡大学
  • シグナル伝達, 九州大学
  • 平滑筋生理学, 九州大学
  • 心臓生理学, 九州大学
  • 循環器内科学・心筋虚血の生理学, 九州大学
  • 生理学一般(植物生理学), 香川大学


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