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上野 正樹 ウエノ マサキ

所属
医学部
医学科
職名教授
Last Updated :2019/06/19

研究者基本情報

学歴

  •  - 1985年, 京都大学, 医学部, 医学科

学位

  • 医学士, 京都大学
  • 医学博士, 京都大学

所属学協会

  • 日本神経病理学会
  • 日本病理学会

経歴

  •   1985年,  - 1986年,  京都大学医学部神経内科, 研修医
  •   1986年,  - 1988年,  宇部興産中央病院, 医師
  •   1988年,  - 1992年,  京都大学医学部大学院医学研究科, 大学院生
  •   1992年,  - 1993年,  医仁会武田総合病院, 医師
  •   1993年,  - 1994年,  康生会武田病院, 医師
  •   1994年,  ニューヨーク州立発達障害基礎研究所
  •   1995年,  - 1999年,  赤心会赤沢病院, 医師
  •   1999年,  - 2002年,  香川医科大学病理学講座, 助手
  •   2002年, - 香川医科大学医学部 病理学講座(現 香川大学医学部 炎症病理学), 助教授
  •   2013年, - 香川大学医学研究院, 教授

研究活動情報

研究分野

  • 神経科学 / 神経解剖学・神経病理学
  • 基礎医学 / 実験病理学

研究キーワード

    Pathology, Neuropathology

Misc

  • Effects of aging and HIF-1alpha deficiency on permeability of hippocampal vessels, Microscopy Research and Technique, 69, 29 - 35,   2006年
  • Two-pathways of apoptosis are simultaneously induced in the embryonal brains of neural cell-specific HIF-1a-deficient mice, Histochemistry and Cell Biology, 125, (5), 535 - 544,   2006年
  • Oxidative danmage in cerebral vessels of diabetic db/db mice, Diabetes Metab Res Rev, 21, 554 - 559,   2005年
  • Cultered murine dermal fibroblast-like cells from Senescence-Accelerated Mice as in vitro models for higher oxidative stress due to mitochondrial alterations, J Gerontol A Biol Sci, 60A, (9), 1087 - 1098,   2005年
  • Blood-brain barrier disruption in the hypothalamus of young adult spontaneously hypertensive rats., Histochem Cell Biol, 122, 131 - 137,   2004年
  • Blood-brain barrier is impaired in the hippocampus of young adult spontaneously hypertensive rats, Acta Neuropathol, 107, 532 - 538,   2004年
  • Tissue distribution, biochemical properties, and transmission of mouse type A AApoAII amyloid fibrils., Am J Pathol, 164, (5), 1597 - 1606,   2004年
  • A novel mechanism for imatinib mesylate-induced cell death of BCR-ABL-positive human leukemic cells: caspase-independent, necrosis-like programmed cell death mediated by serine protease activity., Blood, 103, (6), 2299 - 2307,   2004年
  • Immunohistochemical study of transferrin receptor expression in the placenta of pre-eclamptic pregnancy, Placenta, 24, 870 - 876,   2003年
  • Blood-brain barrier disruption in white matter lesions in a rat model of chronic cerebral hypoperfusion "jointly worked", Journal of Cerebral Blood Flow & Metabolism, 22, 97 - 104,   2002年
  • Ultrastructural and permeability features of microvessels in the periventricular area of senescence-accelerated mice (SAM), Microscopy Research and Technique, 53, 232 - 238,   2001年
  • Change of adrenomedullin concentrations in plasma and amniotic fluid, and human placental adrenomedullin expression with advancing gestation, Placenta, 22, 244 - 250,   2001年
  • Effects of aging and blood pressure on the structure of the thoracic aorta in SAM mice: a model of age-associated degenerative vascular changes, Experimental Gerontology, 36, 111 - 124,   2001年
  • Glycoprotein Ibalpha-bound thrombin functions as a serine protease to produce macromolecular activators of phagocytosis from platelets, SAKAMOTO H, UENO M, WU Y, KHATUN R, TANAKA S, MIYABE K, OGAWA Y, ONODERA M, Biochemical and Biophysical Research Communications, 270, (2), 377 - 382,   2000年
  • Immunohistochemical adrenomedullin expression is decreased in the placenta from pregnancies with pre-eclampsia, KANENISHI K, KUWABARA H, UENO M, SAKAMOTO H, HATA T, Pathology International, 50, (7), 536 - 540,   2000年
  • Dendritic cell-like immunoreactivity in the glomerulus of the olfactory bulb and olfactory nerves of mice, NeuroReport, 11, 3573 - 3576,   2000年
  • Blood-brain barrier permeability in the periventricular areas of the normal mouse brain "jointly worked", Acta Neuropathologica, 99, 385 - 392,   2000年
  • Aging and blood-brain barrier and neuronal cells of eye and ear in SAM mice, Neurobiology of Aging, 20, 117 - 123,   1999年
  • The passage of blood-borne horseradish peroxidase into the amygdaloid area of the mouse brain, Histochemistry and Cell Biology, 112, 265 - 270,   1999年
  • Accumulation of triosephosphate isomerase, with sequence homology to beta amyloid peptides, in vessel walls of the newborn piglet hippocampus, Microscopy Research and Technique, 70, 648 - 655,   2007年
  • Factor XIIIa-positive dermal dendritic cells in keloids and hypertrophic and mature scars, ONODERA Masayuki, ONODERA Masayuki, UENO Masaki, ITO Osamu, SUZUKI Shigehiko, IGAWA Hiroharu H., SAKAMOTO Haruhiko, Pathology International, 57, (6), 337 - 342,   2007年
  • Molecular anatomy of the brain endothelial barrier: an overview of the distributional features, Current Medicinal Chemistry, 14, 1199 - 1206,   2007年
  • のう胞状の肉眼型を示した回盲部原発のびまん性大細胞型B細胞リンパ腫の一例, 診断病理, 24, (2), 224 - 229,   2007年
  • Evaluation of a urinary multi-parameter biomarker set for oxidative stress in children, adolescents and young adults, TAMURA Satoshi, TSUKAHARA Hirokazu, UENO Masaki, MAEDA Masayuki, KAWAKAMI Hisako, SEKINE Kyouichi, MAYUMI Mitsufumi, Free Radical Research, 40, (11), 1198 - 1205,   2006年
  • Ultrastructural and permeability features of microvessels in the hippocampus, cerebellum and pons of senescence-accelerated mice(SAM) "jointly worked", UENO Masaki, SAKAMOTO Haruhiko, KANENISHI Kenji, ONODERA Masayuki, AKIGUCHI Ichiro, HOSOKAWA Masanori, Neurobiology of Aging, 22, 469-478,   2001年, [査読有り]
  • Oxidative damage in cerebral vessels of diabetic db/db mice, LIAO, Y.J., UENO, Masaki, NAKAGAWA, T, HUANG, C,, KANENISHI, Kenji, ONODERA, Masayuki, SAKAMOTO, Haruhiko, Diabetes Metab Res Rev, 21, 554-559,   2005年11月, [査読有り]
  • Involvement of retinoic acid-inducible gene-I in inflammation of rheumatoid fibroblast-like synoviocytes, T. Imaizumi, T. ARIKAWA, T. SATO, R. UESATO, T. MATSUMIYA, H. YOSHIDA, M. Ueno, S. YAMASAKI, T. NAKAJIMA, M. HIRASHIMA, T. SAKATA, Y. ISHIBASHI, S. TOH, C. OHYAMA, K. SATOH, Clinical & Experimental Immunology, 153, 240-244,   2008年, [査読有り]
  • Medulloblastoma with myogenic differentiation showing double immunopositivity for synaptophysin and myoglobin, Mizue KIDO, Masaki UENO, Masayuki ONODERA, Kouichi MATSUMOTO, Tadashi IMAI, Reiji HABA, Takashi TAMIYA, Cheng-long Huang, Haruhiko SAKAMOTO, Pathology International, 59, 255-260,   2009年, [査読有り]
  • The expression of P-glycoprotein is increased in vessels with blood-brain barrier impairment in a stroke-prone hypertensive model, M. Ueno, T. NAKAGAWA, Cheng-long Huang, M. UEKI, T. KUSAKA, N. HOSOMI, K. KANENISHI, M. ONODERA, B. WU, H. SAKAMOTO, Neuropathology and Applied Neurobiology, 35, 147-155,   2009年, [査読有り]
  • Abcb1a and Abcb1b expression in senescence-accelerated mouse (SAM), Bin WU, Masaki UENO, Takashi KUSAKA, Masayuki ONODERA, Cheng-long HUANG, Naohisa HOSOMI, Kenji KANENISHI, Haruhiko SAKAMOTO, Neuroscience Letters, 456, 34-38,   2009年, [査読有り]
  • The expression of matrix metalloproteinase-13 is increased in vessels with blood-brain barrier impairment in a stroke-prone hypertensive model, Masaki UENO, Bin WU, Akira NISHIYAMA, Cheng-long HUANG, Naohisa HOSOMI, Takashi KUSAKA, Toshitaka NAKAGAWA, Masayuki ONODERA, Mizue KIDO, Haruhiko SAKAMOTO, Hypertension Research, 32, 332-338,   2009年, [査読有り]
  • RAGE, LDL receptor, and LRP1 expression in the brains of SAMP8, Bin WU, Masaki UENO, Masayuki ONODERA, Takashi KUSAKA, Cheng-long HUANG, Naohisa HOSOMI, Kenji KANENISHI, Haruhiko SAKAMOTO, Neuroscience Letters, 461, 100-105,   2009年, [査読有り]
  • Age-related changes in P-glycoprotein expression in, Bin WU, Masaki UENO, Masayuki ONODERA, Takashi KUSAKA, Cheng-long HUANG, Naohisa HOSOMI, Kenji KANENISHI, Haruhiko SAKAMOTO, Current Aging Science, 2, 187-192,   2009年, [査読有り]
  • Mechanisms of the penetration of blood-borne substances into the brain, Masaki UENO, Current Neuropharmacology, 7, 142-149,   2009年, [査読有り]
  • The expression of LDL receptor in vessels with blood-brain barrier impairment in a stroke-prone hypertensive model, Masaki Ueno, Bin Wu, Toshitaka Nakagawa, Yukiko Nagai, Masayuki Onodera, Takashi Kusaka, Kenji Kanenishi, Haruhiko Sakamoto, Histochemistry and Cell Biology, 133, 669-676,   2010年06月, [査読有り]
  • Roleof hypoxia-inducible factor 1alpha in T cells as a negative regulator in development of vascular remodeling, Hirotugu Kurobu, Masahisa Urata, Masaki Ueno, Masaaki Ueki, Shiro Ono, Yuki Izawa-Ishizawa, Yayoi Fukuhara, Yu Lei, Adiratna Mat Ripen, Tamotsu Kanbara, Ken-ichi Aihara, Keisuke Ishizawa, Masashi Akaike, Franka J. Gonzalez, Toshiaki Tamaki, Yousuke Takaha, Arteriosclerosis, Thrombosis, and Vascular Biology, 30, 210-217,   2010年02月, [査読有り]
  • Curcumin ameliorates cisplatin-induced dephrotoxicity by inhibiting renal inflammation in mice, Masaaki Ueki, Masaki Ueno, Jun Morishita, Nobuhiro Maekawa, Journal of Bioscience and Bioengineering, 115, (5), 547-551,   2013年, [査読有り]
  • A possible role of galectin-9 in the pulmonary fibrosis of patients with interstitial pneumonia, Nobuhiro Matsumoto, Shigeki Katoh, Shigehisa Yanagi, Yasuji Arimura, Masatoshi Tokojima, Masaki Ueno, Mitsuomi Hirashima, Masamitsu Nakazato, Lung, 191, 191-198,   2013年, [査読有り]
  • D-Ribose ameliorates cisplatin-induced nephrotoxicity by inhibiting renal inflammation in mice, Masaki Ueno, Masaaki Ueki, Jun Morishita, Nobuhiro Maekawa, Tohoku Journal of Experimental Medicine, 229, 195-201,   2013年, [査読有り]
  • CD36 expression in the brains of SAMP8, Bin Wu, Masaki Ueno, Takashi Kusaka, Takanori Miki, Nagai Yukiko, Toshitaka Nakagawa, Kenji Kanenishi, Naohisa Hosomi, Haruhiko Sakamoto, 56, (1), 75-79,   2013年01月, [査読有り]
  • An immunohistochemical study of human platelets using a rabbit antibody against H18-K24 of apolipoprotein CIII (HATKTAK), Takao Yamanaka, Haruhiko Sakamoto, Toshitaka Nakagawa, Sumiko Tanaka, Kouichi Matsumoto, Masaki Ueno, Pathology International, 63, 398-407,   2013年, [査読有り]
  • The expression of CD36 in vessels with blood-brain barrier impairment in a stroke-prone hypertensive model, 上野正樹, Toshitaka Nakagawa, Yukiko Nagai, Nozomu Nishi, Takashi Kusaka, Kenji Kanenishi, Masayuki Onodera, Naohisa Hosomi, Cheng-long Huang, Hiroyasu Yokomise, Hidekazu Tomimoto, Haruhiko Sakamoto(Masaki Ueno, Toshitaka Nakagawa, Yukiko Nagai, Nozomu Nishi,, Neuropathology and Applied Neurobiology, 37, 727-737,   2011年, [査読有り]
  • Immunoreactivity of glucose transporter 5 is located in epithelial cells of the choroid plexus and ependymal cells, Masaki Ueno, Nozomu Nishi, Toshitaka Nakagawa, Yoichi Chiba, Ikuko Tsukamoto, Takashi Kusaka, Takanori Miki, Haruhiko Sakamoto, Fuminori Yamaguchi, Masaaki Tokuda, Neuroscience, 260, 149-157,   2014年02月, [査読有り]
  • Immunohistochemical analysis of transporters related to clearance of amyloid-beta peptides through clood-cerebrospinal fluid barrier in human brain, Koichi Matsumoto, Yoichi Chiba, Ryuji Fujihara, Hiroyuki Kubo, Haruhiko Sakamoto, Masaki Ueno, 144, (6), 597-611,   2015年12月, [査読有り]
  • Blood-barin barrier damage in vascular dementia, Masaki Ueno, Yoichi Chiba, Koichi Matsumoto, Ryuta Murakami, Ryuji Fujihara, Machi Kawauchi, Hiroshi Miyanaka, Toshitaka Nakagawa, Neuropathology, 36, (2), 115-124,   2016年04月, [査読有り]
  • Blood-brain barrier and blood-cerebrospinal fluid barrier in normal and pathological conditions, Masaki Ueno, Yoichi Chiba, Ryuta Murakami, Koichi Matsumoto, Machi Kawauchi, Ryuji Fujihara, Brain Tumor Pathology, 33, (2), 89-96,   2016年04月, [査読有り]
  • Immunoreactivity of glucose transporter 8 is located in the epithelial cells of the choroid plexus and in ependymal cells, Ryuta Murakami, Yoichi Chiba, Kazuto Tsuboi, Koichi Matsumoto, Machi Kawauchi, Ryuji Fujihara, Masato Mashima, Kenji Kanenishi, Tetsuji Yamamoto, Masaki Ueno, Histochemistry and Cell Biology, 146, (2), 231-236,   2016年08月, [査読有り]
  • Albumin microvascular leakage in brains with diabetes mellitus, Ryuji Fujihara, Yoichi Chiba, Toshitaka Nakagawa, Nozomu Nishi, Ryuta Murakami, Koichi Matsumoto, Machi Mawauchi, Tetsuji Yamamoto, Masaki Ueno, Microscopy Research and Technique, 79, (9), 833-837,   2016年09月, [査読有り]
  • Glucose transporter 8 immunoreactivity in astrocytic and microglial cells in subependymal areas of human brains, Masato Mashima, Yoichi Chiba, Ryuta Murakami, Naoya Uemura, koichi Matsumoto, Machi Kawauchi, Kenji Kanenishi, Toshiyuki Hata, Masaki Ueno, Neuroscience Letters, 636, 90-94,   2017年01月, [査読有り]
  • Immunoreactivity of urate transporters, GLUT9 and URAT1, is located in epithelial cells of the choroid plexus of human brains, Naoya Uemura, Ryuta Murakami, Yoichi Chiba, Ken Yanase, Ryuji Fujihara, Masato Mashima, Koichi Matsumoto, Machi Kawauchi, Gotaro Shikami, Masaki Ueno, Neuroscience Letters, 659, 99-103,   2017年10月, [査読有り]

書籍等出版物

  • The pineal gland and melatonin, NOVA,   2012年, ISBN:978-1-60876-717-5
  • Pediatric cancer, Springer,   2012年
  • Alzheimer's disease pathogenesis, InTech,   2011年

講演・口頭発表等

  • The mechanism of blood-brain barrier dysfunction in vascular dementia., The Second Congress of Asian Society of Neuropathology,   2011年
  • 血液脳関門障害血管における分子メカニズム解明から血管性認知症の治療へ, 第57回日本病理学会秋期特別総会,   2011年
  • Gene analyses in vessels with blood-brain barrier impairment, XVIIth International Congress of Neuropathology,   2010年
  • Therapeutic targets for vascular dementia, NeuroTalk-2010,   2010年
  • 右第3指に発生した皮下腫瘤の一切除例, 第90回日本病理学会 中四国支部学術集会,   2006年
  • 新生仔豚の海馬脳血管におけるアミロイドベータ蛋白様triosephosphate isomerase の沈着について, 第95回日本病理学会総会,   2006年
  • 稀な肉眼像を呈した回盲部原発のdiffuse large B cell lymphomaの一例, 第95回日本病理学会総会,   2006年
  • Hypoxia Inducible Factor (HIF-1) によるT細胞機能の制御, 第26回日本炎症・再生医学会,   2005年
  • 抗炎症脂質N-アシルエタノールアミンを生成する新規ホスホリパーゼD型酵素(NAPE-PLD)のcDNAクローニングと発現部位の解析, 生体防御機能異常ワークショップ2005,   2005年
  • Listeria monocytogenes敗血症による化膿性脳脊髄膜炎、心外膜炎の1剖検例, 第94回日本病理学会総会,   2005年

受賞

  •   2011年, 日本病理学会学術研究賞

競争的資金

  • 認知症性疾患における血液脳関門機能の役割
  • Blood-brain barrier and dementia,   1988年