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呉 哲彦 ゴ テツヒコ

所属
医学部
附属病院
職名講師
Last Updated :2020/09/17

研究者基本情報

学歴

  •  - 現在, 金沢大学

学位

  • 医学博士, 金沢大学

所属学協会

  • 日本呼吸器外科学会

経歴

  •   2010年07月, 香川大学 医学部 呼吸器乳腺内分泌外科

研究活動情報

研究分野

  • ライフサイエンス / 呼吸器外科学
  • ライフサイエンス / 心臓血管外科学

研究キーワード

    再生医療, 手術, 胸部外科

論文

  • Thoracoscopic resection of parosteal lipoma of the rib using orthopedic electric micro drill., 呉 哲彦, Gen Thorac Cardiovasc Surg, Gen Thorac Cardiovasc Surg, 66, (11) 675 - -678,   2018年11月, [査読有り]
  • T4肺癌切除症例の検討, 呉 哲彦, 胸部外科, 胸部外科, 70, (11) 903 - 907,   2017年12月

Misc

  • The role of surgery for carcinomatous pleuritis in non-small cell lung cancer: as a part of multi-modality treatment, Tetsuhiko Go, Hiroyasu Yokomise, Surgery Today,   2014年07月, [査読有り]
  • 右I期肺癌術後乳糜胸に対しオクトレオチド投与が有効であったと考えられる1例, 呉哲彦, 張 性洙, 三崎伯幸, 石川 真也, 横見瀬 裕保, T, suhiko Go, Sung Soo Chang, Noriyuki Misaki, Shinya Ishikawa, Hiroyasu Yokomise, 日本呼吸器外科学会雑誌, 25, (4), 74-78,   2011年05月, [査読有り]
  • Both epithelial cells and mesenchymal stem cell-derived chondrocytes contribute to the survival of tissue-engineered airway transplants in pigs, Tetsuhiko Go, Philipp Jungebluth, Silvia Baiguero, Adelaide Asnaghi, Jaume Martorell, Helmut Ostertag, Sara Mantero, Martin Birchall, Augustinus Bader, Paolo Macchiarini, JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY, 139, (2), 437 - 443,   2010年02月, [査読有り]
    Objective: We sought to determine the relative contributions of epithelial cells and mesenchymal stem cell-derived chondrocytes to the survival of tissue-engineered airway transplants in pigs. Methods: Nonimmunogenic tracheal matrices were obtained by using a detergent-enzymatic method. Major histocompatibility complex-unmatched animals (weighing 65 +/- 4 kg) were divided into 4 groups (each n = 5), and 6 cm of their tracheas were orthotopically replaced with decellularized matrix only (group I), decellularized matrix with autologous mesenchymal stem cell-derived chondrocytes externally (group II), decellularized matrix with autologous epithelial cells internally (group III), or decellularized matrix with both cell types (group IV). Autologous cells were recovered, cultured, and expanded. Mesenchymal stem cells were differentiated into chondrocytes by using growth factors. Both cell types were seeded simultaneously with a dual-chamber bioreactor. Animals were not immunosuppressed during the entire study. Biopsy specimens and blood samples were taken from recipients continuously, and animals were observed for a maximum of 60 days. Results: Matrices were completely covered with both cell types within 72 hours. Survival of the pigs was significantly affected by group (P<.05; group I, 11 +/- 2 days; group II, 29 +/- 4 days; group III, 34 +/- 4 days; and group IV, 60 +/- 1 days). Cause of death was a combination of airway obstruction and infection (group I), mainly infection (group II), or primarily stenosis (group III). However, pigs in group IV were alive, with no signs of airway collapse or ischemia and healthy epithelium. There were no clinical, immunologic, or histologic signs of rejection despite the lack of immunosuppression. Conclusions: We confirm the clinical potential of autologous cell-and tissue-engineered tracheal grafts, and suggest that the seeding of both epithelial and mesenchymal stem cell-derived chondrocytes is necessary for optimal graft survival. (J Thorac Cardiovasc Surg 2010;139:437-43)

講演・口頭発表等

  • 胸腔鏡手術; 定義とアプローチ法統一による共通認識の必要性について, 第31回日本呼吸器外科学会総会,   2014年
  • 完全鏡視下手術:Thoracosopic Surgeryの安全な導入と安定した施術のための工夫, 第113回日本外科学会総会,   2013年
  • 脱細胞化気管ECM (extra cellular matrix)の気道補填材料及び異種移植材料としての可能性について, 第30回日本呼吸器外科学会総会,   2013年
  • Early surgical outcome of thoracoscopioc surgery : results of 101 cases of complete VATS in 2 years., Korea and Japan Thoracoscopic Surgery Summit 2012,   2012年
  • 完全鏡視下肺葉切除手術の導入;姫路市VATS法習得に向けての経験., 第29回日本呼吸器外科学会総会,   2012年
  • 触知不能肺癌症例の切除方法;高解像度CT診断にもとづく一期的葉区切除の可能性および経気道的ICG注入の有用性について, 第65回日本胸部外科学会定期学術集会,   2012年
  • 胸膜播種悪性胸水症例における外科的切除の意義について, 第28回日本呼吸器外科学会総会,   2011年
  • 予後ならびに術後合併症から見た術前導入療法併用肺全摘術の妥当性について, 第64回日本胸部外科学会総会,   2011年
  • Right carinal lobectomy with reconstruction of superior vena cava and pulmonary artery using cryopreserved arterial homograft, 第52回日本肺癌学会総会,   2011年
  • Awake tracheal surgery; 硬膜外麻酔を用いた意識下気管切除の経験, 第27回日本呼吸器外科学会,   2010年
  • Both epithelial cells and mesenchymal stem cell-derived chondrocytes contribute to the survival of tissue-engineered airway transplants in pigs.,   2009年

受賞

  • 第62回日本胸部外科学会 最優秀演題賞

競争的資金

  • 細胞外マトリックスと骨髄幹細胞を用いた気道修復