Researchers Database

Takeshi Fujimori

Last Updated :2026/06/24

2022/04 - Today kagawa university faculty of medicineNeurorogical surgeryAssistant Professor

molecular therapy targeted for (pro) renin receptor against glioblastoma
Japan Society for the Promotion of Science：Grants-in-Aid for Scientific Research
Date (from‐to) : 2022/08 -2024/03
Author : Fujimori Takeshi

The efficacy of PRR antibodies against GBM was investigated using human glioma cell lines and glioma stem cell lines, with each cell line showing efficacy in cell proliferation, sphere formation, apoptosis and migration. The efficacy was confirmed in each cell line in cell proliferation, sphere formation, apoptosis and migration. In vivo studies using U87MG also demonstrated tumour suppression. In addition, focusing on stemness, a correlation was found between stemness markers and PRR in pathological specimens, proving that PRR antibodies also have a suppressive effect on stemness. From these results, it was concluded that PRR antibodies could be used to treat GBM.