Quantitative bone evaluation to monitor in castration-resistant prostate cancer bone metastases
Japan Society for the Promotion of Science:Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)
Date (from‐to) : 2018/04 -2021/03
Author : Tanaka kenichi
Both bone scintigraphy and 18F-NaF PET reflect osteoblastic activity, which is often increased in bone metastases of prostate cancer. Semiquantitative parameters, such as standardized uptake value (SUV), could be useful tools to evaluate biological activity at pathophysiological site. The bone uptake value (BUV), another semiquantitative index obtained from bone SPECT that indicates the degree of radioisotope accumulation, has been used to improve the diagnostic ability for detection of bone metastasis. The purpose of this study was to evaluate the usefulness of SPECT-BUV for assessment of bone metastases and to compare with PET-SUV. SPECT-BUV was significantly lower in bone metastases than PET-SUV. Significant correlation between SPECT-BUV and PET-SUV (P < 0.001) was found. The baseline burden of metastatic disease was demonstrated to be poor outcome. Baseline skeletal tumor burden as demonstrated on SPECT-BUV or PET-SUV may be a prognostic biomarker.