Impacts of Ultrasound Exposure to Adipose Tissue in Metabolic Syndrome
Japan Society for the Promotion of Science:Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)
Date (from‐to) : 2008 -2010
Author : OHMORI Koji; KOHNO Masakazu; NOMA Takahisa; MURAO Koji; SHINOMIYA Kaori; ISHIHARA Yasuhiro; HASAN Ul arif; YOSHIDA Junji; YUKIIRI Kazushi
Because ultrasound radiation alone did not ameliorate adipocyte dysfunction, we investigated the molecular target of frequently used drugs as the adjunct therapy. Pitavastatin enhanced adipocyte proliferation/ maturation, increased small adipocyte count, preserved adiponectin level, and improved insulin resistance ; pioglitazone suppressed a cell-cycle inhibiting factor and increased adipocyte count. Thus, therapeutic ultrasound with the adjunctive drugs would include cell-cycle inhibitors.