Anti-tumor effect of Galectin-9 on metastatic hepatocellular carcinoma and its microRNA basis
Japan Society for the Promotion of Science:Grants-in-Aid for Scientific Research
Date (from‐to) : 2019/04 -2022/03
Author : Masaki Tsutomu
The purpose of this study was to prove the anti-tumor effect of Gal-9 on metastatic liver cancer and to analyze the microRNA changes in the tumor, and to conduct basic research on the possibility that Gal-9 could be a therapeutic strategy for metastatic liver cancer. We proved, in vitro, and in vivo systems whether Gal-9 treatment of OCUC-LM1, a metastatic liver cancer cell line derived from colorectal cancer, produces anti-tumor effects. We also found mcroRNAs associated with the in vitro tumor suppressive effect of Gal -9 in the metastatic liver cancer cell line OCUC-LM1 using array chips.