Detection of brain ischemia in patients with traumatic brain injury using molecular imaging positron emission tomography
Japan Society for the Promotion of Science:Grants-in-Aid for Scientific Research
Date (from‐to) : 2009 -2011
Author : KAWAI Nobuyuki; KAWANISHI Masahiko; KAWAKITA Kenya; YAMOTO Yuka
No hypoxic area was detected in surrounding brain contusion using^<18> F-fluoromisonidazole(FMISO) positron emission tomography(PET) in patients with traumatic brain injury. Then, we tried to detect hypoxic area in patients with ischemic stroke and malignant brain tumor. All patients with acute cerebral infarction showed hypoxic area surrounding cerebral infarction and some of the hypoxic area resulted in cerebral infarction in the subacute phase. In patients with malignant gliomas, all tumors showed tissue hypoxia in the tumor and the hypoxia volume was significantly correlated with the volume of biological aggressiveness determined by methionine PET.