Hashimoto Takeshi

Researcher Information

J-Global ID

• 200901094844079063

Research Interests

• obesity   adipose tissue   adipocyte   adipogenesis   Sphingosine Kinase   S1P   physiology   obesity   adipose tissue   adipocyte   adipogenesis   Sphingosine Kinase   S1P   physiology   

Research Areas

• Life sciences / Metabolism and endocrinology
• Life sciences / Pharmacology
• Life sciences / Clinical pharmacy
• Life sciences / Physiology

Academic & Professional Experience

• 2013  - 香川大学自然生命科学系, 助教
• 2011  - 香川大学医学研究院, 助教
• 2007  - 香川大学医学部形態・機能医学講座 自律機能生理学, 助教
• 2004  - 香川大学医学部形態・機能医学講座 自律機能生理学, 助手

Education

•        - 2004  Osaka University  Graduate School, Division of Medical Sciences
•        - 2004  Osaka University  医学系研究科

Association Memberships

• 日本肥満学会   日本薬理学会   日本生理学会   The Japanese Pharmacological Society   The Physiological Society of Japan   

Published Papers

• Coagulation factor XI induced Ca2+ response and cell migration in vascular smooth muscle cells

  Liu Wenhua; HASHIMOTO Takeshi; YAMASHITA TETSUO; HIRANO Katsuya

  The Jpurnal of Physiological Sciences 68 (Supplement 1) S81  2018/03 [Refereed]
  
• NAD(P)H and low ionic strength suppresses dissociation of apoptosis-inducing factor from E. coli membrane

  YAMASHITA TETSUO; MATSUMOTO Kan; HASHIMOTO Takeshi; IGARASHI Junsuke; KOSAKA Hiroaki; HIRANO Katsuya

  The Journal of Physiological Sciences 67 (supplement 1) S178  2017/03 [Refereed]
  
• Coagulation factor XIa induces Ca2+ influx via L-type Ca2+ channel in vescular smooth muscle cells

  LIU Wenhua; HASHIMOTO Takeshi; YAMASHITA TETSUO; IGARASHI Junsuke; HIRANO Katsuya

  The Journal of Physiological Sciences 67 (supplement 1) S176  2017/03 [Refereed]
  
• Mifepristone, a stroid receptor antagonist, induces hepatic steatosis in association with upregulation of resistin expression in liver

  HASHIMOTO Takeshi; IGARASHI Junsuke; YAMASHITA TETSUO; HIRANO Katsuya

  The Journal of Physiological Sciences 67 (supplement 1) S133  2017/03 [Refereed]
  
• A novel angiogenic agent COA-Cl promotes VEGF secretion from mouse C2C12 steletal myocytes via the activation of cAMP/PKA/CREB/PGC-1a signaling axia

  IGARASHI Junsuke; Ryouji Okamoto; HASHIMOTO Takeshi; YAMASHITA TETSUO; KUBOTA Yasuo; TSUKAMOTO Ikuko; Sakakibara Norikazu; KONISHI Ryoji; HIRANO Katsuya

  The Journal of Physiological Sciences 67 (supple (1)) S44  2017/03 [Refereed]
  
• Increase in tumor suppressor Arf compensates gene dysregulation in in vitro aged adipocytes

  Arif U. Hasan; Koji Ohmori; Takeshi Hashimoto; Kazuyo Kamitori; Fuminori Yamaguchi; Kumi Konishi; Takahisa Noma; Junsuke Igarashi; Tetsuo Yamashita; Katsuya Hirano; Masaaki Tokuda; Tetsuo Minamino; Akira Nishiyama; Masakazu Kohno

  BIOGERONTOLOGY SPRINGER 18 (1) 55 - 68 1389-5729 2017/02 [Refereed]
  
• G Protein-Coupled Receptor 87 (GPR87) Promotes Cell Proliferation in Human Bladder Cancer Cells

  Zhang X; Liu D; Hayashida Yushi; Okazoe H; Hashimoto T; Ueda N; Sugimoto M; Kakehi Y(Zhang Xia; Liu Dage; Hayashida Yushi; Okazoe H; HASHIMOTO Takeshi; Ueda N; Sugimoto M; Kakehi Y

  Int J Mol Sci. 14 (10) 24319-31  2015/10 [Refereed]
  
• Eicosapentaenoic acid upregulates VEGF-A through both GPR120 and PPAR gamma mediated pathways in 3T3-L1 adipocytes

  Arif U. Hasan; Koji Ohmori; Kumi Konishi; Junsuke Igarashi; Takeshi Hashimoto; Kazuyo Kamitori; Fuminori Yamaguchi; Ikuko Tsukamoto; Toru Uyama; Yasuhiro Ishihara; Takahisa Noma; Masaaki Tokuda; Masakazu Kohno

  MOLECULAR AND CELLULAR ENDOCRINOLOGY ELSEVIER IRELAND LTD 406 (C) 10 - 18 0303-7207 2015/05 [Refereed]
  
• A novel angiogenic agent COA-Cl induced PGC-1alpha-mediated VEGF production in cultured human fibroblasts

  OKAMOTO RYUJI; IGARASHI Junsuke; YAMASHITA TETSUO; HASHIMOTO Takeshi; SHOJI KAZUYO; KUBOTA Yasuo; TAKATA MAKI; TSUKAMOTO Ikuko; HIRANO Katsuya

  The Journal of Physiological Sciences 65 (Supplement 1) S168  2015/03 [Refereed]
  
• COA-Cl-induced adipogenesis is associated with an increased cell cycle progression and down-regulation of p27Kip1 in mouse pre-adipocyte 3T3L1 cells

  HASHIMOTO Takeshi; IGARASHI Junsuke; TSUKAMOTO Ikuko; YAMASHITA TETSUO; HIRANO Katsuya

  The Journal of Physiological Sciences 65 (Supplement 1) S229  2015/03 [Refereed]
  
• Involvement of S1P1 receptor pathway in angiogenic effects of a novel adenosine-like nucleic acid analog COA-Cl in cultured human vascular endothelial cells

  Junsuke Igarashi; Takeshi Hashimoto; Yasuo Kubota; Kazuyo Shoji; Tokumi Maruyama; Norikazu Sakakibara; Yoh Takuwa; Yoshihiro Ujihara; Yuki Katanosaka; Satoshi Mohri; Keiji Naruse; Tetsuo Yamashita; Ryuji Okamoto; Katsuya Hirano; Hiroaki Kosaka; Maki Takata; Ryoji Konishi; Ikuko Tsukamoto

  Pharmacology Research and Perspectives Wiley-Blackwell Publishing Ltd 2 (5) e00068  2052-1707 2014/10 [Refereed]
  
• Analysis of the binding mode of AIF to the membrane

  山下哲生; HASHIMOTO Takeshi; IGARASHI Junsuke; KOSAKA Hiroaki

  The Journal of Physiological Sciences 64 (supplement 1) S273  2014/03 [Refereed]
  
• Mifepristone induces non-obese non-alcoholic fatty liver disease.

  Hashimoto T; Igarashi J; 山下哲生; 小坂博昭

  Journal of Pharmacological Sciences 124 (Supple (1)) 131P  2014/03 [Refereed]
  
• Mifepristone Promotes Adiponectin Production and Improves Insulin Sensitivity in a Mouse Model of Diet-Induced-Obesity

  Takeshi Hashimoto; Junsuke Igarashi; Arif U. Hasan; Koji Ohmori; Masakazu Kohno; Yukiko Nagai; Tetsuo Yamashita; Hiroaki Kosaka

  PLOS ONE PUBLIC LIBRARY SCIENCE 8 (11) :e79724  1932-6203 2013/11 [Refereed]
  
• Dexamethasone induces caveolin-1 in vascular endothelial cells: Implications for attenuated responses to VEGF

  Junsuke Igarashi; Takeshi Hashimoto; Kazuyo Shoji; Kozo Yoneda; Ikuko Tsukamoto; Tetsuya Moriue; Yasuo Kubota; Hiroaki Kosaka

  American Journal of Physiology - Cell Physiology 304 (8) C790 - C800 0363-6143 2013/04 [Refereed]
  
• Thr239 suppresses ROS production in yeast mitochondrial NADH dehydrogenase (NDH-2)

  山下哲生; HASHIMOTO Takeshi; IGARASHI Junsuke; KOSAKA Hiroaki

  The Journal of Physiological Sciences 63 (supplement 1) S172  2013/03 [Refereed]
  
• Mifepristone increases anti-inflammatory M2 macrophages in obese adipose tissues

  Hashimoto T; Igarashi J; Yamashita T; Kosaka H

  The Journal of Physiological Sciences 63 S215  2013/03 [Refereed]
  
• Valsartan ameliorates constitutive adipokine expression pattern in mature adipocytes

  Arif U; Hasan; Koji Ohmori; Takeshi Hashimoto; Kazuyo Kamitori; Fuminori Yamaguchi; Yasuhiro Ishihara; Naoko Ishihara; Takahisa Noma; 徳田雅明; Masakazu Kohno

  Hypertension Research 1-37  2013 [Refereed]
  
• Mifepristoneは脂肪組織中のM2マクロファージを増加させる

  橋本剛; 五十嵐淳介; Arif U Hasan; 大森浩二; 山下哲生; 河野雅和; 小坂博昭

  Journal of Japan Society for the Study of Obesity 18(suppl) 160  1343-229X 2012/09
• Mechanism of ROS suppression in yeast single subunit NADH-ubiquinone oxidoreductase (Ndi1)

  YAMASHITA TETSUO; HASHIMOTO Takeshi; IGARASHI Junsuke; KOSAKA Hiroaki

  The Journal of Physiological Sciences 62 (supplement 1) S188  2012/03 [Refereed]
  
• RU486(Mifepristone) improved Diet-induced insulin resistance by increasing blood level of adiponectin

  Hashimoto T; Igarashi J; Arif U Hasan; 永井由紀子; 山下哲生; 小坂博昭

  Journal of Pharmacological Sciences 118 (Supple (1)) 108P  2012/03 [Refereed]
  
• RU486 (Mifepristone) enhances adiponectin secretion from matured adipocytes

  Hashimoto T; Igarashi J; Arif U Hasan; 永井由紀子; Yamashita T; Kosaka H

  The Journal of Physiological Sciences 62(Suppl) S200  2012/03 [Refereed]
  
• RU486(Mifepristone)によるインスリン抵抗性の改善

  橋本剛; 五十嵐淳介; Arif U Hasan; 永井由紀子; 山下哲生; 小坂博昭

  Journal of Japan Society for the Study of Obesity 17(suppl) 195  1343-229X 2011/09 [Refereed]
  
• Pioglitazone promotes preadipocyte proliferation by downregulating p 16(ink4a)

  Hasan AU; 大森浩二; Hashimoto T; Kamitori K; Hirata Y; Ishihara Y; Okamoto N; Noma T; Kosaka H; Tokuda M; Kohno M

  Biochem Biophys Res Commun. 411 (2) 375-380  2011/07 [Refereed]
  
• New insight into mechanism of ROS suppression in single subunit NADH-ibiquinone oxidoreductase (Ndi1) from Saccharomyces cerevisiae

  YAMASHITA TETSUO; Yu Yang; Eiko Nakamaru-Ogiso; HASHIMOTO Takeshi; Masatoshi Murai; IGARASHI Junsuke; Hideto Miyoshi; Akemi Matsuno-Yagi; Takao Yagi; KOSAKA Hiroaki

  The Journal of Physiological Sciences 61 (supplement 1) S250  2011/03 [Refereed]
  
• Enhancement of adipogenesis induced by RU486(Mifepristone) is associated with perturbed expression patterns of cell-cycle proteins, p27kip, and Cyclin B1/D1/E.

  Hashimoto T; Igarashi J; 永井由紀子; 山下哲生; 小坂博昭

  Journal of Pharmacological Sciences 115 (Supple (1)) 68P  2011 [Refereed]
  
• RU486 (Mifepristone) enhances adipogenesis pathways to cyclin-dependent kinase inhibitor, p27kip.

  Hashimoto T; Igarashi J; Nagai Y; Yamashita T; Kosaka H

  The Journal of Physiological Sciences 61 S223  2011 [Refereed]
  
• RU486(Mifepristone), Progesterone/Glucocorticoid receptor antagonist, enhances adipogenesis

  Hashimoto T; Igarashi J; 永井由紀子; 山下哲生; 小坂博昭

  Journal of Pharmacological Sciences 112 (Supple (1)) 65P  2010 [Refereed]
  
• Transforming growth factor-beta 1 downregulates caveolin-1 expression and enhances sphingosine 1-phosphate signaling in cultured vascular endothelial cells

  Junsuke Igarashi; Kazuyo Shoji; Takeshi Hashimoto; Tetsuya Moriue; Kozo Yoneda; Tomoko Takamura; Tetsuo Yamashita; Yasuo Kubota; Hiroaki Kosaka

  AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY AMER PHYSIOLOGICAL SOC 297 (5) C1263 - C1274 0363-6143 2009/11 [Refereed]
  
• Sphingosine kinase is induced in mouse 3T3-L1 cells and promotes adipogenesis

  Takeshi Hashimoto; Junsuke Igarashi; Hiroaki Kosaka

  JOURNAL OF LIPID RESEARCH AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC 50 (4) 602 - 610 0022-2275 2009/04 [Refereed]
  
• Sphingosine Kinase-1, an S1P-producing enzyme, promotes adipogenesis

  Hashimoto T; Igarashi J; Kosaka H

  Journal of Pharmacological Sciences 106 (Supple (1)) 54P  2008 [Refereed]
  
• Hydrogen peroxide induces S1P(1) receptors and sensitizes vascular endothelial cells to sphingosine 1-phosphate, a platelet-derived lipid mediator

  Junsuke Igarashi; Megumi Miyoshi; Takeshi Hashimoto; Yasuo Kubota; Hiroaki Kosaka

  AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY AMER PHYSIOLOGICAL SOC 292 (2) C740 - C748 0363-6143 2007/02 [Refereed]
  
• Statins induce S1P(1) receptors and enhance endothelial nitric oxide production in response to high-density lipoproteins

  J. Igarashi; M. Miyoshi; T. Hashimoto; Y. Kubota; H. Kosaka

  BRITISH JOURNAL OF PHARMACOLOGY NATURE PUBLISHING GROUP 150 (4) 470 - 479 0007-1188 2007/02 [Refereed]
  
• Sphingosine Kinase-1, an S1P-producing enzyme, promotes adipogenesis

  Hashimoto T; Igarashi J; Kosaka H

  The Journal of Physiological Sciences 57 S74  2007 [Refereed]
  
• N-substituted piperidinyl alkyl imidazoles: Discovery of methimepip as a potent and selective histamine H-3 receptor agonist

  R Kitbunnadaj; T Hashimoto; E Poli; OP Zuiderveld; A Menozzi; R Hidaka; IJP de Esch; RA Bakker; WMPB Menge; A Yamatodani; G Coruzzi; H Timmerman; R Leurs

  JOURNAL OF MEDICINAL CHEMISTRY AMER CHEMICAL SOC 48 (6) 2100 - 2107 0022-2623 2005/03 [Refereed]
  
• Formation of two 4-imidazolylmethylphosphonium salts and their synthetic studies toward histamine H-3-ligands

  S Harusawa; M Kawamura; S Koyabu; T Hosokawa; L Araki; Y Sakamoto; T Hashimoto; Y Yamamoto; A Yamatodani; T Kurihara

  SYNTHESIS-STUTTGART GEORG THIEME VERLAG KG (18) 2844 - 2850 0039-7881 2003/12 [Refereed]
  
• A selective human H-4-receptor agonist: (-)-2-cyano-1-methyl-3-{(2R,5R)-5-[1H-imidazol-4(5)-yl]tetrahydrofuran-2-yl}methylguanidine

  T Hashimoto; S Harusawa; L Araki; OP Zuiderveld; MJ Smit; T Imazu; S Takashima; Y Yamamoto; Y Sakamoto; T Kurihara; R Leurs; RA Bakker; A Yamatodani

  JOURNAL OF MEDICINAL CHEMISTRY AMER CHEMICAL SOC 46 (14) 3162 - 3165 0022-2623 2003/07 [Refereed]
  
• Efficient Synthesis of trans- or cis-4(5)-(5-Aminomethyltetrahydrofuran-2- yl)imidazoles via Diazafulvene Intermediates: Synthetic Approach toward Human Histamine H(4)-Ligands.

  Harusawa Shinya; Araki Lisa; Terashima H; Kawamura Makoto; Takashima Seiichiro; Sakamoto Yasuyuki; Hashimoto Takeshi; Yamamoto Yumiko; Yamatodani Atsushi; Kurihara Takushi

  Chem Pharm Bull (Tokyo) 51 (7) 832 - 837 0009-2363 2003 [Refereed]
  
• Possible involvement of the chorda tympani nerve in stimulation of the histaminergic system by leptin

  Morimoto-Ishizuka T; Yada T; Yamamoto Yumiko; Yamamoto Kouichi; Hashimoto Takeshi; Yamatodani Atsushi

  Inflammation Research 51 (Supple (1)) S35-36  2002 [Refereed]
  
• Constitutive activity of histamine H-3 receptors stably expressed in SK-N-MC cells: Display of agonism and inverse agonism by H-3 antagonists

  K Wieland; G Bongers; Y Yamamoto; T Hashimoto; A Yamatodani; WMBP Menge; H Timmerman; TW Lovenberg; R Leurs

  JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS AMER SOC PHARMACOLOGY EXPERIMENTAL THERAPEUTICS 299 (3) 908 - 914 0022-3565 2001/12 [Refereed]
  
• A possible involvement of the chorda tympani in the enhancement of the hypothalamic histamine release by leptin

  T Morimoto-Ishizuka; Y Yamamoto; K Yamamoto; T Hashimoto; A Yamatodani

  HISTAMINE RESEARCH IN THE NEW MILLENNIUM ELSEVIER SCIENCE BV 1224 221 - 225 0531-5131 2001
• Structure-activity relationship of histamine H-3-ligands: Organic synthesis of imidazole C-nucleoside derivatives

  S Harusawa; T Imazu; S Takashima; L Araki; H Ohishi; T Kurihara; Y Sakamoto; Y Yamamoto; T Hashimoto; A Yamatodani

  HISTAMINE RESEARCH IN THE NEW MILLENNIUM ELSEVIER SCIENCE BV 1224 83 - 88 0531-5131 2001

Books etc

• 最新医学大辞典第３版

  医歯薬出版株式会社 2005
• MEDICAL DICTIONARY

  医歯薬出版株式会社 2005
• ○×問題でマスター薬理学

  医歯薬出版株式会社 2004
• ○×問題でマスター薬理学

  医歯薬出版株式会社 2004

Conference Activities & Talks

• Mifepristoneは非肥満非アルコール性脂肪肝を発症する  [Not invited]

  第８７回日本薬理学会  2014
• アディポネクチン分泌促進能を有するMifepristoneの脂肪細胞分化への関与  [Not invited]

  第９１回日本生理学会  2014
• Mifepristoneは脂肪組織中の抗炎症性M2マクロファージを増加させる  [Not invited]

  第９０回日本生理学会  2013
• RU486 (Mifepristone)は脂肪細胞からのアディポネクチン分泌を促進させる  [Not invited]

  第８９回日本生理学会  2012
• RU486:Mifepristoneは血中アディポネクチンを増加させインスリン抵抗性を改善させる  [Not invited]

  第８５回日本薬理学会  2012
• RU486:Mifepristoneはp27(Kip1)の発現レベルを調節することで脂肪細胞への分化能に影響する  [Not invited]

  第８４回日本薬理学会  2011
• RU486 (Mifepristone)はサイクリン依存性キナーゼ阻害因子p27kipの発現抑制することで脂肪生成能を増強する  [Not invited]

  第８８回日本生理学会  2011
• RU486(Mifepristone)によるインスリン抵抗性の改善  [Not invited]

  第３２回日本肥満学会  2011
• Pioglitazone links PPARg dependent adipogenesis pathways to tumor suppressor p53 pathways through p16  [Not invited]

  The 3rd Joint Symposium between CMU and KU  2010
• PPAR-gamma enhances adipogenesis by down-regulating a cell cycle inhibitor, p16INK4a, in adipocytes  [Not invited]

  European Society of Cardiology Congress 2010  2010

Research Grants & Projects

• トロンビン受容体を標的とした新たなインスリン抵抗性改善策の開発

  日本学術振興会：基盤研究(C)

  Date (from‐to) : 2019/04 -2021/03 

  Author : 橋本 剛
• 新たな非肥満非アルコール性脂肪肝モデル動物の開発と脂肪肝改善法確立

  日本学術振興会：基盤研究(C)

  Date (from‐to) : 2017/04 -2019/03 

  Author : 橋本 剛
• サイトカインTGF1による血管成熟化機構－ＶＥＧＦＲ２とのクロストーク－

  日本学術振興会：基盤研究(C)

  Date (from‐to) : 2013/04 -2015/03 

  Author : 五十嵐淳介
• 脂肪組織におけるグルココルチコイドとスフィンゴ脂質分子群とのクロストークの解明

  日本学術振興会：若手研究(B)

  Date (from‐to) : 2013/04 -2015/03 

  Author : 橋本 剛
• 虚血心筋における脂質メディエータースフィンゴシン１リン酸（S1P）の機能解析

  日本学術振興会：基盤研究(C)

  Date (from‐to) : 2009/04 -2011/03 

  Author : 五十嵐淳介
• 脂肪細胞のライフサイクルにおけるスフィンゴシン1-リン酸(S1P)とS1P受容体の生理的メカニズムの解明

  日本学術振興会：若手研究(B)

  Date (from‐to) : 2007/04 -2009/03 

  Author : 橋本剛
• Elucidation of physiological roles of sphingosine 1-phosphate and its receptors in adipose tissue

  Date (from‐to) : 2004 -2006

Other link

researchmap

https://researchmap.jp/read0203119