Kudomi Nobuyuki

Researcher Information

Degree

• 博士理学（Osaka University）

J-Global ID

• 200901028486331224

Research Interests

• Modelling   Nuclear Medicine   PET   Medical Imaging   MRI   

Research Areas

• Life sciences / Radiology
• Other / Other / Laboratory medicine

Academic & Professional Experience

• 2006 - 2009  トゥルクペットセンター, 研究員
• 2001 - 2006  国立循環器病センター, 研究員
• 1999 - 2001  Osaka UniversityResearch Center for Nuclear Physics
• 1996 - 1999  Osaka UniversityResearch Center for Nuclear Physics

Education

•        - 1996  Osaka University  理学研究科
•        - 1991  Osaka University  物理学科

Association Memberships

• 日本医学物理学会   日本脳循環代謝学会   日本核物理談話会   日本核医学会   

Published Papers

• Appearance time of blood in the brain as a possible indicator of oxygen extraction fraction: a feasibility study

  Mitsumasa Murao; Nobuyuki Kudomi; Katsuya Mitamura; Takashi Norikane; Yuri Manabe; Yukito Maeda; Yuka Yamamoto; Tetsuhiro Hatakeyama; Yoshihiro Nishiyama

  EJNMMI Research Springer Science and Business Media LLC 14 (1) 97 - 97 2191-219X 2024/10 [Refereed]
  
• Small animal PET with spontaneous inhalation of 15O-labelled oxygen gases: Longitudinal assessment of cerebral oxygen metabolism in a rat model of neonatal hypoxic-ischaemic encephalopathy.

  Saeka Shimochi; Jukka Ihalainen; Vilhelmiina Parikka; Nobuyuki Kudomi; Tuula Tolvanen; Ari Hietanen; Esa Kokkomäki; Stefan Johansson; Masahiro Tsuji; Shigehiko Kanaya; Emrah Yatkin; Tove J Grönroos; Hidehiro Iida

  Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 271678X231220691  2023/12
• Quantitative [99mTc]Tc-MDP SPECT/CT correlated with [18F]NaF PET/CT for bone metastases in patients with prostate cancer.

  Kenichi Tanaka; Takashi Norikane; Katsuya Mitamura; Yuka Yamamoto; Yukito Maeda; Kengo Fujimoto; Yasukage Takami; Mariko Ishimura; Hanae Arai-Okuda; Yoichiro Tohi; Nobuyuki Kudomi; Mikio Sugimoto; Yoshihiro Nishiyama

  EJNMMI physics 9 (1) 83 - 83 2022/12
• 標識酸素ガスのみ投与画像における機械学習を用いた定量画像作成の検証

  森本 真壽; 久冨 信之; 前田 幸人; 松本 圭祐; 藤田 昇吾; 川崎 宏起; 大石 晃央; 山本 由佳; 岩崎 孝信; 西山 佳宏

  核医学技術 (NPO)日本核医学技術学会 42 (予稿集) 343 - 343 0289-100X 2022/08
• Fractal analysis of 11C-methionine PET in patients with newly diagnosed glioma

  Yukito Maeda; Yuka Yamamoto; Takashi Norikane; Katsuya Mitamura; Tetsuhiro Hatakeyama; Keisuke Miyake; Yoshihiro Nishiyama; Nobuyuki Kudomi

  EJNMMI Physics Springer Science and Business Media LLC 8 (1) 76 - 76 2021/12 [Refereed]
  
• Effect of quantitative values on shortened acquisition duration in brain tumor 11C-methionine PET/CT

  Masatoshi Morimoto; Nobuyuki Kudomi; Yukito Maeda; Takuya Kobata; Akihiro Oishi; Keisuke Matsumoto; Toshihide Monden; Takanobu Iwasaki; Katsuya Mitamura; Takashi Norikane; Yuka Yamamoto; Yoshihiro Nishiyama

  EJNMMI Physics Springer Science and Business Media LLC 8 (1) 34 - 34 2021/12 [Refereed]
  
• 安全かつ有効なGa-68/O-15ガスPET検査のための合理的な放射線管理基準の策定

  志賀 哲; 久下 裕司; 上原 知也; 久冨 信之; 志水 陽一; 下瀬川 恵久; 渡部 浩司

  核医学 (一社)日本核医学会 58 (Suppl.) S188 - S188 0022-7854 2021/10
• Medical 15O production via the 16O(γ,n)15O reaction for blood flow examination

  M. Fujiwara; M. Kurosawa; M. Tamura; N. Kudomi; M. Nishimura

  Journal of Radioanalytical and Nuclear Chemistry Springer Science and Business Media LLC 330 141 - 148 0236-5731 2021/08 [Refereed]
  
• Texture Indices of 18F-FDG PET/CT for Differentiating Squamous Cell Carcinoma and Non-Hodgkin’s Lymphoma of the Oropharynx

  Katsuya Mitamura; Takashi Norikane; Yuka Yamamoto; Ayumi Ihara-Nishishita; Takuya Kobata; Kengo Fujimoto; Yasukage Takami; Nobuyuki Kudomi; Hiroshi Hoshikawa; Yoshihiro Nishiyama

  Acta Med. Okayama 75 (3) 351 - 356 2021/06
• Long-term Multidisciplinary Rehabilitation Efficacy in Older Patients After Traumatic Brain Injury: Assessed by the Functional Independence Measure

  Akio Harada; Nobuyuki Kawai; Tomoya Ogawa; Tetsuhiro Hatakeyama; Takashi Tamiya

  Acta Medica Okayama Okayama University 75 (4) 479 - 486 0386-300X 2021
• Hypoxia and glucose metabolism assessed by FMISO and FDG PET for predicting IDH1 mutation and 1p/19q codeletion status in newly diagnosed malignant gliomas

  Kenta Suzuki; Nobuyuki Kawai; Tomoya Ogawa; Keisuke Miyake; Aya Shinomiya; Yuka Yamamoto; Yoshihiro Nishiyama; Takashi Tamiya

  EJNMMI Research Springer Science and Business Media Deutschland GmbH 11 (1) 2191-219X 2021
• 機械学習を使ったO-gas PET検査による脳血流、酸素摂取率、酸素代謝量画像ノイズ低減の試み

  久冨 信之; 前田 幸人; 畠山 哲宗; 山本 由佳; 西山 佳宏

  核医学 (一社)日本核医学会 58 (1) 108 - 108 0022-7854 2021
• Multiple positron emission tomography tracers for use in the classification of gliomas according to the 2016 World Health Organization criteria

  Keisuke Miyake; Kenta Suzuki; Tomoya Ogawa; Daisuke Ogawa; Tetsuhiro Hatakeyama; Aya Shinomiya; Nobuyuki Kudomi; Yuka Yamamoto; Yoshihiro Nishiyama; Takashi Tamiya

  Neuro-Oncology Advances Oxford University Press (OUP) 3 (1) vdaa172  2021/01 [Refereed]
  
• Texture indices of 4′-[methyl-11C]-thiothymidine uptake predict p16 status in patients with newly diagnosed oropharyngeal squamous cell carcinoma: comparison with 18F-FDG uptake

  Ayumi Ihara-Nishishita; Takashi Norikane; Katsuya Mitamura; Yuka Yamamoto; Kengo Fujimoto; Yasukage Takami; Emi Ibuki; Nobuyuki Kudomi; Hiroshi Hoshikawa; Jun Toyohara; Yoshihiro Nishiyama

  European Journal of Hybrid Imaging Springer Science and Business Media LLC 4 (1) 20 - 20 2020/12 [Refereed]
  
• 脳循環代謝予備能の評価における新規SPECT検査法の有用性について

  三田村 克哉; 久冨 信之; 山本 由佳; 奥田 花江; 前田 幸人; 西山 佳宏

  核医学 (一社)日本核医学会 57 (Suppl.) S163 - S163 0022-7854 2020/10
• Diagnostic value of PET/CT with 11C-methionine (MET) and 18F-fluorothymidine (FLT) in newly diagnosed glioma based on the 2016 WHO classification

  Tomoya Ogawa; Nobuyuki Kawai; Keisuke Miyake; Aya Shinomiya; Yuka Yamamoto; Yoshihiro Nishiyama; Takashi Tamiya

  EJNMMI Research Springer 10 (1) 2191-219X 2020
• Radiosynthesis of 18F-labeled D-allose

  Hiroyuki Yamamotoa,b; Kenji Wadac; Jun Toyoharad; Tetsuro Tagod; Masanobu Ibarakib; Toshibumi Kinoshitab; Yuka Yamamotoe; Yoshihiro Nishiyamae; Nobuyuki Kudomi

  Carbohydrate research 486 107827 - 107827 2019/12 [Refereed]
  
• 機械学習によるFDG-PETグルコース代謝率定量画像生成の検討

  久冨 信之; 前田 幸人; 山本 由佳; 畠山 哲宗; 西山 佳宏

  脳循環代謝 (一社)日本脳循環代謝学会 31 (1) 142 - 142 0915-9401 2019/11
• Myocardial Blood Flow and Metabolic Rate of Oxygen Measurement in the Right and Left Ventricles at Rest and During Exercise Using 15O-Labeled Compounds and PET

  Nobuyuki Kudomi; Kari K. Kalliokoski; Vesa J. Oikonen; Chunlei Han; Jukka Kemppainen; Hannu T. Sipilä; Juhani Knuuti; Ilkka H; A. Heinonen

  Front. Physiol. 10 741  2019/06 [Refereed]
  
• 68Ga-DOTA chelate, a novel imaging agent for assessment of myocardial perfusion and infarction detection in a rodent model.

  Autio A; Uotila S; Kiugel M; Kytö V; Liljenbäck H; Kudomi N; Oikonen V; Metsälä O; Helin S; Knuuti J; Saraste A; Roivainen A

  J Nucl Cardiol. Epub 2019 [Refereed]
  
• [Fully parametric imaging with reversible tracer 18F-FLT within a reasonable time].

  KUDOMI Nobuyuki

  Igaku Butsuri 38 (2) 98 - 98 2018/11
• Liver blood dynamics after bariatric surgery: the effects of mixed-meal test and incretin infusions.

  Honka H; Koffert J; Kauhanen S; Kudomi N; Hurme S; Mari A; Li; qvist A; Wierup N; Parkkola R; Groop L; Nuutila P

  Endocr Connect. 7 (7) 888 - 896 2018/07 [Refereed]
  
• Reconstruction of input functions from a dynamic PET image with sequential administration of 15O2 and H215O for noninvasive and ultra-rapid measurement of CBF, OEF, and CMRO2

  Nobuyuki Kudomi; Yukito Maeda; Hiroyuki Yamamoto; Yuka Yamamoto; Tetsuhiro Hatakeyama; Yoshihiro Nishiyama

  Journal of Cerebral Blood Flow and Metabolism SAGE Publications Ltd 38 (5) 780 - 792 1559-7016 2018/05 [Refereed]
  
• Increased liver fatty acid uptake is partly reversed and liver fat content normalized after bariatric surgery

  Heidi Immonen; Jarna C. Hannukainen; Nobuyuki Kudomi; Jussi Pihlajamäki; Virva Saunavaara; Jukka Laine; Paulina Salminen; Terho Lehtimäki; Tam Pham; Patricia Iozzo; Pirjo Nuutila

  Diabetes Care American Diabetes Association Inc. 41 (2) 368 - 371 1935-5548 2018/02 [Refereed]
  
• Postprandial Oxidative Metabolism of Human Brown Fat Indicates Thermogenesis

  Mueez U Din; Teemu Saari; Juho Raiko; Nobu Kudomi; Stefanie F. Maurer; Minna Lahesmaa; Tobias Fromme; Ez-Zoubir Amri; Martin Klingenspor; Olof Solin; Pirjo Nuutila; Kirsi A. Virtanen

  Cell Metabolism Cell Press 28 (2) 207 - 216 1932-7420 2018 [Refereed]
  
• Human Brown Fat Radiodensity Indicates Underlying Tissue Composition and Systemic Metabolic Health

  Mueez U. Din; Juho Raiko; Teemu Saari; Virva Saunavaara; Nobu Kudomi; Olof Solin; Riitta Parkkola; Pirjo Nuutila; Kirsi A. Virtanen

  JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM OXFORD UNIV PRESS INC 102 (7) 2258 - 2267 0021-972X 2017/07 [Refereed]
  
• Fully parametric imaging with reversible tracer 18F-FLT within a reasonable time

  Nobuyuki Kudomi; Yukito Maeda; Tetsuhiro Hatakeyama; Yuka Yamamoto; Yoshihiro Nishiyama

  Radiological Physics and Technology Springer Tokyo 10 (1) 41 - 48 1865-0341 2017/03 [Refereed]
  
• Intratumoral heterogeneity of F-18-FLT uptake predicts proliferation and survival in patients with newly diagnosed gliomas

  Katsuya Mitamura; Yuka Yamamoto; Nobuyuki Kudomi; Yukito Maeda; Takashi Norikane; Keisuke Miyake; Yoshihiro Nishiyama

  ANNALS OF NUCLEAR MEDICINE SPRINGER 31 (1) 46 - 52 0914-7187 2017/01 [Refereed]
  
• Human brown adipose tissue [O-15]O-2 PET imaging in the presence and absence of cold stimulus

  Mueez U. Din; Juho Raiko; Teemu Saari; Nobu Kudomi; Tuula Tolvanen; Vesa Oikonen; Jarmo Teuho; Hannu T. Sipila; Nina Savisto; Riitta Parkkola; Pirjo Nuutila; Kirsi A. Virtanen

  EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING SPRINGER 43 (10) 1878 - 1886 1619-7070 2016/09 [Refereed]
  
• Reconstruction of an input function from a dynamic PET water image using multiple tissue curves

  Nobuyuki Kudomi; Yukito Maeda; Yuka Yamamoto; Yoshihiro Nishiyama

  PHYSICS IN MEDICINE AND BIOLOGY IOP PUBLISHING LTD 61 (15) 5755 - 5767 0031-9155 2016/08 [Refereed]
  
• Correlation of 4'-[methyl-C-11]-thiothymidine uptake with Ki-67 immunohistochemistry and tumor grade in patients with newly diagnosed gliomas in comparison with C-11-methionine uptake

  Kenichi Tanaka; Yuka Yamamoto; Yukito Maeda; Hiroyuki Yamamoto; Nobuyuki Kudomi; Nobuyuki Kawai; Jun Toyohara; Yoshihiro Nishiyama

  ANNALS OF NUCLEAR MEDICINE SPRINGER 30 (2) 89 - 96 0914-7187 2016/02 [Refereed]
  
• Applicability of emission-based attenuation map for rapid CBF, OEF, and CMRO2 measurements using gaseous 15O-labeled compounds

  Yukito Maeda; Nobuyuki Kudomi; Yasuhiro Sasakawa; Toshihide Monden; Koji Kato; Yuka Yamamoto; Nobuyuki Kawai; Yoshihiro Nishiyama

  EJNMMI Physics Springer International Publishing 2 (1) 1 - 12 2197-7364 2015/12 [Refereed]
  
• Image accuracy and quality test in rate constant depending on reconstruction algorithms with and without incorporating PSF and TOF in PET imaging

  Yukito Maeda; Nobuyuki Kudomi; Hiroyuki Yamamoto; Yuka Yamamoto; Yoshihiro Nishiyama

  ANNALS OF NUCLEAR MEDICINE SPRINGER 29 (7) 561 - 569 0914-7187 2015/08 [Refereed]
  
• The Effects of Bariatric Surgery on Pancreatic Lipid Metabolism and Blood Flow

  Henri Honka; Jukka Koffert; Jarna C. Hannukainen; Jetro J. Tuulari; Henry K. Karlsson; Heidi Immonen; Vesa Oikonen; Tuula Tolvanen; Minna Soinio; Paulina Salminen; Nobu Kudomi; Andrea Mari; Patricia Iozzo; Pirjo Nuutila

  JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM ENDOCRINE SOC 100 (5) 2015 - 2023 0021-972X 2015/05 [Refereed]
  
• Adequacy of a compartment model for CMRO2 quantitation using O-15-labeled oxygen and PET: a clearance measurement of O-15-radioactivity following intracarotid bolus injection of O-15-labeled oxyhemoglobin on Macaca fascicularis

  Hidehiro Iida; Satoshi Iguchi; Noboru Teramoto; Kazuhiro Koshino; Tsutomu Zeniya; Akihide Yamamoto; Nobuyuki Kudomi; Tetsuaki Moriguchi; Yuki Hori; Junichiro Enmi; Hidekazu Kawashima; Nadim Joni Shah; Jyoji Nakagawara

  JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM NATURE PUBLISHING GROUP 34 (9) 1434 - 1439 0271-678X 2014/09 [Refereed]
  
• Pancreatic Metabolism, Blood Flow, and beta-Cell Function in Obese Humans

  Henri Honka; Jarna C. Hannukainen; Miikka Tarkia; Henry Karlsson; Virva Saunavaara; Paulina Salminen; Minna Soinio; Kirsi Mikkola; Nobu Kudomi; Vesa Oikonen; Merja Haaparanta-Solin; Anne Roivainen; Riitta Parkkola; Patricia Iozzo; Pirjo Nuutila

  JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM ENDOCRINE SOC 99 (6) E981 - E990 0021-972X 2014/06 [Refereed]
  
• Myocardial blood flow and its transit time, oxygen utilization, and efficiency of highly endurance-trained human heart

  Ilkka Heinonen; Nobuyuki Kudomi; Jukka Kemppainen; Antti Kiviniemi; Tommi Noponen; Matti Luotolahti; Pauliina Luoto; Vesa Oikonen; Hannu T. Sipila; Jaakko Kopra; Ilkka Mononen; Dirk J. Duncker; Juhani Knuuti; Kari K. Kalliokoski

  BASIC RESEARCH IN CARDIOLOGY SPRINGER HEIDELBERG 109 (4) 413  0300-8428 2014/05 [Refereed]
  
• Cerebral Blood Flow and Oxygen Metabolism Measurements Using Positron Emission Tomography on the First Day after Carotid Artery Stenting

  Nobuyuki Kawai; Tetsuhiro Hatakeyama; Masanobu Okauchi; Masahiko Kawanishi; Atsushi Shindo; Nobuyuki Kudomi; Yuka Yamamoto; Yoshihiro Nishiyama; Takashi Tamiya

  J Stroke Cerebrovasc Dis 23 (2) e55-64  2014/02 [Refereed]
  
• Assessment of blood flow with 68Ga-DOTA PET in experimental inflammation: A validation study using 15O-Water

  Anu Autio; Antti Saraste; 久冨信之; Tiina Saanijoki; Jarkko Johansson; Heidi Liljenb?ck; Miikka Tarkia; Vesa Oikonen; Hannu T Sipil?; Anne Roivainen(Anu Autio; Antti Saraste; N. Kudomi; Tiina Saanijoki; Jarkko Johansson; Heidi Liljenb?ck; Miikka Tarkia, Ve

  Am J Nucl Med Mol Imaging 4 (6) 571-579  2014 [Refereed]
  
• Correlation of F-18-fluoromisonidazole PET findings with HIF-1 alpha and p53 expressions in head and neck cancer: comparison with F-18-FDG PET

  Takashi Norikane; Yuka Yamamoto; Yukito Maeda; Nobuyuki Kudomi; Toru Matsunaga; Reiji Haba; Akinori Iwasaki; Hiroshi Hoshikawa; Yoshihiro Nishiyama

  NUCLEAR MEDICINE COMMUNICATIONS LIPPINCOTT WILLIAMS & WILKINS 35 (1) 30 - 35 0143-3636 2014/01 [Refereed]
  
• Hyperthyroidism Increases Brown Fat Metabolism in Humans

  Minna Lahesmaa; Janne Orava; Camilla Schalin-Jantti; Minna Soinio; Jarna C. Hannukainen; Tommi Noponen; Anna Kirjavainen; Hidehiro Iida; Nobuyuki Kudomi; Sven Enerback; Kirsi A. Virtanen; Pirjo Nuutila

  JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM ENDOCRINE SOC 99 (1) E28 - E35 0021-972X 2014/01 [Refereed]
  
• Unexpected Finding of Cerebral Meningioma on C-11-PiB PET

  Yuka Yamamoto; Yukito Maeda; Nobuyuki Kawai; Nobuyuki Kudomi; Yoshihiro Nishiyama

  CLINICAL NUCLEAR MEDICINE LIPPINCOTT WILLIAMS & WILKINS 38 (4) 292 - 293 0363-9762 2013/04 [Refereed]
  
• Tissue Specificity in Fasting Glucose Utilization in Slightly Obese Diabetic Patients Submitted to Bariatric Surgery

  Silvia Morbelli; Cecilia Marini; Gian Franco Adami; Nobuyuki Kudomi; Giovanni Camerini; Patricia Iozzo; Michela Massollo; Selene Capitanio; Samanta Bodrato; Maria Teresa Verardi; Francesco Papadia; Renzo Cordera; Juhani Knuuti; Nicola Scopinaro; Gianmario Sambuceti

  OBESITY WILEY-BLACKWELL 21 (3) E175 - E181 1930-7381 2013/03 [Refereed]
  
• Rapid quantitative CBF and CMRO2 measurements from a single PET scan with sequential administration of dual O-15-labeled tracers

  Nobuyuki Kudomi; Yoshiyuki Hirano; Kazuhiro Koshino; Takuya Hayashi; Hiroshi Watabe; Kazuhito Fukushima; Hiroshi Moriwaki; Noboru Teramoto; Koji Iihara; Hidehiro Iida

  JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM NATURE PUBLISHING GROUP 33 (3) 440 - 448 0271-678X 2013/03 [Refereed]
  
• Imaging of the appearance time of cerebral blood using [O-15]H2O PET for the computation of correct CBF

  Nobuyuki Kudomi; Yukito Maeda; Yasuhiro Sasakawa; Toshihide Monden; Yuka Yamamoto; Nobuyuki Kawai; Hidehiro Iida; Yoshihiro Nishiyama

  EJNMMI RESEARCH SPRINGER HEIDELBERG 3 (1) 41  2191-219X 2013 [Refereed]
  
• Detection of brain amyloid β deposition in patients with neuropsychological impairment after traumatic brain injury: PET evaluation using Pittsburgh Compound-B.

  Nobuyuki Kawai; Masahiko Kawanishi; Nobuyuki Kudomi; Yukito Maeda; Yuka Yamamoto; Yoshihiro Nishiyama; Takashi Tamiya

  Brain injury 27 (9) 1026 - 31 0269-9052 2013 [Refereed]
  
• Quantitative assessment of regional cerebral blood flow by dynamic susceptibility contrast-enhanced MRI, without the need for arterial blood signals

  Jun-ichiro Enmi; Nobuyuki Kudomi; Takuya Hayashi; Akihide Yamamoto; Satoshi Iguchi; Tetsuaki Moriguchi; Yuki Hori; Kazuhiro Koshino; Tsutomu Zeniya; Nadim Jon Shah; Naoaki Yamada; Hidehiro Iida

  PHYSICS IN MEDICINE AND BIOLOGY IOP PUBLISHING LTD 57 (23) 7873 - 7892 0031-9155 2012/12 [Refereed]
  
• The effect of revascularization of renal artery stenosis on renal perfusion in patients with atherosclerotic renovascular disease

  Niina Koivuviita; Kaisa Liukko; Nobu Kudomi; Vesa Oikonen; Risto Tertti; Ilkka Manner; Tero Vahlberg; Pirjo Nuutila; Kaj Metsarinne

  NEPHROLOGY DIALYSIS TRANSPLANTATION OXFORD UNIV PRESS 27 (10) 3843 - 3848 0931-0509 2012/10
• Cerebral Blood Flow and Metabolism Measurement Using Positron Emission Tomography before and during Internal Carotid Artery Test Occlusions: Feasibility of Rapid Quantitative Measurement of CBF and OEF/CMRO2

  N. Kawai; M. Kawanishi; A. Shindou; N. Kudomi; Y. Yamamoto; Y. Nishiyama; T. Tamiya

  INTERVENTIONAL NEURORADIOLOGY EDIZIONI CENTAURO 18 (3) 264 - 274 1591-0199 2012/09 [Refereed]
  
• Cross-validation of Input Functions Obtained by H-2 O-15 PET Imaging of Rat Heart and a Blood Flow-through Detector

  Nobuyuki Kudomi; Hannu Sipila; Anu Autio; Vesa Oikonen; Heidi Liljenback; Miikka Tarkia; Jarno Laivola; Jarkko Johansson; Mika Teras; Anne Roivainen

  MOLECULAR IMAGING AND BIOLOGY SPRINGER 14 (4) 509 - 516 1536-1632 2012/08 [Refereed]
  
• Quantification of regional cerebral blood flow in rats using an arteriovenous shunt and micro-PET

  Takayuki Ose; Hiroshi Watabe; Takuya Hayashi; Nobuyuki Kudomi; Masaaki Hikake; Hajime Fukuda; Noboru Teramoto; Yasuyoshi Watanabe; Hirotaka Onoe; Hidehiro Iida

  NUCLEAR MEDICINE AND BIOLOGY ELSEVIER SCIENCE INC 39 (5) 730 - 741 0969-8051 2012/07 [Refereed]
  
• Integrated PET system for rapid and quantitative assessment of CMRO2/CBF/CBV using an automated system for production of a series of 15O-labeled gaseous tracers

  Hidehiro Iida; Morita Naomi; Miyake Yoshinori; Hori Yuki; Moriguchi Tetsuro; Koshino Kazuhiro; Zeniya Tsutomu; Kawashima Hidekazu; Iguchi Satoshi; Kudomi . Nobuyuki

  JOURNAL OF NUCLEAR MEDICINE SOC NUCLEAR MEDICINE INC 53 0161-5505 2012/05
• Non-invasive estimation of arterial input function in the 15O-labeled gaseous PET study

  Moriguchi Tetsuaki; Iguchi Satoshi; Hori Yuki; Morita Naomi; Koshino Kazuhiro; Zeniya Tsutomu; Kawashima Hidekazu; Enmi Jun-ichiro; Kudomi Nobuyuki; Iida Hidehiro

  JOURNAL OF NUCLEAR MEDICINE SOC NUCLEAR MEDICINE INC 53 0161-5505 2012/05 [Refereed]
  
• Extraction of Input Function from Rat [F-18]FDG PET Images

  Nobuyuki Kudomi; Marco Bucci; Vesa Oikonen; Mika Silvennoinen; Heikki Kainulainen; Pirjo Nuutila; Patricia Iozzo; Anne Roivainen

  MOLECULAR IMAGING AND BIOLOGY SPRINGER 13 (6) 1241 - 1249 1536-1632 2011/12 [Refereed]
  
• Comparison of C-11-Methionine PET and F-18-FDG PET in Patients with Primary Central Nervous System Lymphoma

  Yoshiro Kawase; Yuka Yamamoto; Reiko Kameyama; Nobuyuki Kawai; Nobuyuki Kudomi; Yoshihiro Nishiyama

  MOLECULAR IMAGING AND BIOLOGY SPRINGER 13 (6) 1284 - 1289 1536-1632 2011/12 [Refereed]
  
• Shortening the Duration of [F-18]FDG PET Brain Examination for Diagnosis of Brain Glioma

  Toshihide Monden; Nobuyuki Kudomi; Yasuhiro Sasakawa; Yuka Yamamoto; Nobuyuki Kawai; Yoshihiro Nishiyama

  MOLECULAR IMAGING AND BIOLOGY SPRINGER 13 (4) 754 - 758 1536-1632 2011/08 [Refereed]
  
• The anti-inflammatory effects of d-allose contribute to attenuation of cerebral ischemia-reperfusion injury

  Dakuan Gao; Nobuyuki Kawai; Takashi Tamiya

  Medical Hypotheses 76 (6) 911 - 913 0306-9877 2011/06
• Omission of [O-15]CO scan for PET CMRO2 examination using O-15-labelled compounds

  Yasuhiro Sasakawa; Nobuyuki Kudomi; Yuka Yamamoto; Toshihide Monden; Nobuyuki Kawai; Yoshihiro Nishiyama

  ANNALS OF NUCLEAR MEDICINE SPRINGER 25 (3) 189 - 196 0914-7187 2011/04 [Refereed]
  
• Correlation of biological aggressiveness assessed by C-11-methionine PET and hypoxic burden assessed by F-18-fluoromisonidazole PET in newly diagnosed glioblastoma

  Nobuyuki Kawai; Yukito Maeda; Nobuyuki Kudomi; Keisuke Miyake; Masaki Okada; Yuka Yamamoto; Yoshihiro Nishiyama; Takashi Tamiya

  EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING SPRINGER 38 (3) 441 - 450 1619-7070 2011/03 [Refereed]
  
• Focal Neuronal Damage in Patients with Neuropsychological Impairment after Diffuse Traumatic Brain Injury: Evaluation Using C-11-Flumazenil Positron Emission Tomography with Statistical Image Analysis

  Nobuyuki Kawai; Yukito Maeda; Nobuyuki Kudomi; Yuka Yamamoto; Yoshihiro Nishiyama; Takashi Tamiya

  JOURNAL OF NEUROTRAUMA MARY ANN LIEBERT INC 27 (12) 2131 - 2138 0897-7151 2010/12 [Refereed]
  
• Optimization of transmission scan duration for O-15 PET study with sequential dual tracer administration using N-index

  Nobuyuki Kudomi; Hiroshi Watabe; Takuya Hayashi; Hisashi Oka; Yoshinori Miyake; Hidehiro Iida

  ANNALS OF NUCLEAR MEDICINE SPRINGER 24 (5) 413 - 420 0914-7187 2010/06 [Refereed]
  
• Quantification of regional myocardial oxygen metabolism in normal pigs using positron emission tomography with injectable O-15-O-2

  Takashi Temma; Hidehiro Iida; Takuya Hayashi; Noboru Teramoto; Youichiro Ohta; Nobuyuki Kudomi; Hiroshi Watabe; Hideo Saji; Yasuhiro Magata

  EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING SPRINGER 37 (2) 377 - 385 1619-7070 2010/02 [Refereed]
  
• A Multi-wire Proportional Counter for Measurement of Positron-emitting Radionuclides during On-line Blood Sampling

  Hannu T. Sipila; Anne Roivainen; Nobuyuki Kudomi; Sven-Johan Heselius

  2010 IEEE NUCLEAR SCIENCE SYMPOSIUM CONFERENCE RECORD (NSS/MIC) IEEE 2213 - 2215 1082-3654 2010 [Refereed]
  
• Non-invasive estimation of hepatic glucose uptake from [F-18]FDG PET images using tissue-derived input functions

  N. Kudomi; M. J. Jarvisalo; J. Kiss; R. Borra; A. Viljanen; T. Viljanen; T. Savunen; J. Knuuti; H. Iida; P. Nuutila; P. Iozzo

  EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING SPRINGER 36 (12) 2014 - 2026 1619-7070 2009/12 [Refereed]
  
• Non-invasive diagnosis of acute mesenteric ischaemia using PET

  Jan Kiss; Alexandru Naum; Nobuyuki Kudomi; Juhani Knuuti; Patricia Iozzo; Timo Savunen; Pirjo Nuutila

  EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING SPRINGER 36 (8) 1338 - 1345 1619-7070 2009/08 [Refereed]
  
• Parametric renal blood flow imaging using [(15)O]H(2)O and PET

  Nobuyuki Kudomi; Niina Koivuviita; Kaisa E. Liukko; Vesa J. Oikonen; Tuula Tolvanen; Hidehiro Iida; Risto Tertti; Kaj Metsarinne; Patricia Iozzo; Pirjo Nuutila

  EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING SPRINGER 36 (4) 683 - 691 1619-7070 2009/04 [Refereed]
  
• A physiologic model for recirculation water correction in CMRO2 assessment with O-15(2) inhalation PET

  Nobuyuki Kudomi; Takuya Hayashi; Hiroshi Watabe; Noboru Teramoto; Rishu Piao; Takayuki Ose; Kazuhiro Koshino; Youichirou Ohta; Hidehiro Iida

  JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM NATURE PUBLISHING GROUP 29 (2) 355 - 364 0271-678X 2009/02 [Refereed]
  
• Non-invasive estimation of hepatic blood perfusion from H(2)(15)O PET images using tissue-derived arterial and portal input functions

  N. Kudomi; L. Slimani; M. J. Jarvisalo; J. Kiss; R. Lautamaki; G. A. Naum; T. Savunen; J. Knuuti; H. Iida; P. Nuutila; P. Iozzo

  EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING SPRINGER 35 (10) 1899 - 1911 1619-7070 2008/10 [Refereed]
  
• Optimal scan time of oxygen-15-labeled gas inhalation autoradiographic method for measurement of cerebral oxygen extraction fraction and cerebral oxygen metabolic rate

  Miho Shidahara; Hiroshi Watabe; Kyeong Min Kim; Nobuyuki Kudomi; Hiroshi Ito; Hidehiro Iida

  ANNALS OF NUCLEAR MEDICINE SPRINGER 22 (8) 667 - 675 0914-7187 2008/10 [Refereed]
  
• Quantification of liver perfusion with [(15)O]H(2)O-PET and its relationship with glucose metabolism and substrate levels

  Lotfi Slimani; Nobuyuki Kudomi; Vesa Oikonen; M. Jarvisalo; Jan Kiss; Alexandru Naum; Ronald Borra; Antti Viljanen; Hannu Sipila; Ele Ferrannini; Timo Savunen; Pirjo Nuutila; Patricia Iozzo

  JOURNAL OF HEPATOLOGY ELSEVIER SCIENCE BV 48 (6) 974 - 982 0168-8278 2008/06 [Refereed]
  
• Quantification of Parametric Images from Non-invasive Input Function in PET

  KUDOMI Nobuyuki

  Medical Imaging Technology The Japanese Society of Medical Imaging Technology 26 (1) 21 - 25 0288-450X 2008 [Refereed]
  
• Acute embolic stroke model in cynomolgus monkeys using autologous blood clot

  Rishu Piao; Takuya Hayashi; Noboru Teramoto; Nobuyuki Kudomi; Youichirou Ohta; Hiroshi Sato; Hiroshi Watabe; Hidehiro Iida

  Journal of Cerebral Blood Flow and Metabolism 27 (1) BP21 - 02 0271-678X 2007/11
• Effect of brain hypothermia on cerebral glucose metabolism in acute brain injury: Evaluation with fluorodeoxyglucose positron emission tomography

  Nobuyuki Kawai; Yoshihiro Nishiyama; Yuka Yamamoto; Takashi Tamiya; Seigo Nagao

  Journal of Cerebral Blood Flow and Metabolism 27 (1) BP11 - 08 0271-678X 2007/11
• Separation of input function for rapid measurement of quantitative CMRO2 and CBF in a single PET scan with a dual tracer administration method

  Nobuyuki Kudomi; Hiroshi Watabe; Takuya Hayashi; Hidehiro Iida

  PHYSICS IN MEDICINE AND BIOLOGY IOP PUBLISHING LTD 52 (7) 1893 - 1908 0031-9155 2007/04 [Refereed]
  
• Neural stem cells transplantation in cortex in a mouse model of Alzheimer's disease

  Qinghua Wang; Yoshihito Matsumoto; Tokuhisa Shindo; Keisuke Miyake; Atsushi Shindo; Masahiko Kawanishi; Nobuyuki Kawai; Takashi Tamiya; Seigo Nagao; Qinghua Wang

  Journal of Medical Investigation 53 (1-2) 61 - 69 1343-1420 2006/02 [Refereed]
  
• Rapid quantitative measurement of CMRO(2) and CBF by dual administration of (15)O-labeled oxygen and water during a single PET scan-a validation study and error analysis in anesthetized monkeys.

  Kudomi N; Hayashi T; Teramoto N; Watabe H; Kawachi N; Ohta Y; Kim KM; Iida H

  Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 9 25 (9) 1209 - 1224 0271-678X 2005/09 [Refereed]
  
• Usefulness of [18F]FDG-PET kinetic analysis in non-enhancing primary central nervous system lymphoma: Case report

  Nobuyuki Kawai; Masahiko Kawanishi; Takashi Tamiya; Seigo Nagao

  Annals of Nuclear Medicine Japanese Society of Nuclear Medicine 19 (5) 415 - 419 0914-7187 2005
• Crossed cerebellar glucose hypermetabolism demonstrated using PET in symptomatic epilepsy - Case report

  Nobuyuki Kawai; Masahiko Kawanishi; Takashi Tamiya; Seigo Nagao

  Annals of Nuclear Medicine Japanese Society of Nuclear Medicine 19 (3) 231 - 234 0914-7187 2005
• Rapid measurement of quantitative CMRO2 and CBF using sequential administration of 15O-labelled oxygen and water

  久冨信之

  J Cereb Blood Flow Metab 25 1209  2005 [Refereed]
  
• Usefulness of FDG-PET in monitoring therapeutic effects on a central nervous system malignant lymphoma: Report of three cases

  Tetsuya Masada; Yoshihito Matsumoto; Nobuyuki Kawai; Takashi Tamiya; Seigo Nagao

  Neurological Surgery 32 (8) 859 - 864 0301-2603 2004/08
• Rapid protocol for quantitative CMRO2 and CBF using PET and O-15 labelled compounds

  Kudomi Nobuyuki; Hayashi Takuya; Teramoto Noboru; Watabe Hiroshi; Kawachi Naoki; Ohta Youichirou; Kim KyonMim; Iida Hidehiro

  International Congress Series 1265 (C) 60 - 68 0531-5131 2004/08 [Refereed]
  
• Improved parametric images of blood flow and vascular volume by: Cluster analysis in H2 15O brain PET study

  Kyeong Min Kim; Hiroshi Watabe; Takuya Hayashi; Nobuyuki Kudomi; Hidehiro Iida

  International Congress Series 1265 (C) 79 - 83 0531-5131 2004/08 [Refereed]
  
• (18)F-FDG accumulation in atherosclerotic plaques: Immunohistochemical and PET imaging study

  M Ogawa; S Ishino; T Mukai; D Asano; N Teramoto; H Watabe; N Kudomi; M Shiomi; Y Magata; H Iida; H Saji

  JOURNAL OF NUCLEAR MEDICINE SOC NUCLEAR MEDICINE INC 45 (7) 1245 - 1250 0161-5505 2004/07 [Refereed]
  
• Neutron reduction of the small cyclotron for production of oxygen-15-labeled gases

  T Inomata; M Fujiwara; H Iida; N Kudomi; Miura, I

  QUANTITATION IN BIOMEDICAL IMAGING WITH PET AND MRI ELSEVIER SCIENCE BV (1265) 97 - 100 0531-5131 2004 [Refereed]
  
• A physiological model for cerebral oxygen delivery and consumption and effective oxygen diffusibility evaluated by PET

  T Hayashi; N Kudomi; N Teramoto; H Watabe; JI Enmi; KM Kim; H Iida

  QUANTITATION IN BIOMEDICAL IMAGING WITH PET AND MRI ELSEVIER SCIENCE BV (1265) 228 - 237 0531-5131 2004 [Refereed]
  
• Electron beam ion trap for study of fusion reactions in nuclear astrophysics

  T Itahashi; N Kudomi; Y Sakemi; T Shima; S Yoshida; T Sakamoto; ED Donets; EE Donets

  Ninth International Symposium on Electron Beam Ion Sources and Traps and Their Applications IOP PUBLISHING LTD 2 75 - 83 1742-6588 2004 [Refereed]
  
• Laboratory condition for fusion reactions in nuclear astrophysics

  T Itahashi; N Kudomi; ED Donets

  PROGRESS OF THEORETICAL PHYSICS SUPPLEMENT PROGRESS THEORETICAL PHYSICS PUBLICATION OFFICE (154) 356 - 364 0375-9687 2004 [Refereed]
  
• Parametric mapping of blood flow and arterial blood volume in dynamic O-15 water brain PET by cluster analysis

  KM Kim; H Watabe; N Kudomi; T Hayashi; K Hayashida; H Iida

  2003 IEEE NUCLEAR SCIENCE SYMPOSIUM, CONFERENCE RECORD, VOLS 1-5 IEEE 3108 - 3109 1082-3654 2004 [Refereed]
  
• Performance improvement of event-based motion correction for PET using a PC cluster

  H Watabe; SK Woo; KM Kim; N Kudomi; H Iida

  2003 IEEE NUCLEAR SCIENCE SYMPOSIUM, CONFERENCE RECORD, VOLS 1-5 IEEE 2407 - 2409 1082-3654 2004 [Refereed]
  
• Future perspectives in in vivo quantitation of bio-physiological parameters

  H Iida; H Watabe; T Hayashi; N Kudomi; KM Kim; T Zeniya; N Teramoto; Y Ohta

  PET AND MOLECULAR IMAGING: STATE OF THE ART AND FUTURE PERSPECTIVES ELSEVIER SCIENCE BV 1264 148 - 157 0531-5131 2004 [Refereed]
  
• Adenosine-induced myocardial flow reactivity in pig as assessed with O-15 water PET

  H Jino; N Kawachi; N Teramoto; Y Ohta; N Kudomi; T Hayashi; H Watabe; IU Yokoyama; H Iida

  PET AND MOLECULAR IMAGING: STATE OF THE ART AND FUTURE PERSPECTIVES ELSEVIER SCIENCE BV 1264 117 - 125 0531-5131 2004 [Refereed]
  
• Imaging of vulnerable atherosclerotic plaque with [(18)F]FDG-PET: an animal atherosclerosis model study

  M Ogawa; T Mukai; S Ishino; N Teramoto; H Watabe; N Kudomi; M Shiomi; Y Magata; H Iida; H Saji

  QUANTITATION IN BIOMEDICAL IMAGING WITH PET AND MRI ELSEVIER SCIENCE BV (1265) 266 - 268 0531-5131 2004 [Refereed]
  
• Precise measurement of the cross section of He-3(He-3,2p)He-4 by using He-3 doubly charged beam

  N Kudomi; M Komori; K Takahisa; S Yoshida; K Kume; H Ohsumi; T Itahashi

  PHYSICAL REVIEW C AMERICAN PHYSICAL SOC 69 (1) 015802-1-13  0556-2813 2004/01 [Refereed]
  
• Search for neutrino-less double beta decay of Ca-48 by CaF2 scintillator

  Ogawa, I; R Hazama; H Miyawaki; S Shiomi; N Suzuki; Y Ishikawa; G Kunitomi; Y Tanaka; M Itamura; K Matsuoka; S Ajimura; T Kishimoto; H Ejiri; N Kudomi; K Kume; H Ohsumi; K Fushimi

  NUCLEAR PHYSICS A ELSEVIER SCIENCE BV 730 (1-2) 215 - 223 0375-9474 2004/01 [Refereed]
  
• Usefulness of Intravascular Ultrasound in Embolization of Dural Arteriovenous Fistula: A Case Report

  Atsushi Shindo; Masahiko Kawanishi; Tetsuya Masada; Nobuyuki Kawai; Takashi Tamiya; Seigo Nagao

  Neurological Surgery 31 (12) 1323 - 1329 0301-2603 2003/12
• A theoretical model of oxygen delivery and metabolism for physiologic interpretation of quantitative cerebral blood flow and metabolic rate of oxygen

  T Hayashi; H Watabe; N Kudomi; KM Kim; JI Enmi; T Hayashida; H Iida

  JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM LIPPINCOTT WILLIAMS & WILKINS 23 (11) 1314 - 1323 0271-678X 2003/11 [Refereed]
  
• Treatment of cold injury-induced brain edema with a nonspecific matrix metalloproteinase inhibitor MMI270 in rats

  Nobuyuki Kawai; Masahiko Kawanishi; Mikiko Okada; Yoshihito Matsumoto; Seigo Nagao

  Journal of Neurotrauma Mary Ann Liebert Inc. 20 (7) 649 - 657 0897-7151 2003/07
• Cross section of He-3(He-3,2p)He-4 measured near the Gamow peak

  T Itahashi; N Kudomi; S Yoshida; K Kume; M Komori; H Ohsumi

  NUCLEAR PHYSICS A ELSEVIER SCIENCE BV 721 1015C - 1018C 0375-9474 2003/06 [Refereed]
  
• Nuclear astrophysics researches in ion trap apparatus

  T Itahashi; N Kudomi; ED Donets; EE Donets

  NUCLEAR PHYSICS A ELSEVIER SCIENCE BV 718 490C - 492C 0375-9474 2003/05 [Refereed]
  
• Cross section of He-3(He-3,2p)He-4 measured near the Gamow energy

  T Itahashi; M Komori; N Kudomi; K Kume; Y Nagai; M Ohsumi; K Takahisa; H Toki; H Ejiri; H Ueda; S Yoshida

  NUCLEAR PHYSICS A ELSEVIER SCIENCE BV 718 466C - 468C 0375-9474 2003/05 [Refereed]
  
• Dependency of energy and spatial distributions of photons on edge of object in brain SPECT.

  Deloar HM; Watabe H; Kudomi N; Kim KM; Aoi T; Iida H

  Annals of nuclear medicine 2 17 (2) 99 - 106 0914-7187 2003/04 [Refereed]
  
• Development of a GSO detector assembly for a continuous blood sampling system

  N Kudomi; E Choi; S Yamamoto; H Watabe; KM Kim; M Shidahara; M Ogawa; N Teramoto; E Sakamoto; H Iida

  IEEE TRANSACTIONS ON NUCLEAR SCIENCE IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC 50 (1) 70 - 73 0018-9499 2003/02 [Refereed]
  
• Model-based background compensation for repeat PET study with multiple tracer administration

  Hidehiro Iida; Hiroshi Watabe; Takuya Hayashi; Nobuyuki Kudomi; Keyong-Min Kim

  IFAC Proceedings Volumes (IFAC-PapersOnline) IFAC Secretariat 36 (15) 29 - 34 1474-6670 2003
• Parametric mapping of blood flow and arterial blood volume in dynamic O-15 water brain PET by cluster analysis

  Kyeong Min Kim; Hiroshi Watabe; Nobuyuki Kudomi; Takuya Hayashi; Kohei Hayashida; Hidehiro Iida

  IEEE Nuclear Science Symposium Conference Record 5 3108 - 3109 1095-7863 2003
• Model-based background compensation for repeat PET study with multiple tracer administration

  H Iida; H Watabe; T Hayashi; N Kudomi; KM Kim

  MODELLING AND CONTROL IN BIOMEDICAL SYSTEMS 2003 (INCLUDING BIOLOGICAL SYSTEMS) PERGAMON-ELSEVIER SCIENCE LTD 29 - 34 0962-9505 2003 [Refereed]
  
• Simulation study of noise property of CMRO2 quantitation methods with inhalation of O-15(2)

  N Kudomi; H Watabe; Y Miyake; KM Kim; M Shidahara; K Hayashida; H Oka; M Sagou; Y Ishida; T Hayashi; H Iida

  2002 IEEE NUCLEAR SCIENCE SYMPOSIUM, CONFERENCE RECORD, VOLS 1-3 IEEE 1116 - 1117 1082-3654 2003 [Refereed]
  
• Performance test and application of GSO detector assembly for a continuous blood sampling system

  N Kudomi; E Choi; S Yamamoto; H Watabe; KM Kim; T Hayashi; M Ogawa; N Teramoto; E Sakamoto; H Iida

  2002 IEEE NUCLEAR SCIENCE SYMPOSIUM, CONFERENCE RECORD, VOLS 1-3 IEEE 1648 - 1651 1082-3654 2003 [Refereed]
  
• Model-based noninvasive estimation of arterial input function from dynamic (H2OPET)-O-15 images

  N Kudomi; H Watabe; KM Kim; T Hayashi; K Hayashida; H Iida

  2002 IEEE NUCLEAR SCIENCE SYMPOSIUM, CONFERENCE RECORD, VOLS 1-3 IEEE 1559 - 1561 1082-3654 2003 [Refereed]
  
• Estimation of input function for rapid dual table ARG method

  N Kudomi; H Watabe; KN Kim; K Hayashida; T Hayashi; H Iida

  2002 IEEE NUCLEAR SCIENCE SYMPOSIUM, CONFERENCE RECORD, VOLS 1-3 IEEE 1339 - 1340 1082-3654 2003 [Refereed]
  
• Search for WIMPs by means of the ELEGANT V NaI Detectors

  S.Yoshida; H. Ejiri; K. Fushimi; K. Hayashi; T. Kishimoto; M. Komori; N. Kudomi; K. Kume; H. Kuramoto; K. Matsuoka; H. Ohsumi; K. Takahisa; S. Umehara

  Proc. of Int. Conf. on Neutrinos and Dark Matter in Nuclear Physics 2003/01 [Refereed]
  
• Determination of Th-chain contamination in a high sensitivity detector

  K Fushimi; S Umehara; K Ichihara; N Koori; S Nakayama; T Shimojo; R Tsubakida; N Kudomi; K Kume; H Kuramoto; K Takahisa; T Tsujimoto; S Yoshida

  NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION A-ACCELERATORS SPECTROMETERS DETECTORS AND ASSOCIATED EQUIPMENT ELSEVIER SCIENCE BV 491 (1-2) 163 - 167 0168-9002 2002/09 [Refereed]
  
• Determination of U-chain concentration in NaI(Tl) scintillator by delayed coincidence method

  S Umehara; K Fushimi; N Koori; N Kudomi; K Kume; H Kuramoto; S Nakayama; T Shimojo; K Takahisa; R Tsubakida; Y Tsujimoto; S Yoshida

  NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION A-ACCELERATORS SPECTROMETERS DETECTORS AND ASSOCIATED EQUIPMENT ELSEVIER SCIENCE BV 490 (1-2) 271 - 275 0168-9002 2002/09 [Refereed]
  
• Limits on Majoron emitting neutrinoless double-beta decay of Mo-100

  K Fushimi; N Kudomi; S Yoshida; H Ejiri; K Hayashi; T Kishimoto; K Kume; H Kuramoto; K Matsuoka; H Ohsumi; K Takahisa

  PHYSICS LETTERS B ELSEVIER SCIENCE BV 531 (3-4) 190 - 194 0370-2693 2002/04 [Refereed]
  
• Supernova-neutrino studies with Mo-100

  H Ejiri; J Engel; N Kudomi

  PHYSICS LETTERS B ELSEVIER SCIENCE BV 530 (1-4) 27 - 32 0370-2693 2002/03 [Refereed]
  
• Design of an ion trap apparatus for nuclear astrophysics research

  T Itahashi; N Kudomi; ED Donets; EE Donets

  REVIEW OF SCIENTIFIC INSTRUMENTS AMER INST PHYSICS 73 (2) 667 - 669 0034-6748 2002/02 [Refereed]
  
• MOON (Mo Observatory of Neutrinos) for neutrino studies in Mo-100 by double beta decays and solar-nu capture reactions

  R Hazama; H Ejiri; J Engel; P Krastev; N Kudomi; M Nomachi; RGH Robertson

  NUCLEAR PHYSICS IN THE 21ST CENTURY AMER INST PHYSICS 610 959 - 963 0094-243X 2002 [Refereed]
  
• Cross section of He-3 (He-3,2p)He-4 measured over the range of 45 to 26keV

  T Itahashi; N Kudomi; S Yoshida; M Komori; K Takahisa; H Ejiri; H Toki; Y Nagai; H Ohsumi

  NUCLEAR PHYSICS IN THE 21ST CENTURY AMER INST PHYSICS 610 446 - 450 0094-243X 2002 [Refereed]
  
• Noninvasive estimation of cerebral blood flow using image-derived carotid input function in (H2O)-O-15 dynamic PET

  KM Kim; H Watabe; M Shidahara; JY Ahn; S Choi; N Kudomi; K Hayashida; Y Miyake; H Iida

  2001 IEEE NUCLEAR SCIENCE SYMPOSIUM, CONFERENCE RECORDS, VOLS 1-4 IEEE 1282 - 1285 1082-3654 2002 [Refereed]
  
• Development of a GSO detector assembly for a continuous blood sampling system

  N Kudomi; E Choi; S Yamamoto; H Watabe; KM Kim; M Shidahara; H Iida

  2001 IEEE NUCLEAR SCIENCE SYMPOSIUM, CONFERENCE RECORDS, VOLS 1-4 IEEE 1255 - 1257 1082-3654 2002 [Refereed]
  
• Cross section of He-3(He-3,2p)He-4 measured over the range of 45 to 26keV

  N Kudomi; T Itahashi; S Yoshida; K Takahisa; H Ejiri; H Toki; Y Nagai

  2001 IEEE NUCLEAR SCIENCE SYMPOSIUM, CONFERENCE RECORDS, VOLS 1-4 IEEE 427 - 431 1082-3654 2002 [Refereed]
  
• Versatile beam calorimeter with a heat flux sensor

  N Kudomi; T Itahashi; K Takahisa; S Yoshida; M Komori

  REVIEW OF SCIENTIFIC INSTRUMENTS AMER INST PHYSICS 72 (7) 2957 - 2960 0034-6748 2001/07 [Refereed]
  
• Limits on the Majorana neutrino mass and right-handed weak currents by neutrinoless double beta decay of Mo-100

  H Ejiri; K Fushimi; K Hayashi; T Kishimoto; N Kudomi; K Kume; H Kuramoto; K Matsuoka; H Ohsumi; K Takahisa; S Yoshida

  PHYSICAL REVIEW C AMERICAN PHYSICAL SOC 63 (6) 065501-1-7  0556-2813 2001/06 [Refereed]
  
• Direct and statistical proton decay from isovector giant resonances in Nb-90

  J Janecke; H Akimune; H Ejiri; R Fox; Y Fujita; M Fujiwara; MB Greenfield; MN Harakeh; R Hazama; T Inomata; N Kudomi; K Pham; DA Roberts; A Tamii; M Tanaka; H Toyokawa; M Yosoi

  NUCLEAR PHYSICS A ELSEVIER SCIENCE BV 687 (1-2) 270C - 275C 0375-9474 2001/04 [Refereed]
  
• Highly sensitive radon monitor and radon emanation rates for detector components

  E Choi; M Komori; K Takahisa; N Kudomi; K Kume; K Hayashi; S Yoshida; H Ohsumi; H Ejiri; T Kishimoto; K Matsuoka; S Tasaka

  NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION A-ACCELERATORS SPECTROMETERS DETECTORS AND ASSOCIATED EQUIPMENT ELSEVIER SCIENCE BV 459 (1-2) 177 - 181 0168-9002 2001/02 [Refereed]
  
• Current status of the WIMP search using CaF2 scintillator at Oto Cosmo Observatory

  T Kishimoto; Ogawa, I; R Hazama; S Ajimura; K Matsuoka; H Miyawaki; S Shiomi; Y Tanaka; Y Ishikawa; M Itamura; K Kishimoto; H Sakai; D Yokoyama; A Katsuki; H Ejiri; N Kudomi; K Kume; H Ohsumi; K Fushimi

  IDENTIFICATION OF DARK MATTER WORLD SCIENTIFIC PUBL CO PTE LTD 379 - 384 2001 [Refereed]
  
• Limits on the Majorana neutrino mass and right-handed weak currents by neutrinoless double [Formula Presented] decay of [Formula Presented]

  H. Ejiri; K. Fushimi; K. Hayashi; T. Kishimoto; N. Kudomi; K. Kume; H. Kuramoto; K. Matsuoka; H. Ohsumi; K. Takahisa; S. Yoshida

  Physical Review C - Nuclear Physics 63 (6) 7  1089-490X 2001 [Refereed]
  
• Search for WIMPS with the Large NaI(Tl) Scintillator of ELEGANT V

  S Yoshida; H Ejiri; K Fushimi; K Hayashi; T Kishimoto; M Komori; N Kudomi; K Kume; H Kuramoto; K Matsuoka; H Ohsumi; K Takahisa; Y Tsujimoto; S Umehara

  IDENTIFICATION OF DARK MATTER WORLD SCIENTIFIC PUBL CO PTE LTD 343 - 348 2001 [Refereed]
  
• First result of the cross sectional measurement of He-3-He-3 solar reaction in OCEAN

  T Itahashi; N Kudomi; K Kume; K Takahisa; S Yoshida; H Ejiri; H Toki; Y Nagai

  4TH SYMPOSIUM ON NUCLEAR PHYSICS AMER INST PHYSICS 561 127 - 136 0094-243X 2001 [Refereed]
  
• Search for Spin Coupled WIMPs with the Large Volume NaI(Tl) Scintillators

  S. Yoshida; H. Ejiri; K. Fushimi; K. Hayashi; T. Kishimoto; N. Kudomi; K. Kume; H. Kuramoto; K. Matsuoka; H. Ohsumi; K. Takahisa; Y. Tsujimoto; S. Umehara

  AIP Conf. Proc. 2001/01 [Refereed]
  
• Spectroscopy of double-beta and inverse-beta decays from Mo-100 for neutrinos

  H Ejiri; J Engel; R Hazama; P Krastev; N Kudomi; RGH Robertson

  PHYSICAL REVIEW LETTERS AMER PHYSICAL SOC 85 (14) 2917 - 2920 0031-9007 2000/10 [Refereed]
  
• Performance of the NANOGUN (TM) electron cyclotron resonance ion source applied for nuclear astrophysics

  T Itahashi; K Kudomi; K Kume; K Takahisa; S Yoshida; H Ejiri; H Toki; Y Nagai; H Ohsumi; M Komori; K Yamasaki

  REVIEW OF SCIENTIFIC INSTRUMENTS AMER INST PHYSICS 71 (2) 1075 - 1078 0034-6748 2000/02 [Refereed]
  
• Neutrinos by Double Beta Decays from $^{100}$Mo and Nuclear Spin Isospin Responses

  N. Kudomi; H. Ejiri; K. Fushimi; K. Hayashi; T. Kishimoto; M. Komori; K. Kume; H. Kuramoto; K. Matsuoka; H. Ohsumi; K. Takahisa; S. Umehara; S. Yoshida

  Proc. of Internatinal Spin Physics Symposium 2000/01 [Refereed]
  
• Annual Signal Modulation to Search for WIMPs and Direct Searching

  E. Choi; H. Ejiri; K. Fushimi; K. Hayashi; N. Koori; K. Kume; N. Kudomi; H. Kuramoto; S. Nakayama; T. Shimojou; K. Takahisa; R. Tsubakida; Y. Tsujimoto; S. Umehara; S. Yoshida

  Sources and Detection of DARK MATTER and DARK ENERGY in the Universe 2000/01 [Refereed]
  
• Limits on the annual modulation of WIMPs-nucleus scattering with large-volume NaI(Tl) scintillators

  K Fushimi; H Ejiri; K Hayashi; R Hazama; T Kishimoto; N Kudomi; K Kume; H Ohsumi

  ASTROPARTICLE PHYSICS ELSEVIER SCIENCE BV 12 (3) 185 - 192 0927-6505 1999/11 [Refereed]
  
• Energy calibration of plastic scintillators for low energy electrons by using Compton scatterings of gamma rays

  N Kudomi

  NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION A-ACCELERATORS SPECTROMETERS DETECTORS AND ASSOCIATED EQUIPMENT ELSEVIER SCIENCE BV 430 (1) 96 - 99 0168-9002 1999/06 [Refereed]
  
• High brightness He-3 ion source and plasma target for nuclear astrophysical applications

  T Itahashi; K Takahisa; N Kudomi; T Iki; S Yoshida; H Toki; H Ejiri

  REVIEW OF SCIENTIFIC INSTRUMENTS AMER INST PHYSICS 69 (2) 1032 - 1034 0034-6748 1998/02 [Refereed]
  
• Search for annual modulation of WIMPs by means of large volume NaI(Tl) detector in ELEGANT V

  K Fushimi; H Ejiri; K Hayashi; N Kudomi; K Kume; K Takahisa; S Yoshida; R Hazama; T Kishimoto; M Komori; K Matsuoka; H Miyawaki; S Shiomi; H Ohsumi

  INTERNATIONAL SYMPOSIUM ON NEW FACET OF SPIN GIANT RESONANCES IN NUCLEI WORLD SCIENTIFIC PUBL CO PTE LTD 459 - 461 1998 [Refereed]
  
• Search for WIMPs by huge NaI detectors and present status of OTO Cosmo Laboratory

  H. Ejiri; E. Choi; K. Hayashi; N. Kudomi; K. Kume; H. Kuramoto; K. Takahisa; Y. Tsujimoto; S. Yoshida; K. Fushimi; S. Umehara; R. Hazama; T. Kishimoto; G. Kunitomi; K. Matsuoka; H. Miyawaki; T. Nitta; I. Ogawa; S. Shiomi; N. Suzuki; Y. Tanaka; H. Ohsumi

  The Identification of Dark Matter 1998/01 [Refereed]
  
• Osaka ELEGANT Project and OTO Cosmo Observatory

  H. Ohsumi; H. Ejiri; K. Fushimi; K. Hayashi; R. Hazama; T. Kishimoto; M. Komori; N. Kudomi; K. Kume; K. Matsuoka; T. Nitta; K. Okada; S. Tasaka

  Proceedings of 2nd RESCEU International Symposium on Dark Matter in the Universe and its Direct Detection 25-30  1997
• Limits on neutrino-less double beta decay of Mo-100

  H Ejiri; K Fushimi; K Hayashi; R Hazama; T Kishimoto; N Kudomi; K Kume; K Nagata; H Ohsumi; K Okada; T Shima; J Tanaka

  NUCLEAR PHYSICS A ELSEVIER SCIENCE BV 611 (1) 85 - 95 0375-9474 1996/12 [Refereed]
  
• Limits on axial coupled dark matters studied by inelastic scattering from I-127 in NaI

  K Fushimi; H Ejiri; K Hayashi; R Hazama; N Kudomi; K Kume; H Ohsumi

  NUCLEAR PHYSICS B ELSEVIER SCIENCE BV 70 - 72 0550-3213 1996/05 [Refereed]
  
• 0 nu beta beta decays of Mo-100 by means of ELEGANT V

  H Ejiri; K Fushimi; K Hayashi; R Hazama; N Kudomi; K Kume; K Nagata; T Nitta; H Ohsumi; K Okada; T Shima; K Shinmyo; J Tanaka

  NUCLEAR PHYSICS B ELSEVIER SCIENCE BV 229 - 231 0550-3213 1996/05 [Refereed]
  
• Double beta decays studied by elegant

  K Kume; K Fushimi; R Hazama; M Kawasaki; N Kudomi; K Nagata; T Nitta; H Ohsumi; K Okada; H Sano; T Senoo; T Shibata; T Shima; K Shinmyo; N Suzuki; J Tanaka; H Ejiri; K Hayashi; Kuts, V; Y Zdesenko

  DOUBLE-BETA DECAY AND RELATED TOPICS WORLD SCIENTIFIC PUBL CO PTE LTD 490 - 495 1996 [Refereed]
  
• The NEW UNDERGROUND LABORATORY "OTO COSMO OBSERVATORY" AND ELEGANT

  H. Ohsumi; H. Ejiri; M. Fujiwara; K. Fushimi; K. Hayashi; R. Hazama; T. Kishimoto; M. Komori; N. Kudomi; K. Kume; K. Matsuoka; H. Miyawaki; T. Nitta; K. Okada; T. Shibata; T. Shima; N. Suzuki; S. Tasaka

  Proceedings of FRONTIER96 274-279  1996
• DOUBLE-BETA DECAYS OF CD-116

  H EJIRI; K FUSHIMI; R HAZAMA; M KAWASAKI; KOUTS, V; N KUDOMI; K KUME; K NAGATA; H OHSUMI; K OKADA; H SANO; T SENOO; T SHIBATA; T SHIMA; J TANAKA; Y ZDESENKO

  JOURNAL OF THE PHYSICAL SOCIETY OF JAPAN PHYSICAL SOC JAPAN 64 (2) 339 - 343 0031-9015 1995/02 [Refereed]
  
• SPIN-ISOSPIN EXCITATIONS IN NUCLEI VIA (HE-3,T) REACTIONS AT 450 MEV

  M FUJIWARA; H AKIMUNE; DAITO, I; H EJIRI; Y FUJITA; MB GREENFIELD; MN HARAKEH; R HAZAMA; T INOMATA; J JANECKE; N KUDOMI; K KUME; S NAKAYAMA; K SHINMYO; A TAMII; M TANAKA; H TOYOKAWA; M YOSOI

  NUCLEAR PHYSICS A ELSEVIER SCIENCE BV 577 (1-2) C43 - C50 0375-9474 1994/09 [Refereed]
  
• DOUBLE-BETA DECAYS STUDIED BY ELEGANTS-V

  H EJIRI; K FUSHIMI; R HAZAMA; N KUDOMI; K NAGATA; H OHSUMI; K OKADA; J TANAKA

  NUCLEAR PHYSICS B ELSEVIER SCIENCE BV 372 - 374 0550-3213 1994/05 [Refereed]
  
• SEARCH FOR EXOTIC NUCLEAR TRANSITION BY USING THE LARGE-VOLUME NAI DETECTOR OF ELEGANTS-V

  K FUSHIMI; H EJIRI; R HAZAMA; N KUDOMI; K NAGATA; H OHSUMI; K OKADA; J TANAKA

  NUCLEAR PHYSICS B ELSEVIER SCIENCE BV 400 - 402 0550-3213 1994/05 [Refereed]
  
• STUDY OF NEUTRINO AND DARK-MATTER BY HIGH-SENSITIVITY BETA-BETA,GAMMA AND X-RAY SPECTROMETER ELEGANTS

  H EJIRI; K FUSHIMI; R HAZAMA; N KUDOMI; K KUME; K NAGATA; H OHSUMI; K OKADA; J TANAKA; Y ZDESENKO

  PROGRESS IN PARTICLE AND NUCLEAR PHYSICS, VOL 32 PERGAMON PRESS LTD 32 119 - 130 0146-6410 1994 [Refereed]
  
• APPLICATION OF A LARGE-VOLUME NAI SCINTILLATOR TO SEARCH FOR DARK MATTER

  K FUSHIMI; H EJIRI; H KINOSHITA; N KUDOMI; K KUME; K NAGATA; H OHSUMI; K OKADA; H SANO; J TANAKA

  PHYSICAL REVIEW C AMERICAN PHYSICAL SOC 47 (2) R425 - R428 0556-2813 1993/02 [Refereed]
  
• PREPARATION OF LARGE AND THIN SOURCE FILMS FOR STUDYING NUCLEAR RARE DECAYS

  N KUDOMI; T SHIMA; H EJIRI; J TANAKA; T WATANABE

  NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION A-ACCELERATORS SPECTROMETERS DETECTORS AND ASSOCIATED EQUIPMENT ELSEVIER SCIENCE BV 322 (1) 53 - 56 0168-9002 1992/10 [Refereed]
  
• DOUBLE-BETA DECAYS OF MO-100 AND CHARGE NONCONSERVING TRANSITIONS IN I-127 STUDIED BY MEANS OF ELEGANTS-V

  H EJIRI; K FUSHIMI; M KAWASAKI; H KINOSHITA; N KUDOMI; K KUME; K NAGATA; H OHSUMI; K OKADA; H SANO; T SHIBATA; T SHIMA; J TANAKA; T WATANABE

  NUCLEAR PHYSICS B ELSEVIER SCIENCE BV 28 (1) 219 - 222 0550-3213 1992 [Refereed]
  
• Double beta decays of Mo100 to excited states in Ru100

  N. Kudomi; H. Ejiri; K. Nagata; K. Okada; T. Shibata; T. Shima; J. Tanaka

  Physical Review C 46 (6) R2132 - R2135 0556-2813 1992 [Refereed]
  

Conference Activities & Talks

• 加速器の基礎的なお話、一般的なお話  [Invited]

  久冨信之

  PETサマーセミナー2024 in 高松  2024/08  高松市  西山佳宏
  
• Non-invasive estimation of input function from PET image Liver study with H215O and 18FDG  [Not invited]

  Turku PET Symposium  2008
• Image-derived input functions for blood flow and glucose uptake quantification in dynamic liver PET scans  [Not invited]

  Annual Congress of the European Association of Nuclear Medicine  2008

MISC

• 盛り上げよう!クリニカルPET 香川大学での15O標識ガスPET検査に対する臨床現場での取り組み

  三田村 克哉; 久冨 信之; 前田 幸人; 山本 由佳; 西山 佳宏  核医学  56-  (Suppl.)  S119  -S119  2019/10
• 脳循環代謝予備能の評価における新規SPECT検査法の開発

  三田村 克哉; 久冨 信之; 前田 幸人; 山本 由佳; 西山 佳宏  核医学  56-  (Suppl.)  S176  -S176  2019/10
• 機械学習に基づく、血流検査画像から疑似酸素摂取率画像を作成する試み

  久冨 信之; 前田 幸人; 山本 由佳; 畠山 哲宗; 西山 佳宏  核医学  56-  (1)  51  -52  2019
• Tc-99m GSA SPECT/CTによる経皮的経肝門脈塞栓術の効果判定

  安賀 文俊; 佐野村 隆行; 奥田 花江; 山本 由佳; 則兼 敬志; 久冨 信之; 岡野 圭一; 西山 佳宏  核医学  55-  (Suppl.)  S165  -S165  2018/11
• Tc-99m GSAを用いた動態解析による術後肝不全の検討

  奥田 花江; 佐野村 隆行; 山本 由佳; 則兼 敬志; 久冨 信之; 岡野 圭一; 西山 佳宏  核医学  55-  (Suppl.)  S165  -S165  2018/11
• 頭頸部領域の悪性リンパ腫と扁平上皮癌の鑑別におけるFDG PETでのテクスチャー解析の有用性について

  三田村 克哉; 山本 由佳; 久冨 信之; 前田 幸人; 西山 佳宏  核医学  55-  (Suppl.)  S198  -S198  2018/11
• 機械学習による脳領域血液到達時間と血流から疑似酸素摂取率画像を生成する検討

  久冨 信之; 前田 幸人; 山本 由佳; 畠山 哲宗; 西山 佳宏  脳循環代謝  30-  (1)  135  -135  2018/10
• PTPE前後の肝機能評価における99mTc-GSA SPECT/CTを用いた解析

  奥田 花江; 佐野村 隆行; 山本 由佳; 三田村 克哉; 則兼 敬志; 久冨 信之; 前田 幸人; 門田 敏秀; 岡野 圭一; 西山 佳宏  核医学  54-  (Suppl.)  S193  -S193  2017/09
• Bariatric Surgery Enhances Postprandial Hepatic Blood Flow Response in Morbidly Obese Subjects with Type 2 Diabetes

  Henri Honka; Jukka Koffert; Saila Kauhanen; Nobu Kudomi; Saija Hurme; Andrea Mari; Andreas Lindqvist; Nils Wierup; Leif Groop; Pirjo Nuutila  DIABETES  66-  A513  -A514  2017/06
• Left ventricular mass and its associations with myocardial perfusion, oxygen extraction and efficiency in healthy and fit humans

  I. Heinonen; N. Kudomi; J. Kemppainen; H. Sipila; D. Duncker; J. Knuuti; K. Kalliokoski  ACTA PHYSIOLOGICA  219-  25  -25  2017/02
• Mitamura K, Yamamoto Y, Kudomi N, Maeda Y, Norikane T, Miyake K, Nishiyama Y.

  三田村克哉; 山本由佳; 久冨信之; 前田幸人; 則包; 三宅啓介; 西山佳宏  Ann Nucl Med.  31-  (1)  46-52  2017/01  [Refereed]
  
• Reconstruction of Input Function for Rapid PET measurement of CBF, OEF, and CMRO2

  N. Kudomi; Y. Maeda; H. Yamamoto; Y. Yamamoto; T. Hatakeyama; Y. Nishiyama  EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING  43-  S80  -S81  2016/10
• Computation strategy for CBV estimation from a single PET scan with sequential administration of (15)O2 and C(15)O2

  N. Kudomi; Y. Maeda; H. Yamamoto; Y. Yamamoto; T. Hatakeyama; Y. Nishiyama  EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING  43-  S617  -S618  2016/10
• 4 '-[methyl-C-11]thiothymidine positron emission tomography in patients with newly diagnosed glioma: Comparison with Gd-DTPA enhanced magnetic resonance imaging

  Y. Fukuda; K. Tanaka; Y. Yamamoto; T. Hatakeyama; N. Kudomi; J. Toyohara; Y. Nishiyama  EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING  43-  S262  -S263  2016/10
• Labelling preparation of Rare-Sugar D-allose with F-18 for assessment of behavior in vivo

  H. Yamamoto; N. Kudomi; K. Wada; Y. Yamamoto; Y. Nishiyama  EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING  43-  S468  -S469  2016/10
• Comparison of delay of appearance time of blood in brain region with elevation of oxygen extraction fraction

  N. Kudomi; Y. Maeda; H. Yamamoto; Y. Yamamoto; T. Hatakeyama; Y. Nishiyama  EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING  43-  S618  -S618  2016/10
• 治療前神経膠腫における11C-4DST PETと造影MRIの比較

  福田 有子; 田中 賢一; 山本 由佳; 則兼 敬志; 畠山 哲宗; 山本 浩之; 久冨 信之; 豊原 潤  核医学  53-  (Suppl.)  S257  -S257  2016/10
• 迅速脳血流・酸素代謝検査法のための入力関数再構成法開発の試み

  久冨 信之; 前田 幸人; 山本 浩之; 山本 由佳; 畠山 哲宗; 西山 佳宏  核医学  53-  (Suppl.)  S262  -S262  2016/10
• 希少糖のin vivoでの動態評価を指向した、18FによるD-alloseの標識化

  山本 浩之; 久冨 信之; 和田 健司; 山本 由佳; 西山 佳宏  核医学  53-  (Suppl.)  S265  -S265  2016/10
• Energy expenditure of human cervico-thoracic muscles during mild cold stress: a positron emission tomography study

  M. U. Din; J. Raiko; N. Kudomi; V. Oikonen; P. Nuutila; K. A. Virtanen  DIABETOLOGIA  59-  S289  -S289  2016/08
• COMPUTATION OF FULL PARAMETRIC IMAGES FOR REVERSIBLE TRACER OF FLT WITHIN REASONABLE TIME

  N. Kudomi; Y. Maeda; T. Hatakeyama; Y. Yamamoto; N. Yoshihiro  JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM  36-  620  -621  2016/06
• Correlation of intratumor textual heterogeneity on 4′-[methyl-11C] thiothymidine PET/CT with Ki-67 immunohistochemistry and tumor grade in patients with newly diagnosed gliomas

  Yuka Yamamoto; Katsuya Mitamura; Yukito Maeda; Tetsuhiro Hatakeyama; Hiroyuki Yamamoto; Nobuyuki Kudomi; Jun Toyohara; Yoshihiro Nishiyama  JOURNAL OF NUCLEAR MEDICINE  57-  2016/05
• Fully Parametric Imaging for Reversible Tracer of FLT within Reasonable Time

  N. Kudomi; A. NIshiyama; Y. Maeda; T. Hatakeyama; Y. Yamamoto; Y. Nishiyama  EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING  42-  S573  -S574  2015/10
• Correlation of 4 '-[Methyl-11C]-Thiothymidine Uptake with Ki-67 Immunohistochemistry in Patients with Newly Diagnosed and Recurrent Gliomas: Comparison with 11C-Methionine Uptake

  Y. Yamamoto; K. Tanaka; H. Yamamoto; N. Kudomi; T. Hatakeyama; J. Toyohara; Y. Nishiyama  EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING  42-  S602  -S602  2015/10
• 消化管癌における¹¹C‐4DST PETと¹⁸F‐FDG PETの比較

  福田有子; 山本由佳; 田中賢一; 山本浩之; 久冨信之; 豊原潤; 西山佳宏  核医学  52-  (3)  249  -249  2015/09
• 神経膠腫診断における2種類のチミジンアナログPETトレーサ(4DSTとFLT)の比較

  河井 信行; 豊田 康則; 畠山 哲宗; 久冨 信之; 山本 由佳; 田宮 隆; 西山 佳宏  核医学  52-  (3)  259  -259  2015/09
• Brown Adipose Tissue CT Radiodensity Is a Marker of Local Vascularity and Stored Triglyceride Content

  Mueez U. Din; Juho Raiko; Teemu Saari; Virva Saunavaara; Nobu Kudomi; Riitta Parkkola; Pirjo Nuutila; Kirsi A. Virtanen  DIABETES  64-  A32  -A32  2015/06
• Different Effects of Meal and Incretin Hormones GIP and GLP-1 on Splanchnic Organs' Blood Flow in Healthy and Morbidly Obese Subjects

  Jukka Koffert; Henri Honka; Saila Kauhanen; Nobuyuki Kudomi; Andreas Lindqvist; Nils Wierup; Leif Groop; Pirjo Nuutila  DIABETES  64-  A529  -A529  2015/06
• V/Q SPECT/CT画像の試み

  三田村 克哉; 山本 由佳; 久冨 信之; 門田 敏秀; 西山 佳宏  核医学  51-  (4)  409  -409  2014/11
• Effect of bariatric surgery on hepatic fatty acid uptake and blood low

  H. M. Immonen; J. C. Hannukainen; N. Kudomi; R. Parkkola; V. Saunavaara; P. Iozzo; P. Nuutila  DIABETOLOGIA  57-  S76  -S76  2014/09
• Myocardial blood flow and oxygen utilization in different ventricular regions of the healthy human heart in untrained subjects and endurance athletes at rest and during exercise

  I. Heinonen; N. Kudomi; H. Sipila; D. Duncker; J. Knuuti; K. Kalliokoski  EUROPEAN HEART JOURNAL  35-  728  -729  2014/09
• 治療前神経膠腫における11C-4DST PETと11C-MET PETの比較

  田中 賢一; 山本 由佳; 前田 幸人; 河井 信行; 久冨 信之; 豊原 潤; 西山 佳宏  核医学  51-  (3)  273  -273  2014/09
• [11C]4DST薬剤供給安定化のための反応条件検討

  山本 浩之; 塚本 隆; 豊原 潤; 久冨 信之; 山本 由佳; 西山 佳宏  核医学  51-  (3)  293  -293  2014/09
• The Effects of Bariatric Surgery on Splanchnic Blood Flow and Metabolism in Morbidly Obese Subjects

  Henri Honka; Jarna C. Hannukainen; Heidi Immonen; Jetro J. Tuulari; Vesa Oikonen; Nobu Kudomi; Paulina Salminen; Riitta Parkkola; Andrea Mari; Patricia Iozzo; Pirjo Nuutila  DIABETES  63-  A515  -A515  2014/06
• Computation of myocardial blood flow and metabolic rate of O2 in right ventricle at rest and during exercise using H215O and 15O2 PET

  N. Kudomi; K. K. Kalliokoski; V. J. Oikonen; C. Han; J. Kemppainen; M. Luotolahti; H. Sipila; D. J. Duncker; J. Knuuti; I. Heinonen  EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING  40-  S269  -S269  2013/10
• Computation of cerebral blood volume from single PET scan with sequential administration of O-15(2) and H-2 O-15

  N. Kudomi; Y. Maeda; Y. Yamamoto; Y. Nishiyama; H. Iida  EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING  40-  S144  -S144  2013/10
• 酸素標識ガスPET検査時間短縮の試み

  前田 幸人; 久冨 信之; 山本 由佳; 谷井 喬; 井手 康裕; 門田 敏秀; 岩崎 孝信; 笹川 泰弘; 加藤 耕二; 河井 信行; 西山 佳宏  核医学技術  33-  (予稿集)  343  -343  2013/10
• Metabolic shift with impaired perfusion of pancreas in type 2 diabetes: positron emission tomography study

  H. Honka; J. C. Hannukainen; H. Karlsson; V. Lepomaki; M. Soinio; P. Salminen; V. Oikonen; R. Parkkola; N. Kudomi; A. Mari; P. Iozzo; P. Nuutila  DIABETOLOGIA  56-  S102  -S102  2013/09
• 肝機能評価における99mTc-GSA dynamic SPECT/CTを用いた定量解析

  新井 花江; 山本 由佳; 久冨 信之; 前田 幸人; 門田 敏秀; 西山 佳宏  核医学  50-  (3)  S196  -S196  2013/09
• 迅速脳血流・酸素代謝検査法による脳血液到達時間推定とOEFの比較

  西山 陽大; 前田 幸人; 山本 由佳; 河井 信行; 飯田 秀博; 西山 佳宏; 久冨 信之  核医学  50-  (3)  S217  -S217  2013/09
• 迅速脳血流・酸素代謝検査法におけるCBV推定法の検討

  久冨 信之; 前田 幸人; 門田 敏秀; 西山 陽大; 山本 由佳; 河井 信行; 飯田 秀博; 西山 佳宏  核医学  50-  (3)  S217  -S217  2013/09
• 頸動脈ステント留置前と翌日のPETによる脳循環代謝測定 過灌流症候群の予測

  河井 信行; 岡内 正信; 川西 正彦; 久冨 信之; 山本 由佳; 西山 佳宏; 田宮 隆  核医学  50-  (3)  S219  -S219  2013/09
• 18F-FDG PET in the diagnosis and treatment of primary central nervous system lymphoma.

  Nobuyuki Kawai; Keisuke Miyake; Yuka Yamamoto; Yoshihiro Nishiyama; Takashi Tamiya  Biomed Res Int.  2013-  247152  2013/06  [Refereed]
  
• Towards Ultra Rapid 15O PET System

  Iida H; Kudomi N; Miyake Y; Yamada N; Morita N  脳と循環  17-  (2)  119  -126  2012/05  [Invited]
  
• Extraction of input function from H215O PET imaging of rat heart

  N. Kudomi; H. Sipila; A. Autio; V. Oikonen; H. Liljenback; M. Tarkia; J. Laivola; J. Johansson; M. Teras; A. Roivainen  EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING  38-  S266  -S266  2011/10
• CBF/CMRO2迅速検査のための非侵襲入力関数推定法の検討

  久冨 信之; 渡部 浩司; 林 拓也; 笹川 泰弘; 山本 由佳; 西山 佳宏; 飯田 秀博  核医学  48-  (3)  S292  -S292  2011/09
• 脳梗塞急性期における局所酸素輸送と組織内酸素分圧の画像診断法の開発と血栓溶解治療の最適化

  飯田秀博; 内藤博昭; 峰松一夫; 飯原弘二; 福島和人; 田口明彦; 銭谷勉; 河嶋秀和; 越野一博; 平野祥之; 古幡博; 畑澤順; 松田博史; 西山佳宏; 久冨信之  新しい医療機器研究  16-  33  -34  2011/03
• 高磁場MRIと核医学・分子イメージングに基づく動脈硬化の高感度かつ定量的な診断と新しい予防戦略の構築

  飯田秀博; 河嶋秀和; 寺本昇; 越野一博; 平野祥之; 野口輝夫; 内藤博昭; 峰松一夫; 山田直明; 福島和人; 植田初江; 飯原弘二; 宮本恵宏; 古本祥三; 田村元; 久冨信之; 大田英揮  新しい医療機器研究  16-  23  -24  2011/03
• Long-term outcome of craniopharyngioma in children: A review

  Takashi Tamiya; Masaki Okada; Keisuke Miyake; Nobuyuki Kawai  Japanese Journal of Neurosurgery  20-  (5)  351  -362  2011
• ¹⁵O‐ガス迅速PET法のシステム構築と正当性評価

  飯田秀博; 堀祐樹; 三宅義徳; 林拓也; 越野一博; 山内美穂; 圓見純一郎; 銭谷勉; 久冨信之; 福島和人; 森田奈緒美  脳循環代謝  23-  (1)  118  2011
• Non-invasive estimation of input function for rapid CBF-CMRO2 measurement using PET with DARG

  N. Kudomi; H. Watabe; T. Hayashi; Y. Sasakawa; Y. Yamamoto; Y. Nishiyama; H. Iida  EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING  37-  S338  -S338  2010/10
• 初発神経膠芽腫における18F-fluoromisonidazoleと11C-methionine PETおよび造影MRI画像との比較

  河井 信行; 三宅 啓介; 山本 由佳; 西山 佳宏; 久冨 信之; 田宮 隆  核医学  47-  (3)  389  -389  2010/09
• 中枢神経原発悪性リンパ腫のC-11 methionine PET F-18 FDG PETとの比較

  川瀬 良郎; 山本 由佳; 亀山 麗子; 外山 芳弘; 西山 佳宏; 前田 幸人; 笹川 泰弘; 保田 定利; 河井 信行; 久冨 信之  核医学  47-  (3)  400  -400  2010/09
• 11C-flumazenil PETの健常者における脳内動態についての検討

  前田 幸人; 笹川 泰弘; 山崎 達也; 門田 敏秀; 三木 章弘; 保田 定利; 加藤 耕二; 久富 信之; 河井 信行; 山本 由佳; 西山 佳宏  核医学技術  30-  (予稿集)  332  -332  2010/09
• 高磁場MRIと核医学・分子イメージングに基づく動脈硬化の高感度かつ定量的な診断と新しい予防戦略の構築

  飯田秀博; 渡部浩司; 寺本昇; 越野一博; 平野祥之; 野々木宏; 野口輝夫; 内藤博昭; 山田直明; 福島和人; 植田初江; 飯原弘二; 宮本恵宏; 古本祥三; 田村元; 久冨信之  新しい医療機器研究  15-  2010
• 11C-フルマゼニルによる中枢性ベンゾジアゼピン受容体測定

  河井 信行; 小川 大輔; 久冨 信之; 山本 由佳; 西山 佳宏; 田宮 隆  脳循環代謝  21-  (1)  151  -151  2009/11
• Non-invasive Parametric Blood Flow Imaging of the Head-and-Neck Tumours Using [15O]H2O and PET/CT

  G. Komar; V. Oikonen; N. Kudomi; M. Seppanen; H. Minn  EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING  36-  S353  -S353  2009/09
• Image-derived input functions for blood flow and glucose uptake quantification in dynamic liver PET scans

  N. Kudomi; L. Slimani; M. Jarvisalo; J. Kiss; R. Lautamaki; A. G. Naum; T. Savunen; J. Knuuti; H. Iida; P. Nuutila; P. Iozzo  EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING  35-  S189  -S189  2008/10
• Clinical and preclinical studies for assessing pathophysiology of brain ischemia using PET and MRI

  Hayashi T; Takebobu Y; Kudomi N; Watabe H; Teramoto N; Sato H; Koshino K; Iwanishi Y; Naganuma M; Moriwaki H; Yokota C; Narutomi H; Minematsu K; Iida H  循環器病研究の進歩  48-  79  -86  2008
• Pathophysiological basis of myocardial viability assessment

  飯田秀博; 寺本昇; 越野一博; 太田洋一郎; 渡部浩司; 久富信之; 林拓也; 猪俣亮; 銭谷勉; 金敬王文; 佐藤博司; PAKU N  臨床放射線  51-  (9)  1035  -1041  2006/09
• MRIと核医学手法の正確な重ね合わせ技術に基づく癌の新しい分子イメージング診断法

  飯田秀博; 佐藤博司; 渡部浩司; 越野一博; 寺本昇; 銭谷勉; 林拓也; 円見純一郎; 三宅義徳; 大田洋一郎; 久冨信之; 猪股亨; 合瀬恭幸; 朴日淑; 樋掛正明; 山本明秀; 山内美穂; 岳野猛; 田原賢吾  新しい医療機器研究  11-  26  -27  2006/03
• 病態生理からみた心筋バイアビリティ

  飯田秀博; 寺本昇; 越野一博; 太田洋一郎; 渡部博司; 久富信之; 林拓也; 猪俣亮; 銭谷勉; 金敬王分  核医学  42-  (3)  224  2005/09
• PET分子イメージングによる創薬支援システムの構築にむけて

  飯田秀博; 林拓也; 渡部浩司; 寺本昇; 越野一博; 円見純一郎; 佐藤博司; 久冨信之; 銭谷勉; KIM K.‐M; 猪股亨; PIAO R; 大田洋一郎; 太田稔宏; 山内美穂; 合瀬恭幸; 赤松哲哉; 山本明秀; 小野寺博和; 栗栖麗; 樋掛正明  日本ME学会大会論文集  44th-  97  2005/04
• Brain imaging for psychiatric disorders. Real-time motion correction system for head.

  飯田秀博; 渡部浩司; 越野一博; 久冨信之; 林拓也  精神疾患における脳の画像解析学的研究 平成14-16年度 総括研究報告書  2005
• ブタ慢性心筋梗塞モデルにおけるH₂ ¹⁵O PETを用いた冠血管予備能の検討

  寺本昇; 越野一博; 大田洋一郎; 久冨信之; 林拓也; 渡部浩司; 横山郁夫; 横山郁夫; 飯田秀博  核医学  42-  (3)  2005
• 急性脳虚血時の酸素供給低下に対する代償機能-サル脳塞栓モデルでの¹⁵O-PETによる検討

  朴日淑; 林拓也; 寺本昇; 久冨信之; 大田洋一郎; 越野一博; 渡部浩司; 飯田秀博  核医学  42-  (3)  2005
• Brain imaging for psychiatric disorders. Statistical analysis of PET list mode data using Bootstrap method.

  飯田秀博; 渡部浩司; 越野一博; 久冨信之; 林拓也  精神疾患における脳の画像解析学的研究 平成14-16年度 総括研究報告書  2005
• Tl‐201ブタSPECTにおけるコントロールおよび薬物負荷中の心筋血流定量のための短時間検査法

  キム キョンミン; 神尾弘; 寺本昇; 渡部浩司; 林拓也; 大田洋一郎; 久冨信之; 河地有木; 銭谷勉  核医学  41-  (3)  327  2004/09
• H₂¹⁵O PET心筋血流量定量におけるBootstrap法を用いた統計解析

  河地有木; 渡部浩司; 寺元昇; 大田洋一郎; 神尾弘; 久冨信之; 越野一博; KIM K M; 林拓也  核医学  41-  (3)  2004
• Quantitative assessment of myocardial blood flow induced by adenosine and CGS-21680 with (H2OPET)-O-15 in miniature pigs

  H Jino; N Teramoto; N Kawachi; Y Ohta; N Kudomi; T Hayashi; H Watabe; Yokoyama, I; H Iida  JOURNAL OF PHARMACOLOGICAL SCIENCES  94-  274P  -274P  2004
• PETによる迅速脳血流・酸素代謝定量法の検討―サルによる従来法との比較

  久冨信之; 林拓也; 寺本昇; 渡部浩司; 金敬文; 大田洋一郎; 河地有木; 神尾弘; 銭谷勉  核医学  40-  (3)  350  2003/08
• PET酸素代謝量の定量測定のためのサルを使った代謝循環水推定法の評価

  久冨信之; 林拓也; 寺本昇; 渡部浩司; 大田洋一郎; 河地有木; 神尾弘; 銭谷勉; 金敬文  核医学  40-  (3)  349  -350  2003/08
• 迅速脳血流・酸素代謝定量法による生理状態変化の評価―サルPET研究

  林拓也; 久冨信之; 寺本昇; 神尾弘; 大田洋一郎; 河地有木; KIM K M; 銭谷勉; 猪俣亨  核医学  40-  (3)  350  2003/08
• Double beta decay study of ⁴⁸Ca by CaF2 scintillator

  I. Ogawa; R. Hazama; S. Ajimura; K. Matsuoka; N. Kudomi; K. Kume; H. Ohsumi; K. Fushimi; N. Suzuki; T. Nitta; H. Miyawaki; S. Shiomi; Y. Tanaka; Y. Ishikawa; M. Itamura; K. Kishimoto; A. Katsuki; H. Sakai; D. Yokoyama; S. Umehara; S. Tomii; K. Mukaida; S. Yoshida; H. Ejiri; T. Kishimoto  Nuclear Physics A  721-  C525  -C528  2003/06
• Search for WIMPs with NaI(Tl) detectors at Oto Cosmo Observatory

  S. Yoshida; H. Eijiri; K. Fushimi; K. Hayashi; T. Kishimoto; N. Kudomi; K. Kume; H. Kuramoto; K. Matsuoka; H. Ohsumi; K. Takahisa; Y. Tsujimoto; S. Umehara  Nuclear Physics A  721-  (0)  1056C  -1059C  2003/06
• Factor analysis for extracting tissue component in O-15(2) gas PET study.

  KM Kim; H Watabe; N Kudomi; T Hayashi; JS Lee; K Hayashida; H Iida  JOURNAL OF NUCLEAR MEDICINE  44-  (5)  251P  -251P  2003/05
• [18F]FDG accumulation to the atherosclerotic vulnerable plaque: Correlation with infiltrated macrophage number.

  M Ogawa; T Mukai; S Ishino; D Asano; N Teramoto; H Watabe; N Kudomi; M Shiomi; Y Magata; H Iida; H Saji  JOURNAL OF NUCLEAR MEDICINE  44-  (5)  189P  -190P  2003/05
• H₂¹⁵O-PETによるadenosine及びCGS-21680誘発ミニブタ心筋血流量の定量的測定

  神尾弘; 河地有木; 寺本昇; 大田洋一郎; 久冨信之; 林拓也; 渡部浩司; 横山郁夫; 飯田秀博  核医学  40-  (3)  2003
• O-15標識水PET検査における局所心筋血流定量化の精度向上

  河地有木; 渡部浩司; 神尾弘; 久冨信之; KIM K M; 林拓也; 飯田秀博  核医学  40-  (3)  2003
• PETリストモード収集と光学式トラッキング装置を用いた頭部PET検査における動き補正法の開発

  渡部浩司; WOO S-K; KIM K-M; 河地有木; 久冨信之; 松浦元; 松本圭一; 林拓也; 飯田秀博  核医学  40-  (3)  2003
• PETによる迅速脳血流・酸素代謝定量法の検討―シュミレーションによる評価およびサルによる従来法との比較

  久冨信之; 林拓也; 寺本昇; 渡部浩司; 大田洋一郎; 河地有木; 神尾弘; 銭谷勉; 金敬王分  日本脳循環代謝学会総会プログラム・抄録集  15th-  116  2003
• [¹⁸F]FDGによる不安定プラーク検出の試み

  小川美香子; 石野誠悟; 向高弘; 寺本昇; 久冨信之; 渡部浩司; 飯田秀博; 佐治英郎  核医学  39-  (3)  364  2002/09
• Double beta decays of Mo-100 and molybdenum observatory of neutrinos

  H Ejiri; J Engel; K Fushimi; K Hayashi; R Hazama; T Kishimoto; P Krastev; N Kudomi; K Kume; H Kuramoto; K Matsuoka; RGH Robertson; K Takahisa; S Yoshida  NUCLEAR PHYSICS B-PROCEEDINGS SUPPLEMENTS  110-  375  -377  2002/07
• A new strategy for rapid clinical imaging of rCMRO2, rCBF and rOEF using PET. Introducti.

  H Iida; Y Miyake; T Hayashi; N Kudomi; M Ogawa; N Teramoto; KM Kim; H Oka; K Hayashida  JOURNAL OF NUCLEAR MEDICINE  43-  (5)  62P  -62P  2002/05
• Non-invasive extraction of blood component using non-negative matrix factorization in dynamic N-13 ammonia cardiac PET studies.

  KM Kim; H Watabe; K Fukuchi; H Oka; N Kudomi; Y Ishida; H Iida  JOURNAL OF NUCLEAR MEDICINE  43-  (5)  144P  -145P  2002/05
• Development and application of a GSO detector assembly for a continuous blood sampling system.

  N Kudomi; E Choi; H Watabe; KM Kim; M Shidahara; M Ogawa; N Teramoto; E Sakamoto; S Yamamoto; H Iida  JOURNAL OF NUCLEAR MEDICINE  43-  (5)  229P  -229P  2002/05
• Noise property of two CMRO2 quantitation methods with a short bolus inhalation of O-15(2).

  N Kudomi; H Watabe; Y Miyake; KM Kim; M Shidahara; K Hayashida; N Oka; M Sagou; Y Ishida; T Hayahsi; H Iida  JOURNAL OF NUCLEAR MEDICINE  43-  (5)  211P  -211P  2002/05
• Absolute Quantitation of Regional Myocardial Blood Flow of Rats Using Dynamic Pinhole SPECT

  T. Aoi; H. Watabe; H.M. Deloar; M. Ogawa; N. Teramoto; N. Kudomi; T. Oota; K.M. Kim; T. Matsuda; H. Iida  IEEE Nuclear Science Symposium and Medical Imaging Conference  3-  1780  -1783  2002  [Refereed]
  
• PET : 血流イメージングの現状と将来

  飯田 秀博; 渡部 浩司; 久富 信之  BME : bio medical engineering  15-  (8)  13  -19  2001/08
• 放射線検出器に含まれるU・Th系列崩壊核種の濃度の精密測定

  伏見賢一; 久冨信之; 久米恭; 蔵本大文; 桑折範彦; 中山信太郎; 下条拓也; 高久圭二; 辻本芳孝; 椿田竜太郎; 梅原さおり; 吉田斉  応用物理学関係連合講演会講演予稿集  48th-  (1)  2001
• Double beta decays of Mo-100 by ELEGANT V at Oto Cosmo Observatory

  N Kudomi; H Ejiri; K Fushimi; K Hayashi; R Hazama; T Kishimoto; K Kume; H Kuramoto; T Matsuoka; H Ohsumi; K Takahisa; Y Tsujimoto; S Yoshida  NUCLEAR PHYSICS B-PROCEEDINGS SUPPLEMENTS  87-  301  -303  2000/06
• Search for WIMPs with the large NaI(T1) scintillator of ELEGANT V

  S. Yoshida; H. Ejiri; K. Fushimi; K. Hayashi; M. Komori; N. Kudomi; K. Kume; H. Kuramoto; K. Matsuoka; H. Ohsumi; K. Takahisa; Y. Tsujimoto; S. Umehara  Nuclear Physics B - Proceedings Supplements  87-  (1-3)  58  -60  2000/06
• Search for Dark Matter with Scintillator I

  Umehara S; Fushimi K; Koori N; Nakayama S; Shimojo T; Tsubakida R; Choi I; Kudomi N; Kume K; Kuramoto H; Takahisa K; Tsujimoto Y; Yoshida S; Matsuoka K  Meeting abstracts of the Physical Society of Japan  55-  (1)  40  -40  2000/03
• Dark matter search with CaF2 scintillators in Osaka

  I. Ogawa; T. Kishimoto; R. Hazama; S. Ajimura; K. Matsuoka; N. Suzuki; T. Nitta; H. Miyawaki; S. Shiomi; Y. Tanaka; H. Ejiri; N. Kudomi; K. Kume; H. Ohsumi; K. Fushimi  Nuclear Physics A  663-664-  2000/01
• 31a-YH-7 Measurement of the double beta plus decays by means of NaI detectors

  Takahisa K.; Tujimoto Y.; Ejiri H.; Choi E.; Kudomi N.; Kume K.; Hayashi K.; Yoshida S.; Kuramoto H.; Matuoka K.; Ohsumi H.  Meeting abstracts of the Physical Society of Japan  54-  (1)  72  -72  1999/03
• Development of Experimental Facility for Nuclear Astrophysics -Solar-neutrino Production Rates in the Sun-

  ITAHASHI T.; TAKAHISA K.; KUDOMI N.; YOSHIDA S.; TOKI H.; EJIRI H.; KOMORI M.; OHSUMI H.; YAMAZAKI K.  Meeting abstracts of the Physical Society of Japan  53-  (2)  65  -65  1998/09
• Dark Matter Search with CaF2 scintillator at sea level

  HAZAMA Ryuta; AJIMURA Shuhei; KISHIMOTO Tadafumi; KUNITOMI Gou; MASUOKA Kenji; MIYAWAKI Hirotomo; NITTA Tetsuya; OGAWA Izumi; SHIOMI Sachie; SUZUKI Nobuhiro; TANAKA Yasuhiro; EJIRI Hiroyasu; KUDOMI Nobuyuki; KUME Kyo; FUSHIMI Kenichi; OHSUMI Hideaki  Meeting abstracts of the Physical Society of Japan  53-  (1)  65  -65  1998/03
• 1p-H-1 Limits on neutrino-less double beta decay of ^<100>Mo and Oto Cosmo Obserbatory

  KUDOMI N.  Meeting abstracts of the Physical Society of Japan  53-  (1)  64  -65  1998/03
• Double beta decays and ELEGANT V and VI at Oto Cosmo Observatory

  N. Kudomi; H. Ejiri; K. Fushimi; K. Hayashi; R. Hazama; T. Kishimoto; M. Komori; K. Kume; G. Kunitomi; T. Matsuoka; H. Miyawaki; K. Nagata; H. Ohsumi; K. Okada; K. Okada; T. Shima; T. Shima; S. Shiomi; K. Takahisa; J. Tanaka; K. Tasaka; T. Watanabe  Nuclear Physics A  629-  (1-2)  527  -530  1998/02
• Optimization of benzen liquid scintillator with wave length shifters

  MORI T.; MINAMI S.; KUDOMI N.; KUME K.; TAMURA K.; NOMACHI M.; MIZUNO Y.; OUTA H.; NAGAE T.; NOUMI H.; FUKUDA T.; AJIMURA S.; TAMAGAWA T.; NAKANO J.; TAMURA H.; MAEDA K.; KISHIMOTO T.; KOHRI H.; SAKAGUCHI A.; SAJI E.; SHIMIZU Y.; SUMIHAMA M.; MATUOKA K.  Meeting Abstracts of the Physical Society of Japan  53-  (0)  52  -52  1998
• 20a-D-5 High brightness 3^He ion source and plasma target for nuclear astrophysics interest

  ITAHASHI Takahisa; IKI Tetsufumi; YOSHIDA Sei; KOMORI Masataka; KUDOMI Nobuyuki; TAKAHISA Keiji; OHSUMI Hideki; TOKI Hiroshi; EJIRI Hiroyasu  Meeting abstracts of the Physical Society of Japan  52-  (2)  52  -52  1997/09
• 31a-YR-1 Performance of CaF2 Scintillators and Dark Matter Search at sea level

  Hazama Ryuta; Ejiri Hiroyasu; Kishimoto Tadafumi; Ajimura Shuhei; Kudomi Nobuyuki; Kume Kyo; Matsuoka Kenji; Suzuki Nobuhiro; Nitta Tetsuya; Ohsumi Hideaki; Miyawaki Hirotomo; Kunitomi Gou; Shiomi Sachie  Meeting abstracts of the Physical Society of Japan  52-  (1)  32  -32  1997/03
• 29a-YT-14 Thermonuclear reaction cross section and solar neutrino problems

  ITAHASHI Takahisa; EJIRI Hiroyasu; TOKI Hiroshi; OHSUMI Hideki; TAKAHISA Keiji; KUDOMI Nobuyuki; KOMORI Masataka; IKI Tetsufumi  Meeting abstracts of the Physical Society of Japan  52-  (1)  68  -68  1997/03
• 0vββ decays of ¹⁰⁰Mo by means of ELEGANT V

  H. Ejiri; K. Fushimi; K. Hayashi; R. Hazama; N. Kudomi; K. Kume; K. Nagata; T. Nitta; H. Ohsumi; K. Okada; T. Shima; K. Shinmyo; J. Tanaka  Nuclear Physics B - Proceedings Supplements  19-  229  -231  1996/05
• Limits on axial coupled dark matters studied by inelastic scattering from 127I in NaI

  K. Fushimi; H. Ejiri; K. Hayashi; R. Hazama; N. Kudomi; K. Kume; H. Ohsumi  Nuclear Physics B - Proceedings Supplements  19-  70  -72  1996/05
• Study of CaF_2 detector in ELEGANTS-VI system:Beckground reduction by means of roll-off analysis

  Suzuki N.; Ejiri H.; Kishimoto T.; Fushimi K.; Kudomi N.; Kume K.; Hazama R.; Nitta T.; Ohsumi H.  Abstracts of the meeting of the Physical Society of Japan. Annual meeting  50-  (1)  100  -100  1995/03
• Study of CaF2 detector in ELEGANTS-VI system:Background reduction by means of roll-off analysis

  Hazama R.; Ejiri H.; Kishimoto T.; Fushimi K.; Kudomi N.; Kume K.; Suzuki N.; Nitta T.; Ohsumi H.  Abstracts of the meeting of the Physical Society of Japan. Annual meeting  50-  (1)  99  -99  1995/03
• Double beta decays of ¹¹⁶Cd

  K. Kume; H. Ejiri; H. Ejiri; K. Fushimi; R. Hazama; K. Kawasaki; V. Koutz; N. Kudomi; K. Nagata; V. Malishko; H. Ohsumi; K. Okada; H. Sano; T. Senoo; T. Shibata; T. Shima; J. Tanaka; Yu Zdesenko  Nuclear Physics, Section A  577-  405  -410  1994/09
• 29p-G-1 High Sensitivity Detector Array for Neutrinos and Dark-Matter studies

  Ejiri H; Fushimi K; Hazama R; Higa K; Kaneko H; Kishimoto T; Kudomi N; Kume K; Matsuoka K; Mizuta T; Senoo T; Suzuki N  Abstracts of the meeting of the Physical Society of Japan. Sectional meeting  1994-  (1)  92  -92  1994/09
• Double beta decays studied by ELEGANTS V.

  H. Ejiri; K. Fushimi; R. Hazama; N. Kudomi; K. Nagata; H. Ohsumi; K. Okada; J. Tanaka  Nuclear Physics B (Proceedings Supplements)  35-  371  -374  1994/01
• Search for exotic nuclear transition by using the large volume NaI detector of ELEGANTS V.

  K. Fushimi; H. Ejiri; R. Hazama; N. Kudomi; K. Nagata; H. Ohsumi; K. Okada; J. Tanaka  Nuclear Physics B (Proceedings Supplements)  35-  400  -402  1994/01
• 5p-PS-8 Preparation of large and thin source films for studying nuclear rare decays

  KUDOMI Nobuyuki; SHIMA Tatsushi; EJIRI Hiroyasu; TANAKA Jun'ichi; WATANABE Takayuki  Abstracts of the meeting of the Physical Society of Japan. Sectional meeting  1993-  (1)  147  -147  1993/09
• DOUBLE BETA DECAYS OF MO-100 TO EXCITED-STATES IN RU-100

  N KUDOMI; H EJIRI; K NAGATA; K OKADA; T SHIBATA; T SHIMA; J TANAKA  PHYSICAL REVIEW C  46-  (6)  R2132  -R2135  1992/12
• 4a-PS-4 Double Beta Decays of ^<100>Mo to Exited States in ^<100>Ru

  Kudomi Nobuyuki  秋の分科会講演予稿集  1992-  (1)  118  -118  1992/09
• Double beta decays of ¹⁰⁰MO and charge nonconserving transitions in ¹²⁷I studied by means of elegants V

  H. Ejiri; K. Fushimi; M. Kawasaki; H. Kinoshita; N. Kudomi; K. Kume; K. Nagata; H. Ohsumi; K. Okada; H. Sano; T. Shibata; T. Shima; J. Tanaka; T. Watanabe  Nuclear Physics B (Proceedings Supplements)  28-  219  -222  1992/01

Industrial Property Rights

• 特開018-030823:無担体放射性ハロゲン標識化デオキシハロゲノ－Ｄ－アロース、非放射性デオキシフルオロ－Ｄ－アロース、およびそれらの前駆体、ならびにそれらの製造方法  2018

  山本浩之, 久冨信之, 和田健司, 山本由佳, 西山佳宏
• 特開2005-127840:放射性薬剤のための放射線重量測定装置と濃度モニター統合装置  2005

  飯田秀博, 久冨信之, 太田稔宏  

  公開番号:2005-127840
• 特開2003-329774:入力関数持続モニタ  2003

  飯田秀博、久冨信之、山本誠一  

  公開番号:2003-329774
• 特許3629536:カロリメータ及び検出器システム  

  板橋隆久, 久冨信之  

  公開番号:2003-167057 / 登録番号:3629536
• 特表2006/043674:ＰＥＴ撮像による画像定量化装置、方法、プログラム及び該画像定量化プログラムを記録したコンピュータ読み出し可能な記録媒体  

  飯田秀博, 渡部浩司, 林拓也, 久冨信之

Awards & Honors

• 2018/04 医学区物理学会 土井賞
   Fully parametric imaging with reversible tracer 18F-FLT within a reasonable time 

  受賞者: 久冨 信之
• 1997 原子核談話会 新人賞
   Neutrino-less Double beta decay の研究 

  受賞者: 久冨 信之

Research Grants & Projects

• PETテクスチャ解析を用いた間質性肺炎合併肺癌術後急性増悪予測バイオマーカー開発

  日本学術振興会：科学研究費助成事業

  Date (from‐to) : 2020/04 -2023/03 

  Author : 室田 真希子; 久冨 信之; 山本 由佳; 西山 佳宏; 石村 茉莉子

   

  間質性肺炎では肺癌合併の頻度が高い。しかし、間質性肺炎合併肺癌における手術療法では術後の間質性肺炎急性増悪が問題となり致死的である。これに対し、近年個々の患者の術後急性増悪発症リスクを予測のため、リスクスコアが利用される様になっており、リスク因子の一つがCTのUIPパターンである。本研究では肺癌術前検査として行われるFDG-PET/CT検査においても急性増悪の指標となり得るのではないかと考え、解析方法を考案した。 前回の検討に引き続きさらにさかのぼって検討し、我々は2016年1月～2019年8月の当施設における肺癌手術例にて18F-FDG PET/CT及び術前のthin-slice CTを含む胸部CTを施行した症例に関して間質性肺炎の有無に関してデータベース化した。間質性肺炎に関しては、UIPパターン, probable UIPパターン, Indeterminate for UIPパターン, Alternative Diagnosisパターンを分類した。その後、CTにてUIPパターン及び今回はprobable UIPパターンの間質性肺炎を認めた23例を抽出し、FDGの集積と間質性肺炎の臨床的指標との関連について検討した。検討不適例は除外し、最終的に男性13例、女性3例、平均76.3歳の16例を検討した。うちUIPパターンは12例で、probable UIPパターンは4例であった。 その結果では、UIP パターン及びprobable UIPパターンの間質性肺炎のすべて含めた検討において、%DlcoとFDG-PETのSUVmax(r=-0.782)及びSUVmean(r=-0.737)にそれぞれ1%未満で有意な相関が認められた。また、UIPパターンのみの検討でも、SUVmax(r=-0.790)及びSUVmean(r=-0.725)と%Dlcoはそれぞれ1%未満で有意な相関認められたが、probable UIPパターンは症例数が少なく解析ができなかった。
• DNA合成および低酸素イメージングにテクスチャ解析を応用した脳腫瘍の病態評価研究

  日本学術振興会：科学研究費助成事業

  Date (from‐to) : 2019/04 -2023/03 

  Author : 山本 由佳; 久冨 信之; 西山 佳宏; 豊原 潤; 畠山 哲宗; 則兼 敬志

   

  低酸素イメージング用薬剤である18F-fluoromisonidazole（FMISO）を用いたPET検査は腫瘍内低酸素状態を非侵襲的に評価することが出来る。悪性腫瘍における低酸素環境は癌細胞の増殖分化および転移・浸潤を助長するとされ、悪性度評価に有用である。また、低酸素環境は化学放射線療法において治療抵抗性を示す一つの要因と考えられており、治療効果予測におけるバイオマーカーとしての役割も期待される。従来の半定量的指標とテクスチャ解析指標を併用することで、悪性度、遺伝子変異予測、予後予測、治療薬の反応性などの判断の向上ができるか否かを明らかにする。 F-18 FMISO PETを新鮮例の脳腫瘍患者71名に実施した。PETの不均一性評価として、テクスチャ解析による6種類のパラメータ(homogeneity, entropy, short-run emphasis(SRE), long-run emphasis (LRE), low-gray-level-zone emphasis (LGZE), high-gray-level-zone emphasis (HGZE)) を測定した。予後評価として生存率を求めた。その結果、平均生存日数は521日であった。4種類のパラメータ(homogeneity (p<0.04),entropy (p<0.03),SRE (p<0.02), HGZE (p<0.004)において、生存率における単変量解析で有意差をみとめた。 従って、F-18 FMISO PETのテクスチャ解析から求められる指標は、予後評価において有用である可能性が示唆された。
• Quantitative bone evaluation to monitor in castration-resistant prostate cancer bone metastases

  Japan Society for the Promotion of Science：Grants-in-Aid for Scientific Research

  Date (from‐to) : 2018/04 -2021/03 

  Author : Tanaka kenichi

   

  Both bone scintigraphy and 18F-NaF PET reflect osteoblastic activity, which is often increased in bone metastases of prostate cancer. Semiquantitative parameters, such as standardized uptake value (SUV), could be useful tools to evaluate biological activity at pathophysiological site. The bone uptake value (BUV), another semiquantitative index obtained from bone SPECT that indicates the degree of radioisotope accumulation, has been used to improve the diagnostic ability for detection of bone metastasis. The purpose of this study was to evaluate the usefulness of SPECT-BUV for assessment of bone metastases and to compare with PET-SUV. SPECT-BUV was significantly lower in bone metastases than PET-SUV. Significant correlation between SPECT-BUV and PET-SUV (P < 0.001) was found. The baseline burden of metastatic disease was demonstrated to be poor outcome. Baseline skeletal tumor burden as demonstrated on SPECT-BUV or PET-SUV may be a prognostic biomarker.
• 脳虚血診断画像に定量精度劣化を与える要因を解明し補正する方法の開発

  科研費：基盤研究C

  Date (from‐to) : 2018/04 -2021/03 

  Author : 久冨 信之
• Novel method for the evaluation of hepatic function befoe and after PTPE

  Japan Society for the Promotion of Science：Grants-in-Aid for Scientific Research

  Date (from‐to) : 2017/04 -2020/03 

  Author : Sanomura Takayuki

   

  Kinetic modeling of Tc-99m GSA measures the total amount of asialoglycoprotein receptor within a subject's liver. The purpose of this study was to evaluate the usefulness of kinetic analysis using dynamic SPECT/CT for assessment of hepatic function. Applying a two-compartment three-parameter model K1, k2 and k3 were obtained. Correlations were determined between these kinetic parameters and the results of biochemical liver function tests which include indocyanine green retention rate at 15 min (ICGR15), serum bilirubin, serum albumin, cholinesterase, prothrombin time, and platelet. The K1 and k3 values correlated with ICGR15, serum albumin and cholinesterase. Kinetic analysis using asialoglycoprotein receptor scintigraphy with Tc-99m GSA dynamic SPECT/CT might be useful for assessment of hepatic function. Tc-99m GSA SPECT/CT showed that PTPE induces a shift in hepatic function from the embolized part to the nonembolized part of the liver.
• Brain tumor PET research using proliferation and hypoxic imaging

  Japan Society for the Promotion of Science：Grants-in-Aid for Scientific Research

  Date (from‐to) : 2016/04 -2019/03 

  Author : Yamamoto Yuka; MITAMURA Katsuya

   

  A novel radiopharmaceutical, C-11 4DST, has been developed as an in vivo cell proliferation marker based on the DNA incorporation method. We evaluated C-11 4DST uptake on PET/CT in patients with newly diagnosed gliomas and correlated the results with proliferative activity and survival. Linear regression analysis indicated a significant correlation between MTV and Ki-67 index. The result of univariate analysis suggested that SUV was associated with OS. Mean survival for patients with SUV values less than 3.0 was longer, compared with those greater than 3.0. Based on the results of this preliminary study using C-11 4DST PET/CT, MTV seems to be useful for assessment of proliferation and SUV may be useful in the assessment of survival, in newly diagnosed gliomas.
• PET定量検査法における非侵襲化法のための非観血入力関数推定法の開発

  科研費：基盤C

  Date (from‐to) : 2014/04 -2017/03 

  Author : 久冨 信之
• Molecular imaging of brain tumor with PET proliferation tracer

  Japan Society for the Promotion of Science：Grants-in-Aid for Scientific Research

  Date (from‐to) : 2013/04 -2016/03 

  Author : Yamamoto Yuka; KUDOMI Nobuyuki; KAWAI Nobuyuki; NISHIYAMA Yoshihiro; TOYOHARA Jun

   

  A novel radiopharmaceutical, 11C-4DST, has been developed as an in vivo cell proliferation marker based on the DNA incorporation method. The purpose of this study was to evaluate 11C-4DST uptake in patients with glioma and to correlate the results with proliferative activity and tumor grade, in comparison with 11C-Methionine and 18F-FLT. 11C-4DST is feasible for imaging of brain gliomas, as well as 11C-Methionine and 18F-FLT. Especially, it showed the highest correlation coefficient between 11C-4DST and Ki-67 index in newly diagnosed gliomas.
• 迅速脳虚血検査システムの構築と病態診断精度の向上による治療法の開発支援

  文科省：特別経費

  Date (from‐to) : 2013/04 -2016/03 

  Author : 久冨 信之
• 重症脳外傷患者における脳内アミロイドβ蛋白沈着と高次脳機能障害の関連

  日本学術振興会：科学研究費助成事業

  Date (from‐to) : 2014/04 -2015/03 

  Author : 河井 信行; 久冨 信之; 山本 由佳; 岡内 正信; 岸本 泰司

   

  アルツハイマー病(AD)モデルマウスであるtriple-transgenic AD-model(3xTg-AD)マウスとwild type(WT)マウスを用い、重さ30ｇの鉄製錘を80cmの高さより自然落下させることでびまん性脳外傷を作成した。 3xTg-ADマウスでは、受傷後7日目の脳外傷群におけるモリス水迷路における空間学習記憶力の障害は非脳外傷群と比較して有意な差を認めず、海馬におけるAβの沈着にも明らかな差がなかった。ところが受傷後28日目には、脳外傷群において明らかな空間学習記憶力の低下を認め、海馬におけるAβ沈着が著名に増加していた。 WTマウスでは、受傷後7日目のモリス水迷路で脳外傷群は非脳外傷群に比較して有意に空間学習記憶力が低下し、病理組織学的検討で海馬におけるアミロイドβ(Aβ)の沈着が増加していたが、受傷28日目になると脳外傷群における空間学習記憶力の低下は改善し、同時に海馬におけるAβ沈着が減少していた。 今回の研究で、3xTg-ADマウスにおいて脳外傷が空間学習記憶力の低下を引き起こし、この障害は海馬におけるAD原因物質と考えられるAβの沈着と関連があることを明らかにした。一方、WTマウスでは脳外傷は急性期に海馬におけるAβ沈着増加を伴った空間学習記憶力障害を認めるが、この障害は慢性期になると改善し、同時に海馬におけるAβ沈着も減少していることを示した。 今回のWTマウスにおける結果は、従来までのヒトにおける病理学的知見とよく一致しており、正常脳では脳外傷急性期に沈着したAβを分解排除するメカニズムが存在すると考えられる。一方、3xTg-ADマウスにおける結果は、高齢者等でAD発症の素因を持つ脳では、脳外傷が遅発性にAβ沈着を伴った空間学習記憶力の低下を引き起こす可能性があると考えられる。
• 迅速脳酸素代謝検査法における動静脈血管容積画像計算法の確立

  科研費：基盤C

  Date (from‐to) : 2011/04 -2014/03 

  Author : 久冨 信之
• The assessment of hypoxia with PET molecular imaging in lung cancer

  Japan Society for the Promotion of Science：Grants-in-Aid for Scientific Research

  Date (from‐to) : 2010 -2012 

  Author : YAMAMOTO Yuka; NISHIYAMA Yoshihiro; HABA Reiji; KUDOMI Nobuyuki; AGA Fumitoshi

   

  Tumor hypoxia induces aggressiveness, increases metastatic potential, and promotes tumor progression and resistance to anticancer therapy. In-vivo measurement of hypoxia in individual patients is of clinical interest. Imaging with radiolabeled imidazole derivatives offers a noninvasive assessment of tumor hypoxia. Nitroimidazoles are metabolized by intracellular nitroreductases and at low oxygen levels serve as competing electron acceptors. The metabolism of nitroimidazoles relies on active electron transport enzymes and thus does not occur in nectrotic tissue. One of the most widely used PET radiotracers for hypoxia is F-18 fluoromisonidazole (F-18 FMISO), a nitroimidazole derivative. The purpose of this study was to evaluate the degree of hypoxia in lung cancer using F-18 FMISO PET and to compare the results with F-18 FDG PET.
• Intratumoral heterogeneity in brain tumor using PET molecular imaging

  Japan Society for the Promotion of Science：Grants-in-Aid for Scientific Research

  Date (from‐to) : 2010 -2012 

  Author : NISHIYAMA Yoshihiro; YAMAMOTO Yuka; KAWAI Nobuyuki; KUDOMI Nobuyuki; AGA Fumitoshi

   

  Heterogeneity is a recognized characteristic of malignant tumor. It has been reported to be associated with factors that influence resistance to therapy such as histological features including cellular proliferation, necrosis, and physiological features including degree of vascularity, gene expression, energy metabolism, and oxygenation. All these aspects of intratumoral heterogeneity may affect the biological behavior of tumors in patients, which may manifest as variability in prognosis and treatment response. The purpose of this study was to quantitatively measure intratumoral heterogeneity, and to delineate the differences in the distribution of F-18 FDG, F-18 FLT, and C-11 methionine in patients with primary brain tumors.
• PET検査の非侵襲化

  科学研究費補助金

  Date (from‐to) : 2009 -2011
• Non-invasive approach for quantitative PET examination

  Grant-in-Aid for Scientific Research

  Date (from‐to) : 2009 -2011
• Non-invasive estimation of input function in ultra-rapid CBF/CMRO2 measurement

  Japan Society for the Promotion of Science：Grants-in-Aid for Scientific Research

  Date (from‐to) : 2009 -2010 

  Author : KUDOMI Nobuyuki

   

  The Purpose of the present study is to develop a non-invasive method for obtaining cerebral blood flow (CBF) and oxygen metabolism (CMRO_2) in rapid PET measurement. In the present approach, a model function was introduced to express a shape and scale of input function, and then tissue response curves for water and oxygen, respectively, was calculated, i.e., model tissue curves were obtained. The model tissue curves were fitted to the measured multiple brain tissue curves and obtained parameters for the model function reconstructed the input functions. In the measured data, the accuracy of CBF and CMRO_2 were 13% using the non-invasive procedure. Also, simulation showed that the accuracy for the present method is around 10%. All these findings supported that the present method would of use for CBF and CMRO_2 PET examination.
• Rapid measurement of quantitative MBF and MMRO2 Image by use of 15O2 and PET

  Sigrid Jusélius Foundation：Grants for senior researcher

  Date (from‐to) : 2006/04 -2008/03 

  Author : Pirjo Nuutilla
• O-15 標識化合物を使った脳酸素代謝・血流超迅 速PET 検査法の確立

  中谷電子計測技術振興財団：助成金

  Date (from‐to) : 2005/04 -2006/03
• PET動態解析

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