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Daisuke Ori

  • Faculty of Medicine
  • School of Medicine
  • Associate Professor
Last Updated :2026/08/27

Researcher Information

J-Global ID

Research Interests

  • ERストレス   オルガネラストレス   炎症   infection   nucleic acid sensing   innate immunity   

Research Areas

  • Life sciences / Cell biology
  • Life sciences / Molecular biology
  • Life sciences / Immunology / innate immunity

Academic & Professional Experience

  • 2026/05 - Today  Nara Institute of Science and Technology先端科学技術研究科招へい准教授
  • 2026/04 - Today  Kagawa UniversityFaculty of Medicine准教授
  • 2018/04 - 2026/03  Nara Institute of Science and Technology先端科学技術研究科助教
  • 2016/07 - 2018/03  Nara Institute of Science and TechnologyGraduate School of Biological Sciences助教
  • 2013/05 - 2016/06  Kyoto UniversityInstitute for Virus Research博士研究員
  • 2013/04 - 2013/04  Kyoto UniversityInstitute for Virus Research研究員

Education

  • 2009/04 - 2013/03  大阪大学大学院  医学系研究科博士課程  予防環境医学専攻
  • 2003/04 - 2009/03  Kitasato University  獣医畜産学部  獣医学科

Association Memberships

  • THE JAPANESE SOCIETY FOR IMMUNOLOGY   

Published Papers

Books etc

  • 免疫・炎症病態x治療Update
    加納資規; 織大祐; 河合太郎 (Contributor１章「自然免疫」)南山堂 2019/05
  • 免疫ペディア
    織 大祐; 河合太郎他 (Contributor２章「自然免疫」)羊土社 2017/07

Conference Activities & Talks

  • 1'-Acetoxychavicol acetate (ACA), acts as an inhibitor of NLRP3 inflammasome  [Invited]
    Daisuke Ori
    USM HC and NAIST Bio Mini-Symposium  2024/12
  • Tropical ginger-derived compound, 1’-Acetoxychavicol acetate, acts as an anti-inflammatory agent and may help fight inflammatory diseases  [Invited]
    Daisuke Ori
    The Tri-lateral NAIST-TLL-CU Joint Symposium 2023  2023/03
  • 1'-acetoxychavicol acetate (ACA) によるNLRP3インフラマソーム抑制効果および関連疾患における病態改善効果の検証  [Invited]
    織大祐
    第5回イムノロジーフォーラム奈良  2020/11
  • 早期の免疫細胞分化におけるZc3h12aとZc3h12cの相補的な機能の解析  [Invited]
    織 大祐
    奈良先端科学技術大学院大学バイオサイエンス研究科セミナー  2016/05

MISC

  • 炎症応答制御に関与する新規環状RNAの同定と機能解析
    廣木秀哉; 織大祐; 加納規資; 河合太郎  第26回免疫サマースクール  2025/08  [Refereed]
  • Exploring the mechanisms of circular RNA involvement in inflammatory response
    Shuya Hiroki; Daisuke Ori; Norisuke Kano; Taro Kawai  Systems Immunology 2025  2025/04
  • Functional analysis of Golgi Stress Response (GSR) in antiviral response
    Rina Toyodome; Daisuke Ori; Norisuke Kano; Taro Kawai  The 53th Annual Meeting of The Japanese Society for Immunology  2024/12
  • Identification and characterization of putative enhancer regions that direct Il6 transcription in murine macrophages
    Norisuke Kano; Takeo Miki; Yurina Uehara; Daisuke Ori; Taro Kawai  The 53th Annual Meeting of The Japanese Society for Immunology  2024/12
  • The role of mitochondria damage in Imiquimod-induced psoriasis
    Daisuke Ori; Haruna Okude; Riko Konishi; Takumi Kawasaki; Taro Kawai  The 53th Annual Meeting of The Japanese Society for Immunology  2024/12
  • Identification of putative Il6 enhancer in murine macrophages
    Norisuke Kano; Takeo Miki; Yurina Uehara; Daisuke Ori; Taro Kawai  The 1st Annual Meeting of the Japanese Cytokine Society  2024/07
  • Comprehensive Identification and Functional Analysis of Circular RNAs Involved in Inflammatory Responses
    Daisuke Ori; Shuya Hiroki; Norisuke Kano; Taro Kawai  The 1st Annual Meeting of the Japanese Cytokine Society  2024/07
  • Exploration and functional analysis of circRNAs regulating inflammatory responses
    廣木秀哉; 織大祐; 加納規資; 河合太郎  第25回日本RNA学会年会  2024/06
  • Manipulation of HSPC lineage priming via antisense-oligonucleotide-mediated expression of Nfkbiz
    Shinnosuke Yamada; Takuya Uehata; Kazunori Toratani; Daisuke Ori; Osamu Takeuchi  The 52th Annual Meeting of The Japanese Society for Immunology  2024/01  [Refereed]
  • The Impact of Chitosan as a Vaccine Adjuvant
    Eri Nagai; Takumi Kawasaki; Daisuke Ori; Taro Kawai  The 52th Annual Meeting of The Japanese Society for Immunology  2024/01  [Refereed]
  • Identification and characterization of putative enhancer regions that direct Il6 transcription in murine macrophages
    Norisuke Kano; Takeo Miki; Yurina Uehara; Daisuke Ori; Taro Kawai  The 52th Annual Meeting of The Japanese Society for Immunology  2024/01  [Refereed]
  • Exploring circular RNAs involved in inflammatory responses
    Shuya Hiroki; Daisuke Ori; Taro Kawai  The 52th Annual Meeting of The Japanese Society for Immunology  2024/01
  • Comprehensive analysis of circular RNAs involved in inflammatory responses
    Shuya Hiroki; Daisuke Ori; Taro Kawai  RNA2023 in OKINAWA  2023/07
  • Characterization of circular RNAs in the regulation of inflammatory responses
    Shuya Hiroki; Daisuke Ori; Taro Kawai  The Now and Future of RNA Therapeutics, AWAJI  2023/06
  • イミキモド誘導性乾癬様皮膚炎の病態形成における小胞体ストレス応答およびミトコンドリアDNAの関与
    織大祐; 奥出遥奈; 小西莉子; 村瀬本弥; 川﨑拓実; 石井健; 中島欽一; 山本雅裕; 河野憲二; 河合太郎  第75回日本細胞生物学会大会  2023/06  [Refereed]
  • Identification and functional analysis of nucleic acid-binding proteins (NBPs) involved in innate immune response
    Kengo Sawamura; Daisuke Ori; Taro Kawai  JSICR/MMCB 2023 Joint Symposium  2023/05
  • The unfolded protein response and pyroptotic mitochondrial DNA release orchestrate to exacerbate imiquimod-induced psoriasis-like dermatitis
    Daisuke Ori; Haruna Okude; Riko Konishi; Motoya Murase; Takumi Kawasaki; Ken J Ishii; Hideyuki Nakashima; Kinichi Nakashima; Miwa Sasai; Masahiro Yamamoto; Akio Tsuru; Kenji Kohno; Taro Kawai  JSICR/MMCB 2023 Joint Symposium  2023/05
  • Regulatory Mechanism in Innate Immune Response by a CCCH-type Zinc Finger Protein, ENZ-1
    Norisuke Kano; Daisuke Ori; Takumi Kawasaki; Taro Kawai  The 51th Annual Meeting of The Japanese Society for Immunology  2022/12  [Refereed]
  • Regulation of Il6 Expression by a Single CpG methylation in the Il6 locus
    Takumi Kawasaki; Benedict Shi Xiang Lian; Daisuke Ori; Taro Kawai  The 51th Annual Meeting of The Japanese Society for Immunology  2022/12  [Refereed]
  • The Regnase-1/3-Nfkbiz axis controls hematopoietic lineage priming
    Takuya Uehata; Daisuke Ori; Masaki Miyazaki; Hiroshi Kawamoto; Osamu Takeuchi  The 51th Annual Meeting of The Japanese Society for Immunology  2022/12  [Refereed]
  • 1′-acetoxychavicol acetate protects against LPS-induced lung injury and acetaminophen-induced acute liver injury
    Daisuke Ori; Guang Han Ong; Candra Trinugraha Afi; Taro Kawai  The 51th Annual Meeting of The Japanese Society for Immunology  2022-  2022/12  [Refereed]
  • 【RNAワクチンの先の基礎研究 核酸と生体防御のメカニズムを解き明かす】異所性DNAの認識機構と生体応答
    織 大祐; 河合 太郎  実験医学  40-  (4)  533  -538  2022/03
  • Identification and functional analysis of nucleic acid-binding proteins (NBPs) involved in innate immune response
    Kengo Sawamura; Daisuke Ori; Taro Kawai  The 50th Annual Meeting of The Japanese Society for Immunology  2021/12  [Refereed]
  • Post-transcriptional regulation of hematopoietic stem and progenitor cell lineage priming by RNases Regnase-1/-3 via Nfkbiz mRNA decay
    Takuya Uehata; Daisuke Ori; Masaki Miyazaki; Amir Giladi; Tomokatsu Ikawa; Hiroshi Kawamoto; Ido Ami; Osamu Takeuchi  The 50th Annual Meeting of The Japanese Society for Immunology  2021/12  [Refereed]
  • 1′-acetoxychavicol acetate inhibits NLRP3-dependent inflammasome activation via mitochondrial ROS suppression
    Daisuke Ori; Sophia Ping Meow Sok; Takumi Kawasaki; Masatoshi Momota; Taro Kawai  The 50th Annual Meeting of The Japanese Society for Immunology  2021/12  [Refereed]
  • Imiquimod (IMQ)による細胞死と炎症誘導機構の解析
    奥出遥奈; 織大祐; 川崎拓実; 百田匡寿; 石井健; 山本雅裕; 河合太郎  第42回日本分子生物学会年会  2019/12
  • The effects of immunomoduratory drug on NLRP3 inflammasome activation
    Guang Han Ong; Daisuke Ori; Takumi Kawasaki; Taro Kawai  The 48th Annual Meeting of The Japanese Society for Immunology  2019/12  [Refereed]
  • Molecular mechanisms of Imiquimod (IMQ)-induced cell death and its role in inflammation
    Haruna Okude; Daisuke Ori; Takumi Kawasaki; Masatoshi Momota; Ken J Ishii; Masahiro Yamamoto; Taro Kawai  The 48th Annual Meeting of The Japanese Society for Immunology  2019/12  [Refereed]
  • Ribonucleases Regnase-1 and Regnase-3 have a critical role in controlling transcriptome biases in LMPP to ensure lymphopoiesis
    Shinnosuke Yamada; Daisuke Ori; Masaki Miyazaki; Takuya Uehata; Osamu Takeuchi  The 48th Annual Meeting of The Japanese Society for Immunology  2019/12  [Refereed]
  • DNA methylation of CpG dinucleotides in the IL-6 gene promoter regulates the level of IL-6 gene expression
    Benedict Shi Xiang Lian; Daisuke Ori; Takumi Kawasaki; Taro Kawai  The 48th Annual Meeting of The Japanese Society for Immunology  2019/12  [Refereed]
  • Inhibitory effects of 1-acetoxychavicol acetate (ACA), a ginger-derived compound, on monosodium urate (MSU) crystal-induced neutrophil recruitment in vivo
    Daisuke Ori; Sophia Ping Meow Sok; Nagoor Noor Hasima; Taro Kawai  The 48th Annual Meeting of The Japanese Society for Immunology  2019/12  [Refereed]
  • Identification and characterization of nucleic acid binding protein regulates innate immune response in paraspeckles
    Naoya Ushijima; Daisuke Ori; Taro Kawai  The 18th Awaji International Forum on Infection and Immunity  2019/09  [Refereed]
  • 免疫細胞を制御するRNA結合タンパク質の機能解析
    植畑拓也; 山田信之輔; 織大祐; 今見考志; 宮崎正輝; 石濱泰; 河本宏; 竹内理  第42回日本分子生物学会年会  2019
  • Elucidation of molecular mechanism of interleukin 33 release
    Mizuka Nagayama; Takumi Kawasaki; Daisuke Ori; Taro Kawai  The 47th Annual Meeting of the Japanese Society for Immunology  2018/12  [Refereed]
  • Inhibition of NLRP3 inflammasome-mediated IL-1b release by 1'-acetoxychavicol acetate (ACA), a ginger-derived compound
    Sophia Ping Meow Sok; Daisuke Ori; Noor Hasima Nagoor; Taro Kawai  The 47th Annual Meeting of the Japanese Society for Immunology  2018/12  [Refereed]
  • Regnase-1 and Regnase-3 regulate cell fate of early lymphoid progenitors in the bone marrow
    Takuya Uehata; Daisuke Ori; Masaki Miyazaki; Hiroshi Kawamoto; Osamu Takeuchi  The 47th Annual Meeting of the Japanese Society for Immunology  2018/12  [Refereed]
  • IL-33産生を制御する分子機構の解明
    長山瑞佳; 川崎拓実; 織大祐; 河合太郎  第41回日本分子生物学会年会  2018/11
  • Elucidation of cell death pathway induced by imiquimod (R837)
    Haruna Okude; Daisuke Ori; Takumi Kawasaki; Motoya Murase; Ken J Ishii; Taro Kawai  EMBO Workshop "The inflammasomes"  2018年度-  2018/09  [Refereed]
  • Tropical ginger compound, 1’-acetoxychavicol acetate (ACA), inhibits NLRP3 inflammasome activation
    Sophia Ping; Meoq Sok; Daisuke Ori; Noor Hasima Nagoor; Taro Kawai  EMBO Workshop "The inflammasomes"  2018年度-  2018/09  [Refereed]
  • RNA分解酵素Regnase‐1とRegnase‐3は血球前駆細胞のリンパ球への分化に必須である
    山田信之輔; 植畑拓也; 織大祐; 宮崎正輝; 竹内理  第41回日本分子生物学会年会  .1P‐0544 (WEB ONLY)  2018
  • Imiquimod(R837)によるTLR7非依存的な細胞死の誘導
    奥出 遥奈; 川崎 拓実; 織 大祐; 村瀬 本弥; 石井 健; 河合 太郎  生命科学系学会合同年次大会  2017年度-  [1P  -1083]  2017/12
  • Induction of cell death by Imiquimod (R837) and its role in immune responses
    Haruna Okude; Takumi Kawasaki; Daisuke Ori; Motoya Murase; Ken Ishii; Taro Kawai  The 46th Annual Meeting of The Japanese Society for Immunology  2017/12  [Refereed]
  • 組織マクロファージの分化・活性化の分子機構
    織大祐; 竹内理  炎症と免疫  24-  (4)  336‐339  2016/06
  • 早期の免疫細胞分化におけるZc3h12aとZc3h12cの相補的な機能の解析
    織大祐  奈良先端科学技術大学院大学バイオサイエンス研究科セミナー  2016/05  [Invited]
  • Arl5BによるMDA5依存的な抗ウイルス自然免疫応答の抑制機構の解明
    鍛代悠一; 織大祐; 末吉拓也; 川崎拓実; 竹内理; 松田正; 審良静男; 河合太郎  日本薬学会年会要旨集(CD-ROM)  136th-  ROMBUNNO.29AB‐AM249  2016
  • Zc3h12a and Zc3h12c redundantly function in early B cell differentiation
    Daisuke Ori; Yasuhiro Murakawa; Hisanori Kiryu; Osamu Takeuchi  RNA Frontier Meeting 2015  2015/12  [Refereed]
  • Arl5BによるMDA5依存的な自然免疫シグナルの抑制機構の解明
    鍛代悠一; 織大祐; 末吉拓也; 村瀬本弥; 川崎拓実; 竹内理; 審良静男; 河合太郎  第37回日本分子生物学会年会  37th-  2P-0726 (WEB ONLY)  2014
  • Essential roles of K63-linked polyubiquitin binding proteins, TAB2 and TAB3, in B cell activation via MAPKs
    Daisuke Ori; Hiroki Kato; Hideki Sanjo; Sarang Tartey; Takashi Mino; Shizuo Akira; Osamu Takeuchi  12th Awaji International Forum on Infection and Immunity  2013/09  [Refereed]
  • Essential roles of K63-linked polyubiquitin binding proteins, TAB2 and TAB3, in B cell activation via MAPKs
    Daisuke Ori; Hiroki Kato; Hideki Sanjo; Sarang Tartey; Takashi Mino; Shizuo Akira; Osamu Takeuchi  11th International Student Seminar  2013/03  [Refereed]
  • 最新の免疫学~自然免疫・獲得免疫~1.自然免疫と炎症制御の分子機構
    織大祐; 織大祐; 竹内理  医薬ジャーナル  49-  (2)  651  -656  2013/02
  • Essential roles of TAB2 and TAB3 in the activation of MAPK, but not NF-B, in B cells
    Daisuke Ori; Hiroki Kato; Hideki Sanjo; Sarang Tartey; Takashi Mino; Shizuo Akira; Osamu Takeuchi  The 41th Annual Meeting of the Japanese Society for Immunology  2012/11  [Refereed]

Research Grants & Projects

  • ACAによる代謝性疾患および自己炎症性疾患改善効果の検証
    日本学術振興会：科学研究費助成事業
    Date (from‐to) : 2021/04 -2024/03 
    Author : 織 大祐
     
    本研究では、東南アジア原産のショウガ種に由来する成分である1'acetoxychavicol acetate (ACA) が、細胞内免疫複合体であるインフラマソームの形成に対してどのような効果を有するのかを評価した。インフラマソームは、NLRP3を代表とした様々な細胞内自然免疫受容体を起点として形成され、炎症性サイトカインであるIL-1betaやIL-18の放出に必須であり、様々な自己炎症性・自己免疫性疾患に関与することが明らかとなっている。マウス骨髄由来マクロファージをACAで処置したのち、細菌毒素であるNigericineや内因性のダメージ関連分子であるATP、細菌の鞭毛成分であるフラジェリン、DNAであるpoly(dA:dT)などの活性化剤を用いてインフラマソーム形成を誘導したところ、ACAはNLRP3を介したインフラマソーム形成を抑制していた。それに伴いACAは、NLRP3活性化時のCaspase-1の活性化やIL-1betaの放出、免疫原性を有するパイロトーシスと呼ばれる細胞死を抑制した。一方、NLRP3以外の自然免疫受容体（NLRC4やAIM2など）を介したインフラマソーム形成に対しては効果を示さなかった。さらに詳細な解析を行ったところ、ACAは、ミトコンドリア内を含む細胞内の活性酸素種の産生を抑制することで、内因性のNLRP3活性化物質である酸化ミトコンドリアDNAの生成および細胞質への放出を抑制していることを見出した。次に、マウスを用いて個体レベルでのACAの効果を評価した。疾患モデルとして、NLRP3インフラマソームが関与することが知られる炎症性腸疾患モデル（DSS腸炎モデル）を選択し、ACAを給餌により投与したところ、その病態の改善が見られた。これらのことから、ACAはNLRP3関連疾患において病態改善効果を有する可能性が示唆された。
  • Elucidating the importance of HuR and identifing novel regulatory factor in innate immune system-regulating mechanisms
    Japan Society for the Promotion of Science：Grants-in-Aid for Scientific Research
    Date (from‐to) : 2017/04 -2019/03 
    Author : ORI Daisuke
     
    Although previous research in our laboratory indicated that HuR positively regulated anti-viral responses, detailed mechanisms have been still unknown. In this research, we revealed that HuR stabilized Plk2 mRNA through 4th one of four AU-rich element in Plk2 mRNA 3’-untranslated region, resulting in the promotion of anti-viral responses by indirectly and positively regulating nuclear translocation of IRF3. Furthermore, we identified two candidate genes which may be involved in the regulation of innate immune responses by performing CRISPR/Cas9 system-based screening focusing on RNA-binding proteins. Currently, we are generating and analyzing genetically modified mice to clarify the physiological importance of these two genes.

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