Role for periarterial adipose tissue in atherosclerosis in obesity
Japan Society for the Promotion of Science:Grants-in-Aid for Scientific Research
Date (from‐to) : 2012/04 -2015/03
Author : OHMORI Koji; HASAN Arif Ul; KOHNO Masakazu; NOMA Takahisa; IMACHI Hitomi; ISHIHARA Yasuhiro; HORII Taiko; YAMASHITA Yoichi
It is hypothesized that periarterial adipose tissue releases vascular endothelial growth factor (VEGF) and proinflammatory cytokines into vascular wall from adventitial side to grow the atherosclerotic plaques. In this study employing mature adipocytes, block of constitutive activity of angiotensin II type-1 receptor by valsartan decreased production of interleukin-6 and increased that of adiponectin. However, another putative anti-atherosclerotic fatty acid, eicosapentaenoic acid promoted the production of VEGF through an integrated mechanism including G-protein coupled receptor 120 and peroxisome-proliferator activated receptor-gamma. These findings provide for the comprehensive understanding of the "out-side-in" mechanisms for atherosclerosis.