Analysis of the molecular mechanism of fusobacterial coaggregation with other oral bacteria
Japan Society for the Promotion of Science:Grants-in-Aid for Scientific Research Grant-in-Aid for Early-Career Scientists
Date (from‐to) : 2020/04 -2022/03
Author : Tada Ayano
Fusobacterium nulceatum co-aggregates with other oral microbes. We found that the culture supernatant of A. naeslundii enhanced the growth and autoaggregation of F. nucleatum. Transcriptome analysis of F. nucleatum revealed that the expression of the genes for D-fructose utilization was up-regulated in response to the culture supernatant of A. naeslundii. In consistent with the finding, D-fructose promoted the growth of F. nucleatum and biofilm formation. Furthermore, the adherence of F. nucleatum to Ca9-22, human gingival cancer cell, when the bacterium was cultured in BHIS medium containing D-fructose. These results indicate that the adaptation of F. nucleatum to environmental changes such as nutritional status closely associates with the formation of complex bacterial consortium in subgingival region, resulting in the progression of periodontal diseases.