Yanagita Ryo

Researcher Information

Degree

• Ph.D. in Agriculture（2009/03 Kyoto University）

Research Interests

• rare sugar   生物有機化学   天然物化学   tumor promoter   drug design   bio-organic chemistry   Natural product chemistry   

Research Areas

• Life sciences / Bioorganic chemistry

Academic & Professional Experience

• 2026/04 - Today  Kagawa University, Academic Group of Life SciencesFaculty of AgricultureProfessor
• 2016/10 - 2026/03  Kagawa University, Academic Group of Life SciencesFaculty of AgricultureAssociate Professor
• 2010/10 - 2016/09  Kagawa UniversityFaculty of AgricultureAssistant Professor
• 2010/08 - 2010/09  Graduate School of Agriculture, Kyoto UniversityResearch fellow
• 2010/04 - 2010/08  Kyoto UniversityCenter for the Promotion of Excllence in Higher EducationLecturer (part-time)
• 2009/04 - 2010/03  Japan Society for the Promotion of ScienceJSPS Research Fellow (PD)
• 2008/04 - 2009/03  Japan Society for the Promotion of ScienceJSPS Research Fellow (DC2)

Education

• 2006/04 - 2009/03  Kyoto University  Graduate School of Agriculture  Division of Food Science and Biotechnology (Doctoral course)
• 2004/04 - 2006/03  Kyoto University  Graduate School of Agriculture  Division of Food Science and Biotechnology (Master course)
• 2000/04 - 2004/03  Kyoto University  Faculty of Agriculture  Department of Biofunctional Science

Association Memberships

• The Society of Synthetic Organic Chemistry, Japan   Japan Society for Bioscience, Biotechnology, and Agrochemistry   American Chemical Society   

Published Papers

• Synthesis, cytotoxicity, and pyoverdine production inhibitory activity of actinomycin lactam analogs

  Kenta Yamanoue; Yasumasa Hara; Ryo C Yanagita; Yusuke Hanaki

  Bioscience, Biotechnology, and Biochemistry Oxford University Press (OUP) 2026/07 [Refereed]
  
• Isolation and characterization of blastmycetin G, a sofa-conformation fixed analog of teleocidin B’s, produced by Streptomyces blastmyceticus

  Shin-ichiro Kajiyama; Ryo C Yanagita; Chihiro Tsukano; Kazuhiro Irie

  Bioscience, Biotechnology, and Biochemistry Oxford University Press (OUP) 90 (6) 741 - 745 2026/03 [Refereed]
  
• Identification of New Cyclocircadins from Cyclocybe erebia and Their Effects on the Circadian Rhythm of Human Osteosarcoma Cells

  Kota Seki; Keisuke Kariya; Ryo Miyata; Daisuke Sasaki; Yusei Kobayashi; Kotomi Ueno; Ryo C. Yanagita; Yu Tahara; Yoshihiro Nakajima; Atsushi Ishihara

  Journal of Natural Products American Chemical Society (ACS) 89 (2) 421 - 432 0163-3864 2026/01 [Refereed]
  
• Synthesis of Unnatural Aplysiatoxin Analogs with High Affinity for Protein Kinase C

  Mana Morishita; Kohei Hada; Yusuke Araki; Keisuke Fukaya; Daisuke Urabe; Ryo C. Yanagita; Jumpei Maki; Yusuke Hanaki; Masaki Kita; Kazuhiro Irie; Toshio Nishikawa

  European Journal of Organic Chemistry Wiley 28 (42) e202500890  1434-193X 2025/10 [Refereed]
  
• Six-step synthesis and epithelial–mesenchymal transition-inhibitory activity of a tetralone-based vitetrifolin analog

  Yusuke Hanaki; Yasunori Sugiyama; Ryo C. Yanagita

  Bioscience, Biotechnology, and Biochemistry Oxford University Press (OUP) 89 (6) 805 - 810 2025/03 [Refereed]
  
• Validation of Machine Learning-assisted Screening of PKC Ligands: PKC Binding Affinity and Activation

  Jumpei Maki; Asami Oshimura; Yudai Shiotani; Maki Yamanaka; Sogen Okuda; Ryo C. Yanagita; Shigeru Kitani; Yasuhiro Igarashi; Yutaka Saito; Yasubumi Sakakibara; Chihiro Tsukano; Kazuhiro Irie

  Bioscience, Biotechnology, and Biochemistry Oxford University Press (OUP) 89 (5) 668 - 679 2025/01 [Refereed]
  
• Identification of sesquiterpene aldehydes as volatile antifungal compounds in Phaeolepiota aurea culture filtrate

  Kota Seki; Tomoya Tanaka; Emiko Shimoda; Shinji Tanio; Ryo C. Yanagita; Tsugumi Miyazaki; Kento Tokumoto; Toshiaki Tazawa; Kumiko Osaki-Oka; Atsushi Ishihara

  Bioscience, Biotechnology, and Biochemistry Oxford University Press (OUP) 88 (12) 1395 - 1402 2024/09 [Refereed]
  
• Effect of phenolic-hydroxy-group incorporation on the biological activity of a simplified aplysiatoxin analog with an (R)-(−)-carvone-based core

  Ryo C. Yanagita; Yoshiyuki Suzuki; Yasuhiro Kawanami; Yusuke Hanaki; Kazuhiro Irie

  Bioscience, Biotechnology, and Biochemistry Oxford University Press (OUP) 88 (9) 992 - 998 2024/06 [Refereed]
  
• A new labdane-type diterpenoid from leaves of Vitex rotundifolia

  Yusuke Hanaki; Rintaro Abe; Yasunori Sugiyama; Yasumasa Hara; Ryo C. Yanagita

  Results in Chemistry Elsevier BV 7 101512  2211-7156 2024/04 [Refereed]
  
• Biological evaluation of a phosphate ester prodrug of 10-methyl-aplog-1, a simplified analogue of aplysiatoxin, as a possible latency-reversing agent for HIV reactivation

  Jumpei Maki; Yusuke Hanaki; Ryo C Yanagita; Masayuki Kikumori; Anastasiia Kovba; Ayaka Washizaki; Chihiro Tsukano; Hirofumi Akari; Kazuhiro Irie

  Bioscience, Biotechnology, and Biochemistry Oxford University Press (OUP) 87 (12) 1453 - 1461 2023/09 [Refereed]
  
• Cell Morphology-Based Screening Identified Vitetrifolin D from Vitex rotundifolia as an Inhibitor of Phorbol Ester–Induced Downregulation of E-Cadherin in HHUA Endometrial Cells

  Yusuke Hanaki; Nichika Iwase; Yasunori Sugiyama; Sena Miyoshi; Ryo C. Yanagita

  BPB Reports Pharmaceutical Society of Japan 6 (3) 103 - 107 2023
• A simplified analog of debromoaplysiatoxin lacking the B-ring of spiroketal moiety retains protein kinase C-binding and antiproliferative activities

  Tomoki Sekido; Kosuke Yamamoto; Ryo C. Yanagita; Yasuhiro Kawamani; Yusuke Hanaki; Kazuhiro Irie

  Bioorganic & Medicinal Chemistry Elsevier BV 73 116988  0968-0896 2022/11 [Refereed]
  
• Structural basis of the 24B3 antibody against the toxic conformer of amyloid β with a turn at positions 22 and 23

  Yumi Irie; Yuka Matsushima; Akiko Kita; Kunio Miki; Tatsuya Segawa; Masahiro Maeda; Ryo C. Yanagita; Kazuhiro Irie

  Biochem. Biophys. Res. Commun. Elsevier BV 621 162 - 167 0006-291X 2022/09 [Refereed]
  
• 12-O-Tetradecanoylphorbol 13-acetate promotes proliferation and epithelial–mesenchymal transition in HHUA cells cultured on collagen type I gel: A feasible model to find new therapies for endometrial diseases

  Yusuke Hanaki; Sena Miyoshi; Yasunori Sugiyama; Ryo C Yanagita; Masashi Sato

  Bioscience, Biotechnology, and Biochemistry Oxford University Press (OUP) 86 (10) 1417 - 1422 2022/08 [Refereed]
  
• Synthesis and Characterization of Propeller- and Parallel-Type Full-Length Amyloid β40 Trimer Models

  Ayumi Uchino; Yumi Irie; Chihiro Tsukano; Taiji Kawase; Kenji Hirose; Yusuke Kageyama; Ikuo Tooyama; Ryo C. Yanagita; Kazuhiro Irie

  ACS Chemical Neuroscience American Chemical Society (ACS) 13 (16) 2517 - 2528 1948-7193 2022/08 [Refereed]
  
• Design, synthesis, and biological activity of a synthetically accessible analog of aplysiatoxin with an (R)-(−)-carvone-based conformation-controlling unit

  Yoshiyuki Suzuki; Keiichi Moritoki; Mizuki Kajiwara; Ryo C Yanagita; Yasuhiro Kawanami; Yusuke Hanaki; Kazuhiro Irie

  Bioscience, Biotechnology, and Biochemistry Oxford University Press (OUP) 86 (8) 1013 - 1023 2022/08 [Refereed]
  
• Analysis of binding mode of vibsanin A with protein kinase C C1 domains: An experimental and molecular dynamics simulation study

  Ryo C. Yanagita; Mao Otani; Satoshi Hatanaka; Hiroto Nishi; Shota Miyake; Yusuke Hanaki; Masashi Sato; Yasuhiro Kawanami; Kazuhiro Irie

  Journal of Molecular Structure Elsevier BV 1260 132866  0022-2860 2022/07 [Refereed]
  
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• AI and computational chemistry-accelerated development of an alotaketal analogue with conventional PKC selectivity

  Jumpei Maki; Asami Oshimura; Chihiro Tsukano; Ryo C. Yanagita; Yutaka Saito; Yasubumi Sakakibara; Kazuhiro Irie

  Chemical Communications Royal Society of Chemistry (RSC) 58 (47) 6693 - 6696 1359-7345 2022/05 [Refereed]
  
• Structure optimization of the toxic conformation model of amyloid β42 by intramolecular disulfide bond formation

  Yuka Matsushima; Yumi Irie; Yusuke Kageyama; Jean-Pierre Bellier; Ikuo Tooyama; Takahito Maki; Toshiaki Kume; Ryo C. Yanagita; Kazuhiro Irie

  ChemBioChem Wiley 23 (8) e202200029  1439-4227 2022/02 [Refereed][Invited]
  
• Oscillatoxin E and Its C7 Epimer Show Distinct Growth Inhibition Profiles against Several Cancer Cell Lines

  Yusuke Hanaki; Yusuke Araki; Toshio Nishikawa; Ryo C. Yanagita

  Heterocycles The Japan Institute of Heterocyclic Chemistry 102 (12) 2353 - 2362 0385-5414 2021/09 [Refereed]
  
• Evaluation of the in vitro cytotoxicity of oscillatoxins E and F under nutrient-starvation culture conditions

  Yusuke Hanaki; Yusuke Araki; Toshio Nishikawa; Ryo C. Yanagita

  Fundamental Toxicological Sciences Japanese Society of Toxicology 8 (3) 69 - 73 2021
• Effects of side chain length of 10-methyl-aplog-1, a simplified analog of debromoaplysiatoxin, on PKC binding, anti-proliferative, and pro-inflammatory activities

  Atsuko Gonda; Koji Takada; Ryo C. Yanagita; Shingo Dan; Kazuhiro Irie

  Biosci. Biotechnol. Biochem. Oxford University Press (OUP) 85 (1) 168 - 180 2021/01 [Refereed]
  
• Synthesis and biological activities of simplified aplysiatoxin analogs focused on the CH/π interaction

  Takumi Kobayashi; Ryo C. Yanagita; Kazuhiro Irie

  Bioorganic & Medicinal Chemistry Letters Elsevier BV 30 (24) 127657  0960-894X 2020/10 [Refereed]
  
• Evaluation of the Anti-Proliferative Activity of Rare Aldohexoses against MOLT-4F and DU-145 Human Cancer Cell Line and Structure-Activity Relationship of D-Idose

  Hironobu Ishiyama; Ryo C. Yanagita; Kazune Takemoto; Natsumi Kitaguchi; Yuuki Uezato; Yasunori Sugiyama; Masashi Sato; Yasuhiro Kawanami

  Journal of Applied Glycoscience The Japanese Society of Applied Glycoscience 67 (3) 95 - 101 1344-7882 2020/09 [Refereed]
  
• Control of the Toxic Conformation of Amyloid β42 by Intramolecular Disulfide Bond Formation

  Yuka Matsushiyma; Ryo C. Yanagita; Kazuhiro Irie

  Chem. Commun. Royal Society of Chemistry (RSC) 56 (29) 4118 - 4121 1359-7345 2020/04 [Refereed]
  
• Development of a D-allose-6-phosphate derivative with anti-proliferative activity against a human leukemia MOLT-4F cell line

  Hironobu Ishiyama; Ryo C. Yanagita; Kazune Takemoto; Katsuya Kobashi; Yasunori Sugiyama; Yasuhiro Kawanami

  Carbohydr. Res. 487 107859  2020/01 [Refereed]
  
• Nematocidal activity of 6-O-octanoyl- and 6-O-octyl-D-allose against larvae of Caenorhabditis elegans

  Hirofumi Sakoguchi; Tomoya Shintani; Hironobu Ishiyama; Ryo C. Yanagita; Yasuhiro Kawanami; Masashi Sato

  Biosci. Biotechnol. Biochem. 83 (12) 2194 - 2197 2019/11 [Refereed]
  
• Synthesis, Conformation, and Biological Activities of a Des-A-Ring Analog of 18-Deoxy-aplog-1, a Simplified Analog of Debromoaplysiatoxin

  Yoshiki Ashida; Ryo C. Yanagita; Yasuhiro Kawanami; Mutsumi Okamura; Shingo Dan; Kazuhiro Irie

  Heterocycles 99 (2) 942 - 957 2019/06 [Refereed][Invited]
  
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• Synthesis and biochemical characterization of quasi-stable trimer models of full-length amyloid β40 with a toxic conformation

  Yumi Irie; Mizuho Hanaki; Kazuma Murakami; Tsuneo Imamoto; Takumi Furuta; Takeo Kawabata; Taiji Kawase; Kenji Hirose; Yoko Monobe; Ken-ichi Akagi; Ryo C. Yanagita; Kazuhiro Irie

  Chem. Commun. Royal Society of Chemistry (RSC) 55 (2) 182 - 185 1359-7345 2019/01 [Refereed]
  
• Synthesis and Biological Activities of Acetal Analogs at Position 3 of 10-Methyl-Aplog-1, a Potential anti-Cancer Lead Derived from Debromoaplysiatoxin

  Koutaro Hayakawa; Yusuke Hanaki; Harukuni Tokuda; Ryo C. Yanagita; Yu Nakagawa; Mutsumi Okamura; Shingo Dan; Kazuhiro Irie

  Heterocycles 97 (1) 478 - 492 2018/09 [Refereed][Invited]
  
• Practical Enantioselective Reduction of Ketones Using Oxazaborolidine Catalysts Generated In Situ from Chiral Lactam Alcohols

  Yasuhiro Kawanami; Ryo C. Yanagita

  Molecules 23 (10) E2408  2018/09 [Refereed][Invited]
  
• Synthesis and inhibitory activity of deoxy-D-allose amide derivative against plant growth

  Tazul Islam Chowdhury; Hikaru Ando; Ryo C. Yanagita; Yasuhiro Kawanami

  Bioscience, Biotechnology and Biochemistry Japan Society for Bioscience Biotechnology and Agrochemistry 82 (5) 775 - 779 1347-6947 2018 [Refereed]
  
• Loss of the Phenolic Hydroxyl Group and Aromaticity from the Side Chain of Anti-Proliferative 10-Methyl-aplog-1, a Simplified Analog of Aplysiatoxin, Enhances Its Tumor-Promoting and Proinflammatory Activities

  Yusuke Hanaki; Masayuki Kikumori; Harukuni Tokuda; Mutsumi Okamura; Shingo Dan; Naoko Adachi; Naoaki Saito; Ryo C. Yanagita; Kazuhiro Irie

  Molecules 22 (4) 631  1420-3049 2017/04 [Refereed]
  
• Inhibitory activity of 6-O-decyl-D-allose and 6-(decanoylamino)-6-deoxy-D-allose against plant growth

  Haruka Yamaashi; Md. Tazul; Islam Chowdhury; Ryo C. Yanagita; Yasuhiro Kawanami

  Tech. Bull. Fac. Agr. Kagawa Univ. 香川大学農学部 69 (122) 17 - 21 0368-5128 2017/02
• Binding mode prediction of aplysiatoxin, a potent agonist of protein kinase C, through molecular simulation and structure-activity study on simplified analogs of the receptor-recognition domain

  Yoshiki Ashida; Ryo C. Yanagita; Chise Takahashi; Yasuhiro Kawanami; Kazuhiro Irie

  Bioorganic & Medicinal Chemistry 24 (18) 4218 - 4227 0968-0896 2016/09 [Refereed]
  
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• Syntheses and biological activities of deoxy-D-allose fatty acid ester analogs

  Md. Tazul Islam Chowdhury; Hikaru Ando; Ryo C. Yanagita; Yasuhiro Kawanami

  Biosci. Biotechnol. Biochem. 80 (4) 676 - 681 0916-8451 2016/04 [Refereed]
  
• Structural optimization of 10-methyl-aplog-1, a simplified analog of debromoaplysiatoxin, as an anticancer lead

  Masayuki Kikumori; Ryo C. Yanagita; Harukuni Tokuda; Kiyotake Suenaga; Hiroshi Nagai; Kazuhiro Irie

  Biosci. Biotechnol. Biochem. 80 (2) 221 - 231 0916-8451 2016/02 [Refereed]
  
• Synthesis and biological activities of the amide derivative of aplog-1, a simplified analog of aplysiatoxin with anti-proliferative and cytotoxic activities

  Yusuke Hanaki; Ryo C. Yanagita; Takahiro Sugahara; Misako Aida; Harukuni Tokuda; Nobutaka Suzuki; Kazuhiro Irie

  Biosci. Biotechnol. Biochem. 79 (6) 888 - 895 0916-8451 2015/06 [Refereed]
  
• Effect of BF₃ on the enantioselective reduction of trifluoromethyl ketones using a chiral lactam alcohol with borane

  Yuki Harauchi; Chihiro Takakura; Toshio Furumoto; Ryo C. Yanagita; Yasuhiro Kawanami

  Tetrahedron: Asymmetry 26 (7) 333 - 337 0957-4166 2015/04 [Refereed]
  
• Synthesis of 6-O-decanoyl-D-altrose and 6-O-decanoyl-D-gulose and evaluation of their biological activity on plant growth

  Md Tazul Islam Chowdhury; Madoka Naito; Ryo C. Yanagita; Yasuhiro Kawanami

  Plant Growth Regulation 75 (3) 707 - 713 0167-6903 2015/04 [Refereed]
  
• Improved and large-scale synthesis of 10-methyl-aplog-1, a potential lead for an anticancer drug

  Masayuki Kikumori; Ryo C. Yanagita; Kazuhiro Irie

  Tetrahedron 70 (52) 9776 - 9782 0040-4020 2014/12 [Refereed]
  
• Synthesis and Biological Activities of Simplified Analogs of the Natural PKC Ligands, Bryostatin-1 and Aplysiatoxin

  Kazuhiro Irie; Ryo C. Yanagita

  Chem. Rec. 14 (2) 251 - 267 1527-8999 2014/04 [Refereed][Invited]
  
• Anti-proliferative activity of 6-O-acyl-D-allose against the human leukemia MOLT-4F cell line

  Ryo C. Yanagita; Katsuya Kobashi; Chisa Ogawa; Yoshiki Ashida; Haruka Yamaashi; Yasuhiro Kawanami

  Biosci. Biotechnol. Biochem. 78 (2) 190 - 194 0916-8451 2014/02 [Refereed]
  
• Effects of two sulfated triterpene saponins echinoside A and holothurin A on the inhibition of dietary fat absorption and obesity reduction

  Yuming Wang; Jiahui Wang; Ryo C. Yanagita; Chunhua Liu; Xiaoqian Hu; Ping Dong; Changhu Xue; Yong Xue

  Biosci. Biotechnol. Biochem. 78 (1) 139 - 146 0916-8451 2014/01 [Refereed]
  
• Effects of the methoxy group in the side chain of debromoaplysiatoxin on its tumor-promoting and anti-proliferative activities

  Ryo C. Yanagita; Hiroaki Kamachi; Masayuki Kikumori; Harukuni Tokuda; Nobutaka Suzuki; Kiyotake Suenaga; Hiroshi Nagai; Kazuhiro Irie

  Bioorganic and Medicinal Chemistry Letters 23 (15) 4319 - 4323 0960-894X 2013/08 [Refereed]
  
• Structure-activity studies on the side chain of a simplified analog of aplysiatoxin (aplog-1) with anti-proliferative activity

  Hiroaki Kamachi; Keisuke Tanaka; Ryo C. Yanagita; Akira Murakami; Kazuma Murakami; Harukuni Tokuda; Nobutaka Suzuki; Yu Nakagawa; Kazuhiro Irie

  Bioorg. Med. Chem. 21 (10) 2695 - 2702 0968-0896 2013/05 [Refereed]
  
• SYNTHESIS OF ANTINEOPLASTIC ANALOGS OF APLYSIATOXIN WITH VARIOUS SIDE CHAIN STRUCTURES

  Yuki Shu; Ryo C. Yanagita; Harukuni Tokuda; Nobutaka Suzuki; Kazuhiro Irie

  Heterocycles 86 (1) 281 - 303 0385-5414 2012/12 [Refereed]
  
• Structure-Activity Studies on the Spiroketal Moiety of a Simplified Analogue of Debromoaplysiatoxin with Antiproliferative Activity

  Masayuki Kikumori; Ryo C. Yanagita; Harukuni Tokuda; Nobutaka Suzuki; Hiroshi Nagai; Kiyotake Suenaga; Kazuhiro Irie

  J. Med. Chem. 55 (11) 5614 - 5626 0022-2623 2012/06 [Refereed]
  
• Identification and Biological Activities of Bryostatins from Japanese Bryozoan

  Sayo Ueno; Ryo C. Yanagita; Kazuma Murakami; Akira Murakami; Harukuni Tokuda; Nobutaka Suzuki; Takeshi Fujiwara; Kazuhiro Irie

  Biosci. Biotechnol. Biochem. 76 (5) 1041 - 1043 0916-8451 2012/05 [Refereed]
  
• Challenges to the development of bryostatin-type anticancer drugs based on the activation mechanism of protein kinase C delta

  Kazuhiro Irie; Ryo C. Yanagita; Yu Nakagawa

  MEDICINAL RESEARCH REVIEWS 32 (3) 518 - 535 0198-6325 2012/05 [Refereed][Invited]
  
• Synthesis and structure-activity studies of simplified analogues of aplysiatoxin with antiproliferative activity like bryostatin-1

  Kazuhiro Irie; Masayuki Kikumori; Hiroaki Kamachi; Keisuke Tanaka; Akira Murakami; Ryo C. Yanagita; Harukuni Tokuda; Nobutaka Suzuki; Hiroshi Nagai; Kiyotake Suenaga; Yu Nakagawa

  Pure Appl. Chem. 84 (6) 1341 - 1351 0033-4545 2012 [Refereed][Invited]
  
• Enantioselective reduction of alpha,beta-enones using an oxazaborolidine catalyst generated in situ from a chiral lactam alcohol

  Yasuhiro Kawanami; Yudai Mikami; Kazuya Kiguchi; Yuki Harauchi; Ryo C. Yanagita

  TETRAHEDRON-ASYMMETRY 22 (20-22) 1891 - 1894 0957-4166 2011/11 [Refereed]
  
• Generation of 'Unnatural Natural Product' library and identification of a small molecule inhibitor of XIAP

  Tatsuro Kawamura; Kohei Matsubara; Hitomi Otaka; Etsu Tashiro; Kazutoshi Shindo; Ryo C. Yanagita; Kazuhiro Irie; Masaya Imoto

  Bioorg. Med. Chem. 19 (14) 4377 - 4385 0968-0896 2011/07 [Refereed]
  
• Synthesis and Biological Evaluation of the 12,12-Dimethyl Derivative of Aplog-1, an Anti-Proliferative Analog of Tumor-Promoting Aplysiatoxin

  Yu Nakagawa; Masayuki Kikumori; Ryo C. Yanagita; Akira Murakami; Harukuni Tokuda; Hiroshi Nagai; Kazuhiro Irie

  Biosci. Biotechnol. Biochem. 75 (6) 1167 - 1173 0916-8451 2011/06 [Refereed]
  
• Role of the phenolic hydroxyl group in the biological activities of simplified analogue of aplysiatoxin with antiproliferative activity

  Ryo C. Yanagita; Hiroaki Kamachi; Keisuke Tanaka; Akira Murakami; Yu Nakagawa; Harukuni Tokuda; Hiroshi Nagai; Kazuhiro Irie

  Bioorg. Med. Chem. Lett. 20 (20) 6064 - 6066 0960-894X 2010/10 [Refereed]
  
• A Simple Analogue of Tumor-Promoting Aplysiatoxin Is an Antineoplastic Agent Rather Than a Tumor Promoter: Development of a Synthetically Accessible Protein Kinase C Activator with Bryostatin-like Activity

  Yu Nakagawa; Ryo C. Yanagita; Naoko Hamada; Akira Murakami; Hideyuki Takahashi; Naoaki Saito; Hiroshi Nagai; Kazuhiro Irie

  J. Am. Chem. Soc. 131 (22) 7573 - 7579 0002-7863 2009/06 [Refereed]
  
• Synthesis, conformational analysis, and biological evaluation of 1-hexylindolactam-V10 as a selective activator for novel protein kinase C isozymes

  Ryo C. Yanagita; Yu Nakagawa; Nobuhiro Yamanaka; Kaori Kashiwagi; Naoaki Saito; Kazuhiro Irie

  J. Med. Chem. 51 (1) 46 - 56 0022-2623 2008/01 [Refereed]
  
• Binding selectivity of 1- or 12-substituted indolactam derivatives for protein kinase C isozymes

  Ryo C. Yanagita; Keiji Torii; Yu Nakagawa; Kazuhiro Irie

  Heterocycles 73 (1) 289 - + 0385-5414 2007/12 [Refereed]
  
• Design and synthesis of 8-octyl-benzolactam-V9, a selective activator for protein kinase C epsilon and eta

  Y Nakagawa; K Irie; RC Yanagita; H Ohigashi; K Tsuda; K Kashiwagi; N Saito

  JOURNAL OF MEDICINAL CHEMISTRY 49 (9) 2681 - 2688 0022-2623 2006/05 [Refereed]
  
• Three genomes differentially contribute to the biosynthesis of benzoxazinones in hexaploid wheat

  T Nomura; A Ishihara; RC Yanagita; TR Endo; H Iwamura

  Proc. Natl. Acad. Sci. U.S.A. 102 (45) 16490 - 16495 0027-8424 2005/11 [Refereed]
  
• Indolactam-V is involved in the CH/pi interaction with pro-11 of the PKC delta C1B domain: Application for the structural optimization of the PKC delta ligand

  Y Nakagawa; K Irie; RC Yanagita; H Ohigashi; K Tsuda

  JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 127 (16) 5746 - 5747 0002-7863 2005/04 [Refereed]
  

Conference Activities & Talks

• ヘキソース6-リン酸の標的分子の同定を指向した分子プローブの合成研究  [Not invited]

  楠姫菜子; 栁田亮; 花木祐輔

  日本農芸化学会中四国支部第 74 回講演会（例会）  2026/06  高知 

  講演番号D-1
• Actinomycin誘導体の合成およびピオベルジン生産阻害活性の評価  [Not invited]

  山上健太; 原康雅; 柳田亮; 花木祐輔

  日本農芸化学会2026年度大会  2026/03  京都 

  講演番号4E1pm12
• Sinulariol C及びXiguscabrol Aの合成研究  [Not invited]

  松原有希; 白井遼太郎; 花木祐輔; 柳田亮

  日本農芸化学会2026年度大会  2026/03  京都 

  講演番号2F1am11
• Spiroiridal型トリテルペノイド類の合成研究  [Not invited]

  藤田楽都; 石井大智; 花木祐輔; 柳田亮

  日本農芸化学会2026年度大会  2026/03  京都 

  講演番号2F1am10
• Vibsanin Aのエステル側鎖改変および生物活性評価  [Not invited]

  梶原康弘; 花木祐輔; 栁田亮

  日本農芸化学会2026年度大会  2026/03  京都 

  講演番号2F1am08
• Vibsanin A単純化アナログの合成および生物活性評価  [Not invited]

  松岡祐作; 花木祐輔; 柳田亮

  日本農芸化学会2026年度大会  2026/03  京都 

  講演番号2F1am09
• スピロイリダール類の合成研究: スピロ環化反応のDFT解析  [Not invited]

  藤田楽都; 石井大智; 柳田亮; 花木祐輔

  日本農芸化学会2025年度関西・中四国・西日本支部合同大会（関西支部第537回講演会、中四国支部第72回講演会、西日本支部第357回講演会）  2025/09  岡山 

  講演番号F-9
• 分子内SS結合により毒性配座に間接固定したAβ42誘導体の構造機能解析  [Not invited]

  景山裕介; 入江由美; 松井温哉; 柳田亮; 西村周泰; 高田和幸; 目良裕; 塚野千尋; 久嶋亮治; 遠山育夫; 入江一浩

  第67回天然有機化合物討論会  2025/09  仙台 

  講演番号P1-42
• Pradimicin Aの糖鎖認識機構に基づく二量体型抗ウイルス薬リードの開発  [Not invited]

  川口真司; 力石涼暉; 木下貴明; 安田二朗; 柳田亮; 五十嵐康弘; 伊藤幸成; 中川優

  第67回天然有機化合物討論会  2025/09  仙台 

  講演番号P1-43
• Synthetic study on a new analog of glucose 6-phosphate to identify its target proteins  [Not invited]

  楠姫菜子; 柳田亮; 花木祐輔

  日本農芸化学会2025年度大会  2025/03  札幌 

  講演番号4B031
• Binding analysis of pradimicin A with SARS-CoV-2 glycans  [Not invited]

  力石涼暉; 柳田亮; 五十嵐康弘; 伊藤幸成; 中川 優

  日本農芸化学会2025年度大会  2025/03  札幌 

  講演番号3B036
• Synthesis and biological evaluation of novel actinomycin analogs as inhibitors of pyoverdine production  [Not invited]

  山上健太; 原康雅; 栁田亮; 花木祐輔

  日本農芸化学会2025年度大会  2025/03  札幌 

  講演番号2B053
• Machine learning-based in silico screening and synthetic study of new PKC ligands  [Not invited]

  白井遼太郎; 柳田亮; 花木祐輔; 入江一浩

  日本農芸化学会2025年度大会  2025/03  札幌 

  講演番号2B042
• Synthetic studies of iridals, PKC activators isolated from Iris plants  [Not invited]

  石井大智; 関戸智紀; 花木祐輔; 柳田亮

  日本農芸化学会2025年度大会  2025/03  札幌 

  講演番号2B041
• 機械学習によりPKC結合能が予測されたベンゾフラン化合物の合成と活性評価  [Not invited]

  山中麻希; 眞木準平; 柳田 亮; 入江一浩; 塚野千尋

  日本農芸化学会関西支部第533回講演会  2024/12  神戸 

  講演番号12
• 海産天然物アプリシアトキシンの骨格に基づいた新規PKC活性化剤の開発  [Not invited]

  森下真菜; 新木悠介; 波田航平; 深谷圭介; 占部大介; 柳田亮; 花木祐輔; 北 将樹; 入江一浩; 西川俊夫

  第41回メディシナルケミストリーシンポジウム  2024/11  京都
• SARS-CoV-2糖鎖由来オリゴマンノースとプラディミシンAの結合解析

  力石涼暉; 藤井将人; 柳田 亮; 五十嵐康弘; 伊藤幸成; 中川 優

  日本農芸化学会中部支部第199回例会  2024/09  名古屋
• 新規Vibsanin A誘導体の合成と生物活性の評価  [Not invited]

  髙渕大斗; 畠中聡之; 柳田亮; 花木祐輔

  日本農芸化学会2024年度中四国支部大会 （第69回講演会）  2024/09  松山 

  講演番号E-5
• SARS-CoV-2糖鎖由来オリゴマンノースとプラディミシンAの結合解析  [Not invited]

  力石涼暉; 藤井将人; 柳田 亮; 五十嵐康弘; 伊藤幸成; 中川 優

  第43回日本糖質学会年会  2024/09  横浜 

  発表番号P-036
• 機械学習により選抜された新規PKCリガンド候補化合物の活性評価とアイソザイム選択性を志向した分子設計  [Not invited]

  眞木準平; 奥田創元; 押村亜沙美; 塩谷侑大; 山中麻希; 柳田 亮; 木谷 茂; 五十嵐康弘; 齋藤 裕; 榊原康文; 塚野千尋; 入江一浩

  第66回天然有機化合物討論会  2024/09  京都 

  発表番号O-18
• 分子内ジスルフィド結合形成によるアミロイドβ42の配座固定誘導体の構造－機能解析と抗毒性配座特異抗体の開発  [Not invited]

  松島由佳; 入江由美; 景山裕介; 遠山育夫; 喜田昭子; 三木邦夫; 瀬川辰也; 前田雅弘; 牧 俊人; 久米利明; 柳田 亮; 入江一浩

  第66回天然有機化合物討論会  2024/09  京都 

  ポスター番号P1-31
• Development of synthetically-accessible analogs of aplysiatoxin, natural protein kinase C activator  [Invited]

  Ryo C. Yanagita

  2nd International Conference on Public Health, Environment, and Education for Sustainable Development Goals and Lifelong Learning  2024/06  Brunei Darussalam  Centre for Lifelong Learning, Universiti Brunei Darussalam
   

  講演番号O14-E3
• フェノキサジン環を持たない新規Actinomycin誘導体の合成及び生物活性評価  [Not invited]

  山上 健太; 花木 祐輔; 原 康雅; 柳田 亮

  日本農芸化学会2024年度大会  2024/03  東京 

  講演番号2B5a05
• ハマゴウに含まれるジテルペン類の単離，構造決定，ならびに生物活性評価  [Not invited]

  花木 祐輔; 安部 凜太郎; 岩瀬 二千翔; 杉山 康憲; 原 康雅; 柳田 亮

  日本農芸化学会2024年度大会  2024/03  東京 

  講演番号2B5a04
• アプリシアトキシンの骨格に基づいたPKC活性化剤の探索研究  [Not invited]

  森下真菜; 新木悠介; 波田航平; 柳田亮; 入江一浩; 北将樹; 西川俊夫

  日本農芸化学会中部・関西支部合同大会 （中部支部第196回例会）（関西支部第527回講演会）  2023  津
• Structural optimization of the toxic dimer and trimer models of amyloid β40  [Not invited]

  Kazuhiro Irie; Ayumi Uchino; Ayaka Chikugo; Yumi Irie; Chihiro Tsukano; Taiji Kawase; Kenji Hirose; Yusuke Kageyama; Ikuo Tooyama; Ryo C. Yanagita; Takahito Maki; Toshiaki Kume

  The 65th Symposium on the Chemistry of Natural Products  2023/09  Tokyo 

  講演番号P1-22
• Development of Simplified Analogs of Aplysiatoxin Having Different Conformation-Controlling Units  [Invited]

  Ryo C. Yanagita

  Second Trilateral Symposium on SDGs  2023/08  Kagawa
• Aplysiatoxin単純化アナログ・10-Me-Aplog-1のリン酸化体のLRA活性と薬物動態  [Not invited]

  眞木 準平; 花木 祐輔; 柳田 亮; 菊森 将之; 鷲崎 彩夏; 塚野 千尋; 明里 宏文; 入江 一浩

  日本農芸化学会2023年度大会  2023/03  広島（オンライン） 

  講演番号3E01-01
• A screening method for therapeutic candidates for adenomyosis that target the collagen-rich microenvironment  [Not invited]

  花木祐輔; 岩瀬二千翔; 三好紗那; 杉山康憲; 柳田亮; 佐藤正資

  日本農芸化学会2023年度大会  2023/03  広島（オンライン開催） 

  講演番号3E01-09
• Analysis of binding mode of vibsanin A with protein kinase C C1 domains  [Not invited]

  畠中聡之; 柳田亮; 大谷真緒; 花木祐輔; 佐藤正資; 川浪康弘; 入江一浩

  日本農芸化学会2023年度大会  2023/03  広島（オンライン開催） 

  講演番号2E01-04
• Azulene型vibsanin誘導体の合成と生物活性評価  [Not invited]

  和田智貴; 柳田亮; 花木祐輔; 川浪康弘

  日本農芸化学会中四国支部第64回講演会  2023/01  岡山県総社市 

  講演番号A-6
• 新規希少糖誘導体Allulofuranosyl allopyranosideの合成  [Not invited]

  大槻芹香; 柳田亮; 花木祐輔; 佐藤正資; 杉山康憲; 川浪康弘

  日本農芸化学会中四国支部第64回講演会  2023/01  岡山県総社市 

  講演番号A-5
• 抗Aβオリゴマー抗体・24B3の毒性配座認識機構の解析  [Not invited]

  入江由美; 松島由佳; 喜田昭子; 三木邦夫; 瀬川辰也; 前田雅弘; 柳田亮; 入江一浩

  第41回日本認知症学会学術集会  2022/11  東京 

  講演番号PB-02-20
• アロタケタール単純化アナログの設計・合成およびPKC結合活性  [Not invited]

  眞木準平; 押村亜沙美; 塚野千尋; 柳田亮; 齋藤裕; 榊原康文; 入江一浩

  第51回複素環化学討論会  2022/09  大阪 

  講演番号1O-20
• Synthesis and PKC binding of a cis-pyran type-simplified analogue of alotaketals  [Not invited]

  奥田 創元; 塚野 千尋; 柳田 亮; 入江 一浩

  日本農芸化学会2022年度大会  2022/03  京都（オンライン開催） 

  講演番号3F09-10
• Synthesis and PKC binding of a trans-decalin type-simplified analogue of alotaketals  [Not invited]

  眞木 準平; 押村 亜沙美; 塚野 千尋; 柳田 亮; 入江 一浩

  日本農芸化学会2022年度大会  2022/03  京都（オンライン開催） 

  講演番号3F09-09
• Synthesis and biological activity of simplified analogs of aplysiatoxin with (R)-(－)-carvone-based core structure  [Not invited]

  鈴木 芳幸; 守時 恵一; 梶原 瑞生; 柳田 亮; 川浪 康弘; 花木 祐輔; 入江 一浩

  日本農芸化学会2022年度大会  2022/03  京都（オンライン開催） 

  講演番号3E05-04
• Synthesis and biological activities of des-B-ring simplified analog of aplysiatoxin  [Not invited]

  関戸 智紀; 山本 剛資; 柳田 亮; 花木 祐輔; 川浪 康弘; 入江 一浩

  日本農芸化学会2022年度大会  2022/03  京都（オンライン開催） 

  講演番号3E05-03
• Synthesis and biological activities of des-A-ring analog of 18-deoxy-aplog-1, a simplified analog of debromoaplysiatoxin  [Not invited]

  Ryo Yanagita; Yoshiki Ashida; Yasuhiro Kawanami; Mutsumi Okamura; Shingo Dan; Kazuhiro Irie

  The 2021 International Chemical Congress of Pacific Basin Societies (Pacifichem 2021)  2021/12  Honolulu (online) 

  Chemical Communications through Natural and Synthetic Bioactive Compounds (#79)
• Development of new protein kinase C ligands using a machine learning model  [Not invited]

  Irie, K; Tsukano, C; Maki, J; Oshimura, A; Okuda, S; Gonda, A; Yanagita, R. C; Saito, Y; Sakakibara, Y

  The 2021 International Chemical Congress of Pacific Basin Societies (Pacifichem 2021)  2021/12
• Molecular dynamics analysis of simplified analogs of aplysiatoxin focused on CH/π interaction  [Not invited]

  Ryo C. YANAGITA; Takumi KOBAYASHI; Atsuko GONDA; Koji TAKADA; Kazuhiro IRIE

  日本農芸化学会2021年度大会  2021/03  仙台（オンライン開催） 

  講演番号3G05-09
• サリチル酸を用いたアプリシアトキシン単純化アナログの合成と生物活性  [Not invited]

  結城千晴; 岡田美砂; 関戸智紀; 川浪康弘; 柳田亮

  日本農芸化学会中四国支部第58回講演会  2021/01  香川（オンライン開催） 

  講演番号D-10
• B環を除去したAplysiatoxin単純化アナログの合成研究  [Not invited]

  山本剛資; 柳田亮; 川浪康弘; 入江一浩

  日本農芸化学会中四国支部第58回講演会  2021/01  香川（オンライン開催） 

  講演番号D-9
• 希少アルドヘキソース誘導体のがん細胞増殖抑制活性の評価  [Not invited]

  北口菜摘; 柳田亮; 川浪康弘

  日本農芸化学会中四国支部第58回講演会  2021/01  香川（オンライン開催） 

  講演番号D-7
• 非天然型リン酸化単糖誘導体の合成と生物活性評価  [Not invited]

  金川優樹; 柳田亮; 川浪康弘

  日本農芸化学会中四国支部第58回講演会  2021/01  香川（オンライン開催） 

  講演番号D-6
• (−)-carvoneを用いたAplysiatoxin単純化アナログの合成  [Not invited]

  守時恵一; 梶原瑞生; 鈴木芳幸; 栁田亮; 川浪康弘

  日本化学会中国四国支部大会  2020/11  島根（オンライン開催） 

  講演番号OR10
• サリチル酸を用いるアプリシアトキシンの合成研究  [Not invited]

  岡田美砂; 関戸智紀; 栁田亮; 川浪康弘

  日本化学会中国四国支部大会  2020/11  島根（オンライン開催） 

  講演番号OR06
• Evaluation of anti-proliferative activity of rare aldohexoses and hexosamines against DU-145 human prostate cancer cell line  [Not invited]

  北口菜摘; 柳田亮; 石山大展; 佐藤正資; 川浪康弘

  日本農芸化学会2020年度大会  2020/03  福岡 

  講演番号2B03a06 (P031)
• (R)-(−)-カルボンを用いたアプリシアトキシン単純化アナログの合成研究  [Not invited]

  梶原瑞生; 守時恵一; 柳田亮; 川浪康弘

  日本化学会第100春季年会  2020/03  野田（千葉県） 

  講演番号2H5-39
• Evaluation of anti-proliferative activity of rare aldohexoses against DU-145 human prostate cancer cell line  [Not invited]

  Natsumi Kitaguchi; Ryo C. Yanagita; Hironobu Ishiyama; Masashi Sato; Yasuhiro Kawanami

  7th International Symposium of International Society of Rare Sugars  2019/12  Takamatsu, Kagawa, Japan 

  講演番号P47
• Evaluation of Anti-proliferative Activity of Rare Aldohexoses and Structure–Activity Relationship Study of D-Idose  [Not invited]

  Hironobu Ishiyama; Ryo C. Yanagita; Kazune Takemoto; Yasunori Sugiyama; Masashi Sato; Yasuhiro Kawanami

  7th International Symposium of International Society of Rare Sugars  2019/12  Takamatsu, Kagawa, Japan 

  講演番号P46
• サリチル酸を用いたアプリシアトキシン単純化アナログの合成  [Not invited]

  岡田美砂; 真鍋茉由; 柳田亮; 川浪康弘

  日本化学会中国四国支部2019年支部大会  2019/11  徳島 

  講演番号1P-028
• 準安定なアミロイドβの毒性オリゴマーモデルの合成と機能解析  [Not invited]

  入江由美; 花木瑞穂; 鈴木天志; 花木祐輔; 村上一馬; 今本恒雄; 古田巧; 川端猛夫; 川瀬泰司; 廣瀬賢治; 柳田亮; 入江一浩

  第61回天然有機化合物討論会  2019/09  広島 

  講演番号01
• Synthesis and biochemical characterization of the toxic-conformer models of amyloid β42 by intramolecular disulfide bond formation  [Not invited]

  松島由佳; 村上一馬; 花木瑞穂; 粟野達也; 高部圭司; 柳田亮; 入江一浩

  日本農芸化学会2019年度大会  2019/03  東京 

  講演番号3D3p14
• Synthesis and PKC binding of the simplified analogs of aplysiatoxin without a spiro-ring structure  [Not invited]

  押村亜沙美; 早川皓太郎; 花木祐輔; 柳田亮; 入江一浩

  日本農芸化学会2019年度大会  2019/03  東京 

  講演番号1D3p12
• Isolation and biological activities of vibsanin diterpenes from flower buds of Viburnum odoratissimum  [Not invited]

  柳田亮; 植松紗和子; 西皓冬; 芦田能基; 川浪康弘; 入江一浩

  日本農芸化学会2019年度大会  2019/03  東京 

  講演番号1D5a12
• サリチルアルコールを用いるアプリシアトキシン単純化アナログの合成研究  [Not invited]

  志田航洋; 梶原瑞生; 岡田美砂; 柳田亮; 川浪康弘

  日本化学会第99春季年会  2019/03 

  講演番号3F3-47
• スピロ環を簡略化したアプリシアトキシン単純化アナログの合成、配座、および生物活性  [Not invited]

  柳田亮; 芦田能基; 川浪康弘; 旦慎吾; 岡村睦美; 入江一浩

  2018年度先端モデル動物支援プラットフォーム成果発表会  2019/01  大津 

  講演番号P-26
• Synthesis, conformation, and biological activities of a des-A-ring analog of 18-deoxy-aplog-1, a simplified analog of debromoaplysiatoxin  [Not invited]

  Yoshiki Ashida; Ryo C. Yanagita; Yasuhiro Kawanami; Mutsumi Okamura; Shingo Dan; Kazuhiro Irie

  The 1st International Symposium on Chemical Communications (ISCC2019)  2019/01  Tokyo, Japan 

  講演番号P-10
• エンヒドリン誘導体の合成とがん細胞増殖抑制活性  [Not invited]

  芦谷直樹; 萱原正隆; 田村啓敏; 柳田亮; 川浪康弘

  日本化学会中国四国支部2018年支部大会  2018/11  松山 

  講演番号2P-089
• サリチルアルコールを用いたアプリシアトキシン単純化アナログの合成  [Not invited]

  梶原瑞生; 芦田能基; 柳田亮; 川浪康弘

  日本化学会中国四国支部2018年支部大会  2018/11  松山 

  講演番号2P-088
• アプリシアトキシン単純化アナログの合成  [Not invited]

  志田航洋; 岡田美砂; 芦田能基; 柳田亮; 川浪康弘

  日本化学会中国四国支部2018年支部大会  2018/11  松山 

  講演番号1E-07
• Synthesis and biological activities of acetal analogs of 10-Me-aplog-1, an anti-cancer lead derived from aplysiatoxin  [Not invited]

  Koutaro Hayakawa; Yusuke Hanaki; Harukuni Tokuda; Ryo C. Yanagita; Yu Nakagawa; Kazuhiro Irie

  60th Symposium on the Chemistry of Natural Products  2018/09  Kurume
• サンゴジュに含まれるビブサニン類のプロテインキナーゼC結合活性の評価と結合様式の予測  [Not invited]

  植松紗和子; 柳田亮; 三宅翔太; 川浪康弘; 入江一浩

  日本農芸化学会2018年度中四国支部大会（第52回講演会）  2018/09  松江
• スピロ環をもたないaplysiatoxin単純化アナログの合成, 配座, および活性  [Not invited]

  芦田能基; 柳田亮; 川浪康弘; 入江一浩

  日本農芸化学会2018年度大会  2018/03  名古屋
• アプリシアトキシン単純化アナログ・10-Methyl-Aplog-1の側鎖誘導体の合成と活性  [Not invited]

  高田晃児; 花木祐輔; 菊森将之; 徳田春邦; 柳田亮; 入江一浩

  日本農芸化学会2018年度大会  2018/03  名古屋
• 抗腫瘍性Aplysiatoxin誘導体・10-Me-Aplog-1のアセタール型アナログの合成と生物活性  [Not invited]

  早川皓太郎; 花木祐輔; 徳田春邦; 柳田亮; 中川優; 入江一浩

  日本農芸化学会2018年度大会  2018/03  名古屋
• アプリシアトキシン単純化アナログの機能指向型合成  [Not invited]

  芦田能基; 志田航洋; 柳田亮; 川浪康弘

  第111回有機合成シンポジウム  2017/06  岡山
• Aplysiatoxin単純化アナログ・10-Me-aplog-1のフェノール性側鎖が各種生物活性に与える影響  [Not invited]

  花木祐輔; 菊森将之; 徳田春邦; 岡村睦美; 旦慎吾; 柳田亮; 入江一浩

  日本農芸化学会2017年度大会  2017/03  京都
• Retarding activity of 6-(decanoylamino)-1,2,6-trideoxy-D-allose on plant growth  [Not invited]

  Md. Tazul; Islam Chowdhury; Hikaru Ando; Ryo C. Yanagita; Yasuhiro Kawanami

  日本農芸化学会2017年度大会  2017/03  京都
• 希少アルドヘキソースのがん細胞増殖抑制活性の評価  [Not invited]

  竹本和音; 柳田亮; 佐藤正資; 川浪康弘

  日本農芸化学会2017年度大会  2017/03  京都
• がん細胞増殖抑制活性を示すD-allose-6-phosphate誘導体の作用機構の解析  [Not invited]

  石山大展; 柳田亮; 杉山康憲; 川浪康弘

  日本農芸化学会2017年度大会  2017/03  京都
• Biological activity of deoxy-D-allose ester derivatives on plant growth  [Not invited]

  Md. Tazul; Islam Chowdhury; Hikaru Ando; Ryo C. Yanagita; Yasuhiro Kawanami

  6th Symposium of International Society of Rare Sugars  2016/11  Takamatsu, Japan
• Toward the development of medicinal lead compounds targeting protein kinase C  [Not invited]

  Ryo C. Yanagita

  The 6th International Symposium in Phytochemicals - Bioactivities and Disease Prevention of Phytochemicals and Natural Products for Health  2016/11  National Chaiyi University, Taiwan
• Synthesis of 6-decanoylamino-1,2,6-trideoxy-allose and its inhibitory activity on plant growth  [Not invited]

  Md. Tazul; Islam Chowdhury; 安藤光; 柳田亮; 川浪康弘

  2016年日本化学会中四国支部大会  2016/11  高松
• 2, 3-ジアシルリボース誘導体の合成とがん細胞増殖抑制活性  [Not invited]

  深井実優; 柳田亮; 川浪康弘

  2016年日本化学会中四国支部大会  2016/11  高松
• アプリシアトキシンおよびジアシルグリセロールの受容体認識部位の構造活性相関研究  [Not invited]

  芦田能基; 柳田亮; 藤井美里; 高橋知世; 川浪康弘; 入江一浩

  2016年日本化学会中四国支部大会  2016/11  高松
• 希少アルドヘキソースのがん細胞増殖抑制活性の評価  [Not invited]

  竹本和音; 柳田亮; 川浪康弘; 佐藤正資

  2016年日本化学会中四国支部大会  2016/11  高松
• ヒドロキシプロリン誘導体を用いた触媒的不斉還元  [Not invited]

  小山耕充; 柳田亮; 川浪康弘

  2016年日本化学会中四国支部大会  2016/11  高松
• リボースエーテル誘導体の合成と白血病細胞に対する増殖抑制活性  [Not invited]

  深井実優; 高倉千尋; 柳田亮; 川浪康弘

  日本農芸化学会中四国支部第45回講演会（支部例会）  2016/06  香川
• Inhibitory activities of deoxy-d-allose fatty acid esters on plant growth  [Not invited]

  Md. Tazul; Islam Chowdhury; Hikaru Ando; Ryo C. Yanagita; Yasuhiro Kawanami

  日本農芸化学会2016年度大会  2016/03  札幌
• アミロイドβの毒性コンホマーにきわめて特異的な抗体の開発とアルツハイマー病診断への応用  [Not invited]

  村上一馬; 徳田真樹; 鈴木天志; 入江由美; 花木瑞穂; 柳田亮; 物部容子; 赤木謙一; 石井亮太郎; 建部陽嗣; 徳田隆彦; 前田雅弘; 久米利明; 泉尾直孝; 清水孝彦; 入江一浩

  日本農芸化学会2016年度大会  2016/03  札幌
• 分子モデリングによるAplysiatoxinとプロテインキナーゼC C1ドメインとの結合様式の予測  [Not invited]

  芦田能基; 柳田亮; 川浪康弘; 入江一浩

  日本農芸化学会2016年度大会  2016/03  札幌
• 膜透過性D-allose-6-phosphate誘導体の合成とヒト白血病MOLT-4F細胞増殖抑制効果  [Not invited]

  石山大展; 小橋克哉; 柳田亮; 川浪康弘

  日本農芸化学会2016年度大会  2016/03  札幌
• ThapsigarginのC1ドメインに対する結合能と結合選択性の評価  [Not invited]

  高橋知世; 柳田亮; 川浪康弘; 入江一浩

  日本農芸化学会2016年度大会  2016/03  札幌
• Structure–activity studies on the PKC-recognitoin domain of aplysiatoxin, a potent tumor-promoter isolated from a sea hare  [Not invited]

  Yoshiki Ashida; Ryo C. Yanagita; Chise Takahashi; Misato Fujii; Yasuhiro Kawanami; Kazuhiro Irie

  PACIFICHEM 2015  2015/12  Honolulu, USA
• Isolation and evaluation of an ability to bind to protein kinase C of (20S)-bryostatin 19 from Japanese bryozoan  [Not invited]

  Ryo C. Yanagita; Kensuke Muraki; Mai Takata; Yasuhiro Kawanami; Kazuhiro Irie

  PACIFICHEM 2015  2015/12  Honolulu, USA
• アラビノース脂肪酸エステルの合成と植物生長抑制活性評価  [Not invited]

  安藤光; Md. Tazul; Islam Chowdhury; 松尾麻未; 柳田亮; 川浪康弘

  日本農芸化学会2015年度中四国・西日本支部合同大会  2015/09  松山
• 日本産フサコケムシからの新規Bryostatin類の単離と活性  [Not invited]

  村木謙介; 柳田亮; 高田舞; 川浪康弘; 入江一浩

  日本農芸化学会2015年度大会  2015/03  岡山
• AplysiatoxinのPKC C1ドメイン認識部位の構造活性相関研究  [Not invited]

  芦田能基; 柳田亮; 川浪康弘; 入江一浩

  日本農芸化学会2015年度大会  2015/03  岡山
• Aplysiatoin単純化アナログのアミド誘導体の合成と活性  [Not invited]

  花木祐輔; 柳田亮; 菅原貴弘; 相田美砂子; 徳田春邦; 鈴木信孝; 入江一浩

  日本農芸化学会2015年度大会  2015/03  岡山
• Synthesis of deoxy-D-allose fatty acid ester and its biological activity on plant growth  [Not invited]

  Md. Tazul; Islam Chowdhury; Hikaru Ando; Ryo C. Yanagita; Yasuhiro Kawanami

  日本農芸化学会2015年度大会  2015/03  岡山
• Synthesis and biological activities of the amide derivative of aplog-1, a simplified analog of splysiatoxin with antiproliferative and cytotoxic activities  [Not invited]

  Yusuke Hanaki; Ryo C. Yanagita; Chise Takahashi; Takahiro Sugahara; Misako Aida; Harukuni Tokuda; Kazuhiro Irie

  PACIFICHEM 2015  2015/03  Honolulu, USA
• ペントース誘導体の合成とMOLT-4F白血病細胞に対する増殖阻害活性  [Not invited]

  高倉千尋; 小橋克哉; 柳田 亮; 川浪康弘

  日本農芸化学会2014年度中四国支部大会  2014/09  徳島
• フラノース型D-アロース中鎖脂肪酸エステルのヒト白血病MOLT-4F細胞増殖抑制活性  [Not invited]

  小橋克哉; 柳田亮; 芦田能基; 山足陽和; 川浪 康弘

  日本農芸化学会2014年度大会  2014/03  川崎
• キラルラクタムアルコールを用いるトリフルオロアセトフェノンの不斉ボラン還元－p-I-PhOHの添加効果－  [Not invited]

  高倉千尋; 柳田亮; 川浪康弘

  日本化学会第94春季年会  2014/03  名古屋
• Synthesis of 6-O-decanoyl-1,2-didehydro-1,2-dideoxy-D-allose and its biological activity on plant growth  [Not invited]

  Md. Tazul; Islam Chowdhury; Ryo C. Yanagita; Yasuhiro Kawanami

  日本農芸化学会中四国支部第38回講演会（例会）  2014/01  高松
• Synthesis of 6-O-decanoyl-D-altrose and its biological activity on plant growth  [Not invited]

  Md. Tazul; Islam Chowdhury; Ryo C. Yanagita; Yasuhiro Kawanami

  日本農芸化学会関西・中四国・西日本支部合同大会（第37回講演会）  2013/09  広島
• D-アロース中鎖脂肪酸エステルのヒト白血病細胞増殖抑制活性  [Not invited]

  柳田亮; 小川知紗; 小橋克哉; 川浪康弘

  日本農芸化学会2013年度大会  2013/03  仙台
• Debromoaplysiatoxin単純化アナログの10位メチル体の発がん促進活性  [Not invited]

  菊森将之; 花木祐輔; 柳田亮; 徳田春邦; 鈴木信孝; 永井宏史; 末永聖武; 入江一浩

  日本農芸化学会2013年度大会  2013/03  仙台
• キラルラクタムアルコールを用いるトリフルオロメチルケトンの触媒的不斉ボラン還元  [Not invited]

  原内勇樹; 柳田亮; 古本敏夫; 川浪 康弘

  日本化学会第93春季年会  2013/03  草津
• LRA activity and pharmacokinetics of phosphate of 10-Me-Aplog-1, a simplified aplysiatoxin analog  [Not invited]

  眞木準平; 花木祐輔; 柳田亮; 菊森将之; 鷲崎彩夏; 塚野千尋; 明里宏文; 入江一浩

  日本農芸化学会2023年度大会  2013/03  広島（オンライン開催） 

  講演番号3E01-01
• Synthesis and biological activity of 6-O-D-allose derivatives  [Not invited]

  R. Yanagita; N. Hashitani; Y. Kawanami

  13th Tetrahedron Symposium Asia edition  2012/11  Taipei, Taiwan
• 植物生長抑制作用を有するD-アロース誘導体の構造活性相関  [Not invited]

  橋谷矩史; 柳田亮; 川浪康弘

  日本農芸化学会中四国支部第34回講演会（支部大会）  2012/09  宇部
• D-グロース脂肪酸エステルの合成と植物生長抑制活性  [Not invited]

  内藤まどか; 柳田亮; 川浪康弘

  日本農芸化学会中四国支部第34回講演会（支部大会）  2012/09  宇部
• Effects of Rare Sugar Fatty acid Esters on the Tube Formation and Prolififeration of Human Umbilical Vein Endothelial Cells  [Not invited]

  Yuki Harauchi; Mai Yoshimura; Yasuhiro Kawanami; Ryo C. Yanagita; Ikuko Tsukamoto

  The 4th Kagawa University-Chiang Mai University Joint Symposium 2012-Healthy Aging and Sustainable Society-  2012/09  Takamatsu, Japan
• 植物生長抑制作用を有するD-アロース誘導体の親水性官能基が生物活性に与える影響  [Not invited]

  柳田亮; 山足陽和; 橋谷矩史; 川浪康弘

  日本農芸化学会2012年度大会  2012/03  京都
• 日本産フサコケムシに含まれるブリオスタチン類の同定と評価  [Not invited]

  植野紗代; 柳田亮; 村上一馬; 村上明; 徳田春邦; 鈴木信孝; 藤原健史; 入江一浩

  日本農芸化学会2012年度大会  2012/03  京都
• 抗腫瘍性Aplysiatoxin単純化アナログの側鎖の構造活性相関を目的とした合成経路の確立  [Not invited]

  朱裕姫; 柳田亮; 徳田春邦; 鈴木信孝; 入江一浩

  日本農芸化学会2012年度大会  2012/03  京都
• 植物生長抑制作用を有するD-アロース誘導体の構造活性相関  [Not invited]

  橋谷矩史; 柳田亮; 川浪康弘

  2011年日本化学会西日本大会  2011/11  徳島
• Role of Polar Functional Group of 6-O-Acyl-D-allose on the Plant Growth-Inhibitory Effect  [Not invited]

  Ryo C. Yanagita; Fuminori Hashitani; Yasuhiro Kawanami

  The 5th Symposium of International Society of Rare Sugar  2011/11  Takamatsu, Japan
• Catalytic Asymmetric Reduction of Ketones Using Chiral Lactam Alcohol  [Not invited]

  Yasuhiro Kawanami; Ryo C. Yanagita; Masatoshi Okazaki; Kazuya Kiguchi; Yuki Harauchi

  BIT's 2nd Annual World Congress of Catalytic Asymmetric Synthesis-2011  2011/08  Beijing, China
• 植物生長抑制作用を有するD-アロース誘導体の構造活性相関研究  [Not invited]

  柳田亮; 橋谷矩史; 川浪康弘

  日本農芸化学会中国四国支部第30回講演会  2011/05  岡山
• 抗腫瘍性Aplysiatoxin誘導体の生物活性におけるフェノール性水酸基の役割  [Not invited]

  柳田亮; 田中啓介; 蒲池弘明; 中川優; 徳田春邦; 入江一浩

  日本農芸化学会2011年度大会  2011/03  京都
• D-グロース脂肪酸エステルの合成と生物活性  [Not invited]

  内藤まどか; 柳田亮; 川浪康弘

  2011年日本化学会西日本大会  2011  徳島
• Screening for activators of protein kinase C using its C1 domain peptide: Identification and biological activities of bryostatin 10 from Japanese bryozoan  [Not invited]

  Ryo C. Yanagita; Takeshi Fujiwara; Kazuhiro Irie

  PACIFICHEM 2010  2010/12  Honolulu, USA
• Structure-Activity Study of an Antineoplastic Protein Kinase C Activator Having a Skeleton of Tumor-promoting Aplysiatoxin  [Not invited]

  Ryo C. Yanagita; Yu Nakagawa; Keisuke Tanaka; Hiroaki Kamachi; Naoaki Saito; Kazuhiro Irie

  The 11th International Kyoto Conference on New Aspects of Organic Chemistry  2009/11  Kyoto, Japan
• Analysis of CH/π Interaction between Tumor Promoters and Protein Kinase C C1 Domains  [Not invited]

  Ryo C. Yanagita; Kazuhiro Irie; Yu Nakagawa; Nobuhiro Yamanaka; Hajime Ohigashi; Kaori Kashiwagi; Naoaki Saito

  ICOB-5 & ISCNP-25 IUPAC International Conference on Biodiversity and Natural Products  2006/07  Kyoto, Japan

MISC

• 機械学習によりPKC結合能が予測されたベンゾフラン化合物の合成と活性評価

  山中麻希; 眞木準平; 柳田亮; 入江一浩; 入江一浩; 塚野千尋  日本農芸化学会関西支部講演会講演要旨集  533rd-  2024
• LRA activity and pharmacokinetics of phosphate of 10-Me-Aplog-1, a simplified aplysiatoxin analog

  眞木準平; 花木祐輔; 柳田亮; 菊森将之; 鷲崎彩夏; 塚野千尋; 明里宏文; 入江一浩  日本農芸化学会大会講演要旨集(Web)  2023-  2023
• Synthesis and PKC binding of a cis-pyran type-simplified analogue of alotaketals

  奥田創元; 塚野千尋; 柳田亮; 入江一浩  日本農芸化学会大会講演要旨集(Web)  2022-  2022
• Synthesis and PKC binding of a trans-decalin type-simplified analogue of alotaketals

  眞木準平; 押村亜沙美; 塚野千尋; 柳田亮; 入江一浩  日本農芸化学会大会講演要旨集(Web)  2022-  2022
• Design, synthesis and PKC surrogate binding of the simplified analogues of alotaketals

  眞木準平; 押村亜沙美; 塚野千尋; 柳田亮; 齋藤裕; 齋藤裕; 榊原康文; 入江一浩  複素環化学討論会講演要旨集  51st-  2022
• Erratum: Generation of 'Unnatural Natural Product' library and identification of a small molecule inhibitor of XIAP (Bioorganic and Medicinal Chemistry (2011) 19 (4377-4385))

  Kawamura T; Matsubara K; Otaka H; Tashiro E; Shindo K; Yanagita R; Irie K; Imoto M  Bioorganic and Medicinal Chemistry  20-  (7)  2012/04
• Debromoaplysiatoxin単純化アナログの10位メチル体の合成と細胞増殖抑制活性

  菊森将之; 柳田亮; 柳田亮; 徳田春邦; 鈴木信孝; 永井宏史; 末永聖武; 入江一浩  日本農芸化学会関西支部講演会講演要旨集  476th-  2012
• 抗腫瘍性aplysiatoxinアナログ・Aplog-1の12-ジメチル体の合成と生物活性

  中川優; 中川優; 柳田亮; 高橋英之; 斎藤尚亮; 永井宏史; 入江一浩  日本農芸化学会大会講演要旨集  2010-  2010
• 発がんプロモーター・アプリシアトキシンの骨格を利用した新規抗腫瘍性PKC活性化剤の開発

  中川優; 中川優; 柳田亮; 濱田直子; 永井宏史; 入江一浩  日本農芸化学会大会講演要旨集  2009-  2009

Awards & Honors

• 2016 2016年度 日本農芸化学会中四国支部奨励賞
   JPN

Research Grants & Projects

• 抗炎症誘導性プロテインキナーゼC活性化剤ビブサニンAの分子構造基盤の解明

  日本学術振興会：科学研究費助成事業

  Date (from‐to) : 2025/04 -2028/03 

  Author : 柳田 亮; 花木 祐輔
• Structural optimization of vibsanins with skeletal diversity as protein kinase C activators

  Japan Society for the Promotion of Science：Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)

  Date (from‐to) : 2022/04 -2025/03 

  Author : YANAGITA Ryo; HANAKI Yusuke
• Structure–activity study and analysis of mechanism of action of vibsanins focused on pro-/anti-inflammatory switching

  Japan Society for the Promotion of Science：Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)

  Date (from‐to) : 2019/04 -2022/03 

  Author : YANAGITA Ryo; KAWANAMI Yasuhiro

   

  Vibsanin A, a protein kinase C (PKC) activator isolated from Viburnum odoratissimum tree, was found to have about 4000-fold binding selectivity between PKCα-C1A and δ-C1B domains, which is the highest among known PKC ligands. Molecular dynamics simulation presented the binding mode of vibsanin A with the PKCδ-C1B domain, wherein CH-O interactions are involved. LC-MS analysis suggested that the chemical instability of vibsanin A is attributable to its susceptibility to oxidation. Furthermore, we found that (8Z)-5,10-di-epi-vibsanin C (vibsanin D), not vibsanin C, has the potential as a lead scaffold for developing novel PKC ligands.
• Unified comprehension of chemical communication by natural PKC ligands and development of new medicinal seeds

  Japan Society for the Promotion of Science：Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

  Date (from‐to) : 2017/06 -2022/03 

  Author : IRIE Kazuhiro; YANAGITA Ryo; TSUKANO Chihiro; MURAKAMI Kazuma

   

  Protein kinase (PKC) isozymes involved in cell surface signal transduction are one of the targets of intractable diseases such as cancer, Alzheimer's disease, and HIV infection. 10-Me-Aplog-1, the simplified analog of proinflammatory aplysiatoxin, is a potent PKC ligand with little tumor-promoting and proinflammatory activities. We showed that 10-Me-Aplog-1 becomes a promising medicinal lead for the above-mentioned intractable diseases through activation of PKCα and δ. In addition, its further structural modification paved the way for development of PKC isozyme-selective ligands. On the other hand, new PKC ligands were searched by machine-learning, and the alotaketals isolated from marine sponge were identified as new PKC ligand candidates. Their simplified analogs designed by the docking simulation against PKCδ-C1B were synthesized to be assayed for PKC isozyme surrogate binding. One of the ligands exhibited a higher affinity for PKCα-C1A than for PKCδ-C1B.
• 非天然型希少リン酸化糖ライブラリの構築と生物活性評価

  香川県：希少糖研究開発加速化支援事業費補助金

  Date (from‐to) : 2017 -2019 

  Author : 柳田 亮
• Development of C1 domain ligand with selectivity for non-PKC type C1 domain-containing proteins

  Japan Society for the Promotion of Science：Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (B)

  Date (from‐to) : 2015/04 -2018/03 

  Author : Yanagita Ryo C.

   

  C1 domain is involved in 1,2-sn-diacylglycerol signaling and also bind natural tumor promoters including phorbol esters. We focused on thapsigargin (Tg), a sesquiterpene lactone isolated from Thapsia garganica, as a candidate for C1 domain ligand, and evaluated its affinity for C1 domains from various proteins. Tg exhibited little ability to bind to C1B domains of novel protein kinase C isozymes, main targets of natural tumor promoters, but exhibited substantial ability to bind to C1 domains of RasGRP4 and β-chimaerin. These results suggest the potential of Tg as a seed for C1 domain ligand with unique selectivity for subset of C1 domain-containing proteins such as RasGRP4 and β-chimaerin．
• Development and mechanistic analysis of new PKC ligands as anti-cancer agents

  Japan Society for the Promotion of Science：Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

  Date (from‐to) : 2011/04 -2016/03 

  Author : IRIE Kazuhiro; YANAGITA Ryo C.

   

  Protein kinase C (PKC) isozymes play central roles in the signal transduction on the cell surface and could serve as promising therapeutic targets of intractable diseases like cancer and Alzheimer's disease. Although natural PKC ligands like phorbol esters have the potential to become therapeutic leads, most of them are potent tumor promoters and proinflammatory on mouse skin. We focused on the skeleton of aplysiatoxin (ATX), a natural PKC ligand isolated from sea hare. We found 10-methyl-aplog-1, a simplified analog of ATX, to have strong anti-proliferative activity against several cancer cell lines with little tumor-promoting and inflammatory activities. In order to examine the anti-cancer activity in vivo and mechanism of action, several hundred milligrams of 10-methyl-aplog-1 was synthesized. 10-Methyl-aplog-1 exhibited significant anti-cancer activity against mouse xenograft models, and its anti-proliferative activity derived in part from activation of protein kinase C α.
• Development and mechanism of action of rare sugar derivatives with antiproliferative effect

  Japan Society for the Promotion of Science：Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (B)

  Date (from‐to) : 2011 -2013 

  Author : YANAGITA Ryo

   

  The objectives of this project is to develop superior derivatives of D-allose, a rare sugar showing antiproliferative effect against human cancer cell lines, and molecular probes for an analysis of its mechanism of action. First, we examined the modification for the C-6 OH group of D-allose and found that D-allose C-6 ester with medium chain fatty acids showed about 30 times higher effect compared to D-allose against human leukemia MOLT-4F cell line. Then, we evaluated the activity of D-allose derivatives with 5-membered furanose form, and found that 6-membered pyranose form might be important for the activity of D-allose esters. Finally, we synthesized cell-permeable prodrugs for monosaccharide 6-phosphate, which could be a lead for molecular probes for an analysis of the mechanism of action.
• Search for novel PKC ligands as therapeutic seeds for intractable diseases

  Japan Society for the Promotion of Science：Grants-in-Aid for Scientific Research Grant-in-Aid for Challenging Exploratory Research

  Date (from‐to) : 2011 -2012 

  Author : IRIE Kazuhiro; YANAGITA Ryo

   

  Protein kinase C (PKC) involved in cellular signal transduction is one of the target enzymes fortherapeutics of cancer and Alzheimer’s disease. To explore PKC ligands with novel skeleton, we employed our screening system utilizing synthetic peptides of PKC C1 domains, to succeed to identify several bryostatins, anti-neoplastic marine macrolides, from Japanese bryozoan Bugula neritina. Structure-activity studies of bryostatins 4, 10 and 14 suggested that the ester group at position C20 was not necessary for binding to and activating PKC. Moreover, we screened novel PKC ligands from marine sponges, and found that a marine sponge Theonellasp. contains PKC ligands with high binding affinitycomparable to bryostatins.
• Development of novel anticancer drug based on protein kinase C activator daphnoretin

  Japan Society for the Promotion of Science：Grants-in-Aid for Scientific Research Grant-in-Aid for JSPS Fellows

  Date (from‐to) : 2008 -2009 

  Author : 柳田 亮

   

  本研究者の所属する研究グループでは,芳香環側鎖がPKC活性化に重要な役割を果たしているaplysiatoxin(ATX)に着目し,ATX単純化アナログaplogの開発に成功している.Aplogは抗がん剤bryostatin-1と同等の抗腫瘍活性を示すことから,大量供給可能な新規抗がん剤のリード化合物として有望である.ATXの芳香環上のヒドロキシル基およびブロモ基は生物活性に影響を与えていることが明らかとなっているが,芳香環上の置換基のaplogの生物活性に与える影響は不明である.そこで,aplogの芳香環上の置換基効果を調べることにした. Aplogあるいはaplogのdibenzyl保護体を原料に,21-Br,19-I,21-I,19-NHAc,21-NHAc体を合成した.得られた誘導体のPKCδ CIBドメインに対する結合能を評価したところ,aplogから疎水性が増大したハロゲン化誘導体はaplogの2-5倍結合能が上昇していたのに対して,親水性が増大したNHAcは結合能が低下していた.特に,21-NHAc体の活性低下が顕著であったことから,21位付近の疎水性が結合能に重要であることが示唆された.これらの誘導体ののヒトがん細胞に対する増殖抑制活性を評価したところ,がん細胞増殖抑制活性とPKC結合能との間に相関が認められた.特に,19-Iおよび21-I体はbryostatin 1よりも高いがん細胞増殖抑制活性を示したことから,新たな抗がん剤シードとなる可能性が考えられる.現在,これらaplog誘導体の発がんプロモーション活性についても評価中である.

Teaching Experience

Ethics in ScienceEthics in Science Kagawa University, Faculty of Agriculture
Basic Chemistry BBasic Chemistry B Kagawa University

Other link

researchmap

https://researchmap.jp/read0153343