Identification of Serum microRNA as a Biomarker in Inflammatory Bowel Diseases
Japan Society for the Promotion of Science:Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (B)
Date (from‐to) : 2017/04 -2019/03
Author : Yachida Tatsuo
Cluster analysis comparing the UC group with the CD group showed that the miR-204-3p and miR-6803-5p miRNA of the UC group were significantly increased, and that of miR-1199-5p, miR-4745-5p, miR-4725-3p, and miR-3621 in the UC group was significantly decreased. In particular, there was a marked difference in miR-204-3p. We found that the miRNA of six out of 2,555 molecules in the UC and CD groups differed markedly, particularly in miR-204-3p. These data suggest that serum miR-204-3p has potential as a useful biomarker for the differentiation between UC and CD. The miR-204-3p has been suggested to be associated with inflammatory cytokine IL-6 in previous reports. Therefore, the difference of miR-204-3p among UC and CD may reflect a difference in each inflammatory disease.