MF Researcher Database

Researchers Database

Advance

Miki Takanori

  • Faculty of Medicine
  • School of Medicine
  • Professor
Last Updated :2026/09/09

Researcher Information

J-Global ID

Research Interests

  • 発達神経科学   Developmental Neuroscience   

Research Areas

  • Life sciences / Anatomy

Academic & Professional Experience

  • 2014 - Today  - 香川大学 医学部, 教授
  • 2014 - Today  - Kagawa University Faculty of Medicine, Professor
  • 2008 - 2014  Kagawa UniversityFaculty of Medicine
  • 2008 - 2014  Kagawa University Faculty of Medicine, Associate Professor
  • 2003 - 2008  Kagawa UniversityFaculty of Medicine
  • 2003 - 2008  Kagawa University Faculty of Medicine, Associate Professor
  • 2001 - 2003  Kagawa Medical University
  • 2001 - 2003  Kagawa Medical University, Associate Professor
  • 1995 - 2001  Kagawa Medical University
  • 1995 - 2001  Kagawa Medical University, Assistant Professor

Education

  •        - 1995  Kagawa Medical University  Graduate School, Division of Medicine  形態・細胞機能
  •        - 1995  Kagawa Medical University  医学研究科  形態・細胞機能
  •        - 1991  Kagawa Medical University  Faculty of Medicine  医学
  •        - 1991  Kagawa Medical University  医学部  医学

Association Memberships

  • 日本赤ちゃん学会   形の科学会   日本先天異常学会   日本解剖学会   

Published Papers

Books etc

  • Early Detection and Rehabilitation Technologies for Dementia: Neuroscience and Biomedical Applications
    IGI Global 2011 9781609605599
  • Effects of electric or magnetic brain stimulation on cortical and subcortical neuron functions in rats
    Springer 2007
  • Effects of electric or magnetic brain stimulation on cortical and subcortical neuron functions in rats
    Springer 2007

Conference Activities & Talks

  • 医学生の解剖学教育におけるThiel固定の有用性  [Not invited]
    福永 りょう、宮武 桜子、太田 健一、粂井 大輝、大給 日香里、鈴木 辰吾、三木 崇範
    第131回日本解剖学会総会・全国学術集会  2026/03  東京慈恵会医科大学
  • BDNF が神経細胞のトランスクリプトームに与える影響
    川合杏奈; 鈴木辰吾; 三浦隆一郎; 太田健一; 三木崇範
    第127回日本解剖学会総会・全国学術集会  2022/03
  • 神経細胞における光誘導型遺伝子発現調節系の開発
    三浦隆一郎; 鈴木辰吾; 川合杏奈; 太田健一; 三木崇範
    第127回日本解剖学会総会・全国学術集会  2022/03
  • 低濃度ホルマリン固定の系統解剖実習における有用性と問題点の検討
    越川幸弥; 太田健一; 天野未悠; 森瑛莉子; 氏原英敏; 鈴木辰吾; 三木崇範
    第127回日本解剖学会総会・全国学術集会  2022/03
  • 母子分離による内側前頭前皮質におけるparvalbumin陽性制御性ニューロンの減少  [Not invited]
    本田航大; 太田健一; 入江加奈子; 氏原英敏; 鈴木辰吾; 三木崇範
    第127回日本解剖学会総会・全国学術集会  2022/03
  • 養育環境は子どもの脳を変える－基礎医学研究からの知見－  [Invited]
    三木 崇範
    第7回新胎児研究会  2019/11
  • 母子分離が引き起こす攻撃性増大と関連する脳領域  [Not invited]
    荒木智尋; 氏原英敏; 太田健一; 鈴木辰吾; 三木崇範
    日本解剖学会第74回中国・四国支部学術集会  2019/11
  • 母子分離による社会的認知能力の低下とその原因  [Not invited]
    太田 健一; 小澤 徹; 鈴木 辰吾; 三木 崇範
    日本解剖学会第73回中国・四国支部学術集会  2018/10
  • 母子分離が破綻させる内側前頭前皮質の興奮/抑制バランス  [Not invited]
    小澤 徹; 太田健一; 鈴木辰吾; 三木崇範
    第123回日本解剖学会総会・全国学術集会  2018/03
  • Long-term Effects of Early Life Stress on the Balance between Neural Excitation and Inhibition in the Rat Amygdala  [Not invited]
    Ken-ichi Ohta; Shingo Suzuki; Takashi Kusaka; Takanori Miki
    第40回日本神経科学大会  2017/07
  • 脳発達期の母子分離による扁桃体の興奮/抑制バランス崩壊  [Not invited]
    太田 健一; 鈴木 辰吾; 天雲 千晶; 日下 隆; 三木 崇範
    第122回日本解剖学会総会・全国学術集会  2017/03
  • 脳発達早期の母子分離は海馬CA1領域におけるBDNF-ERKシグナルと樹状突起スパイン形成に影響を与える  [Not invited]
    太田健一; 鈴木辰吾; 日下隆; 三木崇範
    第5回日本DOHaD学会  2016/07
  • 養育環境と子どもの脳発達：健やかな発育のために基礎医学研究者ができること  [Invited]
    三木 崇範
    第26回日本外科小児科学会年次集会 春季カンファレンス  2016/04
  • 系統解剖学実習中に見出された右鎖骨下動脈の起始異常の一例  [Not invited]
    原田怜; 鈴木辰吾; 太田健一; 割田克彦; 三木崇範
    日本解剖学会第70回中国・四国支部学術集会  2015/10
  • 脳発達期の母子分離による海馬興奮性シナプス形成の異常  [Not invited]
    加地智洋; 太田健一; 鈴木辰吾; 割田克彦; 三木崇範
    日本解剖学会第70回中国・四国支部学術集会  2015/10
  • 養育環境が脳をかえる：分子～症状を双方向に見通す  [Not invited]
    三木崇範; 太田健一; 鈴木辰吾
    日本赤ちゃん学会 15回学術集会  2015/06
  • Early life stress reduces BDNF expression and its related factors in rat hippocampus during brain development  [Not invited]
    Ken-ichi Ohta; Shingo Suzuki; Katsuhiko Warita; Takashi Kusaka; Takanori Miki
    第120回日本解剖学会総会・全国学術集会・第92回日本生理学会大会合同大会  2015/03
  • 脳発達期の母子分離は海馬BDNF発現とその下流シグナルを低下させる  [Not invited]
    加地智洋; 太田健一; 鈴木辰吾; 割田克彦; 三木崇範
    日本解剖学会第69回中国・四国支部学術集会  2014/10
  • 生後早期の母子分離ストレスが、脂肪組織エネルギー代謝関連因子に及ぼす影響  [Not invited]
    第119回日本解剖学会総会・全国学術集会  2014
  • Transsynapic transport of WGA conjugated Amyloid-β in the nucleus of solitary tract of the rat  [Not invited]
    第118回日本解剖学会総会・全国学術集会  2013
  • 幼若期の不遇な養育環境が引き起こす脳発達臨界期AMPA受容体動態の異常  [Not invited]
    第53回日本先天異常学会学術集会  2013
  • The role of WGA for decreasing the accumulation of Aβ：A new approach to promote transsynaptic transport of Aβ in the rat  [Not invited]
    日本解剖学会第68回中国・四国支部学術集会  2013
  • Transsynapic transport of WGA conjugated Amyloid-β in the nucleus of solitary tract of the rat  [Not invited]
    第118回日本解剖学会総会・全国学術集会  2013
  • The role of WGA for decreasing the accumulation of Aβ：A new approach to promote transsynaptic transport of Aβ in the rat  [Not invited]
    日本解剖学会第68回中国・四国支部学術集会  2013
  • Alterations of synaptic transcytosis induced by ethanol exposure: apocrine-like structure in the rat  [Not invited]
    第117回日本解剖学会総会・全国学術集会  2012
  • Early Changes in Cerebral Blood Volume after Asphyxia Impacts for Neuropathological Prognosis in Newborn Piglets  [Not invited]
    The 8th Congress of Asian Society for Pediatric Research  2012
  • Alterations of synaptic transcytosis induced by ethanol exposure: apocrine-like structure in the rat  [Not invited]
    第117回日本解剖学会総会・全国学術集会  2012
  • Early Changes in Cerebral Blood Volume after Asphyxia Impacts for Neuropathological Prognosis in Newborn Piglets  [Not invited]
    The 8th Congress of Asian Society for Pediatric Research  2012
  • 食餌性コレステロールとapoE遺伝子が海馬の神経機能に与える影響  [Not invited]
    第88回日本生理学会大会、第116回日本解剖学会総会・全国学術集会合同大会  2011
  • Neuronal transcytosis of WGA-amyloid beta complex in the rat  [Not invited]
    The 166th Annual meeting of the Japanese Association of Anatomists  2011
  • シナプスにおけるトランスサイトーシス  [Not invited]
    日本顕微鏡学会  2011
  • Cerebral Blood Volume Evaluation Using Near-Infrared Time  [Not invited]
    The 7th Congress of Asian Society for Pediatric Research  2011
  • Which Is the Most Effective Guide To Control Hypoxic/Ischemic Insult in a Newborn Piglet Model? Cerebral Electrocortical Activity Versus Cerebral Blood Volume.  [Not invited]
    The 7th Congress of Asian Society for Pediatric Research  2011
  • Which Is the Most Effective Guide To Control Hypoxic/Ischemic Insult in a Newborn Piglet Model? Cerebral Electrocortical Activity Versus Cerebral Blood Volume.  [Not invited]
    The 7th Congress of Asian Society for Pediatric Research  2011
  • 下垂体後葉における透出および離出様分泌  [Not invited]
    Neuroscience 2011/第34回日本神経科学大会  2011
  • Neuronal transcytosis of WGA-amyloid beta complex in the rat  [Not invited]
    The 166th Annual meeting of the Japanese Association of Anatomists  2011
  • Cerebral Blood Volume Evaluation Using Near-Infrared Time  [Not invited]
    The 7th Congress of Asian Society for Pediatric Research  2011
  • Which Is the Most Effective Guide To Control Hypoxic/Ischemic Insult in a Newborn Piglet Model? Cerebral Electrocortical Activity Versus Cerebral Blood Volume.  [Not invited]
    The 7th Congress of Asian Society for Pediatric Research  2011
  • Which Is the Most Effective Guide To Control Hypoxic/Ischemic Insult in a Newborn Piglet Model? Cerebral Electrocortical Activity Versus Cerebral Blood Volume.  [Not invited]
    The 7th Congress of Asian Society for Pediatric Research  2011
  • Non-vesicular synaptic transport: an approach to transcytosis of protein using WGA-HRP and Rab3A-siRNA  [Not invited]
    第115回 日本解剖学会総会・全国学術集会  2010
  • 短期間アルコール摂取マウス小脳の神経栄養因子リガンド/レセプター系の特異的応答性  [Not invited]
    第115回 日本解剖学会総会・全国学術集会  2010
  • An approach for decrease of β-amyloid deposits in neuron  [Not invited]
    第50回日本先天異常学会学術集会  2010
  • 生後早期の母仔分離ストレスにより惹起される小脳神経栄養因子／受容体発現レベルの変動  [Not invited]
    第50回日本先天異常学会  2010
  • Neuronal transcytosis of protein: application for Amyloid-β in vivo  [Not invited]
    Neuro2010  2010
  • Direct effects of diethylstilbestrol on the gene expression of the cholesterol side-chain cleavage enzyme (P450scc) in testicular Leydig cells  [Not invited]
    The 6th International Symposium on Hormonal Carcinogenesis  2010
  • Dissociative effects of electric or magnetic brain stimulation on cortical neurons in rats  [Not invited]
    29th International Congress of Clinical Neurophysiology  2010
  • Non-vesicular synaptic transport: an approach to transcytosis of protein using WGA-HRP and Rab3A-siRNA  [Not invited]
    第115回 日本解剖学会総会・全国学術集会  2010
  • An approach for decrease of β-amyloid deposits in neuron  [Not invited]
    第50回日本先天異常学会学術集会  2010
  • Neuronal transcytosis of protein: application for Amyloid-β in vivo  [Not invited]
    Neuro2010  2010
  • Direct effects of diethylstilbestrol on the gene expression of the cholesterol side-chain cleavage enzyme (P450scc) in testicular Leydig cells  [Not invited]
    The 6th International Symposium on Hormonal Carcinogenesis  2010
  • Dissociative effects of electric or magnetic brain stimulation on cortical neurons in rats  [Not invited]
    29th International Congress of Clinical Neurophysiology  2010
  • Activin A and eCG recover reproductive dysfunction induced by neonatal exposure to an estrogenic endocrine disruptor in adult male mice  [Not invited]
    6th International Symposium on Electron Microscopy in Medicine and Biology 2009  2009
  • Modulation of the hypothalamopituitary axis in Mini rat: Further studies with hypophysiotropic somatostatin and gonadotroph cells.  [Not invited]
    8th World Congress on Neurohypophysial Hormones (WCNH 2009)  2009
  • Improving anatomical training: dissected cadaver-based anatomy education from a clinicians viewpoint  [Not invited]
    第13回 臨床解剖研究会  2009
  • WGA結合タンパクがもたらすシナプス膜輸送機構の新展開  [Not invited]
    日本解剖学会 第64回中国・四国支部学術集会  2009
  • Revaluation of anterograde synaptic transport of WGA-HRP in the rat.  [Not invited]
    第114回日本解剖学会総会・全国学術集会  2009
  • A protein conjugation of WGA essential for transsynaptic tracer in neuronal system: application for Amyloid-β in vivo  [Not invited]
    The International Symposium on Eary Detectoin and Rehabilitaion Technology of Dementia  2009
  • Revaluation of anterograde synaptic transport of WGA-HRP in the rat.  [Not invited]
    第114回日本解剖学会総会・全国学術集会  2009
  • Modulation of the hypothalamopituitary axis in Mini rat: Further studies with hypophysiotropic somatostatin and gonadotroph cells.  [Not invited]
    8th World Congress on Neurohypophysial Hormones (WCNH 2009)  2009
  • A protein conjugation of WGA essential for transsynaptic tracer in neuronal system: application for Amyloid-β in vivo  [Not invited]
    The International Symposium on Eary Detectoin and Rehabilitaion Technology of Dementia  2009
  • 外因性エストロゲン様化学物質がLeydig 細胞株TTE1 のStAR およびP450scc 遺伝子発現に与える影響とアセチル化ヒストンの変化．  [Not invited]
    第145回日本獣医学会学術年会  2008
  • ライディッヒ細胞株TTE1におけるエストロゲン様化学物質曝露の影響：ステロイドホルモン産生系遺伝子発現とヒストン修飾の変化  [Not invited]
    第2回日本エピジェネティクス研究会学術年会  2008
  • エストロゲン様化学物質曝露によるステロイドホルモン産生系遺伝子の発現変化とヒストンアセチル化解析  [Not invited]
    第48回日本先天異常学会学術集会  2008
  • Y染色体腕間逆位を有するXY女性におけるSRY遺伝子のエピジェネティック異常  [Not invited]
    第48回日本先天異常学会学術集会  2008
  • 医学部における先天異常学教育－香川大学での試み－  [Not invited]
    第48回日本先天異常学会学術集会  2008
  • Epigenetic abnormality of SRY gene in the XY female with pericentric inversion of the Y chromosome  [Not invited]
    21th European Congress of Perinatal Medicine  2008
  • Male reproductive disorder induced by neonatal exposure to estrogenic agents results from dysfunction of hypothalamic-pituitary axis than from dysfunction of lower reproductive organs  [Not invited]
    21th European Congress of Perinatal Medicine  2008
  • Y染色体腕間逆位を有するXY女性：PCAFを介したヒストンアセチル化異常を原因とするSRY遺伝子過剰発現―雄性化の破綻  [Not invited]
    第53回日本人類遺伝学会学術集会  2008
  • 雄性化破綻メカニズムとエピジェネティクス  [Not invited]
    第146回日本獣医学会学術集会  2008
  • フィジカルアセスメント教育に向けた系統解剖学実習の活用法―看護学科における試み―  [Not invited]
    日本解剖学会 第63回中国・四国支部学術集会  2008
  • Epigenetic abnormality of SRY gene in the XY female with pericentric inversion of the Y chromosome  [Not invited]
    21th European Congress of Perinatal Medicine  2008
  • Male reproductive disorder induced by neonatal exposure to estrogenic agents results from dysfunction of hypothalamic-pituitary axis than from dysfunction of lower reproductive organs  [Not invited]
    21th European Congress of Perinatal Medicine  2008
  • 嗅球における発達中の神経系に対するイソフルレン吸入麻酔の影響  [Not invited]
    第112回日本解剖学会総会・全国学術集会  2007
  • 中枢神経発達時期におけるイソフルラン曝露の影響：嗅球における神経影響因子の変化．  [Not invited]
    第47回日本先天異常学会学術集会  2007
  • Fos-immunoreactive neurons in the lateral central nucleus of amygdala activated by hypotension with special reference to the parabrachial nucleus in the rat.  [Not invited]
    Italian Society of Neuroscience 2007 Congress  2007
  • Short-term ethanol exposure caused changes in neurotrophins and its receptors expression in mice cerebellum.  [Not invited]
    日本解剖学会第62回中国・四国支部学術集会  2007
  • 母性剥奪症候群（Maternal Deprivation Syndrome)の発達神経科学的アプローチ  [Not invited]
    日本未熟児新生児学会  2007
  • 外因性エストロゲン様化学物質がLeydig細胞株TTE1のステロイドホルモン産生系遺伝子発現に与える影響とヒストンアセチル化解析  [Not invited]
    第10回環境ホルモン学会学術年会  2007
  • Fos-immunoreactive neurons in the lateral central nucleus of amygdala activated by hypotension with special reference to the parabrachial nucleus in the rat.  [Not invited]
    Italian Society of Neuroscience 2007 Congress  2007
  • ラット骨髄における赤芽球の分化へのエリスロポイエチンの影響  [Not invited]
    第１１１回日本解剖学会全国学術集会  2006
  • 長期アルコール摂取によるラット海馬のミエリン構成タンパク質mRNAの発現量変化  [Not invited]
    第111回日本解剖学会・全国学術集会  2006
  • Neuroprotective Effects of Rare Sugar against Ethanol Toxicity; An Electron Microscopic Study in Mice Hippocampus.  [Not invited]
    Rare Sugar Congress 2006 in Kagawa The 3rd Symposium of International Society of Rare Sugars  2006
  • Activity of a novel PDGF β-receptor enhancer during the cell cycle and upon differentiation of neuroblastoma.  [Not invited]
    日本解剖学会第６１回中国・四国支部学術集会  2006
  • 母子間相互作用の発達神経科学解析；母性剥奪による脳発達への影響  [Not invited]
    日本赤ちゃん学会 第６回学術集会  2006
  • Neuroprotective Effects of Rare Sugar against Ethanol Toxicity; An Electron Microscopic Study in Mice Hippocampus.  [Not invited]
    Rare Sugar Congress 2006 in Kagawa The 3rd Symposium of International Society of Rare Sugars  2006
  • 胎生期Ｘ線照射によるラット大脳皮質における神経路の形成異常  [Not invited]
    第110回日本解剖学会・全国学術集会  2005
  • Global gene expression analysis in the microdissected hypothalamic medial preoptic area of rat neonates exposed perinatally to ethinylestradiol.  [Not invited]
    第110回日本解剖学会・全国学術集会  2005
  • 出生後早期の母仔分離による海馬神経栄養因子の発現変化  [Not invited]
    第110回日本解剖学会・全国学術集会  2005
  • ﾗｯﾄの皮質および皮質下ﾆｭｰﾛﾝに対する脳磁気刺激の効果  [Not invited]
    The First International Conference on Complex medical Engineering  2005
  • Migration mechanism of erythroblastic island in rat bone marrow.  [Not invited]
    13th Conference of the European Society for Clinical Hemorheology (E.S.C.H.)  2005
  • Parabrachial projections to the lateral central nucleus of amygdala with special reference to hypotension in the rat.  [Not invited]
    日本解剖学会第６０回中国・四国地方会  2005
  • Accumulation of β amyloid-like protein in the piglet brain under secondary energy failure  [Not invited]
    The 1st Congress of Asian Society for Pediatric Research  2005
  • ﾗｯﾄ脳の電気および磁気刺激による皮質および皮質下ﾆｭｰﾛﾝ機能の変化  [Not invited]
    XVIII World Congress of Neurology  2005
  • Effects of electric or magnetic brain stimulation on cortical and subcortical neural functions in rats  [Not invited]
    The First International Conference on Complex medical Engineering  2005
  • Migration mechanism of erythroblastic island in rat bone marrow.  [Not invited]
    13th Conference of the European Society for Clinical Hemorheology (E.S.C.H.)  2005
  • Accumulation of β amyloid-like protein in the piglet brain under secondary energy failure  [Not invited]
    The 1st Congress of Asian Society for Pediatric Research  2005
  • Modulation of cortical and subcortical neural functions by electrical and magnetic brain stimulation in rats.  [Not invited]
    XVIII World Congress of Neurology  2005
  • 新生仔期アルコール曝露による神経栄養因子の動態変化  [Not invited]
    第44回日本先天異常学会学術集会  2004
  • Parabrachial inputs to Fos-immunoreactive neurons in the lateral central nucleus of amygdala activated by hypotension: a light and electron microscopic study in the rat.  [Not invited]
    7th International Congress of Neurothology  2004
  • Apoptotic process in the erythroid denucleation in rat bone marrow.  [Not invited]
    日本解剖学会第59回中国・四国地方会  2004
  • Parabrachial inputs to Fos-immunoreactive neurons in the lateral central nucleus of amygdala activated by hypotension: a light and electron microscopic study in the rat.  [Not invited]
    7th International Congress of Neurothology  2004

MISC

  • 精巣捻転症ラットモデルによる精巣虚血再灌流障害に関する研究 病理組織学的分析と遺伝子プロファイリング
    形見 祐人; 藤井 喬之; 田中 彩; 上野 正樹; 鈴木 辰吾; 三木 崇範; 下野 隆一  日本外科学会定期学術集会抄録集  122回-  SF  -1  2022/04
  • 幼少期ストレス経験による攻撃制御機構の破綻
    太田健一; 荒木智尋; 氏原英敏; 井関恵三; 鈴木辰吾; 大給日香里; 粂井大輝; 中村伸嗣; 日下隆; 三木崇範  日本先天異常学会学術集会プログラム・抄録集  62nd (CD-ROM)-  2022
  • 乳幼児期の不遇な養育環境による児の攻撃性増大とその原因となる脳領域
    太田健一; 荒木智尋; 氏原英敏; 井関恵三; 鈴木辰吾; 大給日香里; 粂井大輝; 中村伸嗣; 日下隆; 三木崇範  DOHad研究(Web)  10-  (2)  2022
  • 脳由来神経栄養因子が発達期神経細胞の遺伝子発現に与える影響
    鈴木辰吾; 川合杏奈; 三浦隆一郎; 太田健一; 三木崇範  日本解剖学会総会・全国学術集会講演プログラム・抄録集  125th-  2020
  • 母子間の関係性が児の脳発達及び高次機能に与える影響
    太田健一; 鈴木辰吾; 三木崇範  日本解剖学会総会・全国学術集会講演プログラム・抄録集  125th-  2020
  • 母子分離モデルから紐解く発達障害の原因となる脳領域
    太田健一; 三木崇範; 鈴木辰吾; 日下隆  母子健康協会小児医学助成研究報告書  31st-  2020
  • 母子分離が破綻させる内側前頭前皮質の興奮/抑制バランス
    小澤徹; 太田健一; 鈴木辰吾; 三木崇範  日本解剖学会総会・全国学術集会講演プログラム・抄録集  123rd-  2018
  • 脳発達期の母子分離による扁桃体の興奮/抑制バランス崩壊
    太田健一; 鈴木辰吾; 天雲千晶; 日下隆; 三木崇範  日本解剖学会総会・全国学術集会講演プログラム・抄録集  122nd-  2017
  • 神経毒とNeuroscienceエタノール
    三木 崇範; 太田 健一; 鈴木 辰吾  Clinical Neuroscience  (35)  1393  -1397  2017
  • 早産児脳発達リスクと発達ケア効果の分子機序解明:モデル動物による神経回路網レベルでのアプローチ
    太田健一; 鈴木辰吾; 日下隆; 三木崇範  母子健康協会小児医学助成研究報告書  27th-  2016
  • 養育環境が脳をかえる:分子~症状を双方向に見通す
    三木崇範; 太田健一; 鈴木辰吾  日本赤ちゃん学会学術集会プログラム・要旨集  15th-  2015
  • 癌細胞のスタチン系薬剤感受性を決める因子に関する研究
    割田克彦; 割田克彦; 保坂善真; 三觜友子; 三木崇範; OLTVAI Zoltan  日本獣医学会学術集会講演要旨集  158th-  2015
  • 生後早期の母子分離ストレスが,脂肪組織エネルギー代謝関連因子に及ぼす影響
    三木崇範; 太田健一; 鈴木辰吾; 割田克彦; 日下隆; 横山俊史; 劉俊騫; 矢倉富子; 玉井求宣; 竹内義喜  日本解剖学会総会・全国学術集会講演プログラム・抄録集  119th-  2014
  • 低酸素性虚血性脳症における脳循環・代謝の病態生理とこれからの治療戦略
    日下 隆; 安田 真之; 小谷野 耕佑; 中村 信嗣; 中村 信; 神内 済; 三木 崇範; 上野 正樹; 磯部 健一; 伊藤 進  日本周産期・新生児医学会雑誌  49-  (4)  1172  -1175  2013/12
  • 新生児期の不遇な養育環境が脳・脂肪組織に及ぼす影響-生活習慣病発症の脆弱性分子機構の解明-
    三木崇範; 太田健一; 鈴木辰吾; 日下隆; 横山俊史; 竹内義喜  母子健康協会小児医学助成研究報告書  24th-  2013
  • 脳発達の臨界期にてらした発達障害モデルの考察-胎児性アルコール症候群を例として-
    三木崇範; 太田健一; 鈴木辰吾; 割田克彦; 竹内義喜  日本解剖学会総会・全国学術集会講演プログラム・抄録集  118th-  2013
  • 長期間の食餌性コレステロール摂取が海馬神経栄養因子の動態に及ぼす影響
    三木崇範; 太田健一; 鈴木辰吾; 割田克彦; 日下隆; 横山俊史; 劉俊騫; 矢倉富子; 玉井求宣; 竹内義喜  日本解剖学会総会・全国学術集会講演プログラム・抄録集  118th-  2013
  • 小児期の養育環境が脳と心の発達に与える影響 セロトニン神経系と情動発現の分子基盤
    太田 健一; 三木 崇範; 鈴木 辰吾; 竹内 義喜; 日下 隆; 伊藤 進  成長科学協会研究年報  (35)  113  -116  2012/08
  • BDNFによるニューロンのコレステロール合成誘導とプレシナプス成熟のメカニズム
    鈴木 辰吾; 清末 和之; 邱 紅麗; 沼川 忠広; 伊丹 千晶; 笠間 健嗣; 小島 正己; 田中 光一; 三木 崇範; 竹内 義喜  解剖学雑誌  87-  (2)  43  -43  2012/06
  • 神経細胞におけるトランスサイトーシス 生体内Amyloid-βへの応用(Neuronal transcytosis of protein: application for Amyloid-β in vivo)
    松本 由樹; 三木 崇範; 割田 克彦; 矢倉 富子; 劉 俊騫; 竹内 義喜  神経化学  49-  (2-3)  525  -525  2010/08
  • WGA結合タンパクがもたらすシナプス膜輸送機構の新展開
    松本 由樹; 三木 崇範; 割田 克彦; 汪 治宇; 矢倉 富子; 劉 俊騫; 竹内 義喜  解剖学雑誌  85-  (2)  83  -83  2010/06
  • 非小胞性シナプス輸送 WGA-HRPおよびRab3A-siRNAによる研究
    矢倉 富子; 松本 由樹; 三木 崇範; 割田 克彦; 汪 治宇; 劉 俊騫; 藤田 守; 竹内 義喜  解剖学雑誌  85-  (Suppl.)  192  -192  2010/03
  • 短期間アルコール摂取マウス小脳の神経栄養因子リガンド/レセプター系の特異的応答性
    三木 崇範; 汪 治宇; 横山 俊史; 日下 隆; 住谷 和則; 割田 克彦; 松本 由樹; 矢倉 富子; 劉 俊騫; 王 朝暉; 竹内 義喜  解剖学雑誌  85-  (Suppl.)  194  -194  2010/03
  • 「香川大学のFD活動の実施状況」
    葛城浩一; 竹中龍範; 中島洋樹; 水野康一; 三木崇範; 吉田秀典; 深井誠一  香川大学大学教育開発センター編『香川大学教育研究』  (第7号)  1-17頁  2010/03
  • 生後早期の母仔分離ストレスにより惹起される小脳神経栄養因子/受容体発現レベルの変動
    三木崇範; 横山俊史; 日下隆; 住谷和則; 割田克彦; 松本由樹; 矢倉富子; 劉俊騫; 竹内義喜  日本先天異常学会学術集会プログラム・抄録集  50th-  2010
  • フィジカルアセスメント教育に向けた系統解剖見学実習の活用法 看護学科における試み
    六車 輝美; 松本 由樹; 三木 崇範; 割田 克彦; 汪 治宇; 永田 若; 松岡 美奈子; 笠井 勝代; 竹内 義喜  解剖学雑誌  84-  (2)  67  -67  2009/06
  • ラットにおけるWGA-HRPの順行性シナプス輸送の再評価(Revaluation of anterograde synaptic transport of WGA-HRP in the rat)
    竹内 義喜; 三木 崇範; 横山 俊史; 松本 由樹; 割田 克彦; 汪 治宇; 上野 貴士; 藤田 守  解剖学雑誌  84-  (Suppl.)  183  -183  2009/03
  • Molecular mechanism of maternal care on neuropsychological development: epigenetic analysis of maternal deprivation syndrome
    三木 崇範; 割田 克彦; 日下 隆  研究助成論文集  (45)  142  -150  2009
  • 雄性化破綻メカニズムとエピジェネティクス
    三觜 友子; 割田 克彦; 菅原 照夫; 田渕 圭章; 松本 由樹; 三木 崇範; 石原 可奈; 谷田 任司; 蝦名 康彦; 櫻木 範明; 横山 俊史; 竹内 義喜; 北川 浩; 星 信彦  日本獣医学会学術集会講演要旨集  146回-  148  -148  2008/09
  • 生後早期エタノール曝露による嗅球におけるBDNF-神経相互作用の変化(Early postnatal ethanol exposure alters the BDNF and neural interactions in the olfactory bulb)
    松本 由樹; 三木 崇範; 谷 賀; 割田 克彦; 汪 治宇; 竹内 義喜  解剖学雑誌  83-  (Suppl.)  187  -187  2008/03
  • 外因性エストロゲン様化学物質がLeydig細胞株TTE1のStARおよびP450scc遺伝子発現に与える影響とアセチル化ヒストンの変化
    割田 克彦; 菅原 照夫; 田渕 圭章; 三觜 友子; 松本 由樹; 三木 崇範; 石原 可奈; 谷田 任司; 横山 俊史; 竹内 義喜; 北川 浩; 星 信彦  日本獣医学会学術集会講演要旨集  145回-  163  -163  2008/03
  • 医学部における先天異常教育-香川大学での試み-
    三木崇範; 割田克彦; 松本由樹; 日下隆; 汪治宇; 伊藤進; 竹内義喜  日本先天異常学会学術集会プログラム・抄録集  48th-  (Abstracts)  2008
  • Y染色体腕間逆位を有するXY女性:PCAFを介したヒストンアセチル化異常を原因とするSRY遺伝子過剰発現-雄性化の破綻
    三觜友子; 割田克彦; 田渕圭章; 菅原照夫; 高崎一朗; 松本由樹; 三木崇範; 石原可奈; 谷田任司; 蝦名康彦; 櫻木範明; 横山俊史; 竹内義喜; 北川浩; 星信彦  日本人類遺伝学会大会プログラム・抄録集  53rd-  2008
  • Y染色体腕間逆位を有するXY女性におけるSRY遺伝子のエピジェネティック異常
    三觜友子; 割田克彦; 菅原照夫; 田渕圭章; 高崎一朗; 松本由樹; 三木崇範; 石原可奈; 谷田任司; 蝦名康彦; 櫻木範明; 横山俊史; 竹内義喜; 北川浩; 星信彦  日本先天異常学会学術集会プログラム・抄録集  48th-  (Abstracts)  2008
  • エストロゲン様化学物質曝露によるステロイドホルモン産生系遺伝子の発現変化とヒストンアセチル化解析
    割田克彦; 三觜友子; 菅原照夫; 田渕圭章; 松本由樹; 三木崇範; 石原可奈; 谷田任司; 横山俊史; 竹内義喜; 北川浩; 星信彦  日本先天異常学会学術集会プログラム・抄録集  48th-  (Abstracts)  2008
  • 母性剥奪症候群（Maternal Deprivation Syndrome)の発達神経科学的アプローチ
    三木崇範  日本未熟児新生児学会雑誌  20-  (1)  35  -40  2008
  • 外因性エストロゲン様化学物質がLeydig細胞株TTE1のステロイドホルモン産生系遺伝子発現に与える影響とヒストンアセチル化解析
    割田 克彦; 菅原 照夫; 田渕 圭章; 三觜 友子; 松本 由樹; 三木 崇範; 石原 可奈; 谷田 任司; 横山 俊史; 竹内 義喜; 北川 浩; 星 信彦  環境ホルモン学会研究発表会要旨集  10回-  178  -178  2007/12
  • 嗅球における発達中の神経系に対するイソフルレン吸入麻酔の影響
    横山 俊史; 三木 崇範; 汪 治宇; 楊 衛文; 李 京烈; 植木 正明; 竹内 義喜  解剖学雑誌  82-  (Suppl.)  219  -219  2007/03
  • 中枢神経発達時期におけるイソフルラン曝露の影響:嗅球における神経栄養因子の変化
    三木崇範; 横山俊史; 植木正明; 汪治宇; 割田克彦; 松本由樹; 前川信博; 竹内義喜  日本先天異常学会学術集会プログラム・抄録集  47th-  2007
  • 子供の脳発達と養育環境－母性剥奪症候群のエピジェネティック解析
    三木崇範  財団法人成長科学教会 研究年報  (31)  189  -190  2007
  • Miniラットにおける視床下部-下垂体-精巣系の機能確立とその変動
    松本 由樹; 塚本 康浩; 三木 崇範; 竹内 義喜; 佐々木 文彦  解剖学雑誌  78-  (Suppl.)  345  -345  2003/04
  • ラット海馬神経細胞のステレオロジーによる組織定量学的解析:胎児性アルコール症候群実験動物モデルへの適用
    三木 崇範; 松本 由樹; 谷 賀; SATRIOTOMO Irawan; 李 洪鵬; 熊 宏美; GONZALEZ Daniel; 竹内 義喜  形の科学会誌 = Bulletin of the Society for Science on Form  17-  (1)  31  -32  2002/06
  • 胎内放射線被曝ラットにおける小脳の変化
    李 洪鵬; 三木 崇範; 谷 賀; 松本 由樹; 熊 宏美; 竹内 義喜  解剖学雑誌  77-  (Suppl.)  J.A.A.83  -J.A.A.83  2002/03
  • 胎生期放射線照射のタイミングによる小脳プルキンエ細胞数の変化
    李 洪鵬; 三木 崇範; 谷 賀; Satriotomo Irawan; 松本 由樹; Gonzalez Daniel; 熊 宏美; 竹内 義喜  解剖学雑誌  77-  (Suppl.)  APPENDIX48  -APPENDIX48  2002/03
  • 李 洪鵬; 三木 崇範; 谷 賀; 松本 由樹; 熊 宏美; 竹内 義喜  日本解剖学会 総会・全国学術集会 抄録号  107-  (0)  83  -83  2002
  • Developmental disturbance of rat hippocampus following prenatal γ -irradiation : Developmental disturbance of rat hippocampus following prenatal γ -irradiation
    MIKI Takanori; FUKUI Yoshihiro; ITOH Masahiro; HISANO Setsuji; TAKEUCH Yoshiki  Journal of radiation research  37-  (4)  390  -390  1996
  • Quantitative study of rat cortical neurons following prenatal X-irradiation : Quantitative study of rat cortical neurons following prenatal X-irradiation
    MIKI Takanori; FUKUI Yoshihiro; TAKEUCHI Yoshiki  Journal of radiation research  35-  (4)  312  -312  1994

Awards & Honors

  • 1997 形の科学会奨励賞
     JPN

Research Grants & Projects

  • Development of new epigenome editing therapy technology
    Japan Society for the Promotion of Science：Grants-in-Aid for Scientific Research
    Date (from‐to) : 2026/04 -2029/03 
    Author : 鈴木 辰吾; 三木 崇範; 太田 健一; 大給 日香里
  • Music as a New Strategy for Improving Perinatal Stress-Induced Behavioral Abnormalities: Focusing on Neural Plasticity
    Japan Society for the Promotion of Science：Grants-in-Aid for Scientific Research
    Date (from‐to) : 2026/04 -2029/03 
    Author : 三木 崇範; 太田 健一; 鈴木 辰吾; 大給 日香里; 横山 俊史; 中村 信嗣; 割田 克彦; 金西 賢治; 日下 隆
  • Elucidation of the mechanism of neurodevelopmental disorders caused by maternal deprivation: An approach from the brain-gut interaction
    Japan Society for the Promotion of Science：Grants-in-Aid for Scientific Research
    Date (from‐to) : 2025/04 -2028/03 
    Author : 太田 健一; 三木 崇範; 鈴木 辰吾; 大給 日香里; 中村 信嗣; 日下 隆; 割田 克彦
  • 雄胎子のミュラー管退行時におけるAmhの移行経路の解明―血液循環系と浸潤的移行
    日本学術振興会：科学研究費助成事業
    Date (from‐to) : 2025/04 -2028/03 
    Author : 横山 俊史; 星 信彦; 三木 崇範; 松尾 栄子
  • The optimal hydrogen gas inhalation concentration range for cerebral hemodynamic impairment in hypoxic-ischemic encephalopathy.
    Japan Society for the Promotion of Science：Grants-in-Aid for Scientific Research
    Date (from‐to) : 2023/04 -2026/03 
    Author : 中村 信嗣; 小谷野 耕佑; 三木 崇範; 上野 正樹; 日下 隆
     
    本年度は、新生仔豚4頭を用いて、脳組織の還流後の固定方法を変更し、それが免疫組織染色に適するものかを調べた。その結果、以前の固定法よりも変更後の固定法のほうが、免疫組織染色では反応が安定することが明らかとなった。また、KB染色での正常神経細胞の数を調べ、水素ガスにより、正常神経細胞が増加するかを調べたところ、水素ガスでは吸入時間が6時間でも、軽症負荷では正常神経細胞が増えることが分かった。
  • 妊娠母体炎症が惹起する児の脳-身体の双方向性制御機能の破綻
    日本学術振興会：科学研究費助成事業
    Date (from‐to) : 2022/04 -2026/03 
    Author : 三木 崇範
     
    妊娠中の母体感染が児の脳発達及びエネルギー代謝に与える影響を明らかにするため、妊娠炎症曝露モデルを用いて影響を受ける児脳領域と、それによって変動する行動異常を明らかにする。特に視床下部と自律神経系には特別に焦点を当て、妊娠中の炎症による視床下部への影響と末梢組織（肝・膵・腸管・脂肪組織など）の変化を網羅的に解析し詳細に評価する。これにより、妊娠中の慢性的母体感染が如何なる機序（例えば、神経、内分泌・生理活性物質など）で、脳－末梢臓器の連関を破綻させるのか、そしてそれは将来の肥満を基盤とする生活習慣病の発症に如何に影響するのかを明らかにする。
  • 生体外より遺伝子発現を誘導するシステムの開発
    日本学術振興会：科学研究費助成事業
    Date (from‐to) : 2022/04 -2025/03 
    Author : 鈴木 辰吾; 三木 崇範; 太田 健一; 重藤 元; 大給 日香里
  • 新規の近赤外光時間分解測定を用いた新生児の脳浮腫評価
    日本学術振興会：科学研究費助成事業
    Date (from‐to) : 2022/04 -2025/03 
    Author : 日下 隆; 三木 崇範; 上野 正樹; 中村 信嗣; 光家 努; 星 詳子; 森本 絢; 中尾 泰浩; 有岡 誠
  • 愛着・母子相互作用における子どもと母親の脳酸素代謝、神経活動の律動的同期性の解明
    日本学術振興会：科学研究費助成事業
    Date (from‐to) : 2022/04 -2025/03 
    Author : 谷本 公重; 加藤 育子; 西田 智子; 徳地 暢子; 尾崎 典子; 太田 健一; 鈴木 辰吾; 三木 崇範; 日下 隆
  • New therapy for neonatal resuscitation using hydrogen gas
    Japan Society for the Promotion of Science：Grants-in-Aid for Scientific Research
    Date (from‐to) : 2019/04 -2023/03 
    Author : 中村 信嗣; 安田 真之; 小谷野 耕佑; 三木 崇範; 上野 正樹; 日下 隆; 太田 健一
     
    新生仔豚16頭を用いて、低酸素虚血負荷を行い、無治療群と水素ガス吸入群の2群にわけて、負荷後6時間まで人工呼吸器管理を行い、近赤外光時間分解装置による脳循環酸素代謝変化、脳波計による脳波測定、及びバイタルデータの記録を行った。また、負荷後6時間で、臓器還流固定を行い、脳組織の病理組織評価を行った。その結果、無治療群では、異常脳波を3頭で認め、それらの脳組織における正常神経細胞は認めなかったが、異常神経細胞は１視野あたり10個程度認めた。水素ガス吸入群では、3頭で異常脳波を認め、それらでは、正常細胞を１視野あたり50個程度認め、異常細胞は1頭のみ１視野当たり10個認めた。以上の結果より、水素ガス投与下では、異常脳波を伴う場合でも正常神経細胞が生存可能となることが示唆された。
  • 母子分離モデルから紐解く発達障害発症に関わる脳領域
    日本学術振興会：科学研究費助成事業
    Date (from‐to) : 2019/04 -2022/03 
    Author : 太田 健一; 三木 崇範; 鈴木 辰吾; 中村 信嗣; 割田 克彦; 日下 隆
     
    最終年度では、前年度 (2020年度)に確認された光遺伝学による扁桃体中心核の活性化が攻撃行動を惹起することについて、その信頼性を高めるための追試験と組織学的解析を行った。方法は、アデノ随伴ウイルスを用いて脳定位手術にて9週齢のSDラット雄の扁桃体中心核にチャネルロドプシン-2を発現させ、その直上にLEDカニューラを導入した。2020年度に問題となった再現性を改善すべく導入部位の微調整及びアデノ随伴ウイルスの力価を減少させたところ、非常に高い再現性でLEDでの光刺激(λ=470nm)による攻撃行動の惹起に成功した。また組織学的解析を行ったところ、チャネルロドプシン-2の発現が扁桃体中心核に限局していること、更に光刺激は扁桃体中心核を主に活性化させていることをc-Fos発現で確認できた。最も懸念されるのは、すぐ近傍に存在し攻撃性に関与する事が数多く報告されている扁桃体内側核も同時に活性化されて攻撃行動を惹起してしまった可能性であったが、少なくとも我々の条件下ではチャネルロドプシン-2を扁桃体内側核に発現させ光刺激をくわえても攻撃行動が惹起されなかった。これらの結果は、扁桃体中心核自体の過剰活性が過度な攻撃性（あるいは暴力性）と非常に強く関係している事を示すものであり、2019年度に認められた母子分離されたラット仔の過剰な攻撃行動の一端は扁桃体中心核の過剰な活性状態にその原因があることを支持する結果である。扁桃体中心核の過剰な活性がもたらす攻撃性は’Predatory aggression (略奪的攻撃性)’との関係が指摘されており、それはヒトにおける非行・暴力を伴う犯罪行為に繋がる事が示唆されている。従って本研究課題から見出された結果は母子分離、すなわち幼少期の育児放棄のような不遇な養育環境は将来的な反社会的行動に繋がる根本となる攻撃性に関わる脳領域の発達に影響を与えうることを示唆するものである。
  • Bidirectional signaling mechanism between the intestinal microbiota and brain: Molecular basis of obesity induced by stress.
    Japan Society for the Promotion of Science：Grants-in-Aid for Scientific Research
    Date (from‐to) : 2018/04 -2022/03 
    Author : Takanori Miki
     
    Numerous studies reported on the effects of early life stress on brain and body development. However, little is known about how it alters the intestinal bacterial flora. The new vistas for understanding the brain-gut interactions related to the gut microbiota provide further insights to understanding the developmental mechanism of brain-gut interactions. In this study, we examined the gut microbiota of a maternal separation model in rats and found changes in composition particularly related to lifestyle-related diseases and inflammation. Furthermore, this animal model showed an increased expression of inflammatory cytokines released by microglia in the brain during early life. These results suggest that early life stress alters an inflammation-prone gut microbiota, which may cause inflammation in the brain.
  • Establishment of a new neonatal resuscitation strategy by monitoring cerebral hemodynamcis and oxygen metabolism as an indicator
    Japan Society for the Promotion of Science：Grants-in-Aid for Scientific Research
    Date (from‐to) : 2017/04 -2021/03 
    Author : Kondo Sonoko
     
    We measured cerebral haemoglobin oxygen saturation (ScO2) and cerebral blood volume (CBV) using three-wavelength near-infrared time-resolved spectroscopy in a 5-day survival asphyxiated piglet model. We investigated how changes in ScO2 and CBV during the resuscitation period after hypoxic-ischaemic (HI) insult reflected histopathological brain injury on day 5 after insult. Changes in CBV after HI insult were correlated with histopathological brain injury but changes in ScO2 were not. Clinical study, we examined CBV and ScO2 during 15 min after birth between healthy term neonates delivered vaginally (VD, n=13) and those delivered by elective cesarean section (CS,n=18) using TRS. CBV was significantly higher in the VD group than in the CS group in the 4 min after birth (p<0.05) but not thereafter. There was no significant between-group difference in ScO2 during the transition period.
  • Influence of Early Life Stress on the Brain Development
    Japan Society for the Promotion of Science：Grants-in-Aid for Scientific Research
    Date (from‐to) : 2017/04 -2020/03 
    Author : Suzuki Shingo
     
    Previous studies have suggested that BDNF, which induces synaptic development, induces CYP46 which promotes the biosynthesis of 24-hydroxycholesterol. In the present study, we investigated the possibility that 24-hydroxycholesterol could be a biomarker for synaptic development. Specifically, we evaluated the potential of 24-hydroxycholesterol to serve as a biomarker of synaptic development using repeated maternal separation (MS), a model of preterm birth stress. The results showed that the expression of CYP46 in the hippocampus was reduced by MS. These results suggest that early life stress may have reduced CYP46 expression levels via a reduction in BDNF. Therefore, stress during development may act on the brain to induce a decrease in 24-hydroxycholesterol, suggesting that 24-hydroxycholesterol could be used as a marker for synapse formation.
  • The epigenetic status of Y chromosome in mammalian undifferentiated gonad
    Japan Society for the Promotion of Science：Grants-in-Aid for Scientific Research
    Date (from‐to) : 2017/04 -2020/03 
    Author : YOKOYAMA TOSHIFUMI
     
    The relationship between the modification status of the sex-determining gene Sry on the Y chromosome and the expression of sex-differentiation-related factors was investigated. As a result, it was revealed that Sry expression was different among the commonly used mouse sublines, and that there were spatiotemporal and lateral differences in Sry expression in healthy male individuals. The organ culture system and internal normalizing genes required for validation of Sry expression were also established. Moreover, it was revealed that Amh acts on the Mullerian duct by infiltrating the tissue from the testis toward the mesonephros.
  • Relationship between hyperbilirubinemia and cerebral oxygen metabolism in newborn infants.
    Japan Society for the Promotion of Science：Grants-in-Aid for Scientific Research
    Date (from‐to) : 2016/04 -2020/03 
    Author : Kusaka Takashi
     
    Neonatal hyperbilirubinemia is the unique physiological phenomenon in human. Its biological significance depends on the role of bilirubin as a radical scavenger during neonatal period, when the brain oxygen metabolism develops rapidly. We validated the methods for measurements of both liver glucuronidation and cerebral oxygen consumption in human neonates. We found that serum conjugated bilirubin and bilirubinⅨαare useful for assessments of liver glucuronidation two weeks after birth, because the secretion of conjugated bilirubin is stable at that time. Further, we investigated relationships between cerebral Hb oxygen saturation (ScO2) by near-infrared spectroscopy and Hb oxygen saturation of the internal jugular vein or femoral artery in children with congenital heart diseases, found ScO2 is useful for assessing cerebral oxygenation in neonates.
  • An objective assessment of maternal-infant interaction and developmental changes: using brain oxygen metabolism as an indicator during breastfeeding
    Japan Society for the Promotion of Science：Grants-in-Aid for Scientific Research
    Date (from‐to) : 2015/04 -2020/03 
    Author : Tanimoto Kimie
     
    The purpose of this study was to establish an objective index of maternal-infant interaction and to elucidate the mechanism of attachment formation between mothers and their children. Using a two-channel portable near-infrared tissue oxygen monitor with near-infrared spectroscopy, blood circulation in the prefrontal cortex of the mother and infant simultaneously was measured during the three occasions of "Separation," "Caring," and "Breastfeeding. We examined the correlation of oxygenated hemoglobin in mothers and infants by moving the mother's data time with respect to the child (cross-correlation), and examined the time lag at which the absolute value was maximized. The histogram figure showed a parametric distribution and the largest distribution between 0 and 0.3. We also examined cross-correlation ranks by three occasions and found that there was a tendency to show more stronger correlation during breastfeeding than during caring.
  • The Influences of maternal separation on neural circuit formation during brain development equivalent to preterm infants in human
    Japan Society for the Promotion of Science：Grants-in-Aid for Scientific Research
    Date (from‐to) : 2015/04 -2018/03 
    Author : OHTA Ken-ichi
     
    In this study, we analyzed the influences of maternal separation (MS) during brain development equivalent to preterm infants in human using rat model. Our results showed that MS during brain development increased aggressive behavior and reduced the behavior related to social recognition after maturation. In addition, we found that reduction of various factors (VGAT, Neuroligin-2) related to inhibitory synapse in the amygdala and the medial prefrontal cortex of mature rat exposed to MS. Excitatory/inhibitory imbalance disrupts normal function in these regions, which leads to cause excessive aggression and abnormality of sociability. Our study also revealed these influences of MS are not irreversible, but rather can be recovered depending on nurturing environment after MS.
  • Regulation of energy metabolism between brain and periferal organs; molecular mechanism of stress-induced life style-related diseases
    Japan Society for the Promotion of Science：Grants-in-Aid for Scientific Research
    Date (from‐to) : 2014/04 -2018/03 
    Author : MIKI TAKANORI
     
    This study was carried out to examine the effects of early postnatal maternal separation stress on the developmental crosstalk between the brain and peripheral energy-related organs. Our study can obtain insight understanding etiological mechanisms of life style-related diseases, such as obesity. Maternally separated rats showed abnormal alterations in neurotrophic factor expressions, their signal transduction systems and synapse structure protein phosphorylations. Furthermore, maternal separation stress affected various enzymes that involves in lipid metabolism. Examination on gut microbiota in these animals showed a disturbance in microbial composition leading to cause abnormal metabolism and/or nutrition. Our study showed that maternal separation stress during early postnatal life can affect the functions of both brain and peripheral organs that causes obesity in later life.
  • Effect of BDNF on fatty acid homeositasis during brain development
    Japan Society for the Promotion of Science：Grants-in-Aid for Scientific Research
    Date (from‐to) : 2014/04 -2017/03 
    Author : SUZUKI SHINGO
     
    It is suggested that lower dietary intake of nutrients such as fatty acids during the development is related to the vulnerability to the on-set of psychiatric disorders. However, brain fatty acid homeostasis in the neonatal period has not been fully understand. In this study, we tried to elucidate the brain lipid homeostasis in this period. As a result, it was found that saturated fatty acids are actively desaturated in neonatal brain, that BDNF (Brain-derived neurotrophic factor) is involved in liver SCD-1 activity and can participate in systemic fatty acid homeostasis, and that BDNF induces the expression of HPA axis-related protein.
  • Relationships between the regulation mechanisms of sex differentiation and the epigenetic status in the developing gonad
    Japan Society for the Promotion of Science：Grants-in-Aid for Scientific Research
    Date (from‐to) : 2014/04 -2017/03 
    Author : YOKOYAMA TOSHOFUMI
     
    We examined the relationship between regulation mechanisms of gonadal sex differentiation and disorders of sex development (DSD). In the DSD line mice (YPOS), inappropriate spatiotemporal expression of sex determine gene Sry and sex differentiation related genes in the developing gonad cause different phenotype from the same genetic background. We found new regulatory mechanism about sex differentiation related gene dmrt1 using non-coding region of dmrt1 gene. The epigenetic status of this region was non-methylated both in the testis and ovary in adult mice. Furthermore, it became clear that, there were asymmetries in the expression patterns of dmrt1 and differentiation process of Sertoli cells in the developing chick gonad.
  • The effects of hydrogen gas inhalation for hypoxic-ischemic encephalopathy in piglets.
    Japan Society for the Promotion of Science：Grants-in-Aid for Scientific Research
    Date (from‐to) : 2013/04 -2017/03 
    Author : Kusaka Takashi
     
    The aim of this study is to evaluate the effectiveness of free radical scavenger (edaravone, EV) combined with hypothermia (HT) for hypoxic-ischemic (HI) brain injury, and the safety of hydrogen gas inhalation in neonatal piglets. The following results had been reported. At first, there was a positive linear correlation between changes in cerebral blood volume and low-amplitude aEEG duration during 12 h after the insult in the no-therapy group, but a negative linear correlation between these two parameters in the HT group. Secondly, both HT and HT+EV groups showed lower histopathological cerebral damages compared to that of no-therapy, especially in gray and white matter. However, HT+EV did not show lower damages compared to HT. Lastly, hydrogen gas inhalation had no effects on circulatory and metabolic activities, especially cerebral hemodynamics and oxygen metabolism, and cortical electrical activity. Therefore, hydrogen gas is likely to be used safely in neonatal medicine.
  • Analysis of molecular mechanisms involved in the susceptibility to statins on cancer cells
    Japan Society for the Promotion of Science：Grants-in-Aid for Scientific Research
    Date (from‐to) : 2014/08 -2016/03 
    Author : Warita Katsuhiko; MIKI TAKANORI; HOSAKA YOSHINAO; OHTA KEN-ICHI; SUZUKI SHINGO; WARITA TOMOKO; Oltvai Zoltan N.
     
    The anti-proliferative effect of stains on cancer cells has received widespread attention, since it has been reported that the statins may exhibit an anti-cancer effect in addition to their cholesterol-lowering effect. However, what type of cancer cell statin is effective for is unclear. Our previous study identified E-cadherin as a candidate factor determining the susceptibility to statin. To demonstrate that E-cadherin actually determines the susceptibility of cancer cells to statin, we examined if the regulation of E-cadherin expression has an influence on the susceptibility of cancer cells to statin in the present study. When E-cadherin gene (CDH1) was inserted into the statin-sensitive cells which had no E-cadherin, the half maximal inhibitory concentration (IC50) increased 3.7-fold. On the other hand, E-cadherin knockdown in the statin-resistant cancer cells increased their susceptibility to statin. These results strongly suggest that E-cadherin is a statin resistance factor.
  • Treatment strategy of neonatal hypoxic-ischemic encephalopathy using by newborn piglets asphyxia model
    Japan Society for the Promotion of Science：Grants-in-Aid for Scientific Research
    Date (from‐to) : 2013/04 -2016/03 
    Author : Saneyuki Yasuda; KOYANO Kosuke; MIKI Takanori; UENO Masaki; NAKAMURA Shinji; KUSAKA Takashi
     
    In these studies, we found that combining the cerebral blood volume (CBV) with amplitude-integrated EEG (aEEG) is a more effective guide to control hypoxic/ischemic (HI) insult in a newborn piglet model than aEEG alone, to produce a consistent degree of survivable neuropathological damage. Next, we found that an early CBV increase and longer low-ampitude EEG after insult indicates severe brain injury. Finally, we revealed that Edaravone (a free radical scavenger) reduced histologic neuronal damage related to HI loading in our piglet HI model. However, we also found the histopathological damage, especially kidney tissue. We have to consider the systemic impact by Edaravone.
  • Effects of physical exercise preconditioning on cerebrovascular damage in rat hippocampus.
    Japan Society for the Promotion of Science：Grants-in-Aid for Scientific Research
    Date (from‐to) : 2012/04 -2016/03 
    Author : sumitani kazunori; NAKAMURA Takehiro; MIKI Takanori; OKADA Hiroki
     
    Physical exercise preconditioning is becoming generalized in patients with hypertension to reduce a risk factor of cerebrovascular diseases Based on such therapeutic framework, we examined whether physical exercise preconditioning prior to the intracranial-hemorrhage can attenuate the cerebrovascular damage in rat hippocampus or not. Present study revealed that physical exercise preconditioning prior to intracranial hemorrhage can attenuate neuronal damages in both young and aged animals. However, precise etiological mechanisms involved in the preconditioning effects on the brain is unknown at present. Further studies are needed to clarify this phenomenon.
  • Risk of learning deficit and mental disorder by prolonged maternal separation
    Japan Society for the Promotion of Science：Grants-in-Aid for Scientific Research
    Date (from‐to) : 2012/04 -2015/03 
    Author : OHTA Ken-ichi; TAKEUCHI Yoshiki; MIKI Takanori; SUZUKI Shingo; WARITA Katsuhiko; KUSAKA Takashi
     
    Present study showed that prolonged maternal separation influenced formation of neuronal circuit in the CA1 region of rat hippocampus and hippocampus-dependent learning ability after weaning. In addition, prolonged maternal separation caused the reduction of BDNF-ERK signaling and hyperphosphorylation of GluR1 via CaMKII in the rat hippocampus. Given that these factors are closely related to synaptic formation, functional synapses are commenced to be formed around postnatal days 7-10, these alterations possibly disrupt normal functional acquisition of brain development. Our findings suggest that prolonged maternal separation disturbs the factors related to synaptogenesis during early brain development, which might be in part responsible for abnormalities of formation of neuronal circuit and learning deficit in later life.
  • Alterations of synaptic transcytosis induced by ethanol exposure: non-vesicular synaptic transport in the rat
    Japan Society for the Promotion of Science：Grants-in-Aid for Scientific Research
    Date (from‐to) : 2010/04 -2014/03 
    Author : TAKEUCHI Yoshiki; MIKI Takanori; IMAGAWA Tomohiro; NAKAMURA Kazuhiko; OHTA Kenichi; SUZUKI Shingo; WARITA Katsuhiko; MATSUMOTO Yoshiki
     
    Neuronal tracer of HRP is considered to be transported independently at synapse. To investigate this transport, the solitary nucleus was observed at the electron microscopic level after WGA-HRP injection into the rat vagus nerve. Animals receiving injection of WGA-HRP with Rab3A-siRNA or alcohol treatment revealed apocrine-like structures of terminals which contained HRP reaction product and indented into secondary neurons. Finally, these structures were observed to be separated completely from axon terminals. Quite similar structures were found in the posterior pituitary in animals receiving same injections into the hypothalamus or alcohol treatment. The apocrine-like structures of hypothalamic terminals showed to contain HRP reaction product and large dense core vesicles, and be frequently separated into the vascular space. The present study apparently confirmed the existence of synaptic transport of proteins which was quite different from previous vesicular synaptic transport.
  • Ethiological mechanisms of perinatal stress on lifestyle-related diseases pathogenesis
    Japan Society for the Promotion of Science：Grants-in-Aid for Scientific Research
    Date (from‐to) : 2010/04 -2014/03 
    Author : MIKI Takanori; OHTA Kenichi; SUZUKI Shongo; YOKOYAMA Toshifumi; KUSAKA Takashi; TAKEUCHI Yoshiki
     
    This study was carried out to examine the effects of early postnatal maternal separation stress on the brain development, biological properties of adipose tissue, and the interactions between them. Wistar rats were separated from their mothers in early life. The level of various neurotrophic factor ligands/receptors in the cerebral cortex and cerebellum showed abnormal time-dependent fluctuations. Given that these factors play important roles in brain development, it can be speculated that the altered expression of these factors induced by maternal separation may interrupt normal brain development and ultimately lead to functional disruption. Furthermore, there was a significant change in the level of various mitochondrial energy-expenditure molecules. Given that these molecules influence the mitochondrial metabolism, our study indicates that early postnatal maternal deprivation can influence the fate of adipose tissue proliferation, presumably leading to obesity later in life.
  • Strategy for hypoxic-ischemic encephalopathy in newborn infants to reduce oxygen free radicals by adjusting hydrogen and oxygen
    Japan Society for the Promotion of Science：Grants-in-Aid for Scientific Research
    Date (from‐to) : 2010 -2012 
    Author : KUSAKA Takashi; UENO Masaki; MIKI Takanori; YASUDA Saneyuki; IWASE Takashi; NISHIDA Tomoko
     
    In these studies, we found that combining the cerebral blood volume (CBV) with amplitude-integrated EEG (aEEG) is a more effective guide to control hypoxic/ischemic (HI) insult in a newborn piglet model than aEEG alone, to produce a consistent degree of survivable neuropathological damage. Next, we found that an early CBV increase and longer low-ampitude EEG after insult indicates severe brain injury. Finally, we revealed that Edaravone (a free radical scavenger) reduced histologic neuronal damage related to HI loading in our piglet HI model.
  • Neurotrophic factors and cognitive function after alcohol intoxication in mice model
    Japan Society for the Promotion of Science：Grants-in-Aid for Scientific Research
    Date (from‐to) : 2010 -2012 
    Author : JAMAL Mostofa
     
    Here we investigated the effects of ethanol (EtOH) and acetaldehyde (AcH) on behavior,and mRNA levels of nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF) and c-fos at 30 min after EtOH in Aldehyde dehydrogenase 2 knock (Aldh2-KO), Apolipoprotein E knockout (ApoE-KO) and wild type (WT) mice. Eight-arm-radial maze and Morris-water maze showed that 1) 2.0 g/kg EtOH impaired spatial memory in all three strains, while lower doses did not have consistent memory effects, 2) a probe trial(drug-free state) showed a sustained memory impairment in mice that had received 2.0 g/kg EtOH previously, regardless of strain, 3) ApoE-KO mice learned more slowly than WT mice, and the Aldh2-KO mice learned more quickly.Real time PCR showed that 1) EtOH increased c-fos mRNA expression in ALDH2-KO (1 and 2g/kg) and WT (2.0 g/kg), 2) 2.0 g/kg of EtOH decreased ChAT mRNA in Aldh2-KO mice, while acetylcholinesterase mRNA expression was increased in both strains, 3) acute EtOH failed to alter the mRNA levels of NGF and BDNF and 4)Aldh2-KO mice showed a distinctly lower level of ChAT mRNA and a higher level of NGF mRNA versus WT mice. Our observation suggests that high EtOH and AcH can alter cholinergic markers and this effect did not modify the levels of NGF and BDNF.
  • Cytoarchitectural changes of brain induced by alcohol exposure : effects on Notch signal pathway
    Japan Society for the Promotion of Science：Grants-in-Aid for Scientific Research
    Date (from‐to) : 2006 -2009 
    Author : TAKEUCHI Yoshiki; MIKI Takanori; MATSUMOTO Yoshiki; WARITA Katsuhiko; NAKAMURA Kazuhiko; IMAGAWA Tomohiro; YOKOYAMA Toshifumi
     
    Notch signaling, related with maintenance of Stemness in culture, is well known to play an important role in neuroprotective and proliferative properties. Therefore, alcohol exposure showed to activate the Notch pathway. As results, Notch signaling related receptors, such as Platelet-derived growth factor (PDGF), Brain-derived neurotrophic factor (BDNF) and Nerve growth factor (NGF), were indicated to be strongly expressed. However, there are significant lacunae about formation of neuronal network under expression of these receptors. Particularly, changes of neuronal membranes, axonal transport and synaptic transmission should be studied. In this point, a study of synaptic transport of protein might provide biological solution for psychiatric disorder of alcoholism.
  • Effects of maternal care on brain development : molecular mechanism of mother-infant interactions
    Japan Society for the Promotion of Science：Grants-in-Aid for Scientific Research
    Date (from‐to) : 2006 -2009 
    Author : MIKI Takanori; YOKOYAMA Toshifumi; MATSUMOTO Yoshiki; WARITA Katsuhiko; TAKEUCHI Yoshiki; KUSAKA Takashi; ITOH Susumu
     
    Wistar male rats were separated from their mothers for 3 hours each day between PND10 and 15 (MD group). Nurotrophin ligand and receptor expressions were analyzed. The expression of BDNF/TrkB in MD rats was enhanced in both mRNA and protein levels. In contrast, no significant difference in NGF/TrkA expression level was observed between these groups. On the other hand, OMgp expression was elevated in MD animals. Abnormal fluctuations in those trophic factors cause organic changes, and ultimately lead to functional disturbance.
  • Effects of endocrine disruptor on reproductive function and epigenetic regulation
    Japan Society for the Promotion of Science：Grants-in-Aid for Scientific Research
    Date (from‐to) : 2007 -2008 
    Author : WARITA Katsuhiko; HOSHI Nobuhiko; TAKEUCHI Yoshiki; MIKI Takanori; TABUCHI Yoshiaki; SUGAWARA Teruo; MATSUMOTO Yoshiki; TANIDA Takashi; MITSUHASHI Tomoko
     
    本研究では, 器官形成期におけるエストロゲン様化学物質の曝露が, 如何にして不可逆的な生殖障害を引き起こすのか, そのメカニズムの一端を解明することを試みた. 本研究により, 視床下部-下垂体-性腺軸一連の機能障害メカニズムにおいては, より中枢側の責任が大きいこと, また, 精巣ライディッヒ細胞における側鎖切断酵素P450scc遺伝子は, ヒストン脱アセチル化を引き起こすことにより遺伝子発現が低下し, アンドロゲン産生能の低下に至ることが推察された. 興味深いことに, 天然エストロゲンではP450scc遺伝子のヒストン脱アセチル化が引き起こされず, エストロゲン様内分泌攪乱物質と天然エストロゲンでは, ヒストン修飾のレベルで作用機序が異なることが示された.
  • Developmental changes in cerebral oxygen metabolism during neonatal period
    Japan Society for the Promotion of Science：Grants-in-Aid for Scientific Research
    Date (from‐to) : 2007 -2008 
    Author : KUSAKA Takashi; UENO Masaki; MIKI Takanori; NAMBA Masanori; NISHIDA Tomoko; IWASE Takashi; OKUBO Kensuke; KUBOI Toru
     
    新生児期の脳酸素代謝の特徴は、早産児は正期産児と比較し脳血液量、酸素代謝量が低く、在胎週数と共に増加する。しかし低酸素虚血性脳症や脳室内出血を来たす病態では、出後早期には脳の循環自動調節能が破綻し、脳血液量が増加し、酸素消費量も低下する事が示唆された。特に低酸素虚血性脳症のエネルギー代謝障害時には、軽症例では酸素消費量が減少するが、重症例では脳血流上昇後に脳浮腫が進行し虚血が進行すると考えられた。
  • Molecular biological approach to explore the cause of brain damage after prenatal ethanol exposure
    Japan Society for the Promotion of Science：Grants-in-Aid for Scientific Research
    Date (from‐to) : 2004 -2006 
    Author : FUKUI Yoshihiro; SAWADA Kazuhiko; SAKATA Hiromi; IMAGAWA Tomohiro; MIKI Takanori
     
    To identify genes and factors which are responsible for brain alterations after prenatal ethanol exposure, we examined expression of genes and determination of neurotransmitters or neurotrophic factors in ethanol-exposed rat brains. Immunohistochemical study using anti-5-HT antibody revealed that prenatal ethanol exposure resulted in a reduction in the number and defects of migration of serotonin-positive neurons in the dorsal and medial raphe nuclei of rat fetuses. In ethanol-exposed rat fetuses, amounts of both 5-HT and its metabolite (5-HIAA) were decreased as well. RT-PCR analysis revealed a reduction of sonic hedgehog (Shh) expression in the brains of ethanol-exposed rat fetuses. Because Shh is related to the fate of 5-HT neuron, we concluded that prenatal exposure to ethanol impairs the development of 5-HT neurons, and this might have resulted in the reduction of Shh expressions. Therefore, the reduction of 5-HT neurons seen in the raphe persisted into adulthood, and prenatal ethanol-exposed rats showed anxiety-like behavior. In ethanol-exposed rat cerebellum, BDNF mRNA was decreased but NGF and its receptor (Trk A) mRNA expression were increased. Also, reduction of OMgp and GDNF mRNA expression was observed in the hippocampus and the septum nucleus, respectively. Thus, it is established that ethanol can affect expression of certain neurotrophic factors and their receptors. We monitored the intracellular calcium concentration after glutamate stimulation in ethanol-treated astrocytes derived from the hippocampus of neonatal rat (Day 3), and revealed that the glutamate-reactive cell number was decreased compared to non-ethanol-treated astrocytes. Since the calcium concentration in astrocytes might be related to maturation of synapse, the result suggests that ethanol may affect development of the neural circuit via a calcium signaling cascade in astrocytes.
  • Involvement of reward system in acquisition and maintenance of alcohol independence.
    Japan Society for the Promotion of Science：Grants-in-Aid for Scientific Research
    Date (from‐to) : 2002 -2005 
    Author : TAKEUCHI Yoshiki; MIKI Takanori; YOKOYAMA Toshihumi; WATANABE Takemi
     
    Wistar rats were exposed to a relatively high daily dose of ethanol at postnatal day 10-15 by placing them for 3 h/day in a chamber containing ethanol vapor. These ethanol-treated rats (blood concentration : approximately 430 mg/dl) were found to have slightly but significantly fewer pyramidal cell neurons. The present observations indicate that pyramidal cells in the hippocampus may be vulnerable to a relatively high dose of ethanol exposure during this short period of early postnatal life. In additional experiment, the effects on the frontal cortex and hilar neuron numbers, observed as a result of such short periods of ethanol treatment, appeared to be transitory. With respect to colocalization of taurine and glial fibrillary acidic protein immunoreactivity in mouse hippocampus, induced by short-term ethanol exposure, quantitative analysis revealed that the merged area in ethanol-treated mice was twice that (71.6% vs. 35.8%) of control mice. Since taurine is involved in various neuroprotective functions, the present observations suggest that the expression of taurine immunoreactivity in reactive astrocytes after ethanol exposure might play an important role in neuroprotective processes. Additional analysis was made to investigate the effects on expression of neurotrophic factors. The expression levels of brain- and glia-derived neurotrophic factors (BDNF and GDNF) in the hippocampus were analyzed by RT-PCR analysis. This study revealed that chronic ethanol consumption does not result in significant changes in expression levels of BDNF and GDNF mRNAs. However, it was characteristic in myelin-associated glycoprotein that expression levels of oligodendrocyte myelin glycoprotein (OMgp) mRNA were increased. This appears to be consistent with the neuropathological changes in alcoholics, which have relationship with demyelination.
  • Effects of Maternal Deprivation on Brain Development in Rats
    Japan Society for the Promotion of Science：Grants-in-Aid for Scientific Research
    Date (from‐to) : 2002 -2004 
    Author : MIKI Takanori; YOKOYAMA Toshihumi; KUSAKA Takashi; WATANABE Takemi; ITHO Susumu; TAKEUCHI Yoshiki
     
    We have established the experimental animal (rat) model of maternal deprivation (MD) in human by separating pups from mothers for 3 h/day during postnatal days (PND) 10-15. Effects on body and pituitary weights The body weight of MD rats showed no significant difference at PND16, 20 and 30, whereas at PND60 it was high compared to age-matched control. On the other hand, pituitary weight was low at any time points of observation. Effects on brain weight The brain weight of MD rats showed no significant difference at any time points of observation. Corticosterone concentration During the separation period, blood corticosterone concentration of MD rats was significantly higher (51ng/dL) than that of controls (32ng/dL). After separation, it was declined to 40 ng/dL. Stereological analysis (physical disector) There were no significant difference in total number of pyramidal cells in CA1-3 regions, and granule and hilus neurons in the dentate gyrus of MD rats compared to controls. Additionally, numerical density and the regional volume of MD rats showed no differences compared to controls. Real-time PCR analysis of BDNF mRNA MD rats had less BDNF mRNA in the hippocampus at PND16, whereas at PND 30 and 60 they had much BDNF mRNA than age-matched control animals.
  • Effects on neuronal formation of the hippocampus in developmental abnormalities
    Japan Society for the Promotion of Science：Grants-in-Aid for Scientific Research
    Date (from‐to) : 1998 -2001 
    Author : TAKEUCHI Yoshiki; NAKAMURA Kazuhiko; IWAHASHI Kazuhiko; MIKI Takanori; ITOH Masahiro
     
    The effects of prenatal X - irradiation and ethanol exposure on neuronal development of the hippocampus were investigated in the present study. At six weeks of age in the rats the laminal structure of the hippocampus was deranged with exposure of 0.6 Gy or more. Pyramidal cells in the CA3 region were more susceptible than those in the CA1. Abberant mossy fiber terminals were observed in the stratum onence of the CA3 region with exposure of 0.3 Gy or more. On the other hand, exposing neonate rats to high dose of ethanol affected Purkinje cell numbers in the cerebellum. The period between 4 and 9 day of age was an extremely vulnerable period during which the Purkinje cells were particularly susceptible to the effects of a high dose of ethanol. However, a similar level and duration of ethanol exposure commencing after 10 day of age had no significant effect on the cell numbers. In contrast to granule and pyramidal cells numbers, neurons in the hilus region were indicated to be particularly vulnerable to the effects of a high dose of ethanol exposure during early postnatal life. In addition, short-term ethanol exposure to mice led to a decrease in the total number of calbindin-IR neurons and an increase in GFAP-IR glia cells. The disruption of calbundin and GFAP could affect neuronal - astroghal interaction, resulting in disturbance of behaviors dependent on the hippocampus.
  • ステレオロジーによる組織定量解析
  • 周生期における環境有害因子・ストレスによる脳発達障害メカニズムに関する研究
  • Histological analysis by stereology
  • Brain development and extrinsic insults

Other link

researchmap


Copyright © MEDIA FUSION Co.,Ltd. All rights reserved.