Synergistic effects of COA-Cl, ethanol and/or nicotine on dopamine depletion in the MPTP mouse model of PD
日本学術振興会:科学研究費助成事業
研究期間 : 2023年04月 -2026年03月
代表者 : モストファ ジャーマル
Previously, local perfusion of COA-Cl (0.05-1.0 mM) produced a significant and dose-dependent increase in dopamine (DA) levels, with the highest dose of 1.0 mM COA-Cl producing an approximately 5-fold increase in DA. Additionally, we showed that COA-Cl significantly enhanced DA release by 3.0 to 5.0-fold, accompanied by an increase in tyrosine hydroxylase at Ser31 and Ser40.
Here, we utilized 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced mouse models of Parkinson’s disease to explore whether COA-Cl could reverse the loss of DA caused by MPTP in the dorsal striatum. Preliminary data revealed that COA-Cl restored DA levels, suggesting its potential restorative effects on DA depletion in mouse striatum.