Effects of Deferoxamine on intracerebral hemorrhage-induced brain injury
Japan Society for the Promotion of Science:Grants-in-Aid for Scientific Research
Date (from‐to) : 2017/04 -2020/03
Author : Okauchi Masanobu
We investigated whether Deferoxamine (DFX) is effective on brain injury after ICH in SD rats.Autologous whole blood (100 μL) was injected into the right basal ganglia. We explored optimal DFX dose, potential therapeutic time windows, and optimal therapeutic durations. DFX can reduce ICH-induced brain injury in rats and that a dose 50mg/kg is the optimal dose of DFX. DFX administration, when begun within 12 hours after ICH, reduced brain edema. DFX treatment started 2 hours after ICH and administrated for 7 days attenuated ICH-induced brain atrophy and neurological deficits. DFX attenuated brain atrophy and neurological deficits when begun within 24 hours and administrated for 7 days.