Displacement of bilirubin from albumin by drugs
Japan Society for the Promotion of Science:Grants-in-Aid for Scientific Research
Date (from‐to) : 2016/04 -2019/03
Author : Okada Hitoshi
We selected 113 drugs used in the neonatal intensive care unit (NICU) in Japan, and investigated their bilirubin displacement effect from albumin. Only two drugs were listed in the package insert. Among the remaining 111 drugs, 24 drugs whose displacement effect has not been clarified from the literature, textbook, chemical structure and ratio of albumin binding were selected. According to KD (binding constant to bilirubin binding site of drug) by bilirubin oxidase peroxidase method, bilirubin displacement effect was not shown in the range of clinically used drug concentration. However, further studies are needed to evaluate additives and metabolites.