Effect of regular physical activity on overweight, oxidative stress, and antioxidant biomarkers
Japan Society for the Promotion of Science:Grants-in-Aid for Scientific Research
Date (from‐to) : 2011 -2013
Author : SAKANO Noriko; MIYATAKE Nobuyuki; HIRAO Tomohiro; OGINO Keiki
Serum IL-18 levels were higher in Japanese subjects with obesity than in those without. In addition, serum IL-18 levels were significantly and positively correlated with urinary 8-hydroxy-2'-deoxyguanosine (8-OHdG), which is a biomarker of oxidative damage induced by DNA, and negatively correlated with plasma SOD, which is an antioxidant.
Serum MCP-4 levels in subjects with obesity were also higher than those without. However, those were negatively correlated with oxidative stress marker. Therefore, while the higher levels of MCP-4 linked to visceral fat accumulation; MCP-4 may reduce oxidant stress through increasing antioxidant potential.