Examination of usefulness of miRNA as biomarker in brain trauma
Japan Society for the Promotion of Science:Grants-in-Aid for Scientific Research
Date (from‐to) : 2014/04 -2017/03
Author : Hatakeyama Tetsuhiro
We investigated that miRNA expression patterns and levels in plasma and cerebrospinal fluid are different from those of non-brain trauma patients and examined the possibility that their expression may be a prognostic factor or a biomarker. Plasma of head injured patients was measured with microRNA microarray, and as a result, there were three types with high absolute expression amount, miR-451, miR 223 and miR-16. Regarding the changes in microRNA in the cerebrospinal fluid, the expression levels of miR-451a, miR-21, and miR-16 were three types. MiR-451 was expressed most in all microRNAs. Further studies are needed to determine whether these microRNAs will become biomarkers of brain trauma from now on.